JP2011522070A5 - - Google Patents
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- Publication number
- JP2011522070A5 JP2011522070A5 JP2011509671A JP2011509671A JP2011522070A5 JP 2011522070 A5 JP2011522070 A5 JP 2011522070A5 JP 2011509671 A JP2011509671 A JP 2011509671A JP 2011509671 A JP2011509671 A JP 2011509671A JP 2011522070 A5 JP2011522070 A5 JP 2011522070A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- micelle
- micelle assembly
- block
- assembly according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000693 micelle Substances 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 229920001400 block copolymer Polymers 0.000 claims 7
- 230000000368 destabilizing effect Effects 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000005588 protonation Effects 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5291408P | 2008-05-13 | 2008-05-13 | |
| US5290808P | 2008-05-13 | 2008-05-13 | |
| US61/052,914 | 2008-05-13 | ||
| US61/052,908 | 2008-05-13 | ||
| US9129408P | 2008-08-22 | 2008-08-22 | |
| US61/091,294 | 2008-08-22 | ||
| US11204808P | 2008-11-06 | 2008-11-06 | |
| US61/112,048 | 2008-11-06 | ||
| US14077408P | 2008-12-24 | 2008-12-24 | |
| US61/140,774 | 2008-12-24 | ||
| US17136909P | 2009-04-21 | 2009-04-21 | |
| US61/171,369 | 2009-04-21 | ||
| PCT/US2009/043849 WO2009140429A2 (en) | 2008-05-13 | 2009-05-13 | Micellic assemblies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015107802A Division JP2015221898A (ja) | 2008-05-13 | 2015-05-27 | ミセル集合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011522070A JP2011522070A (ja) | 2011-07-28 |
| JP2011522070A5 true JP2011522070A5 (enExample) | 2012-06-28 |
| JP5755563B2 JP5755563B2 (ja) | 2015-07-29 |
Family
ID=41319324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509671A Expired - Fee Related JP5755563B2 (ja) | 2008-05-13 | 2009-05-13 | ミセル集合体 |
| JP2015107802A Pending JP2015221898A (ja) | 2008-05-13 | 2015-05-27 | ミセル集合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015107802A Pending JP2015221898A (ja) | 2008-05-13 | 2015-05-27 | ミセル集合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9339558B2 (enExample) |
| EP (1) | EP2285853B1 (enExample) |
| JP (2) | JP5755563B2 (enExample) |
| KR (1) | KR101764427B1 (enExample) |
| CN (1) | CN102066444A (enExample) |
| AU (1) | AU2009246329B8 (enExample) |
| BR (1) | BRPI0911989A2 (enExample) |
| CA (1) | CA2724014C (enExample) |
| ES (1) | ES2404136T3 (enExample) |
| IL (1) | IL209239A0 (enExample) |
| MX (1) | MX2010012239A (enExample) |
| WO (1) | WO2009140429A2 (enExample) |
| ZA (1) | ZA201008730B (enExample) |
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| EP2373715A4 (en) | 2008-12-08 | 2014-12-03 | Univ Washington | OMEGA FUNCTIONALIZED POLYMERS, TRANSITIONALIZED BLOCK COPOLYMERS, POLYMER BIOKON JUGATES, AND RADICAL CHAIN EXTENSION POLICY RESPONSE |
-
2009
- 2009-05-13 CN CN2009801234403A patent/CN102066444A/zh active Pending
- 2009-05-13 AU AU2009246329A patent/AU2009246329B8/en not_active Ceased
- 2009-05-13 JP JP2011509671A patent/JP5755563B2/ja not_active Expired - Fee Related
- 2009-05-13 WO PCT/US2009/043849 patent/WO2009140429A2/en not_active Ceased
- 2009-05-13 KR KR1020107027809A patent/KR101764427B1/ko not_active Expired - Fee Related
- 2009-05-13 BR BRPI0911989A patent/BRPI0911989A2/pt not_active IP Right Cessation
- 2009-05-13 US US12/992,525 patent/US9339558B2/en active Active
- 2009-05-13 CA CA2724014A patent/CA2724014C/en active Active
- 2009-05-13 ES ES09747512T patent/ES2404136T3/es active Active
- 2009-05-13 MX MX2010012239A patent/MX2010012239A/es active IP Right Grant
- 2009-05-13 EP EP09747512A patent/EP2285853B1/en not_active Not-in-force
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2010
- 2010-11-10 IL IL209239A patent/IL209239A0/en unknown
- 2010-12-03 ZA ZA2010/08730A patent/ZA201008730B/en unknown
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2015
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