JP2012512175A - 治療薬を徐放するための長時間循環性ナノ粒子 - Google Patents

治療薬を徐放するための長時間循環性ナノ粒子 Download PDF

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JP2012512175A
JP2012512175A JP2011540968A JP2011540968A JP2012512175A JP 2012512175 A JP2012512175 A JP 2012512175A JP 2011540968 A JP2011540968 A JP 2011540968A JP 2011540968 A JP2011540968 A JP 2011540968A JP 2012512175 A JP2012512175 A JP 2012512175A
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therapeutic agent
nanoparticles
nanoparticle composition
biocompatible
patient
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JP2012512175A5 (OSRAM
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ゼイル，スティーブン，イー．
トロイアーノ，グレッグ
アリ，ミル，ムッカラム
フルカッチ，ジェフ
ライト，ジェームズ
ロウ，スーザン
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バインド バイオサイエンシズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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  • Life Sciences & Earth Sciences (AREA)
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  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011540968A 2008-12-15 2009-12-15 治療薬を徐放するための長時間循環性ナノ粒子 Pending JP2012512175A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12247908P 2008-12-15 2008-12-15
US61/122,479 2008-12-15
US24902209P 2009-10-06 2009-10-06
US61/249,022 2009-10-06
US26020009P 2009-11-11 2009-11-11
US61/260,200 2009-11-11
PCT/US2009/068028 WO2010075072A2 (en) 2008-12-15 2009-12-15 Long circulating nanoparticles for sustained release of therapeutic agents

Related Child Applications (1)

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JP2015088181A Division JP2015143268A (ja) 2008-12-15 2015-04-23 治療薬を徐放するための長時間循環性ナノ粒子

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JP2012512175A true JP2012512175A (ja) 2012-05-31
JP2012512175A5 JP2012512175A5 (OSRAM) 2013-02-07

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JP2011540968A Pending JP2012512175A (ja) 2008-12-15 2009-12-15 治療薬を徐放するための長時間循環性ナノ粒子
JP2015088181A Withdrawn JP2015143268A (ja) 2008-12-15 2015-04-23 治療薬を徐放するための長時間循環性ナノ粒子
JP2017125985A Withdrawn JP2017165780A (ja) 2008-12-15 2017-06-28 治療薬を徐放するための長時間循環性ナノ粒子
JP2019081186A Pending JP2019142924A (ja) 2008-12-15 2019-04-22 治療薬を徐放するための長時間循環性ナノ粒子

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JP2015088181A Withdrawn JP2015143268A (ja) 2008-12-15 2015-04-23 治療薬を徐放するための長時間循環性ナノ粒子
JP2017125985A Withdrawn JP2017165780A (ja) 2008-12-15 2017-06-28 治療薬を徐放するための長時間循環性ナノ粒子
JP2019081186A Pending JP2019142924A (ja) 2008-12-15 2019-04-22 治療薬を徐放するための長時間循環性ナノ粒子

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US (5) US20100216804A1 (OSRAM)
EP (1) EP2379064B1 (OSRAM)
JP (4) JP2012512175A (OSRAM)
EA (1) EA201100765A1 (OSRAM)
ES (1) ES2776126T3 (OSRAM)
WO (1) WO2010075072A2 (OSRAM)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016523915A (ja) * 2013-06-28 2016-08-12 バインド セラピューティックス インコーポレイテッド ドセタキセルポリマーナノ粒子及びそれを使用する癌の治療方法
KR20170081659A (ko) * 2014-11-05 2017-07-12 셀렉타 바이오사이언시즈, 인크. 라팔로그를 포함하는 합성 나노담체 제조에서의 저hlb 계면활성제의 사용관 관련된 방법 및 조성물
JP2017527565A (ja) * 2014-09-07 2017-09-21 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 遺伝子発現調節抗ウイルス導入ベクター免疫応答を減弱化するための方法および組成物
US11235057B2 (en) 2011-04-29 2022-02-01 Selecta Biosciences, Inc. Methods for providing polymeric synthetic nanocarriers for generating antigen-specific tolerance immune responses
US11298342B2 (en) 2013-05-03 2022-04-12 Selecta Biosciences, Inc. Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type I and type IV hypersensitivity
US11426451B2 (en) 2017-03-11 2022-08-30 Selecta Biosciences, Inc. Methods and compositions related to combined treatment with antiinflammatories and synthetic nanocarriers comprising an immunosuppressant

Families Citing this family (173)

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WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
JP2009534309A (ja) 2006-03-31 2009-09-24 マサチューセッツ インスティテュート オブ テクノロジー 治療剤の標的化送達のためのシステム
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
EP2144600A4 (en) 2007-04-04 2011-03-16 Massachusetts Inst Technology POLY (AMINIC ACID) TARGET MOLECULES
JP5410434B2 (ja) 2007-09-28 2014-02-05 バインド セラピューティックス インコーポレイテッド ナノ粒子を用いた癌細胞の標的化
EP2620157A3 (en) 2007-10-12 2013-10-16 Massachusetts Institute of Technology Vaccine nanotechnology
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
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