JP2009534470A5 - - Google Patents
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- Publication number
- JP2009534470A5 JP2009534470A5 JP2009507916A JP2009507916A JP2009534470A5 JP 2009534470 A5 JP2009534470 A5 JP 2009534470A5 JP 2009507916 A JP2009507916 A JP 2009507916A JP 2009507916 A JP2009507916 A JP 2009507916A JP 2009534470 A5 JP2009534470 A5 JP 2009534470A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogens
- halogen
- optionally substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 45
- 150000002367 halogens Chemical class 0.000 claims 43
- 229910052739 hydrogen Inorganic materials 0.000 claims 29
- 239000001257 hydrogen Substances 0.000 claims 29
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- -1 difluoro-cyclohexyl Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- LDSZFTOLXSPQAR-FQEVSTJZSA-N (3r)-3-[[2,6-dichloro-4-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)(F)CCC1N1C(=O)[C@H](CC=2C(=CC(=CC=2Cl)C=2C=CC(=CC=2)C(=O)N2CCC(F)(F)CC2)Cl)CC1 LDSZFTOLXSPQAR-FQEVSTJZSA-N 0.000 claims 1
- DNWOQKDNVSQGJG-FQEVSTJZSA-N (3r)-3-[[2,6-dichloro-4-[4-(morpholine-4-carbonyl)phenyl]phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)(F)CCC1N1C(=O)[C@H](CC=2C(=CC(=CC=2Cl)C=2C=CC(=CC=2)C(=O)N2CCOCC2)Cl)CC1 DNWOQKDNVSQGJG-FQEVSTJZSA-N 0.000 claims 1
- VZGUZRHKKJJQGB-NRFANRHFSA-N (3r)-3-[[2,6-dichloro-4-[4-[4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl]phenyl]phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CN(CC(F)(F)F)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(C[C@H]3C(N(C4CCC(F)(F)CC4)CC3)=O)=C(Cl)C=2)C=C1 VZGUZRHKKJJQGB-NRFANRHFSA-N 0.000 claims 1
- VHAPGXKAPDCEOC-FQEVSTJZSA-N (3r)-3-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(C(F)(F)F)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(C[C@H]3C(N(C4CCC(F)(F)CC4)CC3)=O)=C(Cl)C=2)C=C1 VHAPGXKAPDCEOC-FQEVSTJZSA-N 0.000 claims 1
- MTYQFJIIAXYMBM-QHCPKHFHSA-N (3r)-3-[[4-[4-(4-tert-butylpiperazine-1-carbonyl)phenyl]-2,6-dichlorophenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CN(C(C)(C)C)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(C[C@H]3C(N(C4CCC(F)(F)CC4)CC3)=O)=C(Cl)C=2)C=C1 MTYQFJIIAXYMBM-QHCPKHFHSA-N 0.000 claims 1
- GZTYGDICFIUSQQ-BUXCFDRUSA-N (3r)-3-[[4-[4-[4-(2-adamantyl)piperazine-1-carbonyl]phenyl]-2,6-dichlorophenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)(F)CCC1N1C(=O)[C@H](CC=2C(=CC(=CC=2Cl)C=2C=CC(=CC=2)C(=O)N2CCN(CC2)C2C3CC4CC(C3)CC2C4)Cl)CC1 GZTYGDICFIUSQQ-BUXCFDRUSA-N 0.000 claims 1
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 1
- VDNFRPZAKPKKLK-NKKJXINNSA-N F[C@H]1CC[C@H](CC1)N1CC[C@@H](Cc2c(Cl)cc(cc2Cl)-c2ccc(cc2)C(=O)N2CCC(CC2)C(F)(F)F)C1=O Chemical compound F[C@H]1CC[C@H](CC1)N1CC[C@@H](Cc2c(Cl)cc(cc2Cl)-c2ccc(cc2)C(=O)N2CCC(CC2)C(F)(F)F)C1=O VDNFRPZAKPKKLK-NKKJXINNSA-N 0.000 claims 1
- RLYALLJSWVQZDM-IBGZPJMESA-N [4-[3,5-dichloro-4-[[(3R)-1-(4,4-difluorocyclohexyl)pyrrolidin-3-yl]methyl]phenyl]phenyl]-[4-(trifluoromethyl)piperidin-1-yl]methanone Chemical compound ClC=1C=C(C=C(C1C[C@H]1CN(CC1)C1CCC(CC1)(F)F)Cl)C1=CC=C(C=C1)C(=O)N1CCC(CC1)C(F)(F)F RLYALLJSWVQZDM-IBGZPJMESA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74546706P | 2006-04-24 | 2006-04-24 | |
| US60/745,467 | 2006-04-24 | ||
| PCT/US2007/067200 WO2007127693A1 (en) | 2006-04-24 | 2007-04-23 | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534470A JP2009534470A (ja) | 2009-09-24 |
| JP2009534470A5 true JP2009534470A5 (enExample) | 2010-05-27 |
| JP5189078B2 JP5189078B2 (ja) | 2013-04-24 |
Family
ID=38512591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507916A Expired - Fee Related JP5189078B2 (ja) | 2006-04-24 | 2007-04-23 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7816349B2 (enExample) |
| EP (1) | EP2029529B1 (enExample) |
| JP (1) | JP5189078B2 (enExample) |
| CN (1) | CN101432263B (enExample) |
| AT (1) | ATE473210T1 (enExample) |
| AU (1) | AU2007244960B2 (enExample) |
| BR (1) | BRPI0710262A2 (enExample) |
| CA (1) | CA2649650C (enExample) |
| DE (1) | DE602007007614D1 (enExample) |
| DK (1) | DK2029529T3 (enExample) |
| EA (1) | EA016959B1 (enExample) |
| ES (1) | ES2346925T3 (enExample) |
| MX (1) | MX2008013644A (enExample) |
| PL (1) | PL2029529T3 (enExample) |
| PT (1) | PT2029529E (enExample) |
| WO (1) | WO2007127693A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101541747B (zh) * | 2006-04-21 | 2012-11-14 | 伊莱利利公司 | 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物 |
| CA2647677C (en) | 2006-04-21 | 2014-03-18 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| AU2007244955B2 (en) * | 2006-04-24 | 2011-12-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA016415B1 (ru) | 2006-04-24 | 2012-04-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1 |
| EP2016071B1 (en) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| BRPI0710050A2 (pt) | 2006-04-25 | 2011-08-02 | Lilly Co Eli | composto, composição farmacêutica, e, intermediário |
| ATE471311T1 (de) | 2006-04-25 | 2010-07-15 | Lilly Co Eli | Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1 |
| BRPI0710469A2 (pt) | 2006-04-28 | 2011-08-16 | Lilly Co Eli | composto, composição farmacêutica, e, intermediário |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2220048B1 (en) | 2007-11-16 | 2017-01-25 | Boehringer Ingelheim International GmbH | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤 |
| CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| EP2291373B1 (en) * | 2008-05-01 | 2013-09-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2722427A1 (en) * | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CL2009001058A1 (es) * | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
| JP5538365B2 (ja) * | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| WO2009138386A2 (en) | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| WO2010010150A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| RU2539979C2 (ru) | 2008-07-25 | 2015-01-27 | Вайтаи Фармасьютиклз, Инк. | Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1 |
| JP5777030B2 (ja) * | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| WO2010089303A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5750449B2 (ja) | 2009-11-05 | 2015-07-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルリンリガンド |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2576570A1 (en) | 2010-05-26 | 2013-04-10 | Boehringer Ingelheim International GmbH | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| BR112013010021A2 (pt) | 2010-11-02 | 2019-09-24 | Boehringer Ingelheim Int | combinações farmacêuticas para o tratamento de distúrbios metabólicos. |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| US6903102B2 (en) * | 2001-09-06 | 2005-06-07 | Schering Corporation | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| NZ551076A (en) * | 2004-05-07 | 2009-05-31 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| CN101001836B (zh) * | 2004-05-07 | 2010-12-22 | 詹森药业有限公司 | 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物 |
| US8138342B2 (en) | 2004-10-12 | 2012-03-20 | High Point Pharmacueticals, LLC | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| ES2318577T3 (es) * | 2004-10-29 | 2009-05-01 | Eli Lilly And Company | Derivados de cicloalquil lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1'. |
| KR101368228B1 (ko) | 2004-11-10 | 2014-02-27 | 인사이트 코포레이션 | 락탐 화합물 및 약제로서의 이의 용도 |
| ATE399546T1 (de) | 2004-12-20 | 2008-07-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| US7834194B2 (en) | 2004-12-21 | 2010-11-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| CA2647677C (en) | 2006-04-21 | 2014-03-18 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| CN101541747B (zh) | 2006-04-21 | 2012-11-14 | 伊莱利利公司 | 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物 |
| EA016415B1 (ru) | 2006-04-24 | 2012-04-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1 |
| AU2007244955B2 (en) | 2006-04-24 | 2011-12-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP2016071B1 (en) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ATE471311T1 (de) | 2006-04-25 | 2010-07-15 | Lilly Co Eli | Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1 |
| BRPI0710050A2 (pt) | 2006-04-25 | 2011-08-02 | Lilly Co Eli | composto, composição farmacêutica, e, intermediário |
| BRPI0710469A2 (pt) | 2006-04-28 | 2011-08-16 | Lilly Co Eli | composto, composição farmacêutica, e, intermediário |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-23 AU AU2007244960A patent/AU2007244960B2/en not_active Ceased
- 2007-04-23 DE DE602007007614T patent/DE602007007614D1/de active Active
- 2007-04-23 PT PT07761107T patent/PT2029529E/pt unknown
- 2007-04-23 DK DK07761107.7T patent/DK2029529T3/da active
- 2007-04-23 EA EA200870471A patent/EA016959B1/ru not_active IP Right Cessation
- 2007-04-23 BR BRPI0710262-3A patent/BRPI0710262A2/pt not_active IP Right Cessation
- 2007-04-23 EP EP07761107A patent/EP2029529B1/en not_active Not-in-force
- 2007-04-23 CA CA2649650A patent/CA2649650C/en not_active Expired - Fee Related
- 2007-04-23 US US12/297,969 patent/US7816349B2/en not_active Expired - Fee Related
- 2007-04-23 AT AT07761107T patent/ATE473210T1/de active
- 2007-04-23 MX MX2008013644A patent/MX2008013644A/es active IP Right Grant
- 2007-04-23 CN CN2007800148702A patent/CN101432263B/zh not_active Expired - Fee Related
- 2007-04-23 WO PCT/US2007/067200 patent/WO2007127693A1/en not_active Ceased
- 2007-04-23 JP JP2009507916A patent/JP5189078B2/ja not_active Expired - Fee Related
- 2007-04-23 ES ES07761107T patent/ES2346925T3/es active Active
- 2007-04-23 PL PL07761107T patent/PL2029529T3/pl unknown
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