JP2006522141A5 - - Google Patents
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- Publication number
- JP2006522141A5 JP2006522141A5 JP2006509547A JP2006509547A JP2006522141A5 JP 2006522141 A5 JP2006522141 A5 JP 2006522141A5 JP 2006509547 A JP2006509547 A JP 2006509547A JP 2006509547 A JP2006509547 A JP 2006509547A JP 2006522141 A5 JP2006522141 A5 JP 2006522141A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- composition
- benzo
- thieno
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 48
- 239000000203 mixture Substances 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 208000015114 central nervous system disease Diseases 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000002815 pulmonary hypertension Diseases 0.000 claims 3
- 208000037905 systemic hypertension Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 (1-naphthalen-2-ylmethyl-piperidin-4-yl)-(5,6,7,8-tetrahydro-benzo [4,5] thieno [2,3-d] pyrimidin-4-yl) Chemical group 0.000 claims 1
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000006284 3-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])* 0.000 claims 1
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 1
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000000173 4-trifluoromethoxy benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)C([H])([H])* 0.000 claims 1
- 125000001318 4-trifluoromethylbenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(F)(F)F 0.000 claims 1
- 229940127239 5 Hydroxytryptamine receptor antagonist Drugs 0.000 claims 1
- YWDUHOZXYSVKQP-UHFFFAOYSA-N CC(C1=CC=CC=C1)N2CCC(CC2)NC3=C4C5=C(CCCC5)SC4=NC=N3 Chemical compound CC(C1=CC=CC=C1)N2CCC(CC2)NC3=C4C5=C(CCCC5)SC4=NC=N3 YWDUHOZXYSVKQP-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003420 antiserotonin agent Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- JXZYICYIKCJUID-UHFFFAOYSA-N n-(1-benzhydrylpiperidin-4-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1CCCC(C=23)=C1SC3=NC=NC=2NC(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 JXZYICYIKCJUID-UHFFFAOYSA-N 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 239000002400 serotonin 2A antagonist Substances 0.000 claims 1
- 239000002484 serotonin 2C antagonist Substances 0.000 claims 1
- 239000003215 serotonin 5-HT2 receptor antagonist Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45883103P | 2003-03-31 | 2003-03-31 | |
| PCT/US2004/009944 WO2004089312A2 (en) | 2003-03-31 | 2004-03-31 | New piperidinylamino-thieno[2,3-d] pyrimidine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522141A JP2006522141A (ja) | 2006-09-28 |
| JP2006522141A5 true JP2006522141A5 (enExample) | 2007-08-16 |
| JP4677518B2 JP4677518B2 (ja) | 2011-04-27 |
Family
ID=33159606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509547A Expired - Fee Related JP4677518B2 (ja) | 2003-03-31 | 2004-03-31 | 新規ピペリジニルアミノ−チエノ［２，３−ｄ］ピリミジン化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7030240B2 (enExample) |
| EP (1) | EP1622914B1 (enExample) |
| JP (1) | JP4677518B2 (enExample) |
| KR (1) | KR20060013370A (enExample) |
| CN (1) | CN1777612A (enExample) |
| AT (1) | ATE511511T1 (enExample) |
| AU (1) | AU2004227913B2 (enExample) |
| BR (1) | BRPI0408988A (enExample) |
| CA (1) | CA2517833A1 (enExample) |
| MX (1) | MXPA05009818A (enExample) |
| NO (1) | NO20055029L (enExample) |
| NZ (1) | NZ542236A (enExample) |
| WO (1) | WO2004089312A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7488736B2 (en) | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7576211B2 (en) | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US7407966B2 (en) | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| EP1802634A2 (en) * | 2004-10-20 | 2007-07-04 | Compass Pharmaceuticals LLC | Thiophens and their use as anti-tumor agents |
| JP5186219B2 (ja) * | 2005-01-25 | 2013-04-17 | エピックス デラウェア， インコーポレイテッド | 置換アリールアミン化合物および５−ｈｔ６調節因子としてのその使用 |
| WO2007110868A2 (en) | 2006-03-28 | 2007-10-04 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| EP2896624B1 (en) * | 2007-03-28 | 2016-07-13 | Atir Holding S.A. | Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof |
| EA201070334A1 (ru) * | 2007-09-04 | 2010-10-29 | ПиДжиэксХЭЛТ ЭлЭлСи | Пиперидиниламинотиено[2,3-d]пиримидиновые соединения для лечения фиброза |
