JP2009534412A5 - - Google Patents

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Publication number
JP2009534412A5
JP2009534412A5 JP2009506760A JP2009506760A JP2009534412A5 JP 2009534412 A5 JP2009534412 A5 JP 2009534412A5 JP 2009506760 A JP2009506760 A JP 2009506760A JP 2009506760 A JP2009506760 A JP 2009506760A JP 2009534412 A5 JP2009534412 A5 JP 2009534412A5
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JP
Japan
Prior art keywords
tetrahydro
dichloro
pyrrolidin
benzimidazol
ylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009506760A
Other languages
English (en)
Japanese (ja)
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JP2009534412A (ja
JP5236628B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/066907 external-priority patent/WO2007124329A1/en
Publication of JP2009534412A publication Critical patent/JP2009534412A/ja
Publication of JP2009534412A5 publication Critical patent/JP2009534412A5/ja
Application granted granted Critical
Publication of JP5236628B2 publication Critical patent/JP5236628B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009506760A 2006-04-21 2007-04-19 １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としての、シクロヘキシルイミダゾールラクタム誘導体 Expired - Fee Related JP5236628B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74532106P 2006-04-21 2006-04-21
US60/745,321 2006-04-21
PCT/US2007/066907 WO2007124329A1 (en) 2006-04-21 2007-04-19 Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (3)

Publication Number Publication Date
JP2009534412A JP2009534412A (ja) 2009-09-24
JP2009534412A5 true JP2009534412A5 (enExample) 2011-01-13
JP5236628B2 JP5236628B2 (ja) 2013-07-17

Family

ID=38380722

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009506760A Expired - Fee Related JP5236628B2 (ja) 2006-04-21 2007-04-19 １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としての、シクロヘキシルイミダゾールラクタム誘導体

Country Status (11)

Country Link
US (1) US7820659B2 (enExample)
EP (1) EP2029576B1 (enExample)
JP (1) JP5236628B2 (enExample)
CN (1) CN101426780B (enExample)
AU (1) AU2007240450B2 (enExample)
BR (1) BRPI0710273A2 (enExample)
CA (1) CA2646678C (enExample)
EA (1) EA014717B1 (enExample)
ES (1) ES2422165T3 (enExample)
MX (1) MX2008013328A (enExample)
WO (1) WO2007124329A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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AU2007240458B2 (en) 2006-04-21 2012-03-15 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
MY148128A (en) 2006-04-21 2013-02-28 Lilly Co Eli Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ATE473210T1 (de) 2006-04-24 2010-07-15 Lilly Co Eli Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1
DE602007007473D1 (en) * 2006-04-24 2010-08-12 Lilly Co Eli 11-beta-hydroxysteroid-dehydrogenase-1-hemmer
CN101432262B (zh) 2006-04-24 2011-06-01 伊莱利利公司 作为11-β-羟类固醇脱氢酶1的抑制剂的环己基取代的吡咯烷酮类
ES2429570T3 (es) * 2006-04-25 2013-11-15 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
EA015499B1 (ru) 2006-04-25 2011-08-30 Эли Лилли Энд Компани Ингибиторы 11-бета-гидроксистероид дегидрогеназы типа 1
SI2021337T1 (sl) 2006-04-25 2010-05-31 Lilly Co Eli Inhibitorji beta hidroksisteroidne dehidrogenaze
MX2008013844A (es) * 2006-04-28 2008-11-10 Lilly Co Eli Pirrolidinonas substituidas con pieridinilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
EP2069326B1 (en) * 2006-10-04 2015-03-18 Merck Sharp & Dohme Corp. Bicyclic and tricyclic derivatives as thrombin receptor antagonists
JP5470557B2 (ja) * 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
KR20110002492A (ko) 2008-05-01 2011-01-07 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
WO2010010150A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
KR20110050459A (ko) 2008-07-25 2011-05-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
EP2324017B1 (en) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2496589B1 (en) 2009-11-05 2014-03-05 Boehringer Ingelheim International GmbH Novel chiral phosphorus ligands
WO2011068927A2 (en) * 2009-12-04 2011-06-09 Abbott Laboratories 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2576570A1 (en) 2010-05-26 2013-04-10 Boehringer Ingelheim International GmbH 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
AU2011325286B2 (en) 2010-11-02 2015-04-16 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP6020459B2 (ja) 2011-10-18 2016-11-02 アステラス製薬株式会社 二環式ヘテロ環化合物
TW201722957A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產（第二）有限公司 化學化合物

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
CN1980889B (zh) * 2004-05-07 2010-11-10 詹森药业有限公司 11-β羟基类固醇脱氢酶抑制剂的金刚烷基吡咯烷-2-酮衍生物
CN101001836B (zh) 2004-05-07 2010-12-22 詹森药业有限公司 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物
WO2006040329A1 (en) 2004-10-12 2006-04-20 Novo Nordisk A/S 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
US7713979B2 (en) 2004-10-29 2010-05-11 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
TWI400239B (zh) 2004-11-10 2013-07-01 英塞特公司 內醯胺化合物及其作為醫藥品之用途
WO2006068992A1 (en) 2004-12-20 2006-06-29 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2006068991A1 (en) 2004-12-21 2006-06-29 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2006104280A1 (ja) 2005-03-31 2006-10-05 Takeda Pharmaceutical Company Limited 糖尿病の予防・治療剤
US7998959B2 (en) 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
MY148128A (en) 2006-04-21 2013-02-28 Lilly Co Eli Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2007240458B2 (en) 2006-04-21 2012-03-15 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
DE602007007473D1 (en) 2006-04-24 2010-08-12 Lilly Co Eli 11-beta-hydroxysteroid-dehydrogenase-1-hemmer
ATE473210T1 (de) 2006-04-24 2010-07-15 Lilly Co Eli Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1
CN101432262B (zh) 2006-04-24 2011-06-01 伊莱利利公司 作为11-β-羟类固醇脱氢酶1的抑制剂的环己基取代的吡咯烷酮类
SI2021337T1 (sl) 2006-04-25 2010-05-31 Lilly Co Eli Inhibitorji beta hidroksisteroidne dehidrogenaze
ES2429570T3 (es) 2006-04-25 2013-11-15 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
EA015499B1 (ru) 2006-04-25 2011-08-30 Эли Лилли Энд Компани Ингибиторы 11-бета-гидроксистероид дегидрогеназы типа 1
MX2008013844A (es) 2006-04-28 2008-11-10 Lilly Co Eli Pirrolidinonas substituidas con pieridinilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

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