JP2013517263A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013517263A5 JP2013517263A5 JP2012548497A JP2012548497A JP2013517263A5 JP 2013517263 A5 JP2013517263 A5 JP 2013517263A5 JP 2012548497 A JP2012548497 A JP 2012548497A JP 2012548497 A JP2012548497 A JP 2012548497A JP 2013517263 A5 JP2013517263 A5 JP 2013517263A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- formulation
- molecular weight
- skin
- hyaluronan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 82
- 229920002674 hyaluronan Polymers 0.000 claims 38
- 238000009472 formulation Methods 0.000 claims 29
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 20
- 229940099552 hyaluronan Drugs 0.000 claims 20
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 18
- 229960003160 hyaluronic acid Drugs 0.000 claims 18
- 229920000642 polymer Polymers 0.000 claims 15
- 230000002500 effect on skin Effects 0.000 claims 9
- 239000000945 filler Substances 0.000 claims 9
- 230000001815 facial effect Effects 0.000 claims 8
- 239000004615 ingredient Substances 0.000 claims 7
- 230000037303 wrinkles Effects 0.000 claims 7
- 239000003963 antioxidant agent Substances 0.000 claims 6
- 230000003078 antioxidant effect Effects 0.000 claims 6
- 235000006708 antioxidants Nutrition 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 210000002950 fibroblast Anatomy 0.000 claims 5
- 239000000017 hydrogel Substances 0.000 claims 5
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical group C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims 4
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims 4
- 239000000504 antifibrinolytic agent Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims 4
- 230000037390 scarring Effects 0.000 claims 4
- YRCWQPVGYLYSOX-UHFFFAOYSA-N synephrine Chemical compound CNCC(O)C1=CC=C(O)C=C1 YRCWQPVGYLYSOX-UHFFFAOYSA-N 0.000 claims 4
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims 4
- 229960000401 tranexamic acid Drugs 0.000 claims 4
- 239000005526 vasoconstrictor agent Substances 0.000 claims 4
- 206010047139 Vasoconstriction Diseases 0.000 claims 3
- 230000023597 hemostasis Effects 0.000 claims 3
- 239000002085 irritant Substances 0.000 claims 3
- 229960001802 phenylephrine Drugs 0.000 claims 3
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 230000025033 vasoconstriction Effects 0.000 claims 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 2
- 229930182837 (R)-adrenaline Natural products 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims 2
- 206010036790 Productive cough Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 102000008847 Serpin Human genes 0.000 claims 2
- 108050000761 Serpin Proteins 0.000 claims 2
- 229960002684 aminocaproic acid Drugs 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 230000001139 anti-pruritic effect Effects 0.000 claims 2
- 229940030225 antihemorrhagics Drugs 0.000 claims 2
- 239000003908 antipruritic agent Substances 0.000 claims 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229960005139 epinephrine Drugs 0.000 claims 2
- 239000003193 general anesthetic agent Substances 0.000 claims 2
- 229960004194 lidocaine Drugs 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 229960005192 methoxamine Drugs 0.000 claims 2
- 229960005016 naphazoline Drugs 0.000 claims 2
- 229960002748 norepinephrine Drugs 0.000 claims 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 2
- 229960003684 oxedrine Drugs 0.000 claims 2
- 229960001528 oxymetazoline Drugs 0.000 claims 2
- 229960003908 pseudoephedrine Drugs 0.000 claims 2
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims 2
- 239000003001 serine protease inhibitor Substances 0.000 claims 2
- -1 silazoline Chemical compound 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 230000037331 wrinkle reduction Effects 0.000 claims 2
- 229960000833 xylometazoline Drugs 0.000 claims 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims 1
- 208000037534 Progressive hemifacial atrophy Diseases 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 229910052785 arsenic Inorganic materials 0.000 claims 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims 1
- 230000003416 augmentation Effects 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 210000004709 eyebrow Anatomy 0.000 claims 1
- 208000002980 facial hemiatrophy Diseases 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037394 skin elasticity Effects 0.000 claims 1
- 230000036558 skin tension Effects 0.000 claims 1
- 230000036548 skin texture Effects 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/687,048 | 2010-01-13 | ||
| US12/687,048 US20110171286A1 (en) | 2010-01-13 | 2010-01-13 | Hyaluronic acid compositions for dermatological use |
| US12/714,377 US20110172180A1 (en) | 2010-01-13 | 2010-02-26 | Heat stable hyaluronic acid compositions for dermatological use |
| US12/714,377 | 2010-02-26 | ||
| US12/956,542 US20110171310A1 (en) | 2010-01-13 | 2010-11-30 | Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use |
| US12/956,542 | 2010-11-30 | ||
| PCT/IB2011/000052 WO2011086458A1 (en) | 2010-01-13 | 2011-01-13 | Stable hydrogel compositions including additives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015149880A Division JP5960894B2 (ja) | 2010-01-13 | 2015-07-29 | 添加物を含む安定ヒドロゲル組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517263A JP2013517263A (ja) | 2013-05-16 |
| JP2013517263A5 true JP2013517263A5 (OSRAM) | 2014-02-27 |
| JP5788412B2 JP5788412B2 (ja) | 2015-09-30 |
Family
ID=44041744
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548497A Expired - Fee Related JP5788412B2 (ja) | 2010-01-13 | 2011-01-13 | 添加物を含む安定ヒドロゲル組成物 |
| JP2015149880A Expired - Fee Related JP5960894B2 (ja) | 2010-01-13 | 2015-07-29 | 添加物を含む安定ヒドロゲル組成物 |
| JP2016124712A Expired - Fee Related JP6208293B2 (ja) | 2010-01-13 | 2016-06-23 | 添加物を含む安定ヒドロゲル組成物 |
| JP2017171396A Expired - Fee Related JP6509979B2 (ja) | 2010-01-13 | 2017-09-06 | 添加物を含む安定ヒドロゲル組成物 |
| JP2019071516A Ceased JP2019131586A (ja) | 2010-01-13 | 2019-04-03 | 添加物を含む安定ヒドロゲル組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015149880A Expired - Fee Related JP5960894B2 (ja) | 2010-01-13 | 2015-07-29 | 添加物を含む安定ヒドロゲル組成物 |
| JP2016124712A Expired - Fee Related JP6208293B2 (ja) | 2010-01-13 | 2016-06-23 | 添加物を含む安定ヒドロゲル組成物 |
| JP2017171396A Expired - Fee Related JP6509979B2 (ja) | 2010-01-13 | 2017-09-06 | 添加物を含む安定ヒドロゲル組成物 |
| JP2019071516A Ceased JP2019131586A (ja) | 2010-01-13 | 2019-04-03 | 添加物を含む安定ヒドロゲル組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110171310A1 (OSRAM) |
| EP (5) | EP2523701B1 (OSRAM) |
| JP (5) | JP5788412B2 (OSRAM) |
| KR (4) | KR101830591B1 (OSRAM) |
| AU (1) | AU2011206389B2 (OSRAM) |
| CA (2) | CA2786968C (OSRAM) |
| ES (4) | ES2716396T3 (OSRAM) |
| PT (1) | PT2523701T (OSRAM) |
| WO (1) | WO2011086458A1 (OSRAM) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228027B2 (en) | 2008-09-02 | 2016-01-05 | Allergan Holdings France S.A.S. | Threads of Hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof |
| US9050246B2 (en) * | 2009-05-29 | 2015-06-09 | Galderma Research & Development | Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection |
| US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| CA2794254C (en) | 2010-03-22 | 2018-09-04 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
| US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| EP3682911A1 (en) * | 2011-01-13 | 2020-07-22 | Allergan, Inc. | Stable hydrogel compositions including additives |
| EP2484387A1 (en) * | 2011-02-03 | 2012-08-08 | Q-Med AB | Hyaluronic acid composition |
| AU2012262047A1 (en) | 2011-06-03 | 2014-01-16 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| US20130101547A1 (en) | 2011-10-19 | 2013-04-25 | Allergan, Inc. | Thermoresponsive compositions for dermatological use and methods thereof |
| US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| FR2991876B1 (fr) | 2012-06-13 | 2014-11-21 | Vivacy Lab | Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
| FR2994846B1 (fr) * | 2012-08-29 | 2014-12-26 | Vivacy Lab | Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium |
| US20140276354A1 (en) * | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| BE1022012B1 (fr) * | 2013-04-26 | 2016-02-04 | Auriga International | Gel stable d'acide hyaluronique et d'une forme libre de vitamine c et/ou de l'un de ses sels |
| US9011934B2 (en) | 2013-06-14 | 2015-04-21 | SatisPharma, LLC | Multi-purpose anti-itch treatment |
| KR20210108505A (ko) | 2013-07-03 | 2021-09-02 | 광동 클록스 바이오메디컬 그룹 씨오., 엘티디 | 상처를 치료하기 위한 발색단과 겔화제를 포함하는 생체광자성 조성물 |
| ES2933549T3 (es) | 2013-07-10 | 2023-02-10 | Matrix Biology Inst | Composiciones de hialuronano con alta elasticidad y usos de las mismas |
| US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
| KR101459070B1 (ko) * | 2013-12-09 | 2014-11-17 | (주) 뉴메딕 | 지속성을 갖는 히알루론산 겔 조성물 |
| WO2015149177A1 (en) | 2014-04-01 | 2015-10-08 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| KR102232928B1 (ko) * | 2014-08-12 | 2021-03-25 | 주식회사 엘지생활건강 | 시네프린 또는 이의 약학적으로 허용가능한 염을 포함하는 피부 미백, 탄력, 주름개선, 또는 보습용 화장료 또는 약학 조성물 |
| EP3620184A1 (en) * | 2014-09-30 | 2020-03-11 | Allergan Industrie, SAS | Stable hydrogel compositions including additives |
| US9452178B1 (en) | 2014-10-22 | 2016-09-27 | SatisPharma, LLC | Acne formulations, treatments, and pressure sensitive patches for delivery of acne formulations |
| AU2015337786B2 (en) | 2014-10-31 | 2020-03-26 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| KR102759640B1 (ko) | 2015-02-13 | 2025-01-23 | 알러간 인더스트리 에스에이에스 | 턱과 같은 얼굴 이목구비를 조각, 확대 또는 교정하기 위한 임플란트 |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| GB201508024D0 (en) * | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic compositions |
| FR3036035B1 (fr) * | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
| CN108135926A (zh) * | 2015-09-24 | 2018-06-08 | 基质生物研究所 | 高弹性透明质酸组合物及其使用方法 |
| FR3063649B1 (fr) * | 2017-03-07 | 2021-05-21 | Laboratoire De Rhumatologie Appliquee | Nouvelle solution visco-elastique et son utilisation en rhumatologie |
| CN110678166B (zh) * | 2017-04-04 | 2024-01-09 | 抗纤溶酶科技有限责任公司 | 增强非手术医学治疗的方法 |
| KR102202188B1 (ko) * | 2017-07-26 | 2021-01-13 | 주식회사 파이안바이오테크놀로지 | 고분자 히알루론산의 체내 지속성 향상용 조성물 및 이를 포함하는 주사용 피부 필러 조성물 |
| RU2020140481A (ru) * | 2017-09-12 | 2021-02-12 | Шилпа Медикеа Лимитед | Спрей на основе транексамовой кислоты для артропластики коленного сустава |
| ES2960617T3 (es) | 2017-10-19 | 2024-03-05 | Lifecell Corp | Productos de matriz de tejido acelular fluida y métodos de producción |
| US11246994B2 (en) * | 2017-10-19 | 2022-02-15 | Lifecell Corporation | Methods for introduction of flowable acellular tissue matrix products into a hand |
| KR102008667B1 (ko) | 2017-11-02 | 2019-08-08 | 주식회사 엑소코바이오 | 안정화된 엑소좀의 필러 조성물 |
| KR20190051434A (ko) | 2017-11-07 | 2019-05-15 | 주식회사 엑소코바이오 | 신규한 히알루론산 기반의 필러 조성물 및 이의 응용 |
| CA3086428A1 (en) | 2017-12-22 | 2019-06-27 | Nestle Skin Health Sa | Injectable gel product |
| CN110721341A (zh) * | 2018-07-17 | 2020-01-24 | 上海美白臻生物科技有限公司 | 一种长效型玻尿酸制备工艺 |
| KR20200046649A (ko) | 2018-10-25 | 2020-05-07 | (주)뉴크레이티브랩 | 혼합상 히알루론산 제조방법 |
| KR102187439B1 (ko) * | 2019-01-30 | 2020-12-07 | 주식회사 라파스 | 마이크로니들 패취를 이용한 최소 침습적 피부 생체 검사 방법 |
| US12414917B2 (en) | 2019-09-13 | 2025-09-16 | University Of Utah Research Foundation | Opioid independent surgical anesthetic |
| EP4027988A4 (en) * | 2019-09-13 | 2023-09-13 | University of Utah Research Foundation | OPIOID-INDEPENDENT SURGICAL ANESTHETIC |
| NL2024060B1 (en) * | 2019-10-18 | 2021-06-22 | Biomed Elements B V | Dermal filler composition |
| IT201900024208A1 (it) * | 2019-12-17 | 2021-06-17 | Altergon Sa | Miscele iniettabili di acido ialuronico per uso in dermoestetica |
| US11058640B1 (en) | 2020-04-07 | 2021-07-13 | Amc Group, Llc | Hyaluronate compositions and soft tissue fillers |
| FR3111903B1 (fr) | 2020-06-24 | 2022-12-02 | Lab Vivacy | Procede d’incorporation de composes organiques en solution au sein d’un hydrogel |
| WO2021261967A1 (ko) | 2020-06-26 | 2021-12-30 | 주식회사 엘지에너지솔루션 | 리튬이차전지용 세퍼레이터 및 이를 포함하는 리튬이차전지 |
| BR112023002562A2 (pt) * | 2020-08-10 | 2023-03-14 | Gel4Med Inc | Hidrogéis de peptídeo anfifílico de automontagem |
| US20250281676A1 (en) * | 2020-08-10 | 2025-09-11 | Gel4Med, Inc. | Delivery of cells and tissues with self-assembling peptide hydrogel materials |
| JP2024519426A (ja) * | 2020-09-29 | 2024-05-14 | ジロパ・インコーポレイテッド | 疼痛の緩和及び麻痺のための組成物及び方法 |
| WO2022149924A1 (ko) * | 2021-01-07 | 2022-07-14 | 주식회사 엘지화학 | 가교제 및 폴리올을 사용하여 가교된 가교 히알루론산 하이드로겔 및 이를 포함하는 필러 |
| KR102385695B1 (ko) * | 2021-04-15 | 2022-04-12 | 남기준 | 세미-아이피엔 구조를 이루는 연조직 수복 및 확대를 위한 신규한 히알루론-복합 아미노 하이드로 겔 조성물 및 이의 용도 |
| EP4326284A4 (en) * | 2021-04-20 | 2025-03-19 | VSY Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Injectable hyaluronic acid formulations for use in intraarticular, intradermal and ophthalmic applications |
| KR102640893B1 (ko) * | 2021-11-12 | 2024-02-27 | 주식회사 유영제약 | 히알루론산 가교물을 포함하는 조성물의 제조방법 |
| EP4473021A1 (en) | 2022-02-01 | 2024-12-11 | Galderma Holding SA | Methods of producing crosslinked hyaluronic acid hydrogels |
| KR102527411B1 (ko) * | 2022-02-08 | 2023-04-28 | 영남이공대학교 산학협력단 | 습윤 밴드용 조성물, 상기 습윤밴드 및 이의 제조방법 |
| WO2025029805A2 (en) * | 2023-08-03 | 2025-02-06 | Pmidg, Llc | Hemostatic compositions and methods |
| WO2025035070A1 (en) * | 2023-08-09 | 2025-02-13 | Debut Biotechnology, Inc. | Formulations of eriodictyol |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4838158B1 (OSRAM) * | 1970-10-05 | 1973-11-15 | ||
| EP0398484B1 (en) * | 1989-05-19 | 1995-05-31 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Alpha-glycosyl-L-ascorbic acid, and its preparation and uses |
| JP2832848B2 (ja) * | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途 |
| IT1260154B (it) * | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
| IT1277707B1 (it) * | 1995-12-22 | 1997-11-11 | Chemedica Sa | Formulazione oftalmica a base di ialuronato di sodio per uso nella chirurgia oculare |
| US6653462B2 (en) * | 1998-05-29 | 2003-11-25 | Applera Corporation | Nucleotide compounds including a rigid linker |
| FR2780730B1 (fr) * | 1998-07-01 | 2000-10-13 | Corneal Ind | Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique |
| JP2001192336A (ja) * | 2000-01-11 | 2001-07-17 | Hironori Yamamoto | 高粘性物質を用いた内視鏡的粘膜切除術 |
| FR2811996B1 (fr) * | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
| WO2004073759A1 (en) | 2003-02-19 | 2004-09-02 | Aventis Pharmaceuticals Holdings Inc. | Composition and method for intradermal soft tissue augmentation |
| FR2861734B1 (fr) * | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| AU2003901834A0 (en) * | 2003-04-17 | 2003-05-01 | Clearcoll Pty Ltd | Cross-linked polysaccharide compositions |
| US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
| US8124120B2 (en) * | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
| WO2005112888A2 (en) * | 2004-05-20 | 2005-12-01 | Mentor Corporation | Methods for making injectable polymer hydrogels |
| EP1781305A2 (en) * | 2004-08-13 | 2007-05-09 | Angiotech International Ag | Compositions and methods using hyaluronic acid and hyaluronidase inhibitors |
| FR2878444B1 (fr) | 2004-11-30 | 2008-04-25 | Corneal Ind Soc Par Actions Si | Solutions viscoelastiques renfermant du hyaluronate de sodiu et de l'hydroxypropylmethylcellulose, preparation et utilisations |
| FR2894827B1 (fr) * | 2005-12-21 | 2010-10-29 | Galderma Res & Dev | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation,et leurs utilisations |
| FR2909560B1 (fr) * | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| WO2008098019A2 (en) * | 2007-02-05 | 2008-08-14 | Carbylan Biosurgery, Inc. | Polymer formulations for delivery of bioactive agents |
| AU2008256864A1 (en) * | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Coated hyaluronic acid particles |
| US8318695B2 (en) * | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| US8697044B2 (en) * | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
| US20090143348A1 (en) * | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
| US8394782B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US9161970B2 (en) * | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
| WO2009082354A1 (en) * | 2007-12-21 | 2009-07-02 | Encecor Ab | Cross-linked hydrogel containing an active substance |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| FR2938187B1 (fr) * | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
| JP2010202522A (ja) * | 2009-02-27 | 2010-09-16 | Shiseido Co Ltd | 耐塩性増粘剤及びそれを配合した化粧料 |
| US9050246B2 (en) * | 2009-05-29 | 2015-06-09 | Galderma Research & Development | Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection |
| EP2484387A1 (en) * | 2011-02-03 | 2012-08-08 | Q-Med AB | Hyaluronic acid composition |
-
2010
- 2010-11-30 US US12/956,542 patent/US20110171310A1/en not_active Abandoned
-
2011
- 2011-01-13 EP EP11709184.3A patent/EP2523701B1/en active Active
- 2011-01-13 WO PCT/IB2011/000052 patent/WO2011086458A1/en not_active Ceased
- 2011-01-13 CA CA2786968A patent/CA2786968C/en active Active
- 2011-01-13 PT PT117091843T patent/PT2523701T/pt unknown
- 2011-01-13 CA CA2905371A patent/CA2905371C/en active Active
- 2011-01-13 EP EP18206974.0A patent/EP3511028B1/en active Active
- 2011-01-13 ES ES16191450T patent/ES2716396T3/es active Active
- 2011-01-13 KR KR1020177022010A patent/KR101830591B1/ko not_active Expired - Fee Related
- 2011-01-13 ES ES11709184.3T patent/ES2614434T3/es active Active
- 2011-01-13 EP EP16191450.2A patent/EP3138585B1/en active Active
- 2011-01-13 JP JP2012548497A patent/JP5788412B2/ja not_active Expired - Fee Related
- 2011-01-13 KR KR1020127021058A patent/KR101768733B1/ko not_active Expired - Fee Related
- 2011-01-13 EP EP21166261.4A patent/EP3862029A1/en not_active Withdrawn
- 2011-01-13 AU AU2011206389A patent/AU2011206389B2/en not_active Ceased
- 2011-01-13 EP EP15178823.9A patent/EP2959923B1/en active Active
- 2011-01-13 ES ES15178823.9T patent/ES2613528T3/es active Active
-
2012
- 2012-01-13 KR KR1020207017671A patent/KR20200078672A/ko not_active Abandoned
- 2012-01-13 KR KR1020187025113A patent/KR102127060B1/ko not_active Expired - Fee Related
- 2012-01-13 ES ES12703634T patent/ES2805329T3/es active Active
-
2015
- 2015-07-29 JP JP2015149880A patent/JP5960894B2/ja not_active Expired - Fee Related
-
2016
- 2016-06-23 JP JP2016124712A patent/JP6208293B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-06 JP JP2017171396A patent/JP6509979B2/ja not_active Expired - Fee Related
-
2019
- 2019-04-03 JP JP2019071516A patent/JP2019131586A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013517263A5 (OSRAM) | ||
| CN103379892B (zh) | 减少皮肤中皮脂产生的方法 | |
| Zhang et al. | An injectable dipeptide–fullerene supramolecular hydrogel for photodynamic antibacterial therapy | |
| JP6521862B2 (ja) | 皮膚用の注入可能な滅菌組成物 | |
| CA2712527C (en) | Chitosan gel for dermatological use, production method and use of same | |
| CN102711729B (zh) | 局部用凝胶 | |
| JP2020179280A (ja) | 抗酸化物質を含む皮膚充填剤組成物 | |
| Chhillar et al. | Hyaluronic acid‐based self‐healing hydrogels for diabetic wound healing | |
| JP5897164B2 (ja) | 外用組成物 | |
| CN105392472A (zh) | 局部组合物及其使用方法 | |
| JP2004359629A (ja) | 粘膜適用液状組成物 | |
| JP2013544842A5 (OSRAM) | ||
| JP2016533792A (ja) | スプレー式熱傷包帯 | |
| Sheybanikashani et al. | A sustainable and self-healable silk fibroin nanocomposite with antibacterial and drug eluting properties for 3D printed wound dressings | |
| CN115850731B (zh) | 一种可注射多功能糖肽水凝胶、制备方法及其应用 | |
| RS53135B (sr) | Kompleks dobijen iz hijaluronske kiseline ili njene soli i smeša hondroitin sulfata | |
| Zhang et al. | An injectable sequential dual-crosslinking catechol-functionalized hyaluronic acid hydrogel for enhanced regeneration of full-thickness burn injury | |
| JP2011037849A (ja) | 消化性潰瘍及び十二指腸潰瘍の治療及び予防に使用されるヒアルロン酸混合物 | |
| DK2252260T3 (en) | METHOD FOR STABILIZING S-nitrosoglutathione AND COMPOSITION MANUFACTURED BY THE SAME | |
| KR20210020171A (ko) | 고농도 생물 발효 히알루론산 나트륨으로 구성된 국소성 중합체 기지 합성물 및 그 사용 | |
| CN104125964B (zh) | 部分解聚的糖胺聚糖银盐和金盐 | |
| JP2018048195A (ja) | ホメオパシー的療法的方法および組成物 | |
| KR20210096056A (ko) | 흉터 예방 또는 치료를 위한 국소용 약학적 조성물 | |
| CN110693860B (zh) | 一种含酮洛芬的凝胶贴膏及其制备方法 | |
| Lu et al. | pH-Responsive multifunctional drug-loaded covalent organic framework hydrogel dressing for enhanced bacteria-infected wound healing |