| WO2010065743A2 (en) | 2008-12-03 | 2010-06-10 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| CN103119047B (zh) | 2010-07-23 | 2016-06-15 | 哈佛大学校长及研究员协会 | 三环类蛋白酶体活性增强化合物 |
| EP3239154A1 (en) * | 2011-01-10 | 2017-11-01 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| WO2012140642A1 (en) | 2011-04-10 | 2012-10-18 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| EP2872144A4 (en) | 2012-07-11 | 2015-12-02 | Nimbus Iris Inc | IRAQ INHIBITOR AND USES THEREOF |
| WO2014110114A1 (en) | 2013-01-10 | 2014-07-17 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| EP3049086A4 (en) | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| TWI648281B (zh) | 2013-10-17 | 2019-01-21 | 日商安斯泰來製藥股份有限公司 | 含硫二環式化合物 |
| WO2015090226A1 (zh) * | 2013-12-20 | 2015-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | N，n'取代哌啶胺类化合物、其制备方法及用途 |
| USRE49687E1 (en) | 2014-09-09 | 2023-10-10 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
| WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| WO2017161028A1 (en) | 2016-03-16 | 2017-09-21 | Kura Oncology, Inc. | Substituted inhibitors of menin-mll and methods of use |
| US10752639B2 (en) | 2016-03-16 | 2020-08-25 | Kura Oncology, Inc. | Bridged bicyclic inhibitors of menin-MLL and methods of use |
| CN110691779B (zh) | 2017-03-24 | 2023-10-10 | 库拉肿瘤学公司 | 治疗血液系统恶性肿瘤和尤因肉瘤的方法 |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA933923A (en) * | 1969-12-19 | 1973-09-18 | Eichenberger Kurt | Process for the manufacture of new thiopyranes |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| WO1984001151A1 (en) * | 1982-09-24 | 1984-03-29 | Beecham Group Plc | Amino-azabicycloalkyl derivatives as dopamine antagonists |
| DE4008726A1 (de) * | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| GB9117459D0 (en) * | 1991-08-13 | 1991-09-25 | Smithkline Beecham Plc | Novel compounds |
| US5227387A (en) * | 1991-09-03 | 1993-07-13 | Dowelanco | Quinoline nematicidal method |
| US5137894A (en) * | 1991-12-05 | 1992-08-11 | New James S | 4-(4-Piperidinyl-thieno[3,2-c]pyridine derivatives of n-alkylglutarimides |
| DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
| GB9306460D0 (en) | 1993-03-29 | 1993-05-19 | Smithkline Beecham Plc | Novel compounds |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| DE19636769A1 (de) * | 1996-09-10 | 1998-03-12 | Basf Ag | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| NZ335823A (en) * | 1997-04-22 | 2001-06-29 | Neurocrine Biosciences Inc | Thiophenopyridines, preparation as CRF receptor antagonists |
| DE19724980A1 (de) * | 1997-06-13 | 1998-12-17 | Basf Ag | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| DE19756388A1 (de) * | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Substituierte 2-Aryl-4-amino-chinazoline |
| DE19815026A1 (de) | 1998-04-03 | 1999-10-07 | Hoechst Schering Agrevo Gmbh | Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| JP3868811B2 (ja) | 1999-10-01 | 2007-01-17 | 大日本住友製薬株式会社 | 新規キナゾリン誘導体 |
| CN101100472A (zh) * | 2001-04-30 | 2008-01-09 | 美国拜尔公司 | 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 |
| EP1270568A1 (en) | 2001-06-19 | 2003-01-02 | Biofrontera Pharmaceuticals AG | 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist |
| WO2004017950A2 (en) | 2002-08-22 | 2004-03-04 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
-
2004
- 2004-03-31 BR BRPI0408988-0A patent/BRPI0408988A/pt not_active IP Right Cessation
- 2004-03-31 NZ NZ542236A patent/NZ542236A/en not_active IP Right Cessation
- 2004-03-31 CA CA002517833A patent/CA2517833A1/en not_active Abandoned
- 2004-03-31 WO PCT/US2004/009944 patent/WO2004089312A2/en not_active Ceased
- 2004-03-31 US US10/815,417 patent/US7030240B2/en not_active Expired - Fee Related
- 2004-03-31 MX MXPA05009818A patent/MXPA05009818A/es active IP Right Grant
- 2004-03-31 JP JP2006509547A patent/JP4677518B2/ja not_active Expired - Fee Related
- 2004-03-31 KR KR1020057018522A patent/KR20060013370A/ko not_active Abandoned
- 2004-03-31 AT AT04749592T patent/ATE511511T1/de not_active IP Right Cessation
- 2004-03-31 CN CNA200480010507XA patent/CN1777612A/zh active Pending
- 2004-03-31 EP EP04749592A patent/EP1622914B1/en not_active Expired - Lifetime
- 2004-03-31 AU AU2004227913A patent/AU2004227913B2/en not_active Ceased
-
2005
- 2005-10-28 NO NO20055029A patent/NO20055029L/no unknown
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