KR20060013370A - 신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물 - Google Patents

신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물 Download PDF

Info

Publication number
KR20060013370A
KR20060013370A KR1020057018522A KR20057018522A KR20060013370A KR 20060013370 A KR20060013370 A KR 20060013370A KR 1020057018522 A KR1020057018522 A KR 1020057018522A KR 20057018522 A KR20057018522 A KR 20057018522A KR 20060013370 A KR20060013370 A KR 20060013370A
Authority
KR
South Korea
Prior art keywords
compound
piperidin
thieno
pyrimidin
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020057018522A
Other languages
English (en)
Korean (ko)
Inventor
데일 에스 다노아
오렌 베커
실비아 노이만
스리니바사 라오 체루쿠
야엘 마란츠
샤론 샤켐
알렉산더 헤이페츠
보우즈 인발
벤키타사미 케사반
셰이 바-헤임
셰컬 에이 레디
로사 이 멜렌데즈
아누라그 샤라덴두
동글리 첸
Original Assignee
프레딕스 파마슈티컬스 홀딩즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 프레딕스 파마슈티컬스 홀딩즈, 인코포레이티드 filed Critical 프레딕스 파마슈티컬스 홀딩즈, 인코포레이티드
Publication of KR20060013370A publication Critical patent/KR20060013370A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020057018522A 2003-03-31 2004-03-31 신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물 Abandoned KR20060013370A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45883103P 2003-03-31 2003-03-31
US60/458,831 2003-03-31

Publications (1)

Publication Number Publication Date
KR20060013370A true KR20060013370A (ko) 2006-02-09

Family

ID=33159606

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057018522A Abandoned KR20060013370A (ko) 2003-03-31 2004-03-31 신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물

Country Status (13)

