JP2013519695A5 - - Google Patents
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- Publication number
- JP2013519695A5 JP2013519695A5 JP2012553213A JP2012553213A JP2013519695A5 JP 2013519695 A5 JP2013519695 A5 JP 2013519695A5 JP 2012553213 A JP2012553213 A JP 2012553213A JP 2012553213 A JP2012553213 A JP 2012553213A JP 2013519695 A5 JP2013519695 A5 JP 2013519695A5
- Authority
- JP
- Japan
- Prior art keywords
- myristoylamino
- propyl
- weight
- dimethyl
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 150000004682 monohydrates Chemical group 0.000 claims description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 239000008063 pharmaceutical solvent Substances 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 3
- 229960002537 betamethasone Drugs 0.000 claims description 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 208000035473 Communicable disease Diseases 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- 208000031888 Mycoses Diseases 0.000 claims 3
- JQQZCIIDNVIQKO-UHFFFAOYSA-N benzyl-dimethyl-[3-(tetradecanoylamino)propyl]azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC1=CC=CC=C1 JQQZCIIDNVIQKO-UHFFFAOYSA-N 0.000 claims 3
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 239000000604 anti-edema agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960001050 bupivacaine hydrochloride Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims 1
- 210000000883 ear external Anatomy 0.000 claims 1
- 210000003027 ear inner Anatomy 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 229960001347 fluocinolone acetonide Drugs 0.000 claims 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 229960002475 halometasone Drugs 0.000 claims 1
- GGXMRPUKBWXVHE-MIHLVHIWSA-N halometasone Chemical compound C1([C@@H](F)C2)=CC(=O)C(Cl)=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O GGXMRPUKBWXVHE-MIHLVHIWSA-N 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- IFYDWYVPVAMGRO-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]tetradecanamide Chemical compound CCCCCCCCCCCCCC(=O)NCCCN(C)C IFYDWYVPVAMGRO-UHFFFAOYSA-N 0.000 claims 1
- 229960005016 naphazoline Drugs 0.000 claims 1
- 210000001989 nasopharynx Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 239000003883 ointment base Substances 0.000 claims 1
- 229960001528 oxymetazoline Drugs 0.000 claims 1
- 229960001802 phenylephrine Drugs 0.000 claims 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims 1
- 229960000395 phenylpropanolamine Drugs 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229960003908 pseudoephedrine Drugs 0.000 claims 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims 1
- 229960000888 rimantadine Drugs 0.000 claims 1
- 231100000075 skin burn Toxicity 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- JCQBWMAWTUBARI-UHFFFAOYSA-N tert-butyl 3-ethenylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(C=C)C1 JCQBWMAWTUBARI-UHFFFAOYSA-N 0.000 claims 1
- 229960005294 triamcinolone Drugs 0.000 claims 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
- GOZBHBFUQHMKQB-UHFFFAOYSA-N trimecaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C GOZBHBFUQHMKQB-UHFFFAOYSA-N 0.000 claims 1
- 229950002569 trimecaine Drugs 0.000 claims 1
- 210000002229 urogenital system Anatomy 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
- 230000003253 viricidal effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229960000833 xylometazoline Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 7
- 150000001412 amines Chemical class 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- -1 benzyldimethyl 3 [myristoylamino] propyl Chemical group 0.000 description 3
- DKPKKUQZFWYBRB-UHFFFAOYSA-N n,n-dimethyl-3-(tetradecanoylamino)propan-1-amine oxide Chemical compound CCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)[O-] DKPKKUQZFWYBRB-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- PFOOSPWUSQDQIP-UHFFFAOYSA-N CCCCCCCCCCCCCC(=O)NCCC[NH2+]CCC1=CC=CC=C1.[Cl-] Chemical compound CCCCCCCCCCCCCC(=O)NCCC[NH2+]CCC1=CC=CC=C1.[Cl-] PFOOSPWUSQDQIP-UHFFFAOYSA-N 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241001428935 Human coronavirus OC43 Species 0.000 description 1
- 231100000230 acceptable toxicity Toxicity 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/001056 WO2011100994A1 (de) | 2010-02-19 | 2010-02-19 | Arzneimittel enthaltend myramistin |
| EPPCT/EP2010/001056 | 2010-02-19 | ||
| PCT/EP2011/000691 WO2011101113A1 (de) | 2010-02-19 | 2011-02-15 | Arzneimittel enthaltend myramistin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519695A JP2013519695A (ja) | 2013-05-30 |
| JP2013519695A5 true JP2013519695A5 (enExample) | 2014-10-02 |
| JP5746224B2 JP5746224B2 (ja) | 2015-07-08 |
Family
ID=42668884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553213A Active JP5746224B2 (ja) | 2010-02-19 | 2011-02-15 | ミラミスチンを含有する薬剤 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2536400B1 (enExample) |
| JP (1) | JP5746224B2 (enExample) |
| KR (1) | KR101744895B1 (enExample) |
| CN (1) | CN102869354B (enExample) |
| AU (1) | AU2011217530B2 (enExample) |
| BR (1) | BR112012020828B1 (enExample) |
| CY (1) | CY1115833T1 (enExample) |
| DK (1) | DK2536400T3 (enExample) |
| EA (1) | EA022283B1 (enExample) |
| ES (1) | ES2524379T3 (enExample) |
| GE (1) | GEP20135942B (enExample) |
| HR (1) | HRP20141173T1 (enExample) |
| IL (1) | IL221501A (enExample) |
| MD (1) | MD4411C1 (enExample) |
| MX (1) | MX2012009646A (enExample) |
| PL (1) | PL2536400T3 (enExample) |
| PT (1) | PT2536400E (enExample) |
| SI (1) | SI2536400T1 (enExample) |
| UA (1) | UA103968C2 (enExample) |
| WO (2) | WO2011100994A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014175757A1 (ru) * | 2013-04-22 | 2014-10-30 | Общество с ограниченной ответственностью "Нанобиотех" | Антисептический ветеринарный препарат и способы его использования |
| RU2542376C1 (ru) * | 2013-07-30 | 2015-02-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Средство для лечения гнойно-воспалительных процессов мягких тканей и слизистых оболочек |
| CN109456218A (zh) * | 2018-12-17 | 2019-03-12 | 山东诚汇双达药业有限公司 | 一种盐酸三甲卡因的生产方法 |
| GB202003240D0 (en) * | 2020-03-05 | 2020-04-22 | Ecosynth Nv | Antiviral treatment |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2459062A (en) | 1944-02-08 | 1949-01-11 | American Cyanamid Co | Quaternary ammonium compounds |
| US4093711A (en) * | 1976-08-13 | 1978-06-06 | Noxell Corporation | Oral hygiene |
| SU1796185A1 (ru) | 1990-06-23 | 1993-02-23 | Adolina P Rudko | Фунгицид 2 |
| AU2493792A (en) | 1991-07-10 | 1993-02-11 | Jury Semenovich Krivoshein | Pharmaceutical preparation |
| US5393491A (en) | 1993-09-22 | 1995-02-28 | Alcon Laboratories, Inc. | Use of amidoamines in ophthalmic compositions |
| UA30143C2 (uk) * | 1997-12-30 | 2001-11-15 | Юрій Семенович Кривошеін | Лікувальний препарат для профілактики та лікування інфекційних та запальних захворювань |
| RU2157214C2 (ru) | 1998-04-16 | 2000-10-10 | Государственный научный центр лекарственных средств | Противовоспалительное и антимикробное лекарственное средство для местного применения |
| RU2161961C1 (ru) * | 2000-03-17 | 2001-01-20 | Кривошеин Юрий Семенович | Лекарственный препарат |
| RU2177314C2 (ru) | 2000-03-22 | 2001-12-27 | Кривошеин Юрий Семенович | Состав с антисептическими, репаративными и болеутоляющими свойствами |
| RU2173142C1 (ru) | 2000-04-18 | 2001-09-10 | Кривошеин Юрий Семенович | Вагинальный контрацептив |
| RU2164135C1 (ru) * | 2000-04-27 | 2001-03-20 | Рудько Адолина Петровна | Глазной антисептик |
| RU2184534C2 (ru) | 2000-04-27 | 2002-07-10 | Рудько Адолина Петровна | Антисептические таблетки |
| RU2185156C2 (ru) | 2000-06-26 | 2002-07-20 | Рудько Адолина Петровна | Интраназальный антисептик |
| RU2185157C2 (ru) | 2000-06-26 | 2002-07-20 | Рудько Адолина Петровна | Средство для лечения ожоговых ран |
| RU2188005C2 (ru) | 2000-10-04 | 2002-08-27 | Рудько Адолина Петровна | Состав для антисептической обработки кожи рук и операционного поля |
| US20040033208A1 (en) | 2000-12-20 | 2004-02-19 | Cagle Gerald D. | Antifungal compositions containing an antibiotic and one or more amidoamines |
| WO2002049627A2 (en) * | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Antifungal compositions containing an antibiotic and one or more amidoamines |
| WO2002049633A2 (en) | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Use of amidoamines to treat or prevent acanthamoeba and fungal infections |
| RU2234313C1 (ru) | 2003-06-04 | 2004-08-20 | Кривошеин Юрий Семенович | Средство инактивации коронавирусов |
| RU2005100533A (ru) * | 2005-01-13 | 2006-06-20 | Открытое акционерное общество "Система-Венчур" (ОАО "Система-Венчур") (RU) | Средство для ускорения заживления раны |
| US20070264226A1 (en) | 2006-05-10 | 2007-11-15 | Karagoezian Hampar L | Synergistically enhanced disinfecting solutions |
| CN101562971A (zh) * | 2006-05-10 | 2009-10-21 | S.K.药物公司 | 协同增强的消毒溶液 |
| CN101100432B (zh) * | 2006-07-04 | 2010-08-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯甲基二甲基[3-(肉豆蔻酰胺基)丙基]氯化铵的合成方法 |
| DE102008039234A1 (de) * | 2007-10-29 | 2009-05-07 | Neudecker & Jolitz Gmbh & Co. | Motorisch betriebener Türöffner und Motor für einen Türöffner |
| UA30143U (en) | 2007-11-14 | 2008-02-11 | Валерий Михайлович Шарапов | Piezoelectric transformer |
| DE102008039254A1 (de) * | 2008-08-20 | 2010-02-25 | Megainpharm Gmbh | Arzneimittel |
-
2010
- 2010-02-19 WO PCT/EP2010/001056 patent/WO2011100994A1/de not_active Ceased
-
2011
- 2011-02-15 CN CN201180014472.7A patent/CN102869354B/zh active Active
- 2011-02-15 ES ES11708184.4T patent/ES2524379T3/es active Active
- 2011-02-15 BR BR112012020828-4A patent/BR112012020828B1/pt not_active IP Right Cessation
- 2011-02-15 PT PT117081844T patent/PT2536400E/pt unknown
- 2011-02-15 WO PCT/EP2011/000691 patent/WO2011101113A1/de not_active Ceased
- 2011-02-15 AU AU2011217530A patent/AU2011217530B2/en active Active
- 2011-02-15 DK DK11708184.4T patent/DK2536400T3/en active
- 2011-02-15 HR HRP20141173AT patent/HRP20141173T1/hr unknown
- 2011-02-15 JP JP2012553213A patent/JP5746224B2/ja active Active
- 2011-02-15 KR KR1020127024396A patent/KR101744895B1/ko active Active
- 2011-02-15 MX MX2012009646A patent/MX2012009646A/es active IP Right Grant
- 2011-02-15 MD MDA20120079A patent/MD4411C1/ro active IP Right Grant
- 2011-02-15 EP EP11708184.4A patent/EP2536400B1/de active Active
- 2011-02-15 SI SI201130337T patent/SI2536400T1/sl unknown
- 2011-02-15 GE GEAP201112831A patent/GEP20135942B/en unknown
- 2011-02-15 EA EA201201158A patent/EA022283B1/ru unknown
- 2011-02-15 UA UAA201210093A patent/UA103968C2/ru unknown
- 2011-02-15 PL PL11708184T patent/PL2536400T3/pl unknown
-
2012
- 2012-08-16 IL IL221501A patent/IL221501A/en active IP Right Grant
-
2014
- 2014-12-11 CY CY20141101033T patent/CY1115833T1/el unknown
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