MX9702699A - Composiciones farmaceuticas. - Google Patents
Composiciones farmaceuticas.Info
- Publication number
- MX9702699A MX9702699A MX9702699A MX9702699A MX9702699A MX 9702699 A MX9702699 A MX 9702699A MX 9702699 A MX9702699 A MX 9702699A MX 9702699 A MX9702699 A MX 9702699A MX 9702699 A MX9702699 A MX 9702699A
- Authority
- MX
- Mexico
- Prior art keywords
- provides
- macrolide
- class
- compound
- pharmaceutical composition
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- -1 ether diol Chemical class 0.000 abstract 1
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Esta invencion proporciona una composicion topica, en al forma de una emulsion, que comprende un compuesto de la clase de la FK506; un alcanodiol, éter diol o diéter alcohol que contiene hasta 8 átomos de carbono, fisiologicamente aceptables, como solvente para el compuesto de la clase de l FK506; un alcohol graso insaturado en agua. En otro aspecto, está invencion proporciona una composicion farmacéutica topica que comprende un macrolido en suspension. En un aspecto tradicional, esta invencion proporciona el uso de un alcohol graos insaturado para estabilizar un macrolido en una composicion farmacéutica.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9421612A GB9421612D0 (en) | 1994-10-26 | 1994-10-26 | Organic compounds |
| GB9421612.4 | 1994-10-26 | ||
| GB9422306A GB9422306D0 (en) | 1994-11-04 | 1994-11-04 | Organic compounds |
| GB9422306.2 | 1994-11-04 | ||
| GB9503553.1 | 1995-02-22 | ||
| GBGB9503553.1A GB9503553D0 (en) | 1995-02-22 | 1995-02-22 | Organic compounds |
| PCT/EP1995/004208 WO1996013249A1 (en) | 1994-10-26 | 1995-10-26 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MXPA97002699A MXPA97002699A (es) | 1997-06-01 |
| MX9702699A true MX9702699A (es) | 1997-06-28 |
Family
ID=27267447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9702699A MX9702699A (es) | 1994-10-26 | 1995-10-26 | Composiciones farmaceuticas. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6352998B2 (es) |
| EP (2) | EP0786986B1 (es) |
| JP (3) | JP4155593B2 (es) |
| KR (1) | KR100434682B1 (es) |
| CN (2) | CN100335063C (es) |
| AT (2) | ATE214593T1 (es) |
| AU (1) | AU714254B2 (es) |
| BR (1) | BR9509530A (es) |
| CA (1) | CA2200966C (es) |
| CY (1) | CY2211B1 (es) |
| CZ (1) | CZ289773B6 (es) |
| DE (3) | DE19581804T1 (es) |
| DK (2) | DK0786986T3 (es) |
| ES (2) | ES2243369T3 (es) |
| FI (2) | FI119754B (es) |
| GB (1) | GB2308546B (es) |
| HU (1) | HU223840B1 (es) |
| MX (1) | MX9702699A (es) |
| NO (2) | NO316963B1 (es) |
| NZ (2) | NZ331824A (es) |
| PL (1) | PL184750B1 (es) |
| PT (2) | PT786986E (es) |
| SI (1) | SI0786986T1 (es) |
| SK (1) | SK284591B6 (es) |
| WO (1) | WO1996013249A1 (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
| GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| CZ267796A3 (cs) | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
| US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| TW450810B (en) * | 1997-02-20 | 2001-08-21 | Fujisawa Pharmaceutical Co | Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases |
| DE19744621A1 (de) * | 1997-10-09 | 1999-04-15 | Muehlbauer Ernst Kg | Mischung zur Verwendung als Wundverband |
| GB9723669D0 (en) * | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
| DE19802205A1 (de) * | 1998-01-22 | 1999-07-29 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen, enthaltend erhöhte Elektrolytkonzentrationen |
| ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
| CA2326222C (en) * | 1998-04-27 | 2008-09-23 | Fujisawa Pharmaceutical Co., Ltd. | Medicinal compositions |
| GB9814640D0 (en) * | 1998-07-06 | 1998-09-02 | Fujisawa Pharmaceutical Co | New use |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| GB0003932D0 (en) * | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
| NZ540000A (en) * | 2001-02-16 | 2007-05-31 | Abbott Lab Vascular Entpr Ltd | Implants with tacrolimus |
| GB0108498D0 (en) * | 2001-04-04 | 2001-05-23 | Novartis Ag | Organic Compounds |
| AR035293A1 (es) * | 2001-08-23 | 2004-05-05 | Novartis Ag | Composicion oftalmica. |
| AR038628A1 (es) * | 2002-03-04 | 2005-01-19 | Novartis Ag | Composicion oftalmica |
| GB0218996D0 (en) * | 2002-08-14 | 2002-09-25 | Novartis Ag | Organic compounds |
| AU2004212264B9 (en) * | 2003-02-17 | 2009-11-26 | Cipla Limited | Pharmaceutical patch |
| US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| GB0307867D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| GB0307869D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| GB0307866D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| CN1829510A (zh) * | 2003-07-31 | 2006-09-06 | 法马西亚和厄普乔恩公司 | 抗炎剂的可分散性制剂 |
| GB0408070D0 (en) * | 2004-04-08 | 2004-05-12 | Novartis Ag | Pharmaceutical formulations |
| BRPI0509708B8 (pt) * | 2004-04-08 | 2021-05-25 | Meda Pharma S A R L | espuma farmacêutica, composição de espuma de pimecrolimus contendo glicol de hexileno, opcionalmente álcool de oleil, dimetilisosorbídeo e/ou triglicerídeos de cadeia média e uso |
| GB0508827D0 (en) * | 2005-04-29 | 2005-06-08 | Novartis Ag | Cosmeceutical composition |
| WO2008063563A2 (en) | 2006-11-16 | 2008-05-29 | Transderm, Inc. | Methods of treating keratin hyperproliferation disorders using mtor inhibitors |
| EP2016935A1 (en) * | 2007-07-09 | 2009-01-21 | Intendis GmbH | Pharmaceutical composition for topical application of poorly soluble compounds |
| CN101288643B (zh) * | 2008-06-17 | 2012-11-14 | 杨喜鸿 | 含有他克莫司的凝胶剂组合物及其制备方法和药物应用 |
| EP2308468A1 (en) * | 2009-10-08 | 2011-04-13 | Novaliq GmbH | Novel pharmaceutical composition comprising a macrolide immunosuppressant drug |
| GB0917816D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917817D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| EP2366378A1 (en) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
| WO2012011192A1 (ja) * | 2010-07-23 | 2012-01-26 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| JP5674786B2 (ja) * | 2010-07-23 | 2015-02-25 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| CN102552253A (zh) * | 2012-01-17 | 2012-07-11 | 唯美度科技(北京)有限公司 | 一种祛痘用皮肤外用剂 |
| JP6084579B2 (ja) * | 2012-01-25 | 2017-02-22 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| DK2948134T3 (da) * | 2013-01-24 | 2020-06-02 | Palvella Therapeutics Inc | Sammensætninger til transdermal indgivelse af mtor-inhibitorer |
| MX367121B (es) * | 2013-08-02 | 2019-08-06 | Laboratorio Raam De Sahuayo S A De C V | Composición sólida estable de inmunosupresores. |
| DE102013222164A1 (de) * | 2013-10-31 | 2015-04-30 | Deb Ip Limited | Stabilisierte multiple Emulsionen als Hautschutzprodukt |
| US10765665B2 (en) * | 2015-11-24 | 2020-09-08 | Melin Jeffrey | Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases |
| CN105663027B (zh) * | 2016-04-01 | 2018-12-18 | 中国人民解放军广州军区武汉总医院 | 西罗莫司外用制剂、其制备方法及用途 |
| KR102386585B1 (ko) | 2016-04-04 | 2022-04-13 | 엠씨2 테라퓨틱스 리미티드 | 타크롤리무스를 포함하는 국소 조성물 |
| CN110520097B (zh) | 2017-01-06 | 2023-10-27 | 帕尔维拉治疗股份有限公司 | Mtor抑制剂的无水组合物及其使用方法 |
| KR101973065B1 (ko) | 2017-09-13 | 2019-04-26 | (주)썬테크 | 풍력 발전기 및 풍력 발전기의 블레이드 팁 |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| KR101995905B1 (ko) | 2018-03-27 | 2019-07-04 | (주)썬테크 | 풍력 발전기 및 풍력 발전기의 발전모터 |
| WO2019233722A1 (en) * | 2018-06-08 | 2019-12-12 | Almirall, S.A. | Pharmaceutical composition comprising tacrolimus |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク. | mTOR阻害剤の無水組成物および使用方法 |
| WO2024213629A1 (en) * | 2023-04-11 | 2024-10-17 | Bausch Health Ireland Limited | Topical compositions |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299826A (en) | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| CH677448A5 (es) | 1987-11-09 | 1991-05-31 | Sandoz Ag | |
| EP0323042A1 (en) | 1987-12-09 | 1989-07-05 | FISONS plc | Process to macrocyclic compounds |
| KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
| NZ235991A (en) * | 1989-11-09 | 1993-05-26 | Sandoz Ltd | Macrolide compounds and pharmaceutical compositions thereof |
| US5061700A (en) | 1989-11-16 | 1991-10-29 | Gordon Jay Dow | Glyceryl acetate ointment vehicles |
| WO1991013899A1 (en) | 1990-03-12 | 1991-09-19 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds |
| JPH05507915A (ja) | 1990-06-11 | 1993-11-11 | 藤沢薬品工業株式会社 | 特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのfk506等のマクロライド化合物の用途 |
| MY110418A (en) | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
| ES2099112T3 (es) | 1990-09-04 | 1997-05-16 | Fujisawa Pharmaceutical Co | Pomadas que contienen un compuesto triciclico. |
| US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| PH31204A (en) * | 1990-11-02 | 1998-05-05 | Fujisawa Pharmaceutical Co | Pharmaceutical composition. |
| IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
| US5208241A (en) | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
| US5247076A (en) | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
| US5252732A (en) | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
| HUT66531A (en) | 1992-05-07 | 1994-12-28 | Sandoz Ag | Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| JPH06183970A (ja) * | 1992-12-16 | 1994-07-05 | Fujisawa Pharmaceut Co Ltd | 医薬用組成物 |
| MY110603A (en) | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
| CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| WO1995011039A1 (de) | 1993-10-22 | 1995-04-27 | Hexal Pharma Gmbh | Pharmazeutische zusammensetzung mit cyclosporin a und alpha-tocopherol |
-
1995
- 1995-10-26 AT AT95936554T patent/ATE214593T1/de active
- 1995-10-26 BR BR9509530A patent/BR9509530A/pt not_active Application Discontinuation
- 1995-10-26 PL PL95319599A patent/PL184750B1/pl unknown
- 1995-10-26 ES ES01117396T patent/ES2243369T3/es not_active Expired - Lifetime
- 1995-10-26 SI SI9530589T patent/SI0786986T1/xx unknown
- 1995-10-26 CN CNB021243700A patent/CN100335063C/zh not_active Expired - Lifetime
- 1995-10-26 MX MX9702699A patent/MX9702699A/es active IP Right Grant
- 1995-10-26 CZ CZ19971232A patent/CZ289773B6/cs not_active IP Right Cessation
- 1995-10-26 PT PT95936554T patent/PT786986E/pt unknown
- 1995-10-26 SK SK520-97A patent/SK284591B6/sk not_active IP Right Cessation
- 1995-10-26 ES ES95936554T patent/ES2173978T3/es not_active Expired - Lifetime
- 1995-10-26 AT AT01117396T patent/ATE299017T1/de active
- 1995-10-26 GB GB9707484A patent/GB2308546B/en not_active Expired - Lifetime
- 1995-10-26 DE DE19581804T patent/DE19581804T1/de not_active Ceased
- 1995-10-26 DE DE69525957T patent/DE69525957T2/de not_active Expired - Lifetime
- 1995-10-26 KR KR1019970702752A patent/KR100434682B1/ko not_active Expired - Lifetime
- 1995-10-26 DE DE69534306T patent/DE69534306T2/de not_active Expired - Lifetime
- 1995-10-26 PT PT01117396T patent/PT1147766E/pt unknown
- 1995-10-26 HU HU9701928A patent/HU223840B1/hu active IP Right Revival
- 1995-10-26 CA CA002200966A patent/CA2200966C/en not_active Expired - Lifetime
- 1995-10-26 JP JP51431096A patent/JP4155593B2/ja not_active Expired - Lifetime
- 1995-10-26 DK DK95936554T patent/DK0786986T3/da active
- 1995-10-26 NZ NZ331824A patent/NZ331824A/xx not_active IP Right Cessation
- 1995-10-26 WO PCT/EP1995/004208 patent/WO1996013249A1/en not_active Ceased
- 1995-10-26 AU AU38451/95A patent/AU714254B2/en not_active Expired
- 1995-10-26 DK DK01117396T patent/DK1147766T3/da active
- 1995-10-26 CN CN95195900A patent/CN1089233C/zh not_active Expired - Lifetime
- 1995-10-26 NZ NZ295170A patent/NZ295170A/xx not_active IP Right Cessation
- 1995-10-26 EP EP95936554A patent/EP0786986B1/en not_active Expired - Lifetime
- 1995-10-26 EP EP01117396A patent/EP1147766B1/en not_active Expired - Lifetime
-
1997
- 1997-03-11 FI FI971018A patent/FI119754B/fi not_active IP Right Cessation
- 1997-04-25 NO NO19971951A patent/NO316963B1/no not_active IP Right Cessation
-
2000
- 2000-12-01 CY CY0000067A patent/CY2211B1/xx unknown
-
2001
- 2001-01-23 US US09/767,656 patent/US6352998B2/en not_active Expired - Lifetime
-
2004
- 2004-09-08 NO NO2004005C patent/NO2004005I2/no unknown
-
2007
- 2007-02-27 JP JP2007047216A patent/JP2007145860A/ja not_active Withdrawn
- 2007-12-28 FI FI20071025A patent/FI119755B/fi not_active IP Right Cessation
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2012
- 2012-03-29 JP JP2012077545A patent/JP5599422B2/ja not_active Expired - Lifetime
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