Country Link
US (1) US7030240B2 (enExample)
EP (1) EP1622914B1 (enExample)
JP (1) JP4677518B2 (enExample)
KR (1) KR20060013370A (enExample)
CN (1) CN1777612A (enExample)
AT (1) ATE511511T1 (enExample)
AU (1) AU2004227913B2 (enExample)
BR (1) BRPI0408988A (enExample)
CA (1) CA2517833A1 (enExample)
MX (1) MXPA05009818A (enExample)
NO (1) NO20055029L (enExample)
NZ (1) NZ542236A (enExample)
WO (1) WO2004089312A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7407966B2 (en) 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
WO2006044826A2 (en) * 2004-10-20 2006-04-27 Compass Pharmaceuticals Llc Thiophens and their use as anti-tumor agents
US7968538B2 (en) 2005-01-25 2011-06-28 Galenea Corp. Substituted arylamine compounds and methods of treatment
WO2007110868A2 (en) 2006-03-28 2007-10-04 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
WO2008117269A2 (en) * 2007-03-28 2008-10-02 Atir Holding S.A. Heterotri cyciii c compounds as serotonergic and/or dopaminergic agents and uses thereof
CA2698377A1 (en) * 2007-09-04 2009-03-12 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-d] pyrimidine compounds for treating fibrosis
EP2445877B1 (en) 2008-12-03 2014-07-23 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
EP2595993B1 (en) * 2010-07-23 2018-04-18 President and Fellows of Harvard College Tricyclic proteasome activity enhancing compounds
US8703941B2 (en) * 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
WO2012140642A1 (en) 2011-04-10 2012-10-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
BR112015014034A2 (pt) 2013-01-10 2017-07-11 Nimbus Iris Inc inibidores de irak e usos dos mesmos
RU2016110852A (ru) 2013-09-27 2017-10-30 Нимбус Айрис, Инк. Ингибиторы irak и их применения
TWI648281B (zh) 2013-10-17 2019-01-21 日商安斯泰來製藥股份有限公司 含硫二環式化合物
US10023565B2 (en) 2013-12-20 2018-07-17 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China N,N′ substituted piperidinamine compounds, and preparation method and usage thereof
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
CN104592248A (zh) * 2014-12-31 2015-05-06 芜湖杨燕制药有限公司 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法
WO2016197027A1 (en) 2015-06-04 2016-12-08 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
CN114539284A (zh) 2016-03-16 2022-05-27 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
BR112018068702A2 (pt) 2016-03-16 2019-01-15 Kura Oncology Inc inibidores bicíclicos em ponte de menin-mll e métodos de uso
US11944627B2 (en) 2017-03-24 2024-04-02 Kura Oncology, Inc. Methods for treating hematological malignancies and Ewing's sarcoma
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA933923A (en) 1969-12-19 1973-09-18 Eichenberger Kurt Process for the manufacture of new thiopyranes
GB1570494A (en) * 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
EP0126087A1 (en) * 1982-09-24 1984-11-28 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
DE4008726A1 (de) * 1990-03-19 1991-09-26 Basf Ag Thieno(2,3-d)pyrimidinderivate
GB9117459D0 (en) * 1991-08-13 1991-09-25 Smithkline Beecham Plc Novel compounds
US5227387A (en) * 1991-09-03 1993-07-13 Dowelanco Quinoline nematicidal method
US5137894A (en) * 1991-12-05 1992-08-11 New James S 4-(4-Piperidinyl-thieno[3,2-c]pyridine derivatives of n-alkylglutarimides
DE4208254A1 (de) 1992-03-14 1993-09-16 Hoechst Ag Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
GB9306460D0 (en) 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
DE19636769A1 (de) * 1996-09-10 1998-03-12 Basf Ag 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
WO1998047903A1 (en) * 1997-04-22 1998-10-29 Janssen Pharmaceutica N.V. Crf antagonistic thiophenopyridines
DE19724980A1 (de) * 1997-06-13 1998-12-17 Basf Ag 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
DE19756388A1 (de) * 1997-12-18 1999-06-24 Hoechst Marion Roussel De Gmbh Substituierte 2-Aryl-4-amino-chinazoline
DE19815026A1 (de) 1998-04-03 1999-10-07 Hoechst Schering Agrevo Gmbh Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
JP3868811B2 (ja) 1999-10-01 2007-01-17 大日本住友製薬株式会社 新規キナゾリン誘導体
US6849638B2 (en) * 2001-04-30 2005-02-01 Bayer Pharmaceuticals Corporation 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
EP1270568A1 (en) 2001-06-19 2003-01-02 Biofrontera Pharmaceuticals AG 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist
AU2003255845A1 (en) 2002-08-22 2004-03-11 Piramed Limited Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents

Also Published As

Publication number Publication date
AU2004227913B2 (en) 2010-12-02
EP1622914A4 (en) 2008-03-12
CN1777612A (zh) 2006-05-24
EP1622914B1 (en) 2011-06-01
CA2517833A1 (en) 2004-10-21
NO20055029D0 (no) 2005-10-28
WO2004089312A3 (en) 2005-05-12
AU2004227913A1 (en) 2004-10-21
BRPI0408988A (pt) 2006-03-28
MXPA05009818A (es) 2006-03-13
JP4677518B2 (ja) 2011-04-27
NO20055029L (no) 2005-12-08
US20040248904A1 (en) 2004-12-09
NZ542236A (en) 2008-05-30
WO2004089312A2 (en) 2004-10-21
ATE511511T1 (de) 2011-06-15
EP1622914A2 (en) 2006-02-08
JP2006522141A (ja) 2006-09-28
US7030240B2 (en) 2006-04-18

Similar Documents

Publication Publication Date Title
KR20060013370A (ko) 신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물
US7612078B2 (en) Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US20110082157A1 (en) Piperidinylamino-Thieno [2,3-D] Pyrimidine Compounds
US7982040B2 (en) Thienopyridinone compounds and methods of treatment
JP2009520688A (ja) S1p受容体調節化合物およびそれらの使用
ZA200703596B (en) Thienopyridinone compounds and methods of treatment
US7576211B2 (en) Synthesis of thienopyridinone compounds and related intermediates
ZA200609213B (en) Thienopyridinone compounds and methods of teatment

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20050929

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20090323

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20110310

Patent event code: PE09021S01D

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20110518

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20110603

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20111130

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee