JP2012527898A - 生物学的に活性な微生物および/または生物活性材料を含む安定な乾燥粉末組成物およびその製造方法 - Google Patents
生物学的に活性な微生物および/または生物活性材料を含む安定な乾燥粉末組成物およびその製造方法 Download PDFInfo
- Publication number
- JP2012527898A JP2012527898A JP2012513183A JP2012513183A JP2012527898A JP 2012527898 A JP2012527898 A JP 2012527898A JP 2012513183 A JP2012513183 A JP 2012513183A JP 2012513183 A JP2012513183 A JP 2012513183A JP 2012527898 A JP2012527898 A JP 2012527898A
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- temperature
- drying
- bioactive
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
- A23K50/42—Dry feed
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Pediatric Medicine (AREA)
- Physiology (AREA)
Abstract
【選択図】図1
Description
[001]本出願は、2009年5月26日および2009年7月6日にそれぞれ米国特許商標庁に出願された米国仮出願第61/181,248号および第61/223,295号に対する優先権を主張し、その内容をすべての目的のために参照により本明細書に援用する。
[0012]本発明は、生物活性材料、例えば、ペプチド、タンパク質、ホルモン、ビタミン、ミネラル、薬剤、殺微生物剤、殺真菌薬、除草剤、殺虫剤、殺精子剤、核酸、抗体、ワクチン、および/または生物活性微生物、例えば、細菌(プロバイオティックその他)、ウイルス、および/または細胞懸濁液を、貯蔵において保存するための組成物および方法を含む。乾燥方法は、生物活性微生物または生物活性材料、製剤安定化剤、および保護剤を含む製剤の制御可能な膨張方法を提供する。製剤は、真空下でまたは真空なしで、すべての固体成分を溶液に分散することによって調製される。溶液はその凍結温度を上回る温度に冷却され、真空下で乾燥して乾燥組成物とし、これは意外にも高い安定性を示す。本方法は、所望の温度および期間での製剤の第1の乾燥工程、および乾燥材料の望ましい最終水分活性を達成するために最大真空度および高温下での促進された第2の乾燥工程を含む。
[0036]定義
[0054]本発明は、粘性溶液中の生物活性微生物または生物活性材料、安定化剤、および保護剤の製剤組成物を含む。本発明の製剤は、予備冷却せずに乾燥した非粘性のまたは濃縮された製剤とはその物理的構造および機能において本来的に異なることが見出された。例えば、従来技術の製剤は、効果的な乾燥を促すために最初に「泡を形成させた」。泡形成工程は、一般に沸騰が激しく、溶液が噴出する結果となったが、これは液状での真空乾燥において避けられない結果であり、バイアルまたは容器中の材料の非常に低い充填能力(loading capacity)しか達成し得ない(米国特許第6,534,087号を参照のこと。ここでは、泡形成した最終生成物の厚さは2mm未満である)。本発明の組成物および乾燥方法によって、製剤の膨張の抑制および制御が可能となり、これによって材料の乾燥面積あたりのより高い充填が可能となり、その結果、容易にスケールアップして材料を大量製造することができる。
[0062]生物活性微生物保存用の安定な乾燥製剤の調製方法は、濃縮溶液、ペースト、凍結ビード、または乾燥粉末(安定化されたものその他)中に特定の微生物の生培養物を得ること、真空下において生物活性微生物または生物活性材料を安定化剤および保護剤と溶液中で混合することにより製剤を調製すること、製剤をその凍結温度を上回って10℃以下に冷却すること、および製剤に熱を供給しながら減圧下で水分を蒸発させることによって製剤を乾燥することを含む。
Claims (21)
- (i)フレッシュな粉末、凍結粉末、または乾燥粉末としての生物活性微生物または生物活性材料、(ii)少なくとも2種の安定化剤、および(iii)少なくとも2種の保護剤を含む組成物であって、前記生物活性微生物または生物活性材料の液状乾燥および安定化に好適である、組成物。
- 全固形分が、約30重量パーセント〜約70重量パーセントの範囲である、請求項1に記載の組成物。
- 前記生物活性微生物または生物活性材料が、細胞、細菌、ウイルス、培養物、プロバイオティック、酵母、藻類、タンパク質、組換えタンパク質、酵素、ペプチド、ホルモン、ワクチン、薬剤、ビタミン、ミネラル、殺微生物剤、殺真菌薬、除草剤、殺虫剤、または殺精子剤から選択される、請求項1に記載の組成物。
- 前記安定化剤が、多糖類および/またはオリゴ糖である、請求項1に記載の組成物。
- 前記多糖類は、酢酸フタル酸セルロース(CAP)、カルボキシ−メチル−セルロース、ペクチン、アルギン酸ナトリウム、アルギン酸塩、ヒドロキシルプロピルメチルセルロース(HPMC)、メチルセルロース、カラゲナン、グアールガム、アラビアゴム、キサンタンガム、イナゴマメガム、キトサンおよびキトサン誘導体、コラーゲン、ポリグリコール酸、デンプンおよび変性デンプン、シクロデキストリン、ならびにそれらの組み合わせから選択される、請求項4に記載の組成物。
- 前記オリゴ糖が、イヌリン、マルトデキストリン、デキストラン、およびそれらの組み合わせから選択される、請求項4に記載の組成物。
- 前記安定化剤が、約1重量パーセント〜約20重量パーセントの範囲の量で存在する、請求項4に記載の組成物。
- 前記保護剤が、溶液に容易に溶解し、水と接触したときに粘度が高くならずまたは重合しない、請求項1に記載の組成物。
- 前記保護剤が、タンパク質、例えば、ヒトおよびウシ血清アルブミン、卵アルブミン、ゼラチン、免疫グロブリン、単離大豆タンパク質、コムギタンパク質、スキムミルク粉末、カゼイン塩、乳清タンパク質、エンドウ豆タンパク質、および任意のタンパク質加水分解物;単糖(ガラクトース、D−マンノース、ソルボースなど)、二糖類(ラクトース、トレハロース、スクロースなど)、シクロデキストリンを含む炭水化物;アミノ酸、例えば、リシン、グルタミン酸モノナトリウム、グリシン、アラニン、アルギニン、またはヒスチジン、および疎水性アミノ酸(トリプトファン、チロシン、ロイシン、フェニルアラニンなど);メチルアミン、例えば、ベタイン;賦形剤の塩、例えば、硫酸マグネシウム;三価以上の糖アルコールなどのポリオール、例えば、グリセリン、エリスリトール、グリセロール、アラビトール、キシリトール、ソルビトール、およびマンニトール;プロピレングリコール;ポリエチレングリコール;プルロニック;界面活性剤;ならびにそれらの組み合わせである、請求項1に記載の組成物。
- 前記保護剤が、約1重量パーセント〜約80重量パーセントの範囲の量で存在する、請求項9に記載の組成物。
- 前記保護剤の総量が、20〜70重量パーセントである、請求項1に記載の組成物。
- 請求項1に記載の安定な乾燥粉末組成物を調製する方法であって、
(i)真空下において、フレッシュな粉末、凍結粉末、または乾燥粉末の形態の生物活性微生物または生物活性材料、乾燥安定化剤、および乾燥保護剤を水性溶媒中で合わせ、
(ii)前記工程(i)の混合物をその凍結温度を上回る温度に冷却し、
(iii)真空下でその凍結温度を上回る温度で蒸発することにより、前記冷却した混合物の第1の乾燥を行い、
(iv)前記混合物の水分活性を−0.3以下のAwに低減するのに十分な期間、20℃以上の温度で前記混合物の第2の乾燥を行うこと
を含む、方法。 - 前記混合物を、乾燥前にその凍結温度を上回る温度に冷却する、請求項12に記載の方法。
- 前記混合物の乾燥が、蒸発によって行われる、請求項12に記載の方法。
- 前記第1の乾燥工程中の混合物の温度が、その凍結温度を上回る、請求項12に記載の方法。
- 前記混合物の温度がその最初の乾燥温度を少なくとも10℃上回って上昇したときに、前記第2の乾燥工程を開始する、請求項12に記載の方法。
- 前記第2の乾燥工程中の残留溶媒の蒸発速度が、前記温度および/または真空圧を上昇させることによって増す、請求項12に記載の方法。
- 前記製剤の水分活性を−0.3以下のAwに低減するのに十分な時間、前記混合物を乾燥する、請求項12に記載の方法。
- 前記乾燥した混合物を切断し、破砕し、微粉砕化し、またはそれぞれ微粉化して自由流動粉末とする、請求項12に記載の方法。
- 前記乾燥した混合物の粒径が、約1000μm未満である、請求項19に記載の方法。
- 前記還元された液体として、または細粉末として、および食品または食餌品として前記組成物を哺乳動物に投与することをさらに含む、請求項12に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18124809P | 2009-05-26 | 2009-05-26 | |
US61/181,248 | 2009-05-26 | ||
US22329509P | 2009-07-06 | 2009-07-06 | |
US61/223,295 | 2009-07-06 | ||
PCT/US2010/036098 WO2010138522A2 (en) | 2009-05-26 | 2010-05-26 | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012527898A true JP2012527898A (ja) | 2012-11-12 |
JP2012527898A5 JP2012527898A5 (ja) | 2015-08-20 |
JP5841527B2 JP5841527B2 (ja) | 2016-01-13 |
Family
ID=43223330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012513183A Expired - Fee Related JP5841527B2 (ja) | 2009-05-26 | 2010-05-26 | 生物学的に活性な微生物および/または生物活性材料を含む安定な乾燥粉末組成物およびその製造方法 |
Country Status (17)
Country | Link |
---|---|
US (3) | US20120135017A1 (ja) |
EP (1) | EP2435554B1 (ja) |
JP (1) | JP5841527B2 (ja) |
KR (1) | KR101799983B1 (ja) |
CN (2) | CN102459568A (ja) |
AU (1) | AU2010254235B2 (ja) |
BR (1) | BRPI1013809B1 (ja) |
CA (1) | CA2763074C (ja) |
DK (1) | DK2435554T3 (ja) |
ES (1) | ES2643148T3 (ja) |
MX (1) | MX2011012586A (ja) |
MY (1) | MY157343A (ja) |
NZ (1) | NZ597053A (ja) |
PL (1) | PL2435554T3 (ja) |
RU (1) | RU2567668C2 (ja) |
SG (1) | SG176253A1 (ja) |
WO (1) | WO2010138522A2 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012217381A (ja) * | 2011-04-08 | 2012-11-12 | Nisshin Pet Food Kk | ドライペットフード |
JP2014171423A (ja) * | 2013-03-08 | 2014-09-22 | Nissin Foods Holdings Co Ltd | 凍結乾燥菌試料およびその製造方法 |
WO2015156274A1 (ja) * | 2014-04-09 | 2015-10-15 | 株式会社エス・ディー・エス バイオテック | 微生物農薬組成物、その製造方法及び微生物農薬の安定化方法 |
JP2016501868A (ja) * | 2012-11-29 | 2016-01-21 | プロゲル プロプライアタリー リミティド | プロバイオティクス、架橋性試薬、変性タンパク質、ポリオール可塑剤及びトレハロースを含む微小粒子 |
JP2017508754A (ja) * | 2014-03-06 | 2017-03-30 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | プロバイオティクス製剤および使用のための方法 |
JP2018521136A (ja) * | 2015-07-17 | 2018-08-02 | エービー−バイオティクス,エス.エイ. | 口腔ケア用の自己フィルム形成性組成物 |
KR20190034190A (ko) * | 2019-03-25 | 2019-04-01 | 대한민국(농촌진흥청장) | 사카로마이세스 세르비지애 y204의 고체종균 제조방법 |
US10624934B2 (en) | 2014-03-06 | 2020-04-21 | Research Institute At Nationwide Children's Hospital | Prebiotic formulations |
US11484479B2 (en) | 2015-07-14 | 2022-11-01 | Research Institute At Nationwide Children's Hospital | Formulation for the elimination of cariogenic and opportunistic pathogens within the oral cavity |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
DK1973406T3 (da) | 2005-12-28 | 2014-06-23 | Advanced Bionutrition Corp | Fremføringsmiddel til probiotiske bakerier omfattende en tør blanding af polysaccharider, saccharider, polyoler i glasform |
JP5285617B2 (ja) | 2006-12-18 | 2013-09-11 | アドバンスド バイオニュートリション コーポレーション | 生きたプロバイオティクスを含む乾燥食物製品 |
CA2756883C (en) | 2009-03-27 | 2018-01-09 | Advanced Bionutrition Corp. | Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish |
RU2567668C2 (ru) | 2009-05-26 | 2015-11-10 | Эдванст Бионутришн Корпорейшн | Стабильная сухая порошкообразная композиция, содержащая биологически активные микроорганизмы и/или биоактивные материалы, и способ ее изготовления |
US20110070334A1 (en) * | 2009-09-20 | 2011-03-24 | Nagendra Rangavajla | Probiotic Stabilization |
US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
NZ601017A (en) | 2010-01-28 | 2014-07-25 | Advanced Bionutrition Corp | Dry glassy composition comprising a bioactive material |
US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
RS57588B1 (sr) | 2010-08-13 | 2018-11-30 | Advanced Bionutrition Corp | Supstanca za stabilizaciju bioloških materijala za suvo skladištenje |
US9788563B2 (en) * | 2011-04-15 | 2017-10-17 | Pepsico, Inc. | Encapsulation system for protection of probiotics during processing |
US9308271B2 (en) | 2011-06-30 | 2016-04-12 | Chr. Hansen A/S | Compositions |
CN102498926A (zh) * | 2011-10-08 | 2012-06-20 | 金乡县益佳康生物科技有限责任公司 | 一种木耳液体冻干菌种的生产方法 |
CN107821795B (zh) | 2011-12-02 | 2021-12-21 | 普莱瑞阿夸泰克公司 | 用于高质量蛋白质浓缩物的基于微生物的方法 |
ITMI20120131A1 (it) * | 2012-02-01 | 2013-08-02 | Probiotical Spa | Batteri probiotici microincapsulati multistrato, loro produzione ed uso |
US10093894B2 (en) * | 2012-08-20 | 2018-10-09 | Chr. Hansen A/S | Method for optimizing a process for freeze drying a bacteria-containing concentrate |
CN103652322B (zh) * | 2012-09-21 | 2016-02-10 | 临沂思科生物科技有限公司 | 一种含乳酸菌的复合益生菌饲料添加剂的制备方法 |
CN105745319B (zh) * | 2013-05-20 | 2020-06-26 | 美国宝微技术股份有限公司 | 基于微生物的废水处理组合物及其使用方法 |
EP3632208A1 (en) * | 2013-06-13 | 2020-04-08 | Biomatrica, INC. | Cell stabilization |
CN103431024A (zh) * | 2013-07-31 | 2013-12-11 | 中国水产科学研究院南海水产研究所 | 一种低糖、低热量的鱼糜用抗冻剂及其应用 |
EP3154338B1 (en) | 2014-06-10 | 2020-01-29 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
RU2549971C1 (ru) * | 2014-07-01 | 2015-05-10 | Федеральное казённое учреждение здравоохранения Ставропольский научно-исследовательский противочумный институт Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Способ консервации иммунопероксидазного конъюгата |
CA2957920A1 (en) | 2014-08-11 | 2016-02-18 | Butamax Advanced Biofuels Llc | Yeast preparations and methods of making the same |
US10662295B2 (en) | 2014-08-12 | 2020-05-26 | The Regents Of The University Of California | Trehalose hydrogels for stabilization and delivery of proteins |
CN104351938B (zh) * | 2014-10-21 | 2017-08-01 | 吉林农业大学 | 一种食品级肠溶性微胶囊的制备方法 |
US10252928B2 (en) | 2014-10-31 | 2019-04-09 | BiOWiSH Technologies, Inc. | Method for reducing cyanuric acid in recreational water systems |
ES2822957T3 (es) * | 2015-02-11 | 2021-05-05 | Elanco Canada Ltd | Matriz seca mejorada para incorporar bacterias Escherichia coli viables, método para fabricarla y uso de la misma |
CN106063523A (zh) * | 2015-04-20 | 2016-11-02 | 上海绿奥生物科技有限公司 | 促进南美白对虾生长的新型复合益生菌多糖胶及其应用 |
CN104770576A (zh) * | 2015-04-22 | 2015-07-15 | 张奎昌 | 一种益生素-β-环糊精或其衍生物包合物的制备方法 |
FR3035328B1 (fr) * | 2015-04-24 | 2019-08-23 | Maat Pharma | Procede de preparation d'un echantillon de microbiote fecal |
AU2016256863A1 (en) | 2015-05-05 | 2017-10-26 | BiOWiSH Technologies, Inc. | Microbial compositions and methods for denitrification at high dissolved oxygen levels |
US10632157B2 (en) | 2016-04-15 | 2020-04-28 | Ascus Biosciences, Inc. | Microbial compositions and methods of use for improving fowl production |
US10851399B2 (en) | 2015-06-25 | 2020-12-01 | Native Microbials, Inc. | Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon |
US9938558B2 (en) | 2015-06-25 | 2018-04-10 | Ascus Biosciences, Inc. | Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon |
AU2016282996A1 (en) | 2015-06-25 | 2018-01-18 | Ascus Biosciences, Inc. | Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon |
CN106306346B (zh) * | 2015-06-26 | 2021-06-22 | 上海转基因研究中心 | 不使用饲用抗生素的生猪饲养方法 |
EP3317395B1 (en) | 2015-06-30 | 2020-07-15 | Société des Produits Nestlé S.A. | Composition suitable for protecting microorganisms |
WO2017019273A1 (en) | 2015-07-29 | 2017-02-02 | Advanced Bionutrition Corporation | Stable dry probiotic compositions for special dietary uses |
EP3346842A1 (en) * | 2015-09-11 | 2018-07-18 | Novozymes BioAG A/S | Stable inoculant compositions and methods for producing same |
WO2017066719A2 (en) | 2015-10-14 | 2017-04-20 | Research Institute At Nationwide Children's Hospital | Hu specific interfering agents |
US10336636B2 (en) | 2015-11-02 | 2019-07-02 | BiOWiSH Technologies, Inc. | Methods for reducing evaporative loss from swimming pools |
WO2017090766A1 (ja) * | 2015-11-27 | 2017-06-01 | 日東電工株式会社 | 口腔内投与用ワクチン医薬組成物及び口腔内投与用ワクチン医薬組成物の製造方法 |
US10792313B2 (en) * | 2015-12-04 | 2020-10-06 | Advanced Bionutrition Corp. | Stable dry compositions having no or little sugars |
EP4242628A3 (en) | 2015-12-08 | 2023-11-08 | Biomatrica, INC. | Reduction of erythrocyte sedimentation rate |
CN106562036B (zh) * | 2015-12-24 | 2020-08-14 | 陕西正能农牧科技有限责任公司 | 一种公猪饲料及其制备方法 |
NZ743958A (en) | 2016-01-07 | 2023-07-28 | Native Microbials Inc | Methods for improving milk production by administration of microbial consortia |
CN105602867B (zh) * | 2016-01-18 | 2018-11-02 | 黑龙江省科学院微生物研究所 | 一种慢生型大豆根瘤菌保护剂 |
CN105519520B (zh) * | 2016-01-21 | 2018-01-09 | 中国人民解放军第四军医大学 | 一种组织标本保存液 |
RU2624241C1 (ru) * | 2016-03-25 | 2017-07-03 | Акционерное Общество "ГенТерра" | Твердофазный носитель для иммобилизации и/или хранения биологических образцов, содержащих нуклеиновые кислоты |
US10617134B2 (en) | 2016-04-15 | 2020-04-14 | Ascus Biosciences, Inc. | Methods for improving agricultural production of fowl by administration of microbial compositions or purified strains thereof |
CN106178381A (zh) * | 2016-07-04 | 2016-12-07 | 四川行之智汇知识产权运营有限公司 | 一种基于微生物的石油除污剂 |
CN105999288A (zh) * | 2016-07-20 | 2016-10-12 | 安徽东方帝维生物制品股份有限公司 | 一种猪丹毒活疫苗耐热保护剂、制备方法及应用 |
US11246308B2 (en) | 2016-12-20 | 2022-02-15 | Tissue Testing Technologies Llc | Ice-free preservation of large volume tissue samples for viable, functional tissue banking |
EP3562955A4 (en) | 2016-12-28 | 2020-08-12 | Ascus Biosciences, Inc. | METHODS, APPARATUS AND SYSTEMS FOR THE ANALYSIS OF STRAINS OF MICRO-ORGANISMS OF HETEROGENEOUS COMMUNITIES COMPLEX WITH TRACEOR ANALYZES, DETERMINATION OF THEIR INTERACTIONS AND FUNCTIONAL RELATIONSHIPS, AND SUMMARY OF MICROBIAL SETS OF MICROBIAL SETS AND MICROBIAL SETS INCLUDING MICROBIAL SETS AND INGREDIENTS |
CA3048246A1 (en) | 2016-12-28 | 2018-07-05 | Ascus Biosciences, Inc. | Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon |
US20200024586A1 (en) * | 2017-01-20 | 2020-01-23 | Integrated Micro-Chromatography Systems, Inc. | Thermostabile beta-glucuronidase formulations |
CN110913702A (zh) | 2017-04-28 | 2020-03-24 | 埃斯库斯生物科技股份公司 | 利用微生物的人造生物集合在反刍动物中用于支持谷物加强剂和/或能量加强剂饮食的方法 |
GB201708932D0 (en) * | 2017-06-05 | 2017-07-19 | Probi Ab | Microbial compositions |
KR101999693B1 (ko) * | 2017-06-13 | 2019-07-15 | 부산대학교 산학협력단 | 산성 환경에서 프로바이오틱스를 보호하는 프로바이오틱스 전달용 하이드로겔 제제 및 이를 포함하는 프로바이오틱스 전달용 조성물 |
CN107300616B (zh) * | 2017-06-20 | 2019-02-01 | 广东云天抗体生物科技有限公司 | 一种冻干液配方及其应用 |
WO2019014338A1 (en) * | 2017-07-11 | 2019-01-17 | Universal Stabilization Technologies, Inc. | METHOD FOR PRESERVING BIOPHARMACEUTICAL PRODUCTS |
EP3684175A1 (en) * | 2017-09-22 | 2020-07-29 | Technische Universität Graz | Polymeric particles containing microorganisms |
AR113371A1 (es) | 2017-10-18 | 2020-04-22 | Ascus Biosciences Inc | Aumento de la producción de aves de corral mediante la administración de un bioensamblaje sintético de microbios o cepas purificadas de los mismos |
CN107815429B (zh) * | 2017-11-14 | 2021-05-18 | 北京好实沃生物技术有限公司 | 一种耐制粒乳酸菌制剂及其制备方法 |
CN108157661A (zh) * | 2017-12-30 | 2018-06-15 | 天津赫莱恩特生物科技有限公司 | 一种提高抗体滴度的饲料添加剂及其制备方法 |
MX2020008480A (es) * | 2018-02-15 | 2020-10-14 | Nippon Suisan Kaisha Ltd | Alimentador de cefalopodos, metodo de alimentacion y cefalopodo. |
CN108504648A (zh) * | 2018-03-19 | 2018-09-07 | 金华银河生物科技有限公司 | 一种乳酸菌的共价包埋方法及乳酸菌制剂 |
CN108517002A (zh) * | 2018-04-20 | 2018-09-11 | 命之本源医疗科技(北京)有限公司 | 一种干细胞培养上清分泌蛋白的稳定剂 |
CN108277160B (zh) * | 2018-04-22 | 2021-08-06 | 物力(江西)农业技术有限公司 | 一种微生物冻干保护剂 |
CN108514079B (zh) * | 2018-04-28 | 2021-10-29 | 山东润泽制药有限公司 | 一种纳豆冻干粉制备方法 |
CN112352042A (zh) * | 2018-05-04 | 2021-02-09 | 科·汉森有限公司 | 硝酸盐还原酶活性的提高的恢复 |
CA3096300A1 (en) | 2018-05-29 | 2019-12-05 | BiOWiSH Technologies, Inc. | Compositions and methods for improving survivability of aquatic animals |
US11268079B2 (en) | 2018-08-01 | 2022-03-08 | Integrated Micro-Chromatography Systems, Inc. | Compositions of beta-glucuronidase enzyme blends with enhanced enzymatic activity and methods of preparation thereof |
CN109022283A (zh) * | 2018-08-14 | 2018-12-18 | 华侨大学 | 一种稳定液体光合细菌活菌制剂的方法 |
US11421210B2 (en) | 2018-10-08 | 2022-08-23 | Integrated Micro-Chromatography Systems, Inc. | Chimeric and other variant beta-glucuronidase enzymes with enhanced properties |
CN109198319A (zh) * | 2018-10-30 | 2019-01-15 | 天津商业大学 | 一种酸枣果肉与枣仁复合固体饮料及其制作方法 |
CN109182231A (zh) * | 2018-11-14 | 2019-01-11 | 哈尔滨美华生物技术股份有限公司 | 一种乳酸菌菌种长期保藏方法 |
WO2020104612A1 (en) * | 2018-11-21 | 2020-05-28 | Evonik Operations Gmbh | Dried biological compositions and methods thereof |
CN111280181A (zh) * | 2018-12-07 | 2020-06-16 | 成都特普生物科技股份有限公司 | 一种微生物定向培养保存的润粉菌剂 |
CA3136385A1 (en) * | 2019-04-10 | 2020-10-15 | Native Microbials, Inc. | Methods and systems for stabilization and preservation of microbes |
CN110452887B (zh) * | 2019-07-18 | 2020-08-25 | 广东海大集团股份有限公司畜牧水产研究中心 | 一种噬菌体保护剂及其应用 |
WO2021069673A1 (en) * | 2019-10-10 | 2021-04-15 | Chr. Hansen A/S | Control of eyes formation in swiss type cheese and continental cheese type |
CN111826324A (zh) * | 2020-08-05 | 2020-10-27 | 厦门惠盈动物科技有限公司 | 一种鼠李糖乳杆菌菌粉的制备方法 |
CN112106883B (zh) * | 2020-09-27 | 2022-05-06 | 烟台中宠食品股份有限公司 | 一种富含益生菌的宠物干粮的制备方法 |
CA3194598A1 (en) * | 2020-10-07 | 2022-04-14 | Valentina SCREPANTI-SUNDQUIST | Cholera vaccine formulation |
EP4251729A1 (en) | 2020-11-30 | 2023-10-04 | Chr. Hansen A/S | Stabilised lactic acid bacteria compositions |
CN117202797A (zh) | 2020-11-30 | 2023-12-08 | 科·汉森有限公司 | 用于制备细菌产物的方法 |
CN112574919B (zh) * | 2020-12-18 | 2022-11-18 | 广州市微生物研究所有限公司 | 一种菌丝霉素分泌型益生菌剂及其制备方法与应用 |
CN112852666A (zh) * | 2021-01-19 | 2021-05-28 | 新疆河润水业有限责任公司 | 一种微生物菌剂的制备方法及采用微生物菌剂制备的微生物肥料 |
CN113142306A (zh) * | 2021-02-04 | 2021-07-23 | 贝因美(杭州)食品研究院有限公司 | 一种婴幼儿配方奶粉的制备方法 |
CN112899204B (zh) * | 2021-03-19 | 2022-06-28 | 杭州百芮生物科技有限公司 | 一种益生菌冻干外壳复合保护剂及其应用 |
WO2023094649A1 (en) | 2021-11-29 | 2023-06-01 | Chr. Hansen A/S | Improved stability of microbial compositions, and manufacturing methods therefore |
WO2023094652A1 (en) | 2021-11-29 | 2023-06-01 | Chr. Hansen A/S | Compositions for increased stability of bacteria |
CN114196579A (zh) * | 2021-12-13 | 2022-03-18 | 张峰 | 一种建筑通风工程用的甲醛微生物净化器 |
CN114672446B (zh) * | 2022-05-31 | 2022-08-12 | 广东海洋大学 | 一种丁酸梭菌制剂的制备方法及应用 |
CN115074280B (zh) * | 2022-06-27 | 2023-11-21 | 微康益生菌(苏州)股份有限公司 | 一种具有高发酵活力的嗜热链球菌冻干粉及其制备方法与应用 |
CN114854651B (zh) * | 2022-07-06 | 2022-09-30 | 广东顺德鼎一生物科技有限公司 | 复合片球菌制剂及其制备方法和应用 |
CN115039766B (zh) * | 2022-08-13 | 2022-11-18 | 中国农业科学院北京畜牧兽医研究所 | 一种常温猪精液稀释剂 |
CN115491309B (zh) * | 2022-09-19 | 2023-06-16 | 江西省科学院微生物研究所(江西省流域生态研究所) | 一种乳酸菌发酵稳定剂及其制备方法和应用方法 |
CN116121074A (zh) * | 2023-03-16 | 2023-05-16 | 亩巴贝农业科技有限公司 | 一种提升微生物菌稳定性的三层包埋方法及应用 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05246856A (ja) * | 1991-10-23 | 1993-09-24 | Bristol Myers Squibb Co | 改良イフォスファミド凍結乾燥組成物 |
JPH11513700A (ja) * | 1995-10-25 | 1999-11-24 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 凍結しない乾燥過程により生物材料を安定化するための調製物及び方法 |
JP2001505431A (ja) * | 1996-12-05 | 2001-04-24 | クアドラント ホールディングス ケンブリッジ リミテッド | 原核細胞の保存方法およびそれにより得られる組成物 |
JP2002512970A (ja) * | 1998-04-24 | 2002-05-08 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 安定化したウィルス製剤 |
WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
WO2007079147A2 (en) * | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
JP2007522085A (ja) * | 2003-06-27 | 2007-08-09 | スミスクライン・ビーチャム・コーポレイション | 安定化されたトポテカンリポソーム組成物および方法 |
WO2008076975A1 (en) * | 2006-12-18 | 2008-06-26 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
WO2009002481A1 (en) * | 2007-06-26 | 2008-12-31 | Merck & Co., Inc. | Lyophilized anti-fungal composition |
JP2009508866A (ja) * | 2005-09-16 | 2009-03-05 | メリアル リミテッド | 凍結乾燥ワクチン用安定剤 |
Family Cites Families (175)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3241977A (en) | 1962-01-02 | 1966-03-22 | Gen Foods Corp | Effervescent beverage powders |
GB1232057A (ja) | 1968-10-07 | 1971-05-19 | ||
US3897307A (en) | 1974-10-23 | 1975-07-29 | Hansens Lab Inc | Stabilized dry cultures of lactic acid-producing bacteria |
JPS57114527A (en) | 1979-10-29 | 1982-07-16 | Merck & Co Inc | Vaccine stabilizer |
PT71926B (en) | 1979-10-29 | 1982-03-31 | Merck & Co Inc | Process for preparing a liquid vaccine comprising a stabilizer |
US4337242A (en) | 1980-02-05 | 1982-06-29 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
RU1212045C (ru) * | 1984-01-24 | 1994-12-30 | Всесоюзный научно-исследовательский и технологический институт биологической промышленности | Защитная среда для приготовления сухой вирусной вакцины |
US4656767A (en) | 1986-02-18 | 1987-04-14 | Tarrant Thomas G | Cable tag |
EP0259739A1 (en) | 1986-09-10 | 1988-03-16 | Rhone-Poulenc Inc. | Improved stability of freeze-dried cultures |
EP0283085B1 (en) | 1987-03-17 | 1992-11-11 | Akzo N.V. | Adjuvant mixture |
US6451567B1 (en) | 1988-09-07 | 2002-09-17 | Omegatech, Inc. | Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms |
US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
GB9002003D0 (en) | 1990-01-29 | 1990-03-28 | Ici Plc | Stabilized cultures of microorganisms |
US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
EP0471904A1 (en) | 1990-05-09 | 1992-02-26 | Milpak, Inc. | Instant yogurt composition and process |
US5262187A (en) | 1990-06-28 | 1993-11-16 | The Pillsbury Company | Low-fat cereal-grain food composition |
US5658767A (en) | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
TW209174B (ja) | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
JP2558203B2 (ja) | 1992-06-18 | 1996-11-27 | ラウエル エックハルト | 微生物含有培地の凍結乾燥物とその製造方法 |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
JPH08511956A (ja) | 1994-04-07 | 1996-12-17 | アクゾ・ノベル・エヌ・ベー | Rnaを含む凍結乾燥組成物 |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
AUPM823094A0 (en) | 1994-09-16 | 1994-10-13 | Goodman Fielder Limited | Probiotic compositions |
US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
EP0823475B1 (en) | 1995-04-17 | 2009-06-17 | National Institute of Advanced Industrial Science and Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms |
GB9508691D0 (en) | 1995-04-28 | 1995-06-14 | Pafra Ltd | Stable compositions |
US5976580A (en) | 1995-06-07 | 1999-11-02 | Novus International, Inc. | Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals |
ATE239451T1 (de) | 1995-06-07 | 2003-05-15 | Elan Drug Delivery Ltd | Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen |
US6964771B1 (en) | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US5958455A (en) | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
US6509146B1 (en) | 1996-05-29 | 2003-01-21 | Universal Preservation Technologies, Inc. | Scalable long-term shelf preservation of sensitive biological solutions and suspensions |
EP1015826A2 (en) | 1996-05-29 | 2000-07-05 | Universal Preservation Technologies, Inc. | Long-term shelf preservation by vitrification |
US5766520A (en) | 1996-07-15 | 1998-06-16 | Universal Preservation Technologies, Inc. | Preservation by foam formation |
DK0935667T3 (da) | 1996-07-23 | 2007-04-10 | Nagase Chemtex Corp | Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre |
US5715774A (en) | 1996-10-31 | 1998-02-10 | Aquatic Bioenhancement Systems | Animal feedstocks comprising harvested algal turf and a method of preparing and using the same |
EP0862863B9 (en) | 1997-01-09 | 2009-08-12 | Societe Des Produits Nestle S.A. | Cereal product containing probiotics |
US6726934B1 (en) | 1997-10-09 | 2004-04-27 | Vanderbilt University | Micro-particulate and nano-particulate polymeric delivery system |
AU2484399A (en) | 1998-01-30 | 1999-08-16 | Scios Inc. | Controlled release delivery of peptide or protein |
US6338856B1 (en) | 1998-02-27 | 2002-01-15 | Texas Tech University | Seaweed supplement diet for enhancing immune response in mammals and poultry |
US6423345B2 (en) | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
US6306345B1 (en) | 1998-05-06 | 2001-10-23 | Universal Preservation Technologies, Inc. | Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures |
NZ511792A (en) | 1998-11-20 | 2003-08-29 | Skyepharma Canada Inc | Dispersible phospholipid stabilized microparticles |
US6190701B1 (en) | 1999-03-17 | 2001-02-20 | Peter M. Ronai | Composition and method for stable injectable liquids |
ATE366797T1 (de) | 1999-05-04 | 2007-08-15 | Anhydro Ltd | Verfharen zur konservierung von viren und mycoplasma |
US6592663B1 (en) * | 1999-06-09 | 2003-07-15 | Ricoh Company Ltd. | Production of a GaN bulk crystal substrate and a semiconductor device formed on a GaN bulk crystal substrate |
EP1402003A4 (en) | 1999-08-19 | 2004-07-14 | Universal Preservation Technologies Inc | STORAGE OF AMBIENT TEMPERATURE BACTERIAL CELLS |
CA2382652A1 (en) | 1999-08-24 | 2001-03-01 | Teva Pharmaceutical Industries, Ltd. | A vaccine composition and method of using the same |
ES2162746B1 (es) | 1999-10-21 | 2003-02-16 | Lipotec Sa | Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion. |
FR2801316B1 (fr) | 1999-11-18 | 2005-03-25 | Rhodia Food | Procede de sechage des bacteries |
DE19962427A1 (de) | 1999-12-22 | 2001-07-12 | Nutrinova Gmbh | Verkapselte multifunktionelle, biologisch aktive Nahrungsmittelkomponente, Verfahren zu ihrer Herstellung und ihre Anwendung |
US6338866B1 (en) | 2000-02-15 | 2002-01-15 | Applied Food Biotechnology, Inc. | Pet foods using algal or fungal waste containing fatty acids |
GB0005839D0 (en) * | 2000-03-10 | 2000-05-03 | Provita Eurotech Ltd | Storage and delivery of micro-organisms |
US6368602B1 (en) | 2000-06-16 | 2002-04-09 | Hadasit Medical Research Services And Development Ltd | Mucosal immunization against hepatitis A virus (HAV) through rectal administration of HAV vaccine |
AU8184601A (en) | 2000-06-27 | 2002-01-08 | Hoffmann La Roche | Method for preparing a composition |
US6653062B1 (en) | 2000-07-26 | 2003-11-25 | Wisconsin Alumni Research Foundation | Preservation and storage medium for biological materials |
US6592863B2 (en) | 2000-08-22 | 2003-07-15 | Nestec S.A. | Nutritional composition |
US6537666B1 (en) | 2000-10-23 | 2003-03-25 | Universal Preservation Technologies, Inc. | Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals |
US6872357B1 (en) | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
US7153472B1 (en) | 2000-11-22 | 2006-12-26 | Quadrant Drug Delivery Limited | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers |
AU2002248192A1 (en) | 2000-12-15 | 2002-08-12 | Stratagene | Room temperature stable competent cells |
IL156490A0 (en) | 2000-12-18 | 2004-01-04 | Probiohealth | Probiotic compounds derived from lactobacillus casei strain ke01 |
FI109602B (fi) | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
AUPR272901A0 (en) | 2001-01-25 | 2001-02-22 | Gainful Plan Limited | Method of preparing biological materials and preparations produced using same |
DE10107659B4 (de) | 2001-02-19 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin |
US6790453B2 (en) | 2001-03-14 | 2004-09-14 | Mccormick & Company, Inc. | Encapsulation compositions and process for preparing the same |
ATE400189T1 (de) | 2001-03-23 | 2008-07-15 | Advanced Bionutrition Corp | Abgabe von mitteln zur krankheitskontrolle in aquakultur unter verwendung von bioaktive proteine enthaltender hefe |
JP2004526458A (ja) | 2001-05-14 | 2004-09-02 | マーテック・バイオサイエンシーズ・コーポレーション | 飼鳥肉の風味、軟らかさ、および全消費者嗜好性の改善法 |
US20030017192A1 (en) * | 2001-06-19 | 2003-01-23 | Hanny Kanafani | Process for producing extended shelf-life ready-to-use milk compositions containing probiotics |
US20040038825A1 (en) | 2001-08-10 | 2004-02-26 | Leland Jarrod Ethan | Water soluble uv-protective coatings for biological pesticides and process for making same |
WO2003017780A1 (en) | 2001-08-27 | 2003-03-06 | Advanced Bionutrition Corporation | Delivery of disease control in aquaculture and agriculture using nutritional feeds containing bioactive proteins produced by viruses |
AUPR750501A0 (en) | 2001-09-05 | 2001-09-27 | Gauci, Mark | Products comprising quantum of bioparticles and method for production thereof |
US7550647B2 (en) | 2001-09-14 | 2009-06-23 | Advanced Bionutrition | Transfected shrimp as production systems for therapeutic proteins |
US6884866B2 (en) | 2001-10-19 | 2005-04-26 | Avant Immunotherapeutics, Inc. | Bulk drying and the effects of inducing bubble nucleation |
AU2002339112B2 (en) | 2001-11-12 | 2007-10-11 | Mars, Incorporated | Foodstuff |
WO2003072016A2 (en) | 2001-11-19 | 2003-09-04 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
EP1344458A1 (en) | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
US7396548B2 (en) | 2002-03-19 | 2008-07-08 | Advanced Bionutrition Corporation | Microalgal feeds containing arachidonic acid and their production and use |
US6861410B1 (en) | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
WO2003087812A1 (en) | 2002-04-09 | 2003-10-23 | Allnut F C Thomas | Enclosed aquacultural systems for production of purified recombinant proteins |
US7135180B2 (en) | 2002-04-11 | 2006-11-14 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by freeze dried foam |
KR20050011741A (ko) | 2002-04-11 | 2005-01-29 | 메드이뮨 백신즈 인코포레이티드 | 분무 건조에 의한 생물학적 활성 물질의 보존 |
WO2003089579A2 (en) | 2002-04-15 | 2003-10-30 | Advanced Bionutrition Corporation | Incorporation of anaerobic bacteria in feed formulation |
CN1662147A (zh) | 2002-04-16 | 2005-08-31 | 怀泰斯德美国有限公司 | 功能性成分的传递系统 |
WO2003086454A1 (en) | 2002-04-18 | 2003-10-23 | Akzo Nobel N.V. | Antigen-loaded chitosan microparticles for oral vaccination |
GB0212975D0 (en) | 2002-06-06 | 2002-07-17 | Mars Uk Ltd | Mammalian animal composition |
WO2003103692A1 (en) | 2002-06-11 | 2003-12-18 | Moti Harel | Zooplankton enrichment with probionts and prebionts and uses thereof |
US20100120014A1 (en) | 2002-06-18 | 2010-05-13 | Victor Bronshtein | Stability Drying |
US20060121468A1 (en) | 2002-06-26 | 2006-06-08 | Allnutt F C T | Viruses and virus-like particles for multiple antigen and target display |
GB2399084B (en) | 2002-07-30 | 2007-01-31 | Univ Liverpool | Porous beads and method of production thereof |
CA2497264A1 (en) | 2002-09-05 | 2004-03-18 | Kowa Co., Ltd. | Heavy metal adsorbent composition comprising bacillus or staphylococcus bacteria |
US20050266069A1 (en) | 2002-09-06 | 2005-12-01 | Simmons Donald L | Stable probiotic microsphere compositions and their methods of preparation |
US6900173B2 (en) | 2002-09-11 | 2005-05-31 | Kenneth A. Martin | Perioperative multivitamin protein bar for use in preparing an individual for fast surgical recovery |
JP4731907B2 (ja) | 2002-09-16 | 2011-07-27 | アドバンスド バイオニュートリション コーポレーション | 受動免疫のための蛋白質およびペプチド発現 |
WO2004024177A1 (en) | 2002-09-16 | 2004-03-25 | Quest International Services B.V. | Method of treating or preventing obeisity and lipid metabolism disorders and compositions for use therein |
JP2006508651A (ja) | 2002-10-24 | 2006-03-16 | アドバンスド バイオニュートリション コーポレーション | エビおよびその生産 |
WO2004039417A2 (en) | 2002-11-01 | 2004-05-13 | Glaxosmithkline Biologicals S.A. | Drying process |
NZ539900A (en) | 2002-11-07 | 2008-03-28 | Advanced Bionutrition Corp | Nutraceuticals and method of feeding aquatic animals |
EP1578191A4 (en) | 2002-11-14 | 2008-10-29 | Advanced Bionutrition Corp | SUITABLE FOOD FOR THE BREEDING OF WHEELED TOYS, SHRIMPSLARVES AND SEA PLANKTON |
US7122370B2 (en) | 2003-01-14 | 2006-10-17 | Randolph Stanley Porubcan | Formulations to increase in vivo survival of probiotic bacteria and extend their shelf-life |
WO2004080196A2 (en) | 2003-03-07 | 2004-09-23 | Advanced Bionutrition Corporation | Feed formulation for terrestrial and aquatic animals |
US20060265766A1 (en) | 2003-03-19 | 2006-11-23 | Advanced Bionutrition Corporation | Fish and the production thereof |
WO2004091307A2 (en) | 2003-04-08 | 2004-10-28 | Advanced Bionutriton Corporation | Feed additives against diseasse infection in terrestrial and aquatic animals |
US20040241313A1 (en) | 2003-05-27 | 2004-12-02 | Ravi Nana | Food composition and food bars |
DE10328180A1 (de) | 2003-06-16 | 2005-01-13 | Südzucker AG Mannheim/Ochsenfurt | Verwendung von Isomalt als Präbiotikum |
US9072311B2 (en) | 2003-06-19 | 2015-07-07 | Advanced Bionutrition Corporation | Absorption of fat-soluble nutrients |
GB0314624D0 (en) | 2003-06-23 | 2003-07-30 | Advanced Bionutrition Europ Lt | Inflammatory disease treatment |
US8871266B2 (en) | 2003-10-01 | 2014-10-28 | Commonwealth Scientific & Industrial Research Organisation | Probiotic storage and delivery |
WO2005035558A2 (en) | 2003-10-07 | 2005-04-21 | Michel Thiry | Piscirickettsia salmonis antigens and use thereof |
US20050100559A1 (en) | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
ES2235642B2 (es) | 2003-12-18 | 2006-03-01 | Gat Formulation Gmbh | Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos. |
CA2554112A1 (en) | 2004-01-28 | 2005-08-11 | Unilever Plc | Porous bodies and method of production thereof |
AU2005213981A1 (en) | 2004-02-06 | 2005-09-01 | Advanced Bionutrition Corporation | RNA-mediated interference to control disease in terrestrial and aquaculture animals |
WO2005082159A1 (ja) | 2004-02-27 | 2005-09-09 | Nosan Corporation | 食物アレルギー反応低減ペットフード |
GB0404586D0 (en) | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
US7973148B2 (en) | 2004-04-15 | 2011-07-05 | Advanced Bionutrition Corporation | Crustacean expression vector |
GB0409795D0 (en) | 2004-04-30 | 2004-06-09 | Glaxosmithkline Biolog Sa | Drying method |
KR20050105669A (ko) | 2004-05-03 | 2005-11-08 | 전정욱 | 유산균 조성물 |
KR20050106559A (ko) | 2004-05-04 | 2005-11-10 | 삼성전자주식회사 | 문서 양식지 출력 방법 |
EP1750674A4 (en) | 2004-05-27 | 2012-05-23 | Advanced Bionutrition Corp | MICROPARTICLES FOR THE ORAL LEVY |
CA2569276C (en) | 2004-06-02 | 2018-01-23 | Victor Bronshtein | Preservation by vaporization |
EP1616486A1 (en) | 2004-07-13 | 2006-01-18 | Friesland Brands B.V. | Powdered compositions containing an edible oil and their use in food products |
US7282194B2 (en) | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
ITMI20042189A1 (it) | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
GB0502661D0 (en) | 2005-02-09 | 2005-03-16 | Stabilitech Ltd | A desiccated product |
CN101227900A (zh) | 2005-05-11 | 2008-07-23 | 高级生物营养公司 | 稳定形式的鱼油 |
HUP0500582A1 (hu) * | 2005-06-13 | 2007-08-28 | Csaba Jozsef Dr Jaszberenyi | Szinergetikus élettani hatású élelmiszerek, élelmiszer-adalékok és táplálék-kiegészítõk vagy takarmányadalékok |
CN102894371A (zh) * | 2005-07-01 | 2013-01-30 | 努特里希亚公司 | 含水解的蛋白质的婴儿营养品 |
US20070048295A1 (en) | 2005-08-23 | 2007-03-01 | Ming-Ju Chen | Method for preparing alginate capsules |
GB0517688D0 (en) | 2005-08-31 | 2005-10-05 | Cambridge Biostability Ltd | Improvements in the stabilisation of biological materials |
AU2006299310A1 (en) | 2005-10-04 | 2007-04-12 | Alk-Abello A/S | Solid vaccine formulation |
WO2007075988A2 (en) | 2005-12-21 | 2007-07-05 | Advanced Bionutrition Corporation | Non-invasive detection of fish viruses by real-time pcr |
US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
WO2007084500A2 (en) | 2006-01-13 | 2007-07-26 | Advanced Bionutrition Corporation | Continuous spray-capture production system |
DK1983849T3 (da) * | 2006-01-20 | 2013-07-08 | Innova Food Ab | Fødevaresammensætning omfattende aminosyrer |
US7551047B2 (en) | 2006-02-10 | 2009-06-23 | Leviton Manufacturing Co., Inc. | Tamper resistant ground fault circuit interrupter receptacle having dual function shutters |
CA2642761A1 (en) | 2006-02-23 | 2007-08-30 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
BRPI0710665A2 (pt) | 2006-04-03 | 2011-08-16 | Advanced Bionutrition Corp | formulações de ração contendo ácido docosa-hexaenóico |
JP2009537138A (ja) * | 2006-05-18 | 2009-10-29 | バイオバランス エルエルシー | 細菌株、この細菌株を含む組成物およびそのプロバイオティック使用 |
AU2007281104A1 (en) | 2006-08-02 | 2008-02-07 | Solae, Llc | A food composition containing a coagulated protein and a process for making the same |
USRE46912E1 (en) | 2006-08-04 | 2018-06-26 | Bioneer Corporation | Lactic acid bacteria isolated from mother's milk with probiotic activity and inhibitory activity against body weight augmentation |
US20080044081A1 (en) | 2006-08-21 | 2008-02-21 | Adam Lieb | Color indexing for images |
US20100189767A1 (en) | 2006-09-19 | 2010-07-29 | Eyal Shimoni | Probiotic compositions and methods of making same |
EP1911457A1 (en) * | 2006-10-12 | 2008-04-16 | N.V. Nutricia | Composition to treat or prevent gastrointestinal infection |
NL1032840C2 (nl) * | 2006-11-09 | 2008-05-13 | Friesland Brands Bv | Probiotische hydrolysaatvoeding voor kinderen. |
GB2477712A (en) | 2006-12-20 | 2011-08-17 | Advanced Bionutrition Corp | Antigenicity of infectious pancreatic necrosis virus VP2 sub-viral particles expressed in yeast |
US8240065B2 (en) | 2007-02-05 | 2012-08-14 | Praxair Technology, Inc. | Freeze-dryer and method of controlling the same |
GB0705245D0 (en) | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
DK2148923T3 (da) | 2007-05-18 | 2012-12-03 | Medimmune Llc | Konservering af biologisk aktive materialer med frysetørret skum |
US20090041727A1 (en) | 2007-08-08 | 2009-02-12 | Conjugon, Inc. | Compositions and Methods for Microbe Storage and Delivery |
US9096845B2 (en) * | 2007-08-29 | 2015-08-04 | Technion Research & Development Foundation Limited | Encapsulation of bacteria and viruses in electrospun fibers |
CN101820855B (zh) | 2007-10-10 | 2012-11-07 | 荷兰联合利华有限公司 | 处理毛发的方法 |
RU2481008C2 (ru) | 2007-12-20 | 2013-05-10 | Абботт Лаборэтриз | Композиции питательного порошка и детской питательной смеси (варианты) |
US8361534B2 (en) * | 2007-12-20 | 2013-01-29 | Abbott Laboratories | Stable nutritional powder |
WO2009109550A1 (en) | 2008-03-05 | 2009-09-11 | Sanofi Pasteur | Process for stabilizing an adjuvant containing vaccine composition |
US7998502B2 (en) | 2008-03-24 | 2011-08-16 | Advanced Bionutrition Corp. | Encapsulated vaccines for the oral vaccination and boostering of fish and other animals |
CL2009001164A1 (es) | 2008-05-13 | 2010-04-09 | Metodo para la alimentacion del smolt y/o parr de salmon, criado en granja para prepararlos para la transicion desde un habitat de agua dulce a uno de agua salada, que comprende proporcionar una composicion de alimento para smolt y alimentar con la composicion del alimento al smolt y/o parr. | |
WO2010002418A2 (en) | 2008-07-01 | 2010-01-07 | The Johns Hopkins University | Quick-dissolving oral thin film for targeted delivery of therapeutic agents |
US20110223282A1 (en) | 2008-10-20 | 2011-09-15 | Nestec S.A. | Nutritional composition with anti-regurgitation properties |
CN102427740B (zh) | 2009-03-26 | 2016-02-03 | 先进生物营养公司 | 生物活性物质的微囊化及其制造方法 |
CA2756883C (en) | 2009-03-27 | 2018-01-09 | Advanced Bionutrition Corp. | Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish |
WO2010118188A2 (en) | 2009-04-08 | 2010-10-14 | Advanced Bionutrition Corporation | Production of an intact virus in a non-host cell system using a secondary host viral construct |
US20120202249A1 (en) | 2009-04-08 | 2012-08-09 | Dhar Arun K | Production of an intact virus in a mammalian (non-host) cell system using a secondary non-host viral construct |
TWI468157B (zh) | 2009-04-29 | 2015-01-11 | Intervet Int Bv | 形成錠劑的方法,進行該方法的系統及包含該錠劑的包裝物 |
WO2010135495A2 (en) | 2009-05-20 | 2010-11-25 | Aeras Global Tb Vaccine Foundation | Stable, spray dried, immunogenic, viral compositions |
RU2567668C2 (ru) | 2009-05-26 | 2015-11-10 | Эдванст Бионутришн Корпорейшн | Стабильная сухая порошкообразная композиция, содержащая биологически активные микроорганизмы и/или биоактивные материалы, и способ ее изготовления |
RU2410084C1 (ru) | 2009-06-19 | 2011-01-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Фармацевтическая композиция на основе секстафага (пиобактериофага поливалентного) или бактериофага сальмонеллезного и способ ее получения |
US20110070334A1 (en) | 2009-09-20 | 2011-03-24 | Nagendra Rangavajla | Probiotic Stabilization |
US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
NZ601017A (en) | 2010-01-28 | 2014-07-25 | Advanced Bionutrition Corp | Dry glassy composition comprising a bioactive material |
JP2010227125A (ja) | 2010-07-16 | 2010-10-14 | Ina Food Industry Co Ltd | 乳化安定化組成物及びそれを含む大豆発酵物含有食品 |
RS57588B1 (sr) | 2010-08-13 | 2018-11-30 | Advanced Bionutrition Corp | Supstanca za stabilizaciju bioloških materijala za suvo skladištenje |
US8834591B2 (en) | 2010-10-01 | 2014-09-16 | Aaf-Mcquay Inc. | Filter structure for removing contaminants from stream of fluid |
-
2010
- 2010-05-26 RU RU2011151788/10A patent/RU2567668C2/ru active
- 2010-05-26 KR KR1020117031038A patent/KR101799983B1/ko active IP Right Grant
- 2010-05-26 US US13/321,708 patent/US20120135017A1/en not_active Abandoned
- 2010-05-26 EP EP10781100.2A patent/EP2435554B1/en active Active
- 2010-05-26 CN CN2010800293924A patent/CN102459568A/zh active Pending
- 2010-05-26 NZ NZ597053A patent/NZ597053A/en not_active IP Right Cessation
- 2010-05-26 SG SG2011087533A patent/SG176253A1/en unknown
- 2010-05-26 MY MYPI2011005733A patent/MY157343A/en unknown
- 2010-05-26 PL PL10781100T patent/PL2435554T3/pl unknown
- 2010-05-26 DK DK10781100.2T patent/DK2435554T3/en active
- 2010-05-26 CA CA2763074A patent/CA2763074C/en not_active Expired - Fee Related
- 2010-05-26 JP JP2012513183A patent/JP5841527B2/ja not_active Expired - Fee Related
- 2010-05-26 MX MX2011012586A patent/MX2011012586A/es active IP Right Grant
- 2010-05-26 WO PCT/US2010/036098 patent/WO2010138522A2/en active Application Filing
- 2010-05-26 ES ES10781100.2T patent/ES2643148T3/es active Active
- 2010-05-26 BR BRPI1013809-9A patent/BRPI1013809B1/pt not_active IP Right Cessation
- 2010-05-26 CN CN201710034705.9A patent/CN106987525B/zh not_active Expired - Fee Related
- 2010-05-26 AU AU2010254235A patent/AU2010254235B2/en not_active Ceased
-
2018
- 2018-12-20 US US16/227,075 patent/US11214597B2/en active Active
-
2021
- 2021-11-18 US US17/530,036 patent/US20220081471A1/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05246856A (ja) * | 1991-10-23 | 1993-09-24 | Bristol Myers Squibb Co | 改良イフォスファミド凍結乾燥組成物 |
JPH11513700A (ja) * | 1995-10-25 | 1999-11-24 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 凍結しない乾燥過程により生物材料を安定化するための調製物及び方法 |
JP2001505431A (ja) * | 1996-12-05 | 2001-04-24 | クアドラント ホールディングス ケンブリッジ リミテッド | 原核細胞の保存方法およびそれにより得られる組成物 |
JP2002512970A (ja) * | 1998-04-24 | 2002-05-08 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 安定化したウィルス製剤 |
JP2007522085A (ja) * | 2003-06-27 | 2007-08-09 | スミスクライン・ビーチャム・コーポレイション | 安定化されたトポテカンリポソーム組成物および方法 |
WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
JP2009508866A (ja) * | 2005-09-16 | 2009-03-05 | メリアル リミテッド | 凍結乾燥ワクチン用安定剤 |
WO2007079147A2 (en) * | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
WO2008076975A1 (en) * | 2006-12-18 | 2008-06-26 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
WO2009002481A1 (en) * | 2007-06-26 | 2008-12-31 | Merck & Co., Inc. | Lyophilized anti-fungal composition |
Non-Patent Citations (2)
Title |
---|
C.SCHWAB, ET AL, CRYOBIOLOGY, vol. 55, JPN6014032660, 2007, pages 108 - 114, ISSN: 0002868228 * |
P.CAPELA, ET AL, FOOD RESEARCH INTERNATIONAL, vol. 39, JPN6014032657, 2006, pages 203 - 211, ISSN: 0002868227 * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012217381A (ja) * | 2011-04-08 | 2012-11-12 | Nisshin Pet Food Kk | ドライペットフード |
US10188609B2 (en) | 2012-11-29 | 2019-01-29 | Progel Pty Ltd | Microparticles comprising a probiotic, cross-linkable reagent, a denatured protein, polyol plasticiser and trehalose |
JP2016501868A (ja) * | 2012-11-29 | 2016-01-21 | プロゲル プロプライアタリー リミティド | プロバイオティクス、架橋性試薬、変性タンパク質、ポリオール可塑剤及びトレハロースを含む微小粒子 |
JP2014171423A (ja) * | 2013-03-08 | 2014-09-22 | Nissin Foods Holdings Co Ltd | 凍結乾燥菌試料およびその製造方法 |
JP2017508754A (ja) * | 2014-03-06 | 2017-03-30 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | プロバイオティクス製剤および使用のための方法 |
US10369176B2 (en) | 2014-03-06 | 2019-08-06 | Research Institute At Nationwide Children's Hospital | Probiotic formulations and methods for use |
US10624934B2 (en) | 2014-03-06 | 2020-04-21 | Research Institute At Nationwide Children's Hospital | Prebiotic formulations |
US11452748B2 (en) | 2014-03-06 | 2022-09-27 | Research Institute at Nation Children's Hospital | Probiotic formulations and methods for use |
US11497780B2 (en) | 2014-03-06 | 2022-11-15 | Research Institute At Nationwide Children's Hospital | Prebiotic formulations |
JPWO2015156274A1 (ja) * | 2014-04-09 | 2017-04-13 | 株式会社エス・ディー・エス バイオテック | 微生物農薬組成物、その製造方法及び微生物農薬の安定化方法 |
US10111423B2 (en) | 2014-04-09 | 2018-10-30 | Sds Biotech K.K. | Microbial pesticide composition of dried Bacillus |
WO2015156274A1 (ja) * | 2014-04-09 | 2015-10-15 | 株式会社エス・ディー・エス バイオテック | 微生物農薬組成物、その製造方法及び微生物農薬の安定化方法 |
US11484479B2 (en) | 2015-07-14 | 2022-11-01 | Research Institute At Nationwide Children's Hospital | Formulation for the elimination of cariogenic and opportunistic pathogens within the oral cavity |
JP2018521136A (ja) * | 2015-07-17 | 2018-08-02 | エービー−バイオティクス,エス.エイ. | 口腔ケア用の自己フィルム形成性組成物 |
JP6993967B2 (ja) | 2015-07-17 | 2022-02-04 | エービー-バイオティクス,エス.エイ. | 口腔ケア用の自己フィルム形成性組成物 |
KR20190034190A (ko) * | 2019-03-25 | 2019-04-01 | 대한민국(농촌진흥청장) | 사카로마이세스 세르비지애 y204의 고체종균 제조방법 |
KR102093378B1 (ko) * | 2019-03-25 | 2020-03-26 | 대한민국 | 사카로마이세스 세르비지애 y204의 고체종균 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
MY157343A (en) | 2016-05-31 |
RU2011151788A (ru) | 2013-07-10 |
KR20120017460A (ko) | 2012-02-28 |
DK2435554T3 (en) | 2017-10-30 |
BRPI1013809B1 (pt) | 2021-01-19 |
US20120135017A1 (en) | 2012-05-31 |
NZ597053A (en) | 2014-02-28 |
CN102459568A (zh) | 2012-05-16 |
JP5841527B2 (ja) | 2016-01-13 |
US20220081471A1 (en) | 2022-03-17 |
US20190194259A1 (en) | 2019-06-27 |
SG176253A1 (en) | 2011-12-29 |
US11214597B2 (en) | 2022-01-04 |
WO2010138522A3 (en) | 2011-04-21 |
BRPI1013809A2 (pt) | 2016-11-01 |
CA2763074A1 (en) | 2010-12-02 |
EP2435554A4 (en) | 2012-11-07 |
EP2435554A2 (en) | 2012-04-04 |
AU2010254235B2 (en) | 2015-04-02 |
MX2011012586A (es) | 2012-03-26 |
AU2010254235A1 (en) | 2012-01-12 |
CN106987525B (zh) | 2020-10-27 |
RU2567668C2 (ru) | 2015-11-10 |
EP2435554B1 (en) | 2017-07-26 |
CN106987525A (zh) | 2017-07-28 |
KR101799983B1 (ko) | 2017-12-20 |
CA2763074C (en) | 2021-02-23 |
ES2643148T3 (es) | 2017-11-21 |
PL2435554T3 (pl) | 2018-01-31 |
WO2010138522A2 (en) | 2010-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220081471A1 (en) | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making | |
JP5886763B2 (ja) | 生物活性物質を含む乾燥ガラス状組成物 | |
JP5727611B2 (ja) | 生体物質用の乾燥貯蔵安定化組成物 | |
AU2011289272A2 (en) | Dry storage stabilizing composition for biological materials |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130328 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140801 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141031 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150331 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20150630 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150701 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150804 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150818 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150915 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150924 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151019 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20151113 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5841527 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |