JP2013505265A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013505265A5 JP2013505265A5 JP2012529958A JP2012529958A JP2013505265A5 JP 2013505265 A5 JP2013505265 A5 JP 2013505265A5 JP 2012529958 A JP2012529958 A JP 2012529958A JP 2012529958 A JP2012529958 A JP 2012529958A JP 2013505265 A5 JP2013505265 A5 JP 2013505265A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cdcl
- nmr
- mhz
- procedure similar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
化合物Ｃ−６は、化合物Ｃ−１に関して例示されるものと同様の手順であるが、化合物３およびＣ−１ａのスルホン類似体を使用して得た。
１Ｈ ＮＭＲ（４００ ＭＨｚ，ＣＤＣｌ３）δ ７．９３（ｓ，１ Ｈ），７．８９（ｓ，１ Ｈ），７．３５−７．０１（ｍ，５ Ｈ），６．９３（ｄ，Ｊ＝２．８ Ｈｚ，，１ Ｈ），６．５８（ｄ，Ｊ＝２．８ Ｈｚ，１Ｈ），５．７９（ｂｓ，２ Ｈ），４．３０（ｓ，６ Ｈ），４．１１（ｄ，Ｊ＝７．０ Ｈｚ，６Ｈ），３．１０−２．８４（ｍ，３ Ｈ），２．７５（ｓ，３ Ｈ），２．５４（ｓ，６ Ｈ），１．３１−１．１５（ｍ，６ Ｈ）．
３１Ｐ ＮＭＲ（１６２ ＭＨｚ，ＣＤＣｌ３）δ ３．３９，３．３３．
１９Ｆ ＮＭＲ（３７６ ＭＨｚ，ＣＤＣｌ３）δ−１５２．４０
ＬＣ ＭＳ ｍ／ｚ ６５５．２４［Ｍ＋Ｈ＋］。
化合物６
１Ｈ ＮＭＲ（４００ ＭＨｚ，ＣＤＣｌ３）δ ７．９３（ｓ，１ Ｈ），７．８９（ｓ，１ Ｈ），７．３５−７．０１（ｍ，５ Ｈ），６．９３（ｄ，Ｊ＝２．８ Ｈｚ，，１ Ｈ），６．５８（ｄ，Ｊ＝２．８ Ｈｚ，１Ｈ），５．７９（ｂｓ，２ Ｈ），４．３０（ｓ，６ Ｈ），４．１１（ｄ，Ｊ＝７．０ Ｈｚ，６Ｈ），３．１０−２．８４（ｍ，３ Ｈ），２．７５（ｓ，３ Ｈ），２．５４（ｓ，６ Ｈ），１．３１−１．１５（ｍ，６ Ｈ）．
３１Ｐ ＮＭＲ（１６２ ＭＨｚ，ＣＤＣｌ３）δ ３．３９，３．３３．
１９Ｆ ＮＭＲ（３７６ ＭＨｚ，ＣＤＣｌ３）δ−１５２．４０
ＬＣ ＭＳ ｍ／ｚ ６５５．２４［Ｍ＋Ｈ＋］。
化合物６
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24429709P | 2009-09-21 | 2009-09-21 | |
| US61/244,297 | 2009-09-21 | ||
| PCT/US2010/049471 WO2011035231A1 (en) | 2009-09-21 | 2010-09-20 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098728A Division JP6033362B2 (ja) | 2009-09-21 | 2015-05-14 | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505265A JP2013505265A (ja) | 2013-02-14 |
| JP2013505265A5 true JP2013505265A5 (ja) | 2014-12-25 |
| JP5795766B2 JP5795766B2 (ja) | 2015-10-14 |
Family
ID=43031517
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012529958A Active JP5795766B2 (ja) | 2009-09-21 | 2010-09-20 | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 |
| JP2015098728A Active JP6033362B2 (ja) | 2009-09-21 | 2015-05-14 | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 |
| JP2016207475A Withdrawn JP2017075146A (ja) | 2009-09-21 | 2016-10-24 | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098728A Active JP6033362B2 (ja) | 2009-09-21 | 2015-05-14 | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 |
| JP2016207475A Withdrawn JP2017075146A (ja) | 2009-09-21 | 2016-10-24 | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 |
Country Status (32)
| Country | Link |
|---|---|
| EP (2) | EP3150608B1 (ja) |
| JP (3) | JP5795766B2 (ja) |
| KR (2) | KR20180006499A (ja) |
| CN (1) | CN102596958A (ja) |
| AP (1) | AP2012006189A0 (ja) |
| AU (4) | AU2010295373B2 (ja) |
| BR (3) | BR112012006261B1 (ja) |
| CA (1) | CA2773772C (ja) |
| CL (1) | CL2012000707A1 (ja) |
| CR (2) | CR20190103A (ja) |
| CY (1) | CY1118605T1 (ja) |
| DK (1) | DK2480552T3 (ja) |
| EA (1) | EA201200525A1 (ja) |
| EC (1) | ECSP12011817A (ja) |
| ES (2) | ES2730805T3 (ja) |
| HR (1) | HRP20170197T1 (ja) |
| HU (1) | HUE032252T2 (ja) |
| IL (2) | IL218599A (ja) |
| LT (1) | LT2480552T (ja) |
| ME (1) | ME02656B (ja) |
| MX (1) | MX352646B (ja) |
| NZ (1) | NZ599402A (ja) |
| PE (3) | PE20120995A1 (ja) |
| PL (1) | PL2480552T3 (ja) |
| PT (1) | PT2480552T (ja) |
| RS (1) | RS55699B1 (ja) |
| SG (1) | SG179194A1 (ja) |
| SI (1) | SI2480552T1 (ja) |
| SM (1) | SMT201700091B (ja) |
| UA (1) | UA110466C2 (ja) |
| WO (1) | WO2011035231A1 (ja) |
| ZA (1) | ZA201202175B (ja) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ588400A (en) | 2008-04-23 | 2012-08-31 | Gilead Sciences Inc | 1'-substituted carba-nucleoside analogs for antiviral treatment |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| PA8855801A1 (es) | 2008-12-23 | 2010-07-27 | Sintesis de nucleosidos de purina | |
| WO2010075517A2 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Nucleoside analogs |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| JP5767643B2 (ja) * | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | １’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
| RS55699B1 (sr) * | 2009-09-21 | 2017-07-31 | Gilead Sciences | 2' -fluoro supstituisani karba-nukleozidni analozi zaantiviralno lečenje |
| US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| US7973013B2 (en) * | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| ES2551944T3 (es) * | 2010-03-31 | 2015-11-24 | Gilead Pharmasset Llc | (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2H)-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato de isopropilo cristalino |
| TW201201815A (en) * | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| US9090642B2 (en) | 2010-07-19 | 2015-07-28 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| BR122020020745B8 (pt) | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
| TW201305185A (zh) * | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
| KR101879887B1 (ko) * | 2010-09-20 | 2018-07-18 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료용 2'-플루오로 치환된 카바-누클레오시드 유사체 |
| UA114075C2 (xx) | 2010-11-19 | 2017-04-25 | БАГАТОШАРОВА ТАБЛЕТКА, ЩО МІСТИТЬ РИЛПІВІРИН HCl, ЕМТРИЦИТАБІН І ТЕНОФОВІРУ ДИЗОПРОКСИЛФУМАРАТ | |
| CA2822037A1 (en) | 2010-12-20 | 2012-06-28 | Gilead Sciences, Inc. | Methods for treating hcv |
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| DE202012013074U1 (de) | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
| EP2768838A1 (en) | 2011-10-14 | 2014-08-27 | IDENIX Pharmaceuticals, Inc. | Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| US9481704B2 (en) | 2012-03-13 | 2016-11-01 | Gilead Sciences, Inc. | 2′-substituted carba-nucleoside analogs for antiviral treatment |
| EP2909209B1 (en) * | 2012-10-17 | 2022-08-03 | Merck Sharp & Dohme LLC | 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
| US9457039B2 (en) | 2012-10-17 | 2016-10-04 | Merck Sharp & Dohme Corp. | 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| CA2891125A1 (en) | 2012-11-19 | 2014-05-22 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
| CN104144682A (zh) | 2013-01-31 | 2014-11-12 | 吉利德法莫赛特有限责任公司 | 两个抗病毒化合物的联用制剂 |
| EP3010512B1 (en) | 2013-06-18 | 2017-12-27 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| WO2015095419A1 (en) * | 2013-12-18 | 2015-06-25 | Idenix Pharmaceuticals, Inc. | 4'-or nucleosides for the treatment of hcv |
| TWI678369B (zh) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| WO2016023522A2 (en) | 2014-08-15 | 2016-02-18 | Merck Sharp & Dohme Corp. | Substituted phosphoramidate compounds and uses thereof |
| TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | ２’－氯胺基嘧啶酮及嘧啶二酮核苷類 |
| TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| BR112017013858A2 (pt) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos |
| WO2016160646A1 (en) | 2015-04-02 | 2016-10-06 | Merck Sharp & Dohme Corp. | Process for making phosphoramidate protected nucleoside compounds |
| CN104945437B (zh) * | 2015-05-19 | 2017-03-01 | 广州诺威生物技术有限公司 | 一种嘧啶类新化合物 |
| LT3785717T (lt) | 2015-09-16 | 2022-04-11 | Gilead Sciences, Inc. | Coronaviridae infekcijų gydymo būdai |
| TWI740910B (zh) * | 2016-03-09 | 2021-10-01 | 美商艾洛斯生物製藥公司 | 非環抗病毒劑 |
| SG10202009423QA (en) | 2016-03-28 | 2020-11-27 | Incyte Corp | Pyrrolotriazine compounds as tam inhibitors |
| CN106083962B (zh) * | 2016-06-08 | 2018-12-18 | 成都倍特药业有限公司 | 一种具有环磷酰胺结构的化合物及其制备方法 |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| EP3484886B1 (en) * | 2016-07-14 | 2020-03-04 | Hoffmann-La Roche AG | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine and 6,7-dihydro-4h-triazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
| MA45925A (fr) * | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| ES2961460T3 (es) | 2017-03-14 | 2024-03-12 | Gilead Sciences Inc | Métodos para tratar las infecciones por coronavirus felinas |
| AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
| MX2020005392A (es) | 2017-12-07 | 2020-12-07 | Univ Emory | N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos. |
| CN111788204B (zh) | 2018-02-26 | 2023-05-05 | 吉利德科学公司 | 作为hbv复制抑制剂的取代吡咯嗪化合物 |
| CA3129178A1 (en) * | 2019-02-07 | 2020-08-13 | Beigene, Ltd. | Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as tlr7 agonist |
| CN114127082A (zh) | 2019-05-09 | 2022-03-01 | 阿里戈斯治疗公司 | 作为sting调节剂的经修饰的环状二核苷化合物 |
| CA3163424A1 (en) | 2020-01-27 | 2021-08-05 | Gilead Sciences, Inc. | Methods for treating sars cov-2 infections |
| JP7429799B2 (ja) | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス化合物 |
| TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TW202315607A (zh) | 2020-02-18 | 2023-04-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| JP2023516087A (ja) | 2020-03-12 | 2023-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノヌクレオシドを調製する方法 |
| AU2021251689A1 (en) | 2020-04-06 | 2022-11-17 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| US11975012B2 (en) | 2020-05-29 | 2024-05-07 | Gilead Sciences, Inc. | Remdesivir treatment methods |
| WO2021262826A2 (en) | 2020-06-24 | 2021-12-30 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
| TW202228722A (zh) | 2020-08-27 | 2022-08-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
| WO2022219636A1 (en) * | 2021-04-14 | 2022-10-20 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds, and uses thereof |
| WO2022221514A1 (en) | 2021-04-16 | 2022-10-20 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| JP2024518530A (ja) * | 2021-05-14 | 2024-05-01 | ビーエム ファーマ コンサルティング ピーティーワイ リミテッド | ウイルス感染の予防及び治療のための二環式複素環化合物 |
| TW202400185A (zh) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| WO1991019721A1 (en) | 1990-06-13 | 1991-12-26 | Arnold Glazier | Phosphorous produgs |
| DE69129650T2 (de) | 1990-09-14 | 1999-03-25 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| DE19912636A1 (de) | 1999-03-20 | 2000-09-21 | Aventis Cropscience Gmbh | Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel |
| US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
| WO2001060315A2 (en) | 2000-02-18 | 2001-08-23 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| KR101005299B1 (ko) | 2000-10-18 | 2011-01-04 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| CZ20032005A3 (en) * | 2001-01-22 | 2004-04-14 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| WO2003026675A1 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′－支链核苷和黄病毒突变 |
| ES2769377T3 (es) | 2004-09-14 | 2020-06-25 | Gilead Pharmasset Llc | Intermedios de D-ribonolactona con sustitución de 2-fluoro-2-alquilo |
| CN101043893A (zh) * | 2004-10-21 | 2007-09-26 | 默克公司 | 治疗RNA－依赖性RNA病毒感染的氟化吡咯并[2,3－d]嘧啶核苷 |
| EP1804812A4 (en) * | 2004-10-21 | 2009-09-02 | Merck & Co Inc | FLUORINATED PYRROLO [2,3-D] PYRIMIDIN NUCLEOSIDES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRUS INFECTIONS |
| AR056327A1 (es) * | 2005-04-25 | 2007-10-03 | Genelabs Tech Inc | Compuestos de nucleosidos para el tratamiento de infecciones virales |
| WO2006121820A1 (en) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
| WO2007027248A2 (en) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | 3', 5' - cyclic nucleoside analogues for treatment of hcv |
| US8431695B2 (en) | 2005-11-02 | 2013-04-30 | Bayer Intellectual Property Gmbh | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
| WO2008005542A2 (en) * | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc., | Antiviral phosphinate compounds |
| US20080261913A1 (en) * | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| CA2673649A1 (en) | 2007-01-05 | 2008-07-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
| SG177974A1 (en) | 2007-01-12 | 2012-02-28 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
| WO2008116064A2 (en) | 2007-03-21 | 2008-09-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases |
| DK2155758T3 (da) | 2007-05-10 | 2012-11-05 | Biocryst Pharm Inc | Tetrahydrofuro[3,4-d]dioxolanforbindelser til anvendelse i behandlingen af virusinfektioner og cancer |
| US8227431B2 (en) * | 2008-03-17 | 2012-07-24 | Hetero Drugs Limited | Nucleoside derivatives |
| NZ588400A (en) | 2008-04-23 | 2012-08-31 | Gilead Sciences Inc | 1'-substituted carba-nucleoside analogs for antiviral treatment |
| EP2313102A2 (en) * | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| RS55699B1 (sr) * | 2009-09-21 | 2017-07-31 | Gilead Sciences | 2' -fluoro supstituisani karba-nukleozidni analozi zaantiviralno lečenje |
| JP5767643B2 (ja) * | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | １’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
-
2010
- 2010-09-20 RS RS20170152A patent/RS55699B1/sr unknown
- 2010-09-20 PT PT107630832T patent/PT2480552T/pt unknown
- 2010-09-20 PE PE2012000359A patent/PE20120995A1/es not_active Application Discontinuation
- 2010-09-20 CR CR20190103A patent/CR20190103A/es unknown
- 2010-09-20 ME MEP-2017-35A patent/ME02656B/me unknown
- 2010-09-20 NZ NZ599402A patent/NZ599402A/en unknown
- 2010-09-20 AP AP2012006189A patent/AP2012006189A0/xx unknown
- 2010-09-20 DK DK10763083.2T patent/DK2480552T3/en active
- 2010-09-20 AU AU2010295373A patent/AU2010295373B2/en active Active
- 2010-09-20 MX MX2012003391A patent/MX352646B/es active IP Right Grant
- 2010-09-20 CA CA2773772A patent/CA2773772C/en active Active
- 2010-09-20 BR BR112012006261-1A patent/BR112012006261B1/pt active IP Right Grant
- 2010-09-20 KR KR1020187000491A patent/KR20180006499A/ko not_active Application Discontinuation
- 2010-09-20 EP EP16196457.2A patent/EP3150608B1/en active Active
- 2010-09-20 KR KR1020127010076A patent/KR101818779B1/ko active IP Right Grant
- 2010-09-20 CN CN201080041902XA patent/CN102596958A/zh active Pending
- 2010-09-20 ES ES16196457T patent/ES2730805T3/es active Active
- 2010-09-20 WO PCT/US2010/049471 patent/WO2011035231A1/en active Application Filing
- 2010-09-20 UA UAA201204937A patent/UA110466C2/ru unknown
- 2010-09-20 SI SI201031372T patent/SI2480552T1/sl unknown
- 2010-09-20 BR BR122021021135-3A patent/BR122021021135B1/pt active IP Right Grant
- 2010-09-20 HU HUE10763083A patent/HUE032252T2/en unknown
- 2010-09-20 SG SG2012018883A patent/SG179194A1/en unknown
- 2010-09-20 EA EA201200525A patent/EA201200525A1/ru unknown
- 2010-09-20 PL PL10763083T patent/PL2480552T3/pl unknown
- 2010-09-20 ES ES10763083.2T patent/ES2614651T3/es active Active
- 2010-09-20 JP JP2012529958A patent/JP5795766B2/ja active Active
- 2010-09-20 LT LTEP10763083.2T patent/LT2480552T/lt unknown
- 2010-09-20 PE PE2016000070A patent/PE20160217A1/es unknown
- 2010-09-20 PE PE2020000354A patent/PE20210668A1/es unknown
- 2010-09-20 EP EP10763083.2A patent/EP2480552B1/en active Active
- 2010-09-20 BR BR122021012877A patent/BR122021012877B8/pt active IP Right Grant
-
2012
- 2012-03-13 IL IL218599A patent/IL218599A/en active IP Right Grant
- 2012-03-21 CL CL2012000707A patent/CL2012000707A1/es unknown
- 2012-03-23 ZA ZA2012/02175A patent/ZA201202175B/en unknown
- 2012-04-17 CR CR20120186A patent/CR20120186A/es unknown
- 2012-04-19 EC ECSP12011817 patent/ECSP12011817A/es unknown
-
2015
- 2015-05-14 JP JP2015098728A patent/JP6033362B2/ja active Active
-
2016
- 2016-09-28 IL IL248110A patent/IL248110A0/en unknown
- 2016-10-24 JP JP2016207475A patent/JP2017075146A/ja not_active Withdrawn
- 2016-11-23 AU AU2016262676A patent/AU2016262676B2/en active Active
-
2017
- 2017-02-07 CY CY20171100168T patent/CY1118605T1/el unknown
- 2017-02-07 HR HRP20170197TT patent/HRP20170197T1/hr unknown
- 2017-02-09 SM SM201700091T patent/SMT201700091B/it unknown
-
2018
- 2018-06-20 AU AU2018204449A patent/AU2018204449B2/en active Active
-
2020
- 2020-04-17 AU AU2020202600A patent/AU2020202600B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013505265A5 (ja) | ||
| IL246265B (en) | A method for the production of intermediates for the preparation of 5-fluoro-h1-pyrazolopyridines and such compounds | |
| JP2012527477A5 (ja) | ||
| PL2289864T3 (pl) | Proces otrzymywania związków fluorowych | |
| EP2480320A4 (en) | METHOD FOR ENHANCING THE SELECTIVITY OF POLYBENZOXAZOLE MEMBRANES | |
| EP2274266A4 (en) | PROCESS FOR THE PREPARATION OF PROSTAGLANDIN ANALOGS AND THEIR INTERMEDIATES | |
| EP3392368B8 (en) | Use of beta-fesi2 phase material as a solar-thermal conversion member and method of producing it | |
| JP2013532130A5 (ja) | ||
| EP2310347A4 (en) | PROCESS FOR THE PREPARATION OF PERFLUORATED CIS-ALKEN | |
| IL220936A0 (en) | Process for the synthesis of lacosamide | |
| EP3444238A3 (en) | Process for preparing difluoromethylene compounds | |
| JP2011519871A5 (ja) | ||
| JP2010209099A5 (ja) | ||
| HRP20181437T1 (hr) | Postupak proizvodnje (3s,3s') 4,4' disulfanedilbis (3-aminobutan-1-sulfonske kiseline) | |
| JP2012094862A5 (ja) | ||
| IL219913A0 (en) | New process for the preparation of tapentadol and intermediates thereof | |
| ITMI20072262A1 (it) | Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico | |
| IL223066A0 (en) | New process for the synthesis of tapentadol and intermediates thereof | |
| BR112012017828A2 (pt) | ''método para a produção de um produto químico por fermentação contínua'' | |
| ITMI20071261A1 (it) | Procedimento per la preparazione di cinacalcet | |
| ITBS20100012A1 (it) | Procedimento per la preparazione di fluazinam | |
| EP2586763A4 (en) | PROCESS FOR PREPARING 1,1-DICHLOR-2,2,3,3,3-PENTA-FLUORO-PROPANE | |
| HK1186172A1 (zh) | 製備 -氟- -羥基亞甲基－ -氧代丁酸酯的烯醇鹽方法 | |
| JP2014526571A5 (ja) | ||
| IL211266A0 (en) | Improved process for the addition of thiolates to alfa, beta-unsaturated carbonyl or sulfonyl compounds |