AU5804300A - Method for producing morphologically uniform micro and nanoparticles using micromixers - Google Patents

Method for producing morphologically uniform micro and nanoparticles using micromixers

Info

Publication number
AU5804300A
AU5804300A AU58043/00A AU5804300A AU5804300A AU 5804300 A AU5804300 A AU 5804300A AU 58043/00 A AU58043/00 A AU 58043/00A AU 5804300 A AU5804300 A AU 5804300A AU 5804300 A AU5804300 A AU 5804300A
Authority
AU
Australia
Prior art keywords
nanoparticles
micromixers
uniform micro
morphologically uniform
producing morphologically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU58043/00A
Inventor
Stephan Harnisch
Gesine Hildebrand
Johannes Tack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU5804300A publication Critical patent/AU5804300A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B01F33/30121—Interdigital streams, e.g. lamellae the interdigital streams being concentric lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

The invention relates to a novel continuous method for producing morphologically uniform micro or nanoparticles using a micromixer, to the use of this method for encapsulating active substances and to the particles produced with this method.
AU58043/00A 1999-05-26 2000-05-24 Method for producing morphologically uniform micro and nanoparticles using micromixers Abandoned AU5804300A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19925184A DE19925184A1 (en) 1999-05-26 1999-05-26 Continuous process for the production of morphologically uniform micro and nanoparticles by means of a micromixer as well as particles produced by this process
DE19925184 1999-05-26
PCT/DE2000/001677 WO2000072955A1 (en) 1999-05-26 2000-05-24 Method for producing morphologically uniform micro and nanoparticles using micromixers

Publications (1)

Publication Number Publication Date
AU5804300A true AU5804300A (en) 2000-12-18

Family

ID=7909952

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58043/00A Abandoned AU5804300A (en) 1999-05-26 2000-05-24 Method for producing morphologically uniform micro and nanoparticles using micromixers

Country Status (9)

Country Link
EP (1) EP1180062B1 (en)
JP (1) JP2003500202A (en)
AT (1) ATE261337T1 (en)
AU (1) AU5804300A (en)
DE (2) DE19925184A1 (en)
DK (1) DK1180062T3 (en)
ES (1) ES2216907T3 (en)
PT (1) PT1180062E (en)
WO (1) WO2000072955A1 (en)

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US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
DE10010194A1 (en) * 2000-03-02 2001-09-13 Henkel Kgaa Production of micro- and/or nano-capsules used e.g. for encapsulating pharmaceutical and cosmetic active ingredients comprises mixing together the starting materials under laminar conditions and encapsulating in the conventional manner
AR023940A1 (en) * 2000-05-03 2002-09-04 Eriochem Sa PROCEDURE FOR THE PRODUCTION OF PROLONGED WATERPROOF PEPTIDE MICROCAPSULES IN WATER
EP1345542B1 (en) 2000-12-20 2011-02-23 Fox Hollow Technologies, Inc. Debulking catheter
DE10148615B4 (en) * 2001-09-26 2005-03-31 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Method and device for carrying out chemical processes
DE10154045A1 (en) * 2001-11-02 2003-05-22 Basf Coatings Ag Process for the preparation of (co) polymers of olefinically unsaturated monomers
GB0200744D0 (en) * 2002-01-14 2002-02-27 Imperial College Preparation of nanoparticles
DE10205362A1 (en) * 2002-02-08 2003-08-21 Abbott Gmbh & Co Kg Process for the preparation of water-dispersible dry powder of water-poorly soluble compounds
CN1688275B (en) * 2002-09-11 2012-05-30 田边三菱制药株式会社 Process for the production of microspheres
JP4527384B2 (en) * 2002-12-06 2010-08-18 綜研化学株式会社 Manufacturing method of colored spherical particles using microchannel, and microchannel manufacturing apparatus used in the manufacturing method
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
US7485671B2 (en) 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
CA2526965C (en) 2003-05-16 2011-10-11 Velocys Inc. Process for forming an emulsion using microchannel process technology
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JP2005068125A (en) * 2003-08-21 2005-03-17 Rohm & Haas Co Method for preparing biocide-blended material
JP4461900B2 (en) 2004-05-10 2010-05-12 富士ゼロックス株式会社 Method for feeding fine particle dispersion and liquid feeding device for fine particle dispersion
JP4461941B2 (en) 2004-07-21 2010-05-12 富士ゼロックス株式会社 Method for feeding fine particle dispersion and liquid feeding device for fine particle dispersion
US7622509B2 (en) 2004-10-01 2009-11-24 Velocys, Inc. Multiphase mixing process using microchannel process technology
GB0516549D0 (en) 2005-08-12 2005-09-21 Sulaiman Brian Milling system
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
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US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
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Also Published As

Publication number Publication date
DK1180062T3 (en) 2004-07-05
WO2000072955A1 (en) 2000-12-07
EP1180062A1 (en) 2002-02-20
DE50005599D1 (en) 2004-04-15
DE19925184A1 (en) 2000-11-30
ATE261337T1 (en) 2004-03-15
EP1180062B1 (en) 2004-03-10
PT1180062E (en) 2004-08-31
ES2216907T3 (en) 2004-11-01
JP2003500202A (en) 2003-01-07

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase