JP2019517553A5 - - Google Patents
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- JP2019517553A5 JP2019517553A5 JP2018564340A JP2018564340A JP2019517553A5 JP 2019517553 A5 JP2019517553 A5 JP 2019517553A5 JP 2018564340 A JP2018564340 A JP 2018564340A JP 2018564340 A JP2018564340 A JP 2018564340A JP 2019517553 A5 JP2019517553 A5 JP 2019517553A5
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- Prior art keywords
- rna
- peptide
- diseases
- polymer
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 125000002091 cationic group Chemical group 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 239000002105 nanoparticle Substances 0.000 claims 7
- -1 nucleic acid compound Chemical class 0.000 claims 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 239000004055 small Interfering RNA Substances 0.000 claims 4
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 208000035473 Communicable disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 102000039471 Small Nuclear RNA Human genes 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 108020004566 Transfer RNA Proteins 0.000 claims 2
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- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
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- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108020004418 ribosomal RNA Proteins 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
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- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
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- 229920001612 Hydroxyethyl starch Polymers 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
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- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- 108091092724 Noncoding DNA Proteins 0.000 claims 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
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- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
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- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 claims 1
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- 201000011510 cancer Diseases 0.000 claims 1
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- 239000003814 drug Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 230000009395 genetic defect Effects 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- DNZMDASEFMLYBU-RNBXVSKKSA-N hydroxyethyl starch Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]1O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]1OCCO DNZMDASEFMLYBU-RNBXVSKKSA-N 0.000 claims 1
- 229940050526 hydroxyethylstarch Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 108091027963 non-coding RNA Proteins 0.000 claims 1
- 102000042567 non-coding RNA Human genes 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001562 poly(N-(2-hydroxypropyl)methacrylamide) Polymers 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- 229920002946 poly[2-(methacryloxy)ethyl phosphorylcholine] polymer Polymers 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
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- 230000008685 targeting Effects 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2016/063226 | 2016-06-09 | ||
| EP2016063226 | 2016-06-09 | ||
| PCT/EP2017/064059 WO2017212009A1 (en) | 2016-06-09 | 2017-06-09 | Hybrid carriers for nucleic acid cargo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019517553A JP2019517553A (ja) | 2019-06-24 |
| JP2019517553A5 true JP2019517553A5 (enExample) | 2020-07-16 |
| JP7145579B2 JP7145579B2 (ja) | 2022-10-03 |
Family
ID=56134336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564340A Active JP7145579B2 (ja) | 2016-06-09 | 2017-06-09 | 核酸カーゴ用のハイブリッド担体 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11478552B2 (enExample) |
| EP (1) | EP3468613A1 (enExample) |
| JP (1) | JP7145579B2 (enExample) |
| KR (1) | KR20190029576A (enExample) |
| CN (1) | CN109475640B (enExample) |
| AU (1) | AU2017277731B2 (enExample) |
| BR (1) | BR112018075479A2 (enExample) |
| CA (1) | CA3023174A1 (enExample) |
| MX (1) | MX2018013919A (enExample) |
| RU (1) | RU2751001C2 (enExample) |
| SG (1) | SG11201809912UA (enExample) |
| WO (1) | WO2017212009A1 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| MX2019002345A (es) | 2012-03-27 | 2022-08-24 | Curevac Ag | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. |
| AU2014220957A1 (en) | 2013-02-22 | 2015-07-30 | Curevac Ag | Combination of vaccination and inhibition of the PD-1 pathway |
| CN105473157A (zh) | 2013-08-21 | 2016-04-06 | 库瑞瓦格股份公司 | 组合疫苗 |
| BR112016003361A2 (pt) | 2013-08-21 | 2017-11-21 | Curevac Ag | vacina do vírus sincicial respiratório (rsv) |
| EP3590529A1 (en) | 2014-03-12 | 2020-01-08 | CureVac AG | Combination of vaccination and ox40 agonists |
| DK4023755T5 (da) | 2014-12-12 | 2024-07-29 | CureVac SE | Kunstige nukleinsyremolekyler til forbedret proteinudtrykkelse |
| DK3294885T3 (da) | 2015-05-08 | 2020-08-10 | Curevac Real Estate Gmbh | Fremgangsmåde til at fremstille rna |
| DE202016009003U1 (de) | 2015-05-29 | 2021-05-28 | Curevac Real Estate Gmbh | Zusammensetzung umfassend in vitro transkribierte RNA erhältlich durch ein Verfahren zur Herstellung und Reinigung von RNA mit mindestens einem Schritt mit einer tangentialen Flussfiltration |
| WO2017064146A1 (en) | 2015-10-12 | 2017-04-20 | Curevac Ag | Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution |
| WO2017081110A1 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Rotavirus vaccines |
| EP3701963A1 (en) | 2015-12-22 | 2020-09-02 | CureVac AG | Method for producing rna molecule compositions |
| US11248223B2 (en) | 2015-12-23 | 2022-02-15 | Curevac Ag | Method of RNA in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof |
| US11723967B2 (en) | 2016-02-17 | 2023-08-15 | CureVac SE | Zika virus vaccine |
| EP3423595A1 (en) | 2016-03-03 | 2019-01-09 | CureVac AG | Rna analysis by total hydrolysis |
| WO2017186928A1 (en) | 2016-04-29 | 2017-11-02 | Curevac Ag | Rna encoding an antibody |
| WO2017191258A1 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Influenza mrna vaccines |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP4631970A3 (en) | 2016-05-04 | 2026-01-07 | CureVac SE | Nucleic acid molecules and uses thereof |
| SG11201809912UA (en) | 2016-06-09 | 2018-12-28 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| US11279923B2 (en) | 2016-11-28 | 2022-03-22 | Curevac Ag | Method for purifying RNA |
| US11542490B2 (en) | 2016-12-08 | 2023-01-03 | CureVac SE | RNAs for wound healing |
| JP2020501545A (ja) | 2016-12-08 | 2020-01-23 | キュアバック アーゲー | 肝疾患の処置または予防のためのｒｎａ |
| EP3558355A2 (en) | 2016-12-23 | 2019-10-30 | CureVac AG | Henipavirus vaccine |
| US11464847B2 (en) | 2016-12-23 | 2022-10-11 | Curevac Ag | Lassa virus vaccine |
| US11141476B2 (en) | 2016-12-23 | 2021-10-12 | Curevac Ag | MERS coronavirus vaccine |
| CA3050616A1 (en) | 2017-03-24 | 2018-09-27 | Curevac Ag | Nucleic acids encoding crispr-associated proteins and uses thereof |
| US12297489B2 (en) | 2017-05-17 | 2025-05-13 | CureVac Manufacturing GmbH | Method for determining at least one quality parameter of an RNA sample |
| JP7722629B2 (ja) | 2017-07-04 | 2025-08-13 | キュアバック エスイー | 新規核酸分子 |
| EP3673069A1 (en) | 2017-08-22 | 2020-07-01 | CureVac AG | Bunyavirales vaccine |
| CN111511924A (zh) | 2017-11-08 | 2020-08-07 | 库瑞瓦格股份公司 | Rna序列调整 |
| EP3723796A1 (en) | 2017-12-13 | 2020-10-21 | CureVac AG | Flavivirus vaccine |
| US11525158B2 (en) | 2017-12-21 | 2022-12-13 | CureVac SE | Linear double stranded DNA coupled to a single support or a tag and methods for producing said linear double stranded DNA |
| EP3773702A2 (en) | 2018-04-05 | 2021-02-17 | CureVac AG | Novel yellow fever nucleic acid molecules for vaccination |
| SG11202008225PA (en) | 2018-04-17 | 2020-11-27 | Curevac Ag | Novel rsv rna molecules and compositions for vaccination |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3813874A1 (en) | 2018-06-27 | 2021-05-05 | CureVac AG | Novel lassa virus rna molecules and compositions for vaccination |
| EP4273266A3 (en) | 2018-06-28 | 2024-03-13 | CureVac RNA Printer GmbH | Bioreactor for rna in vitro transcription |
| BR112021009422A2 (pt) | 2018-12-21 | 2021-10-26 | Curevac Ag | Rna para vacinas contra malária |
| CA3122645A1 (en) | 2018-12-21 | 2020-06-25 | Curevac Ag | Methods for rna analysis |
| EP4491229A3 (en) | 2019-02-08 | 2025-05-14 | CureVac SE | Coding rna administered into the suprachoroidal space in the treatment of ophtalmic diseases |
| CA3130108A1 (en) * | 2019-02-22 | 2020-08-27 | Life Technologies Corporation | Suspension system for adeno associated virus production |
| CN110124020B (zh) * | 2019-05-05 | 2023-03-14 | 海南医学院 | 基于胞外诱捕网原理制成的肿瘤细胞疫苗及其制备方法 |
| EP3986452A1 (en) | 2019-06-18 | 2022-04-27 | CureVac AG | Rotavirus mrna vaccine |
| AU2020328855A1 (en) | 2019-08-14 | 2022-03-03 | CureVac SE | RNA combinations and compositions with decreased immunostimulatory properties |
| CN110448695B (zh) * | 2019-08-23 | 2021-07-27 | 中山大学肿瘤防治中心 | 一种mRNA疫苗递送载体及其制备方法 |
| JP7709164B2 (ja) * | 2019-10-25 | 2025-07-16 | 国立大学法人高知大学 | 核酸送達促進剤 |
| CN111041025B (zh) | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法 |
| CN112111524B (zh) * | 2020-01-10 | 2024-02-27 | 深圳瑞吉生物科技有限公司 | mRNA-GalNAc靶向分子的制备方法及其体内递送系统和应用 |
| US12194089B2 (en) | 2020-02-04 | 2025-01-14 | CureVac SE | Coronavirus vaccine |
| MX2022009460A (es) | 2020-02-04 | 2022-12-16 | Curevac Ag | Vacuna contra el coronavirus. |
| US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
| US12194157B2 (en) | 2020-04-09 | 2025-01-14 | Finncure Oy | Carrier for targeted delivery to a host |
| WO2021205077A1 (en) | 2020-04-09 | 2021-10-14 | Finncure Oy | Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses |
| MX2022015132A (es) | 2020-05-29 | 2023-03-08 | CureVac SE | Vacunas combinadas a base de acidos nucleicos. |
| CN111744019B (zh) | 2020-07-01 | 2023-08-04 | 深圳瑞吉生物科技有限公司 | 基于甘露糖的mRNA靶向递送系统及其应用 |
| CA3189373A1 (en) * | 2020-07-17 | 2022-01-20 | Sanofi Pasteur | Cleavable lipidic compounds, compositions containing thereof, and uses thereof |
| US20230272052A1 (en) | 2020-07-31 | 2023-08-31 | CureVac SE | Nucleic acid encoded antibody mixtures |
| CA3170743A1 (en) | 2020-08-31 | 2022-03-03 | Susanne RAUCH | Multivalent nucleic acid based coronavirus vaccines |
| BR112023012303A2 (pt) | 2020-12-22 | 2024-02-15 | CureVac SE | Vacina de rna contra variantes de sars-cov-2 |
| CN112662644B (zh) * | 2021-01-19 | 2022-04-22 | 华南理工大学 | 一种甘油磷酸二酯磷酸二酯酶突变体及其应用 |
| WO2022162027A2 (en) | 2021-01-27 | 2022-08-04 | Curevac Ag | Method of reducing the immunostimulatory properties of in vitro transcribed rna |
| CN113144182B (zh) * | 2021-04-22 | 2023-03-10 | 成都欧林生物科技股份有限公司 | 一种幽门螺杆菌口服缓释疫苗及其制备与应用 |
| CA3171589A1 (en) | 2021-05-03 | 2022-11-03 | Moritz THRAN | Improved nucleic acid sequence for cell type specific expression |
| CN115521359B (zh) * | 2021-06-25 | 2025-02-18 | 深圳厚存纳米药业有限公司 | 多肽纳米粒组合物 |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN116813493A (zh) * | 2022-03-21 | 2023-09-29 | 苏州科锐迈德生物医药科技有限公司 | 一种脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CA3248209A1 (en) | 2022-05-25 | 2023-11-30 | CureVac SE | Escherichia coli Antigenic Polypeptide-Based Nucleic Acid Vaccine (FIMH) |
| WO2024044663A2 (en) * | 2022-08-25 | 2024-02-29 | Ohio State Innovation Foundation | Peptide and nucleic acid methods to modulate delivery of nucleic acid structures, polypeptides, and their cargoes |
| EP4608442A1 (en) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Nucleic acid based vaccine |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| WO2025027060A1 (en) | 2023-07-31 | 2025-02-06 | CureVac SE | Nucleic acid encoded runx3 transcription factor |
| WO2025144938A1 (en) | 2023-12-26 | 2025-07-03 | Emmune, Inc. | Systems for nucleic acid transfer |
| CN120818073B (zh) * | 2025-09-16 | 2025-11-21 | 吉林大学 | 一种用于预防布鲁氏菌病的融合重组蛋白abt的构建及其在制备保护性疫苗中的应用 |
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| WO1999015206A1 (en) | 1997-09-23 | 1999-04-01 | Megabios Corporation | Methods for preparing lipids/polynucleotide transfection complexes |
| US6770740B1 (en) | 1999-07-13 | 2004-08-03 | The Regents Of The University Of Michigan | Crosslinked DNA condensate compositions and gene delivery methods |
| DE69943068D1 (de) | 1999-09-09 | 2011-02-03 | Curevac Gmbh | Transfer von mRNA unter Verwendung von polykationischen Verbindungen |
| GB9930533D0 (en) | 1999-12-23 | 2000-02-16 | Mitsubishi Tokyo Pharm Inc | Nucleic acid delivery |
| WO2001092543A2 (en) | 2000-05-30 | 2001-12-06 | Ich Productions Limited | Improved methods of transfection |
| ATE464317T1 (de) | 2001-06-05 | 2010-04-15 | Curevac Gmbh | Stabilisierte mrna mit erhöhtem g/c-gehalt für die gentherapie |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| EP3006043B1 (en) | 2002-04-04 | 2019-05-29 | Zoetis Belgium S.A. | Immunostimulatory g,u-containing oligoribonucleotides |
| DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
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| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP4631970A3 (en) | 2016-05-04 | 2026-01-07 | CureVac SE | Nucleic acid molecules and uses thereof |
| US20180126003A1 (en) | 2016-05-04 | 2018-05-10 | Curevac Ag | New targets for rna therapeutics |
| WO2017203008A1 (en) | 2016-05-25 | 2017-11-30 | Curevac Ag | Novel biomarkers |
| EP3468612A1 (en) | 2016-06-09 | 2019-04-17 | CureVac AG | Hybrid carriers for nucleic acid cargo |
| WO2017212006A1 (en) | 2016-06-09 | 2017-12-14 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| SG11201809912UA (en) | 2016-06-09 | 2018-12-28 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| WO2017212007A1 (en) | 2016-06-09 | 2017-12-14 | Curevac Ag | Cationic carriers for nucleic acid delivery |
| BR112019000598A2 (pt) | 2016-08-19 | 2019-07-02 | Curevac Ag | rna para terapia de câncer |
| WO2018078053A1 (en) | 2016-10-26 | 2018-05-03 | Curevac Ag | Lipid nanoparticle mrna vaccines |
| JP7722629B2 (ja) | 2017-07-04 | 2025-08-13 | キュアバック エスイー | 新規核酸分子 |
-
2017
- 2017-06-09 SG SG11201809912UA patent/SG11201809912UA/en unknown
- 2017-06-09 EP EP17730741.0A patent/EP3468613A1/en not_active Withdrawn
- 2017-06-09 CA CA3023174A patent/CA3023174A1/en active Pending
- 2017-06-09 JP JP2018564340A patent/JP7145579B2/ja active Active
- 2017-06-09 KR KR1020197000593A patent/KR20190029576A/ko not_active Ceased
- 2017-06-09 MX MX2018013919A patent/MX2018013919A/es unknown
- 2017-06-09 BR BR112018075479-0A patent/BR112018075479A2/pt not_active IP Right Cessation
- 2017-06-09 CN CN201780036069.1A patent/CN109475640B/zh not_active Expired - Fee Related
- 2017-06-09 US US16/308,632 patent/US11478552B2/en active Active
- 2017-06-09 AU AU2017277731A patent/AU2017277731B2/en not_active Ceased
- 2017-06-09 RU RU2018140462A patent/RU2751001C2/ru active
- 2017-06-09 WO PCT/EP2017/064059 patent/WO2017212009A1/en not_active Ceased
-
2022
- 2022-10-20 US US18/048,423 patent/US20230302146A1/en not_active Abandoned
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