JP2012525428A5 - - Google Patents

Info

Publication number

JP2012525428A5

JP2012525428A5 JP2012508737A JP2012508737A JP2012525428A5 JP 2012525428 A5 JP2012525428 A5 JP 2012525428A5 JP 2012508737 A JP2012508737 A JP 2012508737A JP 2012508737 A JP2012508737 A JP 2012508737A JP 2012525428 A5 JP2012525428 A5 JP 2012525428A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

bacillus coagulans

immune response

pathogen

Prior art date

2010-04-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 241000193749 Bacillus coagulans Species 0.000 claims description 17
• 229940054340 bacillus coagulans Drugs 0.000 claims description 13
• 230000028993 immune response Effects 0.000 claims description 12
• 239000000203 mixture Substances 0.000 claims description 11
• 244000052769 pathogen Species 0.000 claims description 8
• 230000001717 pathogenic effect Effects 0.000 claims description 8
• 239000000047 product Substances 0.000 claims description 8
• 230000001965 increasing effect Effects 0.000 claims description 7
• 241000894006 Bacteria Species 0.000 claims description 6
• 241000282414 Homo sapiens Species 0.000 claims description 6
• 210000002421 cell wall Anatomy 0.000 claims description 6
• 210000000224 granular leucocyte Anatomy 0.000 claims description 6
• 244000000010 microbial pathogen Species 0.000 claims description 6
• 108010074328 Interferon-gamma Proteins 0.000 claims description 4
• 108010002350 Interleukin-2 Proteins 0.000 claims description 4
• 102000000588 Interleukin-2 Human genes 0.000 claims description 4
• 206010057249 Phagocytosis Diseases 0.000 claims description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
• 239000002775 capsule Substances 0.000 claims description 4
• 230000016396 cytokine production Effects 0.000 claims description 4
• 230000002434 immunopotentiative effect Effects 0.000 claims description 4
• 230000008782 phagocytosis Effects 0.000 claims description 4
• 239000006187 pill Substances 0.000 claims description 4
• 239000000725 suspension Substances 0.000 claims description 4
• 241000712461 unidentified influenza virus Species 0.000 claims description 4
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
• 102000004127 Cytokines Human genes 0.000 claims description 2
• 108090000695 Cytokines Proteins 0.000 claims description 2
• 102100025137 Early activation antigen CD69 Human genes 0.000 claims description 2
• 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims description 2
• 102100037850 Interferon gamma Human genes 0.000 claims description 2
• 102000008070 Interferon-gamma Human genes 0.000 claims description 2
• 108090000174 Interleukin-10 Proteins 0.000 claims description 2
• 108090000978 Interleukin-4 Proteins 0.000 claims description 2
• 108090001005 Interleukin-6 Proteins 0.000 claims description 2
• 206010062106 Respiratory tract infection viral Diseases 0.000 claims description 2
• 241000725681 Swine influenza virus Species 0.000 claims description 2
• 241000700605 Viruses Species 0.000 claims description 2
• 210000004027 cell Anatomy 0.000 claims description 2
• 230000012292 cell migration Effects 0.000 claims description 2
• 230000035605 chemotaxis Effects 0.000 claims description 2
• 230000002708 enhancing effect Effects 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• 210000002865 immune cell Anatomy 0.000 claims description 2
• 230000037451 immune surveillance Effects 0.000 claims description 2
• 208000015181 infectious disease Diseases 0.000 claims description 2
• 206010022000 influenza Diseases 0.000 claims description 2
• 229960003130 interferon gamma Drugs 0.000 claims description 2
• 230000011268 leukocyte chemotaxis Effects 0.000 claims description 2
• 210000001616 monocyte Anatomy 0.000 claims description 2
• 210000000822 natural killer cell Anatomy 0.000 claims description 2
• 239000006228 supernatant Substances 0.000 claims description 2
• 241000701161 unidentified adenovirus Species 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 230000004083 survival effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 18
• 239000000463 material Substances 0.000 description 3