JP2012509983A5 - - Google Patents
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- JP2012509983A5 JP2012509983A5 JP2011538669A JP2011538669A JP2012509983A5 JP 2012509983 A5 JP2012509983 A5 JP 2012509983A5 JP 2011538669 A JP2011538669 A JP 2011538669A JP 2011538669 A JP2011538669 A JP 2011538669A JP 2012509983 A5 JP2012509983 A5 JP 2012509983A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- block
- hydrophobic
- hydrophilic
- block copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001400 block copolymer Polymers 0.000 claims 25
- 230000002209 hydrophobic effect Effects 0.000 claims 23
- 239000000693 micelle Substances 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 229920002125 Sokalan® Polymers 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 229920002873 Polyethylenimine Polymers 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 5
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 5
- 229920000805 Polyaspartic acid Polymers 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 5
- 150000004676 glycans Chemical class 0.000 claims 5
- 229920002674 hyaluronan Polymers 0.000 claims 5
- 229960003160 hyaluronic acid Drugs 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 229920001603 poly (alkyl acrylates) Polymers 0.000 claims 5
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims 5
- 229920002401 polyacrylamide Polymers 0.000 claims 5
- 229920002643 polyglutamic acid Polymers 0.000 claims 5
- 229920001451 polypropylene glycol Polymers 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 5
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims 4
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical group C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 4
- 229920000359 diblock copolymer Polymers 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920006030 multiblock copolymer Polymers 0.000 claims 4
- 229920001713 poly(ethylene-co-vinyl alcohol) Polymers 0.000 claims 4
- 229920000917 poly(propylene sulfide) Polymers 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- OQXNUCOGMMHHNA-UHFFFAOYSA-N 4-methyl-1,3,2-dioxathiolane 2,2-dioxide Chemical compound CC1COS(=O)(=O)O1 OQXNUCOGMMHHNA-UHFFFAOYSA-N 0.000 claims 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- -1 acyl hydrazone Chemical class 0.000 claims 1
- 229940009456 adriamycin Drugs 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229920001038 ethylene copolymer Polymers 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11789208P | 2008-11-25 | 2008-11-25 | |
| US61/117,892 | 2008-11-25 | ||
| PCT/US2009/065693 WO2010068432A1 (en) | 2008-11-25 | 2009-11-24 | Block copolymers and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217197A Division JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509983A JP2012509983A (ja) | 2012-04-26 |
| JP2012509983A5 true JP2012509983A5 (enExample) | 2013-01-17 |
| JP5814793B2 JP5814793B2 (ja) | 2015-11-17 |
Family
ID=42243027
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538669A Active JP5814793B2 (ja) | 2008-11-25 | 2009-11-24 | ブロックコポリマーおよびその使用 |
| JP2014217197A Active JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
| JP2016100375A Active JP6409020B2 (ja) | 2008-11-25 | 2016-05-19 | ブロックコポリマーおよびその使用 |
| JP2018119659A Active JP6641423B2 (ja) | 2008-11-25 | 2018-06-25 | ブロックコポリマーおよびその使用 |
| JP2019238237A Pending JP2020073678A (ja) | 2008-11-25 | 2019-12-27 | ブロックコポリマーおよびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217197A Active JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
| JP2016100375A Active JP6409020B2 (ja) | 2008-11-25 | 2016-05-19 | ブロックコポリマーおよびその使用 |
| JP2018119659A Active JP6641423B2 (ja) | 2008-11-25 | 2018-06-25 | ブロックコポリマーおよびその使用 |
| JP2019238237A Pending JP2020073678A (ja) | 2008-11-25 | 2019-12-27 | ブロックコポリマーおよびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (5) | US9271929B2 (enExample) |
| EP (1) | EP2356228B1 (enExample) |
| JP (5) | JP5814793B2 (enExample) |
| WO (1) | WO2010068432A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007008300A2 (en) | 2005-05-31 | 2007-01-18 | ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| US9271929B2 (en) * | 2008-11-25 | 2016-03-01 | École Polytechnique Fédérale De Lausanne (Epfl) | Block copolymers and uses thereof |
| EP2572780B1 (en) * | 2010-05-21 | 2018-07-11 | Japan Science And Technology Agency | Vesicles with encapsulated substance and production method therefor |
| CN102971002B (zh) * | 2010-07-09 | 2019-04-05 | 国立大学法人东京大学 | 核酸递送用组合物及载体组合物、使用其的药物组合物以及核酸递送方法 |
| EP2961758A4 (en) | 2013-02-26 | 2016-10-19 | Univ California | AMPHIPHIL DERIVATIVES OF BLOCK COPOLYPEPTIDES WITH THIOETHERS |
| WO2015013510A1 (en) * | 2013-07-25 | 2015-01-29 | Ecole Polytechnique Federale De Lausanne Epfl | High aspect ratio nanofibril materials |
| WO2015058141A1 (en) * | 2013-10-18 | 2015-04-23 | Virginia Tech Intellectual Properties, Inc. | Nucleobase-containing monomers and copolymers |
| WO2015070080A2 (en) * | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Nucleic acid nanostructures for in vivo agent delivery |
| WO2016154120A1 (en) | 2015-03-20 | 2016-09-29 | The Regents Of The University Of California | Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions |
| US10456452B2 (en) * | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| EP3124495A1 (en) | 2015-07-31 | 2017-02-01 | Centre National de la Recherche Scientifique (C.N.R.S.) | Derivatives of elastin-like polypeptides and uses thereof |
| EP3426598B1 (en) | 2016-03-11 | 2021-07-28 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| WO2017189860A1 (en) | 2016-04-27 | 2017-11-02 | The Regents Of The University Of California | Preparation of functional homocysteine residues in polypeptides and peptides |
| US11213594B2 (en) | 2016-04-29 | 2022-01-04 | Poseida Therapeutics, Inc. | Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids |
| CN109153758B (zh) * | 2016-06-16 | 2021-04-27 | 株式会社Lg化学 | 两亲性三嵌段聚合物 |
| WO2018022457A1 (en) * | 2016-07-29 | 2018-02-01 | The Regents Of The University Of California | Accelerated healing by injectable multi-arm branched amphiphilic scaffolds loaded with hydrophobic drugs |
| EP3494124B1 (en) | 2016-08-02 | 2022-03-09 | President and Fellows of Harvard College | Crisscross cooperative self-assembly |
| JP6912876B2 (ja) * | 2016-10-06 | 2021-08-04 | 三洋化成工業株式会社 | アクリル系医薬固形製剤用添加剤 |
| CN107236106B (zh) * | 2017-06-13 | 2020-01-07 | 青岛科技大学 | 含酰腙键的芳香族端羟基扩链剂、自修复聚氨酯及其制备方法 |
| US10376468B2 (en) * | 2017-12-05 | 2019-08-13 | International Business Machines Corporation | Block copolymers and self-assembling nanoparticles formed therefrom |
| CN108904446B (zh) * | 2018-06-11 | 2021-05-11 | 中山大学 | 一种动脉斑块微环境响应的载药纳米胶束的制备方法及应用 |
| JP7154568B2 (ja) * | 2018-06-22 | 2022-10-18 | 国立大学法人福井大学 | 両親媒性高分子、およびその利用 |
| US20220031849A1 (en) * | 2018-10-22 | 2022-02-03 | Takeda Pharmaceutical Company Limited | Nanoparticle encapsulation to target g protein-coupled receptors in endosomes |
| US12268748B2 (en) | 2019-04-10 | 2025-04-08 | President And Fellows Of Harvard College | Nucleic acid nanostructures crosslinked with oligolysine |
| WO2020247724A1 (en) | 2019-06-07 | 2020-12-10 | Dana-Farber Cancer Institute, Inc. | Dna nanostructure-based vaccines |
| KR102329966B1 (ko) * | 2020-03-23 | 2021-11-23 | 전남대학교산학협력단 | 양친성 고분자 화합물, 이를 이용한 약물 전달체 및 종양 치료 시스템 |
| CA3194032A1 (en) * | 2020-09-04 | 2022-03-10 | The University Of Chicago | Materials and methods of treating viral infection with amphiphilic block copolymers |
| KR102418116B1 (ko) * | 2020-10-08 | 2022-07-06 | 강원대학교산학협력단 | 양친매성 공중합체로 안정화된 산화 응답성 에멀젼 |
| JP7775439B2 (ja) * | 2021-07-21 | 2025-11-25 | サムヤン、ホールディングス、コーポレーション | 組織修復用粉末製剤及びその製造方法、並びにそれを含む組織修復用注射剤組成物 |
| WO2025145010A1 (en) * | 2023-12-29 | 2025-07-03 | The University Of Chicago | Amphiphilic block copolymers, polymersomes, and methods of use |
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2009
- 2009-11-24 US US13/130,892 patent/US9271929B2/en active Active
- 2009-11-24 JP JP2011538669A patent/JP5814793B2/ja active Active
- 2009-11-24 WO PCT/US2009/065693 patent/WO2010068432A1/en not_active Ceased
- 2009-11-24 EP EP09832335.5A patent/EP2356228B1/en active Active
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2014
- 2014-10-24 JP JP2014217197A patent/JP5995939B2/ja active Active
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- 2016-05-19 JP JP2016100375A patent/JP6409020B2/ja active Active
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2018
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2019
- 2019-07-01 US US16/459,039 patent/US20200000936A1/en not_active Abandoned
- 2019-12-27 JP JP2019238237A patent/JP2020073678A/ja active Pending
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2021
- 2021-07-02 US US17/366,846 patent/US20220168448A1/en not_active Abandoned
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2024
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