AU2002232824A1 - Induced phase transition method for the production of microparticles containing hydrophobic active agents - Google Patents

Induced phase transition method for the production of microparticles containing hydrophobic active agents

Info

Publication number
AU2002232824A1
AU2002232824A1 AU2002232824A AU3282402A AU2002232824A1 AU 2002232824 A1 AU2002232824 A1 AU 2002232824A1 AU 2002232824 A AU2002232824 A AU 2002232824A AU 3282402 A AU3282402 A AU 3282402A AU 2002232824 A1 AU2002232824 A1 AU 2002232824A1
Authority
AU
Australia
Prior art keywords
production
active agents
phase transition
microparticles containing
induced phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002232824A
Inventor
Celal Albayrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Inhale Therapeutics Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26946029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2002232824(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inhale Therapeutics Systems Inc filed Critical Inhale Therapeutics Systems Inc
Publication of AU2002232824A1 publication Critical patent/AU2002232824A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Abstract

Microparticles and a method for their production is described. The process of the present invention provides a simple, quick, and efficient one-pot process for the production of microparticles containing a hydrophilic active agent of various and uniform morphologies, including microcapsules, microspheres, and microsponges. The microparticles are preferably used for pharmaceutical applications.
AU2002232824A 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophobic active agents Abandoned AU2002232824A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25752700P 2000-12-21 2000-12-21
US60/257,527 2000-12-21
US30002101P 2001-06-21 2001-06-21
US60/300,021 2001-06-21
PCT/US2001/050259 WO2002049620A2 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophobic active agents

Publications (1)

Publication Number Publication Date
AU2002232824A1 true AU2002232824A1 (en) 2002-07-01

Family

ID=26946029

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2002232824A Abandoned AU2002232824A1 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophobic active agents
AU2002235253A Abandoned AU2002235253A8 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents
AU2002235253A Abandoned AU2002235253A1 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2002235253A Abandoned AU2002235253A8 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents
AU2002235253A Abandoned AU2002235253A1 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents

Country Status (10)

Country Link
US (2) US7252842B2 (en)
EP (2) EP1343480B2 (en)
JP (2) JP2004516263A (en)
AT (2) ATE361057T1 (en)
AU (3) AU2002232824A1 (en)
CA (2) CA2432904C (en)
DE (2) DE60130917T2 (en)
DK (1) DK1343480T4 (en)
ES (2) ES2292634T3 (en)
WO (2) WO2002049620A2 (en)

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