KR20060013370A - 신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물 - Google Patents
신규한 피페리디닐아미노-티에노[2,3-d]피리미딘 화합물 Download PDFInfo
- Publication number
- KR20060013370A KR20060013370A KR1020057018522A KR20057018522A KR20060013370A KR 20060013370 A KR20060013370 A KR 20060013370A KR 1020057018522 A KR1020057018522 A KR 1020057018522A KR 20057018522 A KR20057018522 A KR 20057018522A KR 20060013370 A KR20060013370 A KR 20060013370A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- piperidin
- thieno
- pyrimidin
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- ADSGKJVJNPJWJS-UHFFFAOYSA-N n-piperidin-1-ylthieno[2,3-d]pyrimidin-2-amine Chemical class C1CCCCN1NC1=NC=C(C=CS2)C2=N1 ADSGKJVJNPJWJS-UHFFFAOYSA-N 0.000 title abstract description 5
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- JECRKFNVAIHXCS-UHFFFAOYSA-N n-[1-(3-phenylpropyl)piperidin-4-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1CC(NC=2C=3C=4CCCCC=4SC=3N=CN=2)CCN1CCCC1=CC=CC=C1 JECRKFNVAIHXCS-UHFFFAOYSA-N 0.000 claims description 3
- BTSIVWASKOYFDK-UHFFFAOYSA-N n-[1-[(3-fluorophenyl)methyl]piperidin-4-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound FC1=CC=CC(CN2CCC(CC2)NC=2C=3C=4CCCCC=4SC=3N=CN=2)=C1 BTSIVWASKOYFDK-UHFFFAOYSA-N 0.000 claims description 3
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- QKYLIMHGFGMIGO-UHFFFAOYSA-N n-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1=CC(F)=CC=C1CN1CCC(NC=2C=3C=4CCCCC=4SC=3N=CN=2)CC1 QKYLIMHGFGMIGO-UHFFFAOYSA-N 0.000 claims description 2
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- XONXMYIGHPCAKC-UHFFFAOYSA-N n-[1-[[4-(trifluoromethoxy)phenyl]methyl]piperidin-4-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1=CC(OC(F)(F)F)=CC=C1CN1CCC(NC=2C=3C=4CCCCC=4SC=3N=CN=2)CC1 XONXMYIGHPCAKC-UHFFFAOYSA-N 0.000 claims 1
- BRINQHBWQRPIBP-UHFFFAOYSA-N n-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1CN1CCC(NC=2C=3C=4CCCCC=4SC=3N=CN=2)CC1 BRINQHBWQRPIBP-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7576211B2 (en) | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US7407966B2 (en) | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| WO2006044826A2 (en) * | 2004-10-20 | 2006-04-27 | Compass Pharmaceuticals Llc | Thiophens and their use as anti-tumor agents |
| US7968538B2 (en) | 2005-01-25 | 2011-06-28 | Galenea Corp. | Substituted arylamine compounds and methods of treatment |
| WO2007110868A2 (en) | 2006-03-28 | 2007-10-04 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| WO2008117269A2 (en) * | 2007-03-28 | 2008-10-02 | Atir Holding S.A. | Heterotri cyciii c compounds as serotonergic and/or dopaminergic agents and uses thereof |
| CA2698377A1 (en) * | 2007-09-04 | 2009-03-12 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-d] pyrimidine compounds for treating fibrosis |
| EP2445877B1 (en) | 2008-12-03 | 2014-07-23 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| EP2595993B1 (en) * | 2010-07-23 | 2018-04-18 | President and Fellows of Harvard College | Tricyclic proteasome activity enhancing compounds |
| US8703941B2 (en) * | 2011-01-10 | 2014-04-22 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| WO2012140642A1 (en) | 2011-04-10 | 2012-10-18 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| HK1210696A1 (en) | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| BR112015014034A2 (pt) | 2013-01-10 | 2017-07-11 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| RU2016110852A (ru) | 2013-09-27 | 2017-10-30 | Нимбус Айрис, Инк. | Ингибиторы irak и их применения |
| TWI648281B (zh) | 2013-10-17 | 2019-01-21 | 日商安斯泰來製藥股份有限公司 | 含硫二環式化合物 |
| US10023565B2 (en) | 2013-12-20 | 2018-07-17 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof |
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
| WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
| AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| CN114539284A (zh) | 2016-03-16 | 2022-05-27 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
| BR112018068702A2 (pt) | 2016-03-16 | 2019-01-15 | Kura Oncology Inc | inibidores bicíclicos em ponte de menin-mll e métodos de uso |
| US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| WO2019060365A1 (en) | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE |
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| CA933923A (en) | 1969-12-19 | 1973-09-18 | Eichenberger Kurt | Process for the manufacture of new thiopyranes |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| EP0126087A1 (en) * | 1982-09-24 | 1984-11-28 | Beecham Group Plc | Amino-azabicycloalkyl derivatives as dopamine antagonists |
| DE4008726A1 (de) * | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| GB9117459D0 (en) * | 1991-08-13 | 1991-09-25 | Smithkline Beecham Plc | Novel compounds |
| US5227387A (en) * | 1991-09-03 | 1993-07-13 | Dowelanco | Quinoline nematicidal method |
| US5137894A (en) * | 1991-12-05 | 1992-08-11 | New James S | 4-(4-Piperidinyl-thieno[3,2-c]pyridine derivatives of n-alkylglutarimides |
| DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
| GB9306460D0 (en) | 1993-03-29 | 1993-05-19 | Smithkline Beecham Plc | Novel compounds |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| DE19636769A1 (de) * | 1996-09-10 | 1998-03-12 | Basf Ag | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| WO1998047903A1 (en) * | 1997-04-22 | 1998-10-29 | Janssen Pharmaceutica N.V. | Crf antagonistic thiophenopyridines |
| DE19724980A1 (de) * | 1997-06-13 | 1998-12-17 | Basf Ag | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| DE19756388A1 (de) * | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Substituierte 2-Aryl-4-amino-chinazoline |
| DE19815026A1 (de) | 1998-04-03 | 1999-10-07 | Hoechst Schering Agrevo Gmbh | Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| JP3868811B2 (ja) | 1999-10-01 | 2007-01-17 | 大日本住友製薬株式会社 | 新規キナゾリン誘導体 |
| US6849638B2 (en) * | 2001-04-30 | 2005-02-01 | Bayer Pharmaceuticals Corporation | 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions |
| EP1270568A1 (en) | 2001-06-19 | 2003-01-02 | Biofrontera Pharmaceuticals AG | 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist |
| AU2003255845A1 (en) | 2002-08-22 | 2004-03-11 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
-
2004
- 2004-03-31 CN CNA200480010507XA patent/CN1777612A/zh active Pending
- 2004-03-31 AT AT04749592T patent/ATE511511T1/de not_active IP Right Cessation
- 2004-03-31 AU AU2004227913A patent/AU2004227913B2/en not_active Ceased
- 2004-03-31 BR BRPI0408988-0A patent/BRPI0408988A/pt not_active IP Right Cessation
- 2004-03-31 NZ NZ542236A patent/NZ542236A/en not_active IP Right Cessation
- 2004-03-31 WO PCT/US2004/009944 patent/WO2004089312A2/en not_active Ceased
- 2004-03-31 EP EP04749592A patent/EP1622914B1/en not_active Expired - Lifetime
- 2004-03-31 CA CA002517833A patