EA201200525A1 - 2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения - Google Patents

2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения

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Publication number
EA201200525A1
EA201200525A1 EA201200525A EA201200525A EA201200525A1 EA 201200525 A1 EA201200525 A1 EA 201200525A1 EA 201200525 A EA201200525 A EA 201200525A EA 201200525 A EA201200525 A EA 201200525A EA 201200525 A1 EA201200525 A1 EA 201200525A1
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EA
Eurasian Patent Office
Prior art keywords
triazinyl
fluorinary
carb
nucleoside analogues
virus treatment
Prior art date
Application number
EA201200525A
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English (en)
Inventor
Аесоп Чо
Чоун У. Ким
Самуэль Е. Метобо
Эдриан С. Рей
Цзе Сюй
Original Assignee
Гайлид Сайэнсиз, Инк.
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Application filed by Гайлид Сайэнсиз, Инк. filed Critical Гайлид Сайэнсиз, Инк.
Publication of EA201200525A1 publication Critical patent/EA201200525A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
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    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
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    • G03C7/36—Couplers containing compounds with active methylene groups
    • G03C7/38—Couplers containing compounds with active methylene groups in rings
    • G03C7/381—Heterocyclic compounds
    • G03C7/382—Heterocyclic compounds with two heterocyclic rings
    • G03C7/3825—Heterocyclic compounds with two heterocyclic rings the nuclei containing only nitrogen as hetero atoms
    • G03C7/3835—Heterocyclic compounds with two heterocyclic rings the nuclei containing only nitrogen as hetero atoms four nitrogen atoms

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Представлены пирроло[1,2-f][1,2,4]триазинильные, имидазо[1,5-f][1,2,4]триазинильные, имидазо[1,2-f][1,2,4]триазинильные и [1,2,4]триазоло[4,3-f][1,2,4]триазинильные нуклеозиды, нуклеозидные фосфаты и их пролекарства, где 2' положение нуклеозидного сахара замещено галогеновыми и углеродными заместителями. Представленные соединения, композиции и способы являются полезными для лечения вирусных инфекций Flaviviridae, в особенности инфекций гепатита С, вызванных как штаммами дикого типа, так и мутантными штаммами вируса гепатита С.
EA201200525A 2009-09-21 2010-09-20 2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения EA201200525A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24429709P 2009-09-21 2009-09-21
PCT/US2010/049471 WO2011035231A1 (en) 2009-09-21 2010-09-20 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment

Publications (1)

Publication Number Publication Date
EA201200525A1 true EA201200525A1 (ru) 2012-09-28

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EA201200525A EA201200525A1 (ru) 2009-09-21 2010-09-20 2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения

Country Status (32)

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EP (2) EP2480552B1 (ru)
JP (3) JP5795766B2 (ru)
KR (2) KR101818779B1 (ru)
CN (1) CN102596958A (ru)
AP (1) AP2012006189A0 (ru)
AU (4) AU2010295373B2 (ru)
BR (3) BR122021012877B8 (ru)
CA (1) CA2773772C (ru)
CL (1) CL2012000707A1 (ru)
CR (2) CR20190103A (ru)
CY (1) CY1118605T1 (ru)
DK (1) DK2480552T3 (ru)
EA (1) EA201200525A1 (ru)
EC (1) ECSP12011817A (ru)
ES (2) ES2730805T3 (ru)
HR (1) HRP20170197T1 (ru)
HU (1) HUE032252T2 (ru)
IL (2) IL218599A (ru)
LT (1) LT2480552T (ru)
ME (1) ME02656B (ru)
MX (1) MX352646B (ru)
NZ (1) NZ599402A (ru)
PE (3) PE20120995A1 (ru)
PL (1) PL2480552T3 (ru)
PT (1) PT2480552T (ru)
RS (1) RS55699B1 (ru)
SG (1) SG179194A1 (ru)
SI (1) SI2480552T1 (ru)
SM (1) SMT201700091B (ru)
UA (1) UA110466C2 (ru)
WO (1) WO2011035231A1 (ru)
ZA (1) ZA201202175B (ru)

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US9090642B2 (en) 2010-07-19 2015-07-28 Gilead Sciences, Inc. Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
US9724360B2 (en) 2014-10-29 2017-08-08 Gilead Sciences, Inc. Methods for treating Filoviridae virus infections
US10065958B2 (en) 2010-07-22 2018-09-04 Gilead Sciences, Inc. Methods and compounds for treating Paramyxoviridae virus infections
US10251904B2 (en) 2015-09-16 2019-04-09 Gilead Sciences, Inc. Methods for treating arenaviridae and coronaviridae virus infections
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
US10836787B2 (en) 2017-05-01 2020-11-17 Gilead Sciences, Inc. Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
US10988498B2 (en) 2009-09-21 2021-04-27 Gilead Sciences, Inc. Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs

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