JP2011521054A5 - - Google Patents
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- JP2011521054A5 JP2011521054A5 JP2011509670A JP2011509670A JP2011521054A5 JP 2011521054 A5 JP2011521054 A5 JP 2011521054A5 JP 2011509670 A JP2011509670 A JP 2011509670A JP 2011509670 A JP2011509670 A JP 2011509670A JP 2011521054 A5 JP2011521054 A5 JP 2011521054A5
- Authority
- JP
- Japan
- Prior art keywords
- copolymer
- group
- alkyl
- normal physiological
- block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001577 copolymer Polymers 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 7
- 239000000470 constituent Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000002091 cationic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000005588 protonation Effects 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5291408P | 2008-05-13 | 2008-05-13 | |
| US5290808P | 2008-05-13 | 2008-05-13 | |
| US61/052,908 | 2008-05-13 | ||
| US61/052,914 | 2008-05-13 | ||
| US9129408P | 2008-08-22 | 2008-08-22 | |
| US61/091,294 | 2008-08-22 | ||
| US11204808P | 2008-11-06 | 2008-11-06 | |
| US11205408P | 2008-11-06 | 2008-11-06 | |
| US61/112,048 | 2008-11-06 | ||
| US61/112,054 | 2008-11-06 | ||
| US12076908P | 2008-12-08 | 2008-12-08 | |
| US61/120,769 | 2008-12-08 | ||
| US14077408P | 2008-12-24 | 2008-12-24 | |
| US14077908P | 2008-12-24 | 2008-12-24 | |
| US61/140,779 | 2008-12-24 | ||
| US61/140,774 | 2008-12-24 | ||
| US17137709P | 2009-04-21 | 2009-04-21 | |
| US61/171,377 | 2009-04-21 | ||
| PCT/US2009/043847 WO2009140427A2 (en) | 2008-05-13 | 2009-05-13 | Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015200236A Division JP6239565B2 (ja) | 2008-05-13 | 2015-10-08 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521054A JP2011521054A (ja) | 2011-07-21 |
| JP2011521054A5 true JP2011521054A5 (enExample) | 2012-07-05 |
| JP5911723B2 JP5911723B2 (ja) | 2016-04-27 |
Family
ID=41319323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509670A Expired - Fee Related JP5911723B2 (ja) | 2008-05-13 | 2009-05-13 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
| JP2015200236A Active JP6239565B2 (ja) | 2008-05-13 | 2015-10-08 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015200236A Active JP6239565B2 (ja) | 2008-05-13 | 2015-10-08 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9476063B2 (enExample) |
| EP (2) | EP2281011B1 (enExample) |
| JP (2) | JP5911723B2 (enExample) |
| KR (1) | KR101661636B1 (enExample) |
| CN (2) | CN103342789B (enExample) |
| AU (1) | AU2009246327B8 (enExample) |
| BR (1) | BRPI0912159B8 (enExample) |
| CA (3) | CA3065577C (enExample) |
| ES (1) | ES2404131T3 (enExample) |
| IL (1) | IL209238A (enExample) |
| MX (1) | MX2010012238A (enExample) |
| WO (1) | WO2009140427A2 (enExample) |
| ZA (1) | ZA201008729B (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103342789B (zh) | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| CN102066444A (zh) | 2008-05-13 | 2011-05-18 | 华盛顿大学 | 胶束装配体 |
| WO2009140421A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| US8822213B2 (en) | 2008-11-06 | 2014-09-02 | University Of Washington | Bispecific intracellular delivery vehicles |
| MX2011004242A (es) | 2008-11-06 | 2011-07-20 | Univ Washington | Copolimeros multibloque. |
| WO2010077678A2 (en) | 2008-12-08 | 2010-07-08 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
| WO2011060281A1 (en) * | 2009-11-13 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Hydrophobic block conjugated therapeutic agents |
| WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
| JP2013528665A (ja) | 2010-03-26 | 2013-07-11 | メルサナ セラピューティックス， インコーポレイテッド | ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法 |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RS63430B1 (sr) | 2010-10-01 | 2022-08-31 | Modernatx Inc | Ribonukleinske kiseline koje sadrže n1-metil-pseudouracile i njihove primene |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| PH12014500214A1 (en) | 2011-08-26 | 2019-03-22 | Arrowhead Res Corporation | Poly (vinyl ester) polymers for in vivo nucleic acid delivery |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| BR112014005978A8 (pt) * | 2011-09-13 | 2017-09-12 | Monsanto Technology Llc | Métodos e composições quimicas agricolas para controle de planta, método de redução de expressão de um gene gs em uma planta, cassete de expressão microbiana, método para fazer um polinucleotídeo e método de identificação de polinucleotídeos úteis na modulação de expressão do gene gs |
| DK3682905T3 (da) | 2011-10-03 | 2022-02-28 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer og anvendelser deraf |
| DE12858350T1 (de) | 2011-12-16 | 2021-10-07 | Modernatx, Inc. | Modifizierte mrna zusammensetzungen |
| HK1206601A1 (en) | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| JP2015515530A (ja) | 2012-04-18 | 2015-05-28 | アローヘッド リサーチ コーポレイション | インビボ核酸送達のためのポリ（アクリラート）ポリマー |
| EP2842546A4 (en) | 2012-04-27 | 2015-12-30 | Univ Tokyo | PHARMACEUTICAL COMPOSITION WITH UNIT STRUCTURE FOR NUCLEIC ACID RELIEF |
| AR091143A1 (es) | 2012-05-24 | 2015-01-14 | Seeds Ltd Ab | Composiciones y metodos para silenciar la expresion genetica |
| US9463261B2 (en) | 2012-09-21 | 2016-10-11 | Vanderbilt University | Poly(thioketal-urethane) scaffolds and methods of use |
| US10046086B2 (en) | 2012-09-21 | 2018-08-14 | Vanderbilt University | Poly(thioketal-urethane) scaffolds and methods of use |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| AU2014296278C1 (en) * | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| WO2015051214A1 (en) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
| CA2939950C (en) | 2014-03-09 | 2023-08-22 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of ornithine transcarbamylase (otc) deficiency |
| CA2944141C (en) * | 2014-03-28 | 2023-03-28 | Aposense Ltd. | Compounds and methods for trans-membrane delivery of molecules |
| US9993563B2 (en) * | 2014-03-28 | 2018-06-12 | Aposense Ltd. | Compounds and methods for trans-membrane delivery of molecules |
| US11318206B2 (en) | 2014-03-28 | 2022-05-03 | Aposense Ltd | Compounds and methods for trans-membrane delivery of molecules |
| US10695288B2 (en) | 2014-11-19 | 2020-06-30 | Vanderbilt University | Reactive oxygen species (ROS)-responsive compositions and methods thereof |
| WO2016118697A1 (en) * | 2015-01-21 | 2016-07-28 | Phaserx, Inc. | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| WO2016176191A1 (en) | 2015-04-27 | 2016-11-03 | The Trustees Of The University Of Pennsylvania | Dual aav vector system for crispr/cas9 mediated correction of human disease |
| ES3009026T3 (en) | 2015-07-22 | 2025-03-25 | Univ Duke | High-throughput screening of regulatory element function with epigenome editing technologies |
| EA201890565A1 (ru) | 2015-08-25 | 2019-04-30 | Дьюк Юниверсити | Композиции и способы улучшения специфичности в геномной инженерии с применением рнк-направляемых эндонуклеаз |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| KR101949181B1 (ko) * | 2016-03-29 | 2019-04-29 | 주식회사 엘지화학 | 블록 중합체 및 이를 포함하는 고분자 전해질막 |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| EP3487523B1 (en) | 2016-07-19 | 2023-09-06 | Duke University | Therapeutic applications of cpf1-based genome editing |
| EP3506909B1 (en) | 2016-09-02 | 2022-06-29 | Dicerna Pharmaceuticals, Inc. | 4'-phosphate analogs and oligonucleotides comprising the same |
| US11684584B2 (en) | 2016-12-30 | 2023-06-27 | Genevant Sciences Gmbh | Branched peg molecules and related compositions and methods |
| KR20190104392A (ko) | 2017-01-09 | 2019-09-09 | 아포센스 엘티디. | 분자의 막투과 전달을 위한 화합물 및 방법 |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| JP7275111B2 (ja) | 2017-08-31 | 2023-05-17 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子の生成方法 |
| CN111050752B (zh) | 2017-08-31 | 2022-08-16 | 国立大学法人东京大学 | 搭载核酸的单元型聚离子复合物 |
| WO2019130319A1 (en) | 2018-01-01 | 2019-07-04 | Aposense Ltd. | Compounds and methods for trans-membrane delivery of molecules |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US20220008346A1 (en) * | 2018-10-30 | 2022-01-13 | Vanderbilt University | Graft copolymers, methods of forming graft copolymers, and methods of use thereof |
| WO2020145206A1 (ja) * | 2019-01-09 | 2020-07-16 | デンカ株式会社 | トリブロック共重合体及びトリブロック共重合体の製造方法 |
| MX2021011928A (es) | 2019-03-29 | 2022-01-04 | Dicerna Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de enfermedades o trastornos asociados con kras. |
| SG11202111077RA (en) | 2019-05-03 | 2021-11-29 | Dicerna Pharmaceuticals Inc | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| WO2021146488A1 (en) | 2020-01-15 | 2021-07-22 | Dicerna Pharmaceuticals, Inc. | 4'-o-methylene phosphonate nucleic acids and analogues thereof |
| US20230167223A1 (en) * | 2020-04-30 | 2023-06-01 | Dow Global Technologies Llc | Process for preparing olefin-acrylate block copolymers |
| JP2023537499A (ja) | 2020-08-04 | 2023-09-01 | ディセルナ ファーマシューティカルズ インコーポレイテッド | オリゴヌクレオチドの全身送達 |
| CN113087017A (zh) * | 2021-04-06 | 2021-07-09 | 中国科学院理化技术研究所 | 一种偏钒酸钠纳米球及其制备方法和应用 |
| CN119731321A (zh) | 2022-06-24 | 2025-03-28 | 图恩疗法股份有限公司 | 通过靶向基因阻遏减少低密度脂蛋白的组合物、系统和方法 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025072893A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for non-viral gene delivery |
| WO2025250979A1 (en) | 2024-05-31 | 2025-12-04 | Battelle Memorial Institute | Polymer nanoparticle compositions for non-viral gene delivery |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4877603A (en) | 1987-12-18 | 1989-10-31 | The Procter & Gamble Company | Oral compositions |
| US6359054B1 (en) | 1994-11-18 | 2002-03-19 | Supratek Pharma Inc. | Polynucleotide compositions for intramuscular administration |
| FR2767829B1 (fr) | 1997-09-01 | 1999-12-03 | Georges Sturtz | Composes phosphonates ou gem-bisphosphonates acryliques ou methacryliques |
| KR20010032878A (ko) | 1997-12-12 | 2001-04-25 | 김윤 | 유전자전달을 위한 혼성 다인자 생분해성 미포 |
| US6410057B1 (en) | 1997-12-12 | 2002-06-25 | Samyang Corporation | Biodegradable mixed polymeric micelles for drug delivery |
| US6383811B2 (en) | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| CA2317549C (en) | 1998-01-05 | 2006-04-11 | University Of Washington | Composition for enhancing transport through lipid-containing membranes, and uses thereof |
| US6306994B1 (en) * | 1999-05-14 | 2001-10-23 | E. I. Du Pont De Nemours And Company | Inks with enhanced substrate binding characteristics |
| US7098032B2 (en) | 2001-01-02 | 2006-08-29 | Mirus Bio Corporation | Compositions and methods for drug delivery using pH sensitive molecules |
| US7033607B2 (en) | 1999-12-31 | 2006-04-25 | Mirus Bio Corporation | pH-titratable polyampholytes for delivering polyions to a cell |
| AU2764801A (en) | 2000-01-07 | 2001-07-24 | University Of Washington | Enhanced transport of agents using membrane disruptive agents |
| US20030134420A1 (en) | 2000-02-18 | 2003-07-17 | Lollo Charles Peter | Methods and compositions for gene delivery |
| WO2001087227A2 (en) | 2000-05-17 | 2001-11-22 | Labopharm, Inc. | Drug containing polymeric micelles |
| US6852816B2 (en) | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
| SE517421C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav |
| WO2003087188A1 (en) | 2001-04-26 | 2003-10-23 | Nanosphere, Inc. | Oligonucleotide-modified romp polymers and co-polymers |
| US6780428B2 (en) | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
| US7094810B2 (en) | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
| US6939564B2 (en) | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| WO2003059382A2 (en) | 2001-12-28 | 2003-07-24 | Supratek Pharma Inc. | Pharmaceutical compositions comprising polyanionic polymers and amphiphilic block copolymers and methods of use thereof to improve gene expression |
| EP1480619B1 (en) | 2002-03-07 | 2013-08-07 | Biocompatibles UK Limited | Drug carriers comprising amphiphilic block copolymers |
| US7229973B2 (en) | 2002-05-19 | 2007-06-12 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
| EP1400555A1 (en) | 2002-09-17 | 2004-03-24 | Kawamura Institute Of Chemical Research | Water-soluble block copolymer and production method therefor |
| EP1558658B1 (fr) | 2002-11-07 | 2012-12-19 | Rhodia Chimie | Copolymere a structure controlee presentant une partie amphotere ou zwitterionique. |
| US20070010632A1 (en) | 2002-11-27 | 2007-01-11 | Kaplan David L | Antioxidant-functionalized polymers |
| KR101045504B1 (ko) | 2002-12-30 | 2011-06-30 | 넥타르 테라퓨틱스 | 약물 전달 부형제로서의 멀티-아암 폴리펩티드-폴리(에틸렌글리콜) 블록 공중합체 |
| US7871818B2 (en) | 2003-01-31 | 2011-01-18 | Roche Madison Inc. | Membrane active polymers |
| US7217776B1 (en) | 2003-02-14 | 2007-05-15 | Iowa State University Research Foundation | pH-sensitive methacrylic copolymer gels and the production thereof |
| US20040162235A1 (en) | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| JP4535229B2 (ja) | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
| FR2868784B1 (fr) * | 2004-04-09 | 2006-05-26 | Oreal | Copolymere sequence, composition le comprenant et procede de traitement cosmetique |
| US7632905B2 (en) | 2004-04-09 | 2009-12-15 | L'oreal S.A. | Block copolymer, composition comprising it and cosmetic treatment process |
| US20080274454A1 (en) | 2004-04-07 | 2008-11-06 | Mirkin Chad A | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles |
| US8821859B2 (en) | 2004-05-19 | 2014-09-02 | Agency For Science, Technology And Research | Methods and articles for the delivery of therapeutic agents |
| GB0418123D0 (en) | 2004-08-13 | 2004-09-15 | Asahi Chemical Ind | Polymers useful as medical materials |
| WO2006060723A2 (en) | 2004-12-03 | 2006-06-08 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
| WO2006071769A1 (en) | 2004-12-28 | 2006-07-06 | The Trustees Of The University Of Pennsylvania | Controlled release from block co-polymer worm micelles |
| US20060171980A1 (en) | 2005-02-01 | 2006-08-03 | Helmus Michael N | Implantable or insertable medical devices having optimal surface energy |
| AU2006230247A1 (en) | 2005-03-31 | 2006-10-05 | A.P. Pharma, Inc. | PEG-polyacetal and PEG-polyacetal-POE graft copolymers and pharmaceutical compositions |
| US8574604B2 (en) | 2005-04-15 | 2013-11-05 | Interface Biologics, Inc. | Methods and compositions for the delivery of biologically active agents |
| US9139850B2 (en) | 2005-05-19 | 2015-09-22 | L'oreal | Vectorization of dsRNA by cationic particles and topical use |
| US9505867B2 (en) | 2005-05-31 | 2016-11-29 | Ecole Polytechmique Fédérale De Lausanne | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| FR2890859B1 (fr) | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
| US7718193B2 (en) | 2006-03-16 | 2010-05-18 | University Of Washington | Temperature- and pH-responsive polymer compositions |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| US8512757B2 (en) | 2006-07-05 | 2013-08-20 | Agency For Science, Techology And Research | Micelles for drug delivery |
| JP5274461B2 (ja) | 2006-08-18 | 2013-08-28 | アローヘッド リサーチ コーポレイション | ポリヌクレオチドのインビボ送達のためのポリ結合体 |
| WO2008085556A2 (en) | 2006-09-12 | 2008-07-17 | University Of South Florida | Surfactant-free nanoparticles for drug delivery |
| US20080081075A1 (en) | 2006-10-02 | 2008-04-03 | National Tsing Hua University | Multifunctional mixed micelle of graft and block copolymers and preparation thereof |
| US20100137206A1 (en) | 2006-12-15 | 2010-06-03 | The Governors Of The University Of Alberta | Novel ligand guided block copolymers for targeted drug delivery |
| EP2121030A4 (en) | 2007-01-17 | 2013-06-19 | Immunomedics Inc | POLYMER CARRIER OF THERAPEUTIC AGENTS AND RECOGNITION RISKS FOR TARGETED TREATMENT OF ANTIBODY BASED DISEASES |
| US20080311045A1 (en) | 2007-06-06 | 2008-12-18 | Biovaluation & Analysis, Inc. | Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
| EP2173382A4 (en) | 2007-06-08 | 2012-11-14 | Univ Queensland | WOUND REPAIR COMPOSITION AND METHOD |
| US20080312134A1 (en) | 2007-06-11 | 2008-12-18 | Thomas Hirt | Vesicles for active macromolecule delivery |
| US20110008395A1 (en) | 2007-07-06 | 2011-01-13 | Vladimir Torchilin | Mixed micelles including amphipathic conjugates of rna agents, and uses thereof |
| US20090036625A1 (en) | 2007-08-01 | 2009-02-05 | Chung Yuan Christian University | Amphiphilic Polymer, Method for Forming the Same and Application thereof |
| EP2025348A1 (en) | 2007-08-13 | 2009-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted block copolymer micelles |
| CN102066444A (zh) | 2008-05-13 | 2011-05-18 | 华盛顿大学 | 胶束装配体 |
| KR20110020804A (ko) | 2008-05-13 | 2011-03-03 | 유니버시티 오브 워싱톤 | 치료제의 세포내 전달을 위한 미셀 |
| WO2009140421A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| WO2009140423A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Targeted polymer bioconjugates |
| CN103342789B (zh) | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| DK2180004T3 (da) | 2008-10-22 | 2011-09-05 | Clariant Finance Bvi Ltd | Olefinisk umættede phosphonatforbindelser, polymere fremstillet ud fra disse og deres anvendelse |
| US8822213B2 (en) | 2008-11-06 | 2014-09-02 | University Of Washington | Bispecific intracellular delivery vehicles |
| MX2011004242A (es) | 2008-11-06 | 2011-07-20 | Univ Washington | Copolimeros multibloque. |
| US20110281934A1 (en) | 2008-11-06 | 2011-11-17 | Phaserx, Inc. | Micelles of hydrophilically shielded membrane-destabilizing copolymers |
| US20100150952A1 (en) | 2008-11-07 | 2010-06-17 | University Of Washington | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY |
| WO2010077678A2 (en) | 2008-12-08 | 2010-07-08 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
-
2009
- 2009-05-13 CN CN201310232498.XA patent/CN103342789B/zh not_active Expired - Fee Related
- 2009-05-13 CA CA3065577A patent/CA3065577C/en active Active
- 2009-05-13 MX MX2010012238A patent/MX2010012238A/es active IP Right Grant
- 2009-05-13 AU AU2009246327A patent/AU2009246327B8/en active Active
- 2009-05-13 EP EP09747510A patent/EP2281011B1/en active Active
- 2009-05-13 KR KR1020107027808A patent/KR101661636B1/ko active Active
- 2009-05-13 CA CA2972694A patent/CA2972694C/en active Active
- 2009-05-13 BR BRPI0912159A patent/BRPI0912159B8/pt active IP Right Grant
- 2009-05-13 JP JP2011509670A patent/JP5911723B2/ja not_active Expired - Fee Related
- 2009-05-13 US US12/992,517 patent/US9476063B2/en active Active
- 2009-05-13 WO PCT/US2009/043847 patent/WO2009140427A2/en not_active Ceased
- 2009-05-13 CN CN2009801228883A patent/CN102083878B/zh not_active Expired - Fee Related
- 2009-05-13 ES ES09747510T patent/ES2404131T3/es active Active
- 2009-05-13 EP EP13156237.3A patent/EP2620161A1/en not_active Withdrawn
- 2009-05-13 CA CA2724105A patent/CA2724105C/en active Active
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2010
- 2010-11-10 IL IL209238A patent/IL209238A/en active IP Right Grant
- 2010-12-03 ZA ZA2010/08729A patent/ZA201008729B/en unknown
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2015
- 2015-10-08 JP JP2015200236A patent/JP6239565B2/ja active Active
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2016
- 2016-09-13 US US15/264,392 patent/US9862792B2/en active Active
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- 2017-11-30 US US15/828,078 patent/US20180171056A1/en not_active Abandoned
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