JP2012131827A5 - - Google Patents
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- Publication number
- JP2012131827A5 JP2012131827A5 JP2012077545A JP2012077545A JP2012131827A5 JP 2012131827 A5 JP2012131827 A5 JP 2012131827A5 JP 2012077545 A JP2012077545 A JP 2012077545A JP 2012077545 A JP2012077545 A JP 2012077545A JP 2012131827 A5 JP2012131827 A5 JP 2012131827A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- amount
- composition
- desoxyascomycin
- epi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- KASDHRXLYQOAKZ-OLHLVPFQSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-OLHLVPFQSA-N 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 229940055577 oleyl alcohol Drugs 0.000 claims 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9421612.4 | 1994-10-26 | ||
| GB9421612A GB9421612D0 (en) | 1994-10-26 | 1994-10-26 | Organic compounds |
| GB9422306.2 | 1994-11-04 | ||
| GB9422306A GB9422306D0 (en) | 1994-11-04 | 1994-11-04 | Organic compounds |
| GBGB9503553.1A GB9503553D0 (en) | 1995-02-22 | 1995-02-22 | Organic compounds |
| GB9503553.1 | 1995-02-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007047216A Division JP2007145860A (ja) | 1994-10-26 | 2007-02-27 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012131827A JP2012131827A (ja) | 2012-07-12 |
| JP2012131827A5 true JP2012131827A5 (https=) | 2013-05-30 |
| JP5599422B2 JP5599422B2 (ja) | 2014-10-01 |
Family
ID=27267447
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51431096A Expired - Lifetime JP4155593B2 (ja) | 1994-10-26 | 1995-10-26 | 医薬組成物 |
| JP2007047216A Withdrawn JP2007145860A (ja) | 1994-10-26 | 2007-02-27 | 医薬組成物 |
| JP2012077545A Expired - Lifetime JP5599422B2 (ja) | 1994-10-26 | 2012-03-29 | 医薬組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51431096A Expired - Lifetime JP4155593B2 (ja) | 1994-10-26 | 1995-10-26 | 医薬組成物 |
| JP2007047216A Withdrawn JP2007145860A (ja) | 1994-10-26 | 2007-02-27 | 医薬組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6352998B2 (https=) |
| EP (2) | EP1147766B1 (https=) |
| JP (3) | JP4155593B2 (https=) |
| KR (1) | KR100434682B1 (https=) |
| CN (2) | CN100335063C (https=) |
| AT (2) | ATE299017T1 (https=) |
| AU (1) | AU714254B2 (https=) |
| BR (1) | BR9509530A (https=) |
| CA (1) | CA2200966C (https=) |
| CY (1) | CY2211B1 (https=) |
| CZ (1) | CZ289773B6 (https=) |
| DE (3) | DE69534306T2 (https=) |
| DK (2) | DK1147766T3 (https=) |
| ES (2) | ES2243369T3 (https=) |
| FI (2) | FI119754B (https=) |
| GB (1) | GB2308546B (https=) |
| HU (1) | HU223840B1 (https=) |
| MX (1) | MX9702699A (https=) |
| NO (2) | NO316963B1 (https=) |
| NZ (2) | NZ331824A (https=) |
| PL (1) | PL184750B1 (https=) |
| PT (2) | PT1147766E (https=) |
| SI (1) | SI0786986T1 (https=) |
| SK (1) | SK284591B6 (https=) |
| WO (1) | WO1996013249A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
| GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| CZ283516B6 (cs) * | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
| US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| TW450810B (en) | 1997-02-20 | 2001-08-21 | Fujisawa Pharmaceutical Co | Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases |
| DE19744621A1 (de) * | 1997-10-09 | 1999-04-15 | Muehlbauer Ernst Kg | Mischung zur Verwendung als Wundverband |
| GB9723669D0 (en) * | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
| DE19802205A1 (de) * | 1998-01-22 | 1999-07-29 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen, enthaltend erhöhte Elektrolytkonzentrationen |
| ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
| CA2326222C (en) * | 1998-04-27 | 2008-09-23 | Fujisawa Pharmaceutical Co., Ltd. | Medicinal compositions |
| GB9814640D0 (en) * | 1998-07-06 | 1998-09-02 | Fujisawa Pharmaceutical Co | New use |
| GB9826656D0 (en) * | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| GB0003932D0 (en) * | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
| EP1372753B1 (de) * | 2001-02-16 | 2007-08-01 | Abbott Laboratories Vascular Enterprises Limited | Implantate mit fk506 zur restenosebehandlung und -prophylaxe |
| GB0108498D0 (en) * | 2001-04-04 | 2001-05-23 | Novartis Ag | Organic Compounds |
| TWI324925B (en) * | 2001-08-23 | 2010-05-21 | Novartis Ag | Ophthalmic composition |
| PE20030828A1 (es) * | 2002-03-04 | 2003-11-04 | Novartis Ag | Composicion oftalmica que comprende ascomicina |
| GB0218996D0 (en) * | 2002-08-14 | 2002-09-25 | Novartis Ag | Organic compounds |
| EP1594484A2 (en) * | 2003-02-17 | 2005-11-16 | Cipla Ltd. | Pharmaceutical patch |
| US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| GB0307867D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| GB0307866D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| GB0307869D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| JP2007500691A (ja) * | 2003-07-31 | 2007-01-18 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗炎症剤の分散性製剤 |
| PT1734927E (pt) * | 2004-04-08 | 2012-09-05 | Meda Pharma S A R L | Composição em espuma de pimecrolimus contendo hexilenoglicol, opcionalmente álcool oleílico, dimetilisossorbida e/ou triglicéridos de cadeia média |
| GB0408070D0 (en) * | 2004-04-08 | 2004-05-12 | Novartis Ag | Pharmaceutical formulations |
| GB0508827D0 (en) * | 2005-04-29 | 2005-06-08 | Novartis Ag | Cosmeceutical composition |
| US9205080B2 (en) | 2006-11-16 | 2015-12-08 | Transderm, Inc. | Methods of treating keratin hyperproliferation disorders using mTOR inhibitors |
| EP2016935A1 (en) * | 2007-07-09 | 2009-01-21 | Intendis GmbH | Pharmaceutical composition for topical application of poorly soluble compounds |
| CN101288643B (zh) * | 2008-06-17 | 2012-11-14 | 杨喜鸿 | 含有他克莫司的凝胶剂组合物及其制备方法和药物应用 |
| EP2308468A1 (en) * | 2009-10-08 | 2011-04-13 | Novaliq GmbH | Novel pharmaceutical composition comprising a macrolide immunosuppressant drug |
| GB0917816D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917817D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| EP2366378A1 (en) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
| JP5674786B2 (ja) * | 2010-07-23 | 2015-02-25 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| WO2012011192A1 (ja) * | 2010-07-23 | 2012-01-26 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| CN102552253A (zh) * | 2012-01-17 | 2012-07-11 | 唯美度科技（北京）有限公司 | 一种祛痘用皮肤外用剂 |
| JP6084579B2 (ja) * | 2012-01-25 | 2017-02-22 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| AU2014209141B2 (en) * | 2013-01-24 | 2018-05-10 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mTOR inhibitors |
| MX367121B (es) * | 2013-08-02 | 2019-08-06 | Laboratorio Raam De Sahuayo S A De C V | Composición sólida estable de inmunosupresores. |
| DE102013222164A1 (de) * | 2013-10-31 | 2015-04-30 | Deb Ip Limited | Stabilisierte multiple Emulsionen als Hautschutzprodukt |
| US10765665B2 (en) | 2015-11-24 | 2020-09-08 | Melin Jeffrey | Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases |
| CN105663027B (zh) * | 2016-04-01 | 2018-12-18 | 中国人民解放军广州军区武汉总医院 | 西罗莫司外用制剂、其制备方法及用途 |
| CA3020157C (en) * | 2016-04-04 | 2024-01-16 | Drug Delivery Solutions Limited | Topical composition comprising tacrolimus |
| EP3565520B1 (en) | 2017-01-06 | 2026-02-25 | Palvella Therapeutics, Inc. | Anhydrous compositions of mtor inhibitors and methods of use |
| KR101973065B1 (ko) | 2017-09-13 | 2019-04-26 | (주)썬테크 | 풍력 발전기 및 풍력 발전기의 블레이드 팁 |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| KR101995905B1 (ko) | 2018-03-27 | 2019-07-04 | (주)썬테크 | 풍력 발전기 및 풍력 발전기의 발전모터 |
| WO2019233722A1 (en) * | 2018-06-08 | 2019-12-12 | Almirall, S.A. | Pharmaceutical composition comprising tacrolimus |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| WO2024213629A1 (en) * | 2023-04-11 | 2024-10-17 | Bausch Health Ireland Limited | Topical compositions |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299826A (en) | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| DK175235B1 (da) | 1987-11-09 | 2004-07-19 | Novartis Ag | Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf |
| WO1989005304A1 (en) | 1987-12-09 | 1989-06-15 | Fisons Plc | Macrocyclic compounds |
| KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
| DK0427680T3 (da) * | 1989-11-09 | 1995-12-18 | Sandoz Ltd | Heteroatom-holdige cykliske forbindelser |
| US5061700A (en) | 1989-11-16 | 1991-10-29 | Gordon Jay Dow | Glyceryl acetate ointment vehicles |
| WO1991013899A1 (en) | 1990-03-12 | 1991-09-19 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds |
| JPH05507915A (ja) | 1990-06-11 | 1993-11-11 | 藤沢薬品工業株式会社 | 特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのｆｋ５０６等のマクロライド化合物の用途 |
| MY110418A (en) | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
| ES2099112T3 (es) * | 1990-09-04 | 1997-05-16 | Fujisawa Pharmaceutical Co | Pomadas que contienen un compuesto triciclico. |
| US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| PH31204A (en) * | 1990-11-02 | 1998-05-05 | Fujisawa Pharmaceutical Co | Pharmaceutical composition. |
| CA2054983A1 (en) | 1990-11-08 | 1992-05-09 | Sotoo Asakura | Suspendible composition and process for preparing the same |
| US5252732A (en) | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
| US5247076A (en) | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
| US5208241A (en) | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
| HUT66531A (en) | 1992-05-07 | 1994-12-28 | Sandoz Ag | Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| JPH06183970A (ja) * | 1992-12-16 | 1994-07-05 | Fujisawa Pharmaceut Co Ltd | 医薬用組成物 |
| MY110603A (en) | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
| CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| DE59409377D1 (de) | 1993-10-22 | 2000-06-29 | Hexal Ag | Pharmazeutische zusammensetzung mit cyclosporin a, einen vitamin e derivat und einen emulgator |
-
1995
- 1995-10-26 CN CNB021243700A patent/CN100335063C/zh not_active Expired - Lifetime
- 1995-10-26 ES ES01117396T patent/ES2243369T3/es not_active Expired - Lifetime
- 1995-10-26 SK SK520-97A patent/SK284591B6/sk not_active IP Right Cessation
- 1995-10-26 DE DE69534306T patent/DE69534306T2/de not_active Expired - Lifetime
- 1995-10-26 CA CA002200966A patent/CA2200966C/en not_active Expired - Lifetime
- 1995-10-26 CN CN95195900A patent/CN1089233C/zh not_active Expired - Lifetime
- 1995-10-26 CZ CZ19971232A patent/CZ289773B6/cs not_active IP Right Cessation
- 1995-10-26 SI SI9530589T patent/SI0786986T1/xx unknown
- 1995-10-26 PT PT01117396T patent/PT1147766E/pt unknown
- 1995-10-26 DE DE19581804T patent/DE19581804T1/de not_active Ceased
- 1995-10-26 PT PT95936554T patent/PT786986E/pt unknown
- 1995-10-26 DK DK01117396T patent/DK1147766T3/da active
- 1995-10-26 MX MX9702699A patent/MX9702699A/es active IP Right Grant
- 1995-10-26 WO PCT/EP1995/004208 patent/WO1996013249A1/en not_active Ceased
- 1995-10-26 ES ES95936554T patent/ES2173978T3/es not_active Expired - Lifetime
- 1995-10-26 NZ NZ331824A patent/NZ331824A/xx not_active IP Right Cessation
- 1995-10-26 HU HU9701928A patent/HU223840B1/hu active IP Right Revival
- 1995-10-26 EP EP01117396A patent/EP1147766B1/en not_active Expired - Lifetime
- 1995-10-26 KR KR1019970702752A patent/KR100434682B1/ko not_active Expired - Lifetime
- 1995-10-26 AT AT01117396T patent/ATE299017T1/de active
- 1995-10-26 NZ NZ295170A patent/NZ295170A/xx not_active IP Right Cessation
- 1995-10-26 DK DK95936554T patent/DK0786986T3/da active
- 1995-10-26 AU AU38451/95A patent/AU714254B2/en not_active Expired
- 1995-10-26 BR BR9509530A patent/BR9509530A/pt not_active Application Discontinuation
- 1995-10-26 DE DE69525957T patent/DE69525957T2/de not_active Expired - Lifetime
- 1995-10-26 GB GB9707484A patent/GB2308546B/en not_active Expired - Lifetime
- 1995-10-26 AT AT95936554T patent/ATE214593T1/de active
- 1995-10-26 PL PL95319599A patent/PL184750B1/pl unknown
- 1995-10-26 JP JP51431096A patent/JP4155593B2/ja not_active Expired - Lifetime
- 1995-10-26 EP EP95936554A patent/EP0786986B1/en not_active Expired - Lifetime
-
1997
- 1997-03-11 FI FI971018A patent/FI119754B/fi not_active IP Right Cessation
- 1997-04-25 NO NO19971951A patent/NO316963B1/no not_active IP Right Cessation
-
2000
- 2000-12-01 CY CY0000067A patent/CY2211B1/xx unknown
-
2001
- 2001-01-23 US US09/767,656 patent/US6352998B2/en not_active Expired - Lifetime
-
2004
- 2004-09-08 NO NO2004005C patent/NO2004005I2/no unknown
-
2007
- 2007-02-27 JP JP2007047216A patent/JP2007145860A/ja not_active Withdrawn
- 2007-12-28 FI FI20071025A patent/FI119755B/fi not_active IP Right Cessation
-
2012
- 2012-03-29 JP JP2012077545A patent/JP5599422B2/ja not_active Expired - Lifetime
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