JP2018537421A5 - - Google Patents
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- JP2018537421A5 JP2018537421A5 JP2018520394A JP2018520394A JP2018537421A5 JP 2018537421 A5 JP2018537421 A5 JP 2018537421A5 JP 2018520394 A JP2018520394 A JP 2018520394A JP 2018520394 A JP2018520394 A JP 2018520394A JP 2018537421 A5 JP2018537421 A5 JP 2018537421A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr3
- cdr1
- cdr2
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245188P | 2015-10-22 | 2015-10-22 | |
| US62/245,188 | 2015-10-22 | ||
| US201662276352P | 2016-01-08 | 2016-01-08 | |
| US62/276,352 | 2016-01-08 | ||
| PCT/EP2016/075558 WO2017068186A1 (en) | 2015-10-22 | 2016-10-24 | Gitr agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537421A JP2018537421A (ja) | 2018-12-20 |
| JP2018537421A5 true JP2018537421A5 (https=) | 2019-11-07 |
| JP7084870B2 JP7084870B2 (ja) | 2022-06-15 |
Family
ID=57211500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520394A Active JP7084870B2 (ja) | 2015-10-22 | 2016-10-24 | Ｇｉｔｒアゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11059899B1 (https=) |
| EP (1) | EP3365371B1 (https=) |
| JP (1) | JP7084870B2 (https=) |
| CN (1) | CN108473579B (https=) |
| AU (1) | AU2016341403B2 (https=) |
| CA (1) | CA3002711A1 (https=) |
| ES (1) | ES3057922T3 (https=) |
| WO (1) | WO2017068186A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016297249B2 (en) * | 2015-07-23 | 2020-11-12 | Inhibrx Biosciences, Inc. | Multivalent and multispecific GITR-binding fusion proteins |
| EP3365371B1 (en) | 2015-10-22 | 2025-10-08 | Ablynx NV | Gitr agonists |
| TWI781934B (zh) | 2016-05-27 | 2022-11-01 | 美商艾吉納斯公司 | 抗-tim-3抗體及其使用方法 |
| CN109641967A (zh) | 2016-07-01 | 2019-04-16 | 戊瑞治疗有限公司 | 用GITR激动剂和CpG的组合的抗肿瘤疗法 |
| SG10201912663YA (en) | 2016-10-11 | 2020-03-30 | Agenus Inc | Anti-lag-3 antibodies and methods of use thereof |
| CN110869392A (zh) | 2017-05-16 | 2020-03-06 | 百时美施贵宝公司 | 用抗gitr激动性抗体治疗癌症 |
| US20200131263A1 (en) | 2017-06-30 | 2020-04-30 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-gitr antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
| CN110357958A (zh) * | 2018-03-26 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 抗糖皮质激素诱导的肿瘤坏死因子受体(gitr)的小型化抗体、其聚合物及应用 |
| CN113150141B (zh) * | 2018-06-06 | 2022-02-18 | 暨南大学 | 一种抗重组人碱性成纤维细胞生长因子纳米抗体及其应用 |
| WO2020023553A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| RU2734432C1 (ru) | 2019-04-23 | 2020-10-16 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело, которое специфически связывается с GITR |
| JP7657797B2 (ja) | 2019-12-06 | 2025-04-07 | アブリンクス エン．ヴェー． | ＴＮＦαおよびＩＬ－２３を標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| MX2023003522A (es) * | 2020-09-25 | 2023-04-19 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l. |
| KR20230123497A (ko) * | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드 |
| CN112851811B (zh) * | 2021-01-28 | 2022-08-09 | 姜国胜 | 一种cd44v6纳米抗体及其作为白血病研究试剂的应用 |
| AU2022272117A1 (en) * | 2021-05-10 | 2024-01-04 | Medimabbio Inc. | Anti-gitr antibodies and uses thereof |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| KR20250034101A (ko) | 2022-07-01 | 2025-03-10 | 트랜스진 | 계면활성제-단백질-d 및 tnfsf의 구성원을 포함하는 융합 단백질 |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| JP2026506075A (ja) | 2023-02-17 | 2026-02-20 | アブリンクス エン．ヴェー． | 新生児型ｆｃ受容体に結合するポリペプチド |
| US20250270274A1 (en) * | 2024-02-26 | 2025-08-28 | Serpentide Inc. | Super long-lasting glp1 or glp1/gip analogue drug for type-2 diabetes and obesity |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200509143B (en) * | 2003-05-23 | 2007-03-28 | Wyeth Corp | GITR ligand and GITR ligand-related molecules and antibodies and uses thereof |
| AU2006230099B2 (en) * | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| CN101218257A (zh) * | 2005-03-25 | 2008-07-09 | 托勒克斯股份有限公司 | Gitr结合分子及其用途 |
| EP2473531A4 (en) * | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| SG10201912986PA (en) * | 2014-05-28 | 2020-02-27 | Agenus Inc | Anti-gitr antibodies and methods of use thereof |
| PT3151921T (pt) | 2014-06-06 | 2019-11-21 | Bristol Myers Squibb Co | Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos |
| CA2988115A1 (en) * | 2015-06-03 | 2016-12-08 | Bristol-Myers Squibb Company | Anti-gitr antibodies for cancer diagnostics |
| AU2016297249B2 (en) * | 2015-07-23 | 2020-11-12 | Inhibrx Biosciences, Inc. | Multivalent and multispecific GITR-binding fusion proteins |
| EP3365371B1 (en) | 2015-10-22 | 2025-10-08 | Ablynx NV | Gitr agonists |
-
2016
- 2016-10-24 EP EP16788484.0A patent/EP3365371B1/en active Active
- 2016-10-24 ES ES16788484T patent/ES3057922T3/es active Active
- 2016-10-24 JP JP2018520394A patent/JP7084870B2/ja active Active
- 2016-10-24 WO PCT/EP2016/075558 patent/WO2017068186A1/en not_active Ceased
- 2016-10-24 US US15/769,205 patent/US11059899B1/en active Active
- 2016-10-24 CN CN201680075294.1A patent/CN108473579B/zh active Active
- 2016-10-24 AU AU2016341403A patent/AU2016341403B2/en active Active
- 2016-10-24 CA CA3002711A patent/CA3002711A1/en active Pending
-
2021
- 2021-05-14 US US17/320,395 patent/US11919966B2/en active Active
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