JP2012527898A - 生物学的に活性な微生物および/または生物活性材料を含む安定な乾燥粉末組成物およびその製造方法 - Google Patents
生物学的に活性な微生物および/または生物活性材料を含む安定な乾燥粉末組成物およびその製造方法 Download PDFInfo
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Abstract
【選択図】図1
Description
[001]本出願は、2009年5月26日および2009年7月6日にそれぞれ米国特許商標庁に出願された米国仮出願第61/181,248号および第61/223,295号に対する優先権を主張し、その内容をすべての目的のために参照により本明細書に援用する。
[0012]本発明は、生物活性材料、例えば、ペプチド、タンパク質、ホルモン、ビタミン、ミネラル、薬剤、殺微生物剤、殺真菌薬、除草剤、殺虫剤、殺精子剤、核酸、抗体、ワクチン、および/または生物活性微生物、例えば、細菌(プロバイオティックその他)、ウイルス、および/または細胞懸濁液を、貯蔵において保存するための組成物および方法を含む。乾燥方法は、生物活性微生物または生物活性材料、製剤安定化剤、および保護剤を含む製剤の制御可能な膨張方法を提供する。製剤は、真空下でまたは真空なしで、すべての固体成分を溶液に分散することによって調製される。溶液はその凍結温度を上回る温度に冷却され、真空下で乾燥して乾燥組成物とし、これは意外にも高い安定性を示す。本方法は、所望の温度および期間での製剤の第1の乾燥工程、および乾燥材料の望ましい最終水分活性を達成するために最大真空度および高温下での促進された第2の乾燥工程を含む。
[0036]定義
[0054]本発明は、粘性溶液中の生物活性微生物または生物活性材料、安定化剤、および保護剤の製剤組成物を含む。本発明の製剤は、予備冷却せずに乾燥した非粘性のまたは濃縮された製剤とはその物理的構造および機能において本来的に異なることが見出された。例えば、従来技術の製剤は、効果的な乾燥を促すために最初に「泡を形成させた」。泡形成工程は、一般に沸騰が激しく、溶液が噴出する結果となったが、これは液状での真空乾燥において避けられない結果であり、バイアルまたは容器中の材料の非常に低い充填能力(loading capacity)しか達成し得ない(米国特許第6,534,087号を参照のこと。ここでは、泡形成した最終生成物の厚さは2mm未満である)。本発明の組成物および乾燥方法によって、製剤の膨張の抑制および制御が可能となり、これによって材料の乾燥面積あたりのより高い充填が可能となり、その結果、容易にスケールアップして材料を大量製造することができる。
[0062]生物活性微生物保存用の安定な乾燥製剤の調製方法は、濃縮溶液、ペースト、凍結ビード、または乾燥粉末(安定化されたものその他)中に特定の微生物の生培養物を得ること、真空下において生物活性微生物または生物活性材料を安定化剤および保護剤と溶液中で混合することにより製剤を調製すること、製剤をその凍結温度を上回って10℃以下に冷却すること、および製剤に熱を供給しながら減圧下で水分を蒸発させることによって製剤を乾燥することを含む。
Claims (21)
- (i)フレッシュな粉末、凍結粉末、または乾燥粉末としての生物活性微生物または生物活性材料、(ii)少なくとも2種の安定化剤、および(iii)少なくとも2種の保護剤を含む組成物であって、前記生物活性微生物または生物活性材料の液状乾燥および安定化に好適である、組成物。
- 全固形分が、約30重量パーセント〜約70重量パーセントの範囲である、請求項1に記載の組成物。
- 前記生物活性微生物または生物活性材料が、細胞、細菌、ウイルス、培養物、プロバイオティック、酵母、藻類、タンパク質、組換えタンパク質、酵素、ペプチド、ホルモン、ワクチン、薬剤、ビタミン、ミネラル、殺微生物剤、殺真菌薬、除草剤、殺虫剤、または殺精子剤から選択される、請求項1に記載の組成物。
- 前記安定化剤が、多糖類および/またはオリゴ糖である、請求項1に記載の組成物。
- 前記多糖類は、酢酸フタル酸セルロース(CAP)、カルボキシ−メチル−セルロース、ペクチン、アルギン酸ナトリウム、アルギン酸塩、ヒドロキシルプロピルメチルセルロース(HPMC)、メチルセルロース、カラゲナン、グアールガム、アラビアゴム、キサンタンガム、イナゴマメガム、キトサンおよびキトサン誘導体、コラーゲン、ポリグリコール酸、デンプンおよび変性デンプン、シクロデキストリン、ならびにそれらの組み合わせから選択される、請求項4に記載の組成物。
- 前記オリゴ糖が、イヌリン、マルトデキストリン、デキストラン、およびそれらの組み合わせから選択される、請求項4に記載の組成物。
- 前記安定化剤が、約1重量パーセント〜約20重量パーセントの範囲の量で存在する、請求項4に記載の組成物。
- 前記保護剤が、溶液に容易に溶解し、水と接触したときに粘度が高くならずまたは重合しない、請求項1に記載の組成物。
- 前記保護剤が、タンパク質、例えば、ヒトおよびウシ血清アルブミン、卵アルブミン、ゼラチン、免疫グロブリン、単離大豆タンパク質、コムギタンパク質、スキムミルク粉末、カゼイン塩、乳清タンパク質、エンドウ豆タンパク質、および任意のタンパク質加水分解物;単糖(ガラクトース、D−マンノース、ソルボースなど)、二糖類(ラクトース、トレハロース、スクロースなど)、シクロデキストリンを含む炭水化物;アミノ酸、例えば、リシン、グルタミン酸モノナトリウム、グリシン、アラニン、アルギニン、またはヒスチジン、および疎水性アミノ酸(トリプトファン、チロシン、ロイシン、フェニルアラニンなど);メチルアミン、例えば、ベタイン;賦形剤の塩、例えば、硫酸マグネシウム;三価以上の糖アルコールなどのポリオール、例えば、グリセリン、エリスリトール、グリセロール、アラビトール、キシリトール、ソルビトール、およびマンニトール;プロピレングリコール;ポリエチレングリコール;プルロニック;界面活性剤;ならびにそれらの組み合わせである、請求項1に記載の組成物。
- 前記保護剤が、約1重量パーセント〜約80重量パーセントの範囲の量で存在する、請求項9に記載の組成物。
- 前記保護剤の総量が、20〜70重量パーセントである、請求項1に記載の組成物。
- 請求項1に記載の安定な乾燥粉末組成物を調製する方法であって、
(i)真空下において、フレッシュな粉末、凍結粉末、または乾燥粉末の形態の生物活性微生物または生物活性材料、乾燥安定化剤、および乾燥保護剤を水性溶媒中で合わせ、
(ii)前記工程(i)の混合物をその凍結温度を上回る温度に冷却し、
(iii)真空下でその凍結温度を上回る温度で蒸発することにより、前記冷却した混合物の第1の乾燥を行い、
(iv)前記混合物の水分活性を−0.3以下のAwに低減するのに十分な期間、20℃以上の温度で前記混合物の第2の乾燥を行うこと
を含む、方法。 - 前記混合物を、乾燥前にその凍結温度を上回る温度に冷却する、請求項12に記載の方法。
- 前記混合物の乾燥が、蒸発によって行われる、請求項12に記載の方法。
- 前記第1の乾燥工程中の混合物の温度が、その凍結温度を上回る、請求項12に記載の方法。
- 前記混合物の温度がその最初の乾燥温度を少なくとも10℃上回って上昇したときに、前記第2の乾燥工程を開始する、請求項12に記載の方法。
- 前記第2の乾燥工程中の残留溶媒の蒸発速度が、前記温度および/または真空圧を上昇させることによって増す、請求項12に記載の方法。
- 前記製剤の水分活性を−0.3以下のAwに低減するのに十分な時間、前記混合物を乾燥する、請求項12に記載の方法。
- 前記乾燥した混合物を切断し、破砕し、微粉砕化し、またはそれぞれ微粉化して自由流動粉末とする、請求項12に記載の方法。
- 前記乾燥した混合物の粒径が、約1000μm未満である、請求項19に記載の方法。
- 前記還元された液体として、または細粉末として、および食品または食餌品として前記組成物を哺乳動物に投与することをさらに含む、請求項12に記載の方法。
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KR20190034190A (ko) * | 2019-03-25 | 2019-04-01 | 대한민국(농촌진흥청장) | 사카로마이세스 세르비지애 y204의 고체종균 제조방법 |
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ES2643148T3 (es) | 2017-11-21 |
PL2435554T3 (pl) | 2018-01-31 |
MX2011012586A (es) | 2012-03-26 |
DK2435554T3 (en) | 2017-10-30 |
RU2567668C2 (ru) | 2015-11-10 |
CA2763074C (en) | 2021-02-23 |
US20120135017A1 (en) | 2012-05-31 |
WO2010138522A3 (en) | 2011-04-21 |
BRPI1013809B1 (pt) | 2021-01-19 |
KR20120017460A (ko) | 2012-02-28 |
KR101799983B1 (ko) | 2017-12-20 |
US20190194259A1 (en) | 2019-06-27 |
EP2435554B1 (en) | 2017-07-26 |
AU2010254235A1 (en) | 2012-01-12 |
JP5841527B2 (ja) | 2016-01-13 |
EP2435554A4 (en) | 2012-11-07 |
NZ597053A (en) | 2014-02-28 |
MY157343A (en) | 2016-05-31 |
CN102459568A (zh) | 2012-05-16 |
EP2435554A2 (en) | 2012-04-04 |
US11214597B2 (en) | 2022-01-04 |
US20220081471A1 (en) | 2022-03-17 |
BRPI1013809A2 (pt) | 2016-11-01 |
CN106987525A (zh) | 2017-07-28 |
SG176253A1 (en) | 2011-12-29 |
CA2763074A1 (en) | 2010-12-02 |
RU2011151788A (ru) | 2013-07-10 |
AU2010254235B2 (en) | 2015-04-02 |
WO2010138522A2 (en) | 2010-12-02 |
CN106987525B (zh) | 2020-10-27 |
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