CL2016001148A1 - Sistema multiparticulado para la administración oral de drogas, que comprende partículas de microgel que contienen un ingrediente farmacéutico activo, donde las partículas de microgel están dispersas en una composición líquida no acuosa proceso para prepararlo cápsulas que lo comprenden. - Google Patents
Sistema multiparticulado para la administración oral de drogas, que comprende partículas de microgel que contienen un ingrediente farmacéutico activo, donde las partículas de microgel están dispersas en una composición líquida no acuosa proceso para prepararlo cápsulas que lo comprenden.Info
- Publication number
- CL2016001148A1 CL2016001148A1 CL2016001148A CL2016001148A CL2016001148A1 CL 2016001148 A1 CL2016001148 A1 CL 2016001148A1 CL 2016001148 A CL2016001148 A CL 2016001148A CL 2016001148 A CL2016001148 A CL 2016001148A CL 2016001148 A1 CL2016001148 A1 CL 2016001148A1
- Authority
- CL
- Chile
- Prior art keywords
- microgel particles
- multiparticulate system
- dispersed
- aqueous liquid
- active pharmaceutical
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000002775 capsule Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 title 1
- 229920001661 Chitosan Polymers 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 229920001817 Agar Polymers 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- 239000005662 Paraffin oil Substances 0.000 abstract 1
- 241000978776 Senegalia senegal Species 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 108010046377 Whey Proteins Proteins 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000000205 acacia gum Substances 0.000 abstract 1
- 239000008272 agar Substances 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 235000010418 carrageenan Nutrition 0.000 abstract 1
- 239000000679 carrageenan Substances 0.000 abstract 1
- 229920001525 carrageenan Polymers 0.000 abstract 1
- 229940113118 carrageenan Drugs 0.000 abstract 1
- 238000001647 drug administration Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 235000010987 pectin Nutrition 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000021119 whey protein Nutrition 0.000 abstract 1
- 239000000230 xanthan gum Substances 0.000 abstract 1
- 235000010493 xanthan gum Nutrition 0.000 abstract 1
- 229920001285 xanthan gum Polymers 0.000 abstract 1
- 229940082509 xanthan gum Drugs 0.000 abstract 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Sistema multiparticulado para administración oral de drogas, que comprende partículas de microgel que contienen al menos un polímero formador de geles que se selecciona del grupo que consiste en quitosano, derivados de quitosano que son quitosanos alquilados yo carboxialquilados yo PEGilados, en los cuales los grupos hidroxilo yo amino pueden estar alquilados yo carboxialquilados de una manera parcial o total ácidos poliacrílicos alginatos carrageninas goma arábiga goma gellan proteínas totales como la albúmina y las proteínas del suero goma xantana gelatina, agar pectina ácido hialurónico y las sales de cualquiera de estos, y un ingrediente farmacéutico activo, donde las partículas de microgel están dispersas en una composición líquida no acuosa, que es una composición lipídica y no contiene aceite de parafina. Además se divulga un proceso para preparar un sistema multiparticulado y una cápsula que contiene al sistema multiparticulado para administrar drogas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13192657 | 2013-11-13 | ||
| EP14157427 | 2014-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016001148A1 true CL2016001148A1 (es) | 2016-11-25 |
Family
ID=51900424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016001148A CL2016001148A1 (es) | 2013-11-13 | 2016-05-12 | Sistema multiparticulado para la administración oral de drogas, que comprende partículas de microgel que contienen un ingrediente farmacéutico activo, donde las partículas de microgel están dispersas en una composición líquida no acuosa proceso para prepararlo cápsulas que lo comprenden. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20160287521A1 (es) |
| EP (1) | EP3068381B1 (es) |
| JP (2) | JP2016537352A (es) |
| KR (1) | KR20160085269A (es) |
| CN (1) | CN105899197A (es) |
| AU (1) | AU2014350208B2 (es) |
| CA (1) | CA2930277A1 (es) |
| CL (1) | CL2016001148A1 (es) |
| CR (1) | CR20160263A (es) |
| CU (1) | CU20160069A7 (es) |
| EA (1) | EA201600387A1 (es) |
| HK (1) | HK1224219A1 (es) |
| MD (1) | MD20160061A2 (es) |
| MX (1) | MX2016006275A (es) |
| NZ (1) | NZ720512A (es) |
| PE (1) | PE20160850A1 (es) |
| PH (1) | PH12016500847A1 (es) |
| TN (1) | TN2016000160A1 (es) |
| WO (1) | WO2015071366A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019072877A1 (en) | 2017-10-10 | 2019-04-18 | Capsugel Belgium Nv | GETTING MULTIPARTICULAR COMPOSITIONS |
| KR102154565B1 (ko) * | 2018-11-13 | 2020-09-10 | 한국화학연구원 | 천연 오일을 함유하는 미세캡슐 및 이의 제조방법 |
| CN111388759B (zh) * | 2020-04-28 | 2021-09-07 | 四川大学 | 一种骨水泥复合材料及其制备方法 |
| WO2024101250A1 (ja) * | 2022-11-11 | 2024-05-16 | 公立大学法人名古屋市立大学 | マイクロゲル製造方法、及び加飾性マイクロゲル集合体の製造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0657653B2 (ja) * | 1985-08-23 | 1994-08-03 | 藤沢薬品工業株式会社 | 油性懸濁型直腸注入剤 |
| EP0531497B1 (en) * | 1991-04-02 | 1997-08-13 | Biotech Australia Pty. Limited | Oral delivery systems for microparticles |
| US5879712A (en) * | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
| FR2754177B1 (fr) * | 1996-10-07 | 1999-08-06 | Sanofi Sa | Microspheres pharmaceutiques d'acide valproique pour administration orale |
| CN1361683A (zh) * | 1999-06-07 | 2002-07-31 | 比克·古尔顿·劳姆贝尔格化学公司 | 含有一种对酸不稳定的活性化合物的新型制剂和药物剂型 |
| FR2814380B1 (fr) * | 2000-09-25 | 2002-11-08 | Serobiologiques Lab Sa | Poudre de microcapsules et procede d'obtention |
| JP4046313B2 (ja) * | 2001-01-12 | 2008-02-13 | 株式会社資生堂 | 油中水型乳化組成物およびこれを用いた乳化化粧料 |
| US7993749B2 (en) * | 2005-12-16 | 2011-08-09 | University Of Kansas | Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof |
| WO2007076295A2 (en) * | 2005-12-16 | 2007-07-05 | University Of Kansas | Nanoclusters for delivery of therapeutics |
| PT103476B (pt) * | 2006-05-10 | 2008-09-19 | Univ De Coimbra | Processo de produção e isolamento de micro- e nanopartículas poliméricas contendo macromoléculas de natureza hidrofílica e termolábil |
| DK2217363T3 (en) * | 2007-11-14 | 2019-01-21 | Univ Queensland | APPLICATION OF A DEVICE AND PROCEDURE FOR MANUFACTURING MICROPARTICLES |
| EP2111854A1 (en) * | 2008-04-22 | 2009-10-28 | Lek Pharmaceuticals D.D. | Self-microemulsifying systems incorporated into liquid core microcapsules |
-
2014
- 2014-11-13 EP EP14798839.8A patent/EP3068381B1/en active Active
- 2014-11-13 KR KR1020167012571A patent/KR20160085269A/ko not_active Application Discontinuation
- 2014-11-13 PE PE2016000631A patent/PE20160850A1/es not_active Application Discontinuation
- 2014-11-13 CR CR20160263A patent/CR20160263A/es unknown
- 2014-11-13 AU AU2014350208A patent/AU2014350208B2/en not_active Ceased
- 2014-11-13 US US15/036,279 patent/US20160287521A1/en not_active Abandoned
- 2014-11-13 JP JP2016530207A patent/JP2016537352A/ja active Pending
- 2014-11-13 MX MX2016006275A patent/MX2016006275A/es unknown
- 2014-11-13 TN TN2016000160A patent/TN2016000160A1/en unknown
- 2014-11-13 NZ NZ720512A patent/NZ720512A/en not_active IP Right Cessation
- 2014-11-13 CN CN201480070156.5A patent/CN105899197A/zh active Pending
- 2014-11-13 EA EA201600387A patent/EA201600387A1/ru unknown
- 2014-11-13 CA CA2930277A patent/CA2930277A1/en not_active Abandoned
- 2014-11-13 MD MDA20160061A patent/MD20160061A2/ro not_active Application Discontinuation
- 2014-11-13 WO PCT/EP2014/074501 patent/WO2015071366A1/en active Application Filing
-
2016
- 2016-05-06 PH PH12016500847A patent/PH12016500847A1/en unknown
- 2016-05-12 CL CL2016001148A patent/CL2016001148A1/es unknown
- 2016-05-13 CU CUP2016000069A patent/CU20160069A7/es unknown
- 2016-11-03 HK HK16112642.9A patent/HK1224219A1/zh unknown
-
2019
- 2019-02-14 JP JP2019024239A patent/JP2019112413A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160085269A (ko) | 2016-07-15 |
| NZ720512A (en) | 2018-01-26 |
| HK1224219A1 (zh) | 2017-08-18 |
| CR20160263A (es) | 2017-04-05 |
| JP2019112413A (ja) | 2019-07-11 |
| EA201600387A1 (ru) | 2016-08-31 |
| TN2016000160A1 (en) | 2017-10-06 |
| MD20160061A2 (ro) | 2016-10-31 |
| CA2930277A1 (en) | 2015-05-21 |
| PE20160850A1 (es) | 2016-09-23 |
| PH12016500847A1 (en) | 2016-06-20 |
| WO2015071366A1 (en) | 2015-05-21 |
| CN105899197A (zh) | 2016-08-24 |
| CU20160069A7 (es) | 2016-10-28 |
| EP3068381A1 (en) | 2016-09-21 |
| EP3068381B1 (en) | 2019-09-11 |
| US20160287521A1 (en) | 2016-10-06 |
| MX2016006275A (es) | 2017-01-05 |
| AU2014350208B2 (en) | 2017-09-07 |
| JP2016537352A (ja) | 2016-12-01 |
| AU2014350208A1 (en) | 2016-06-16 |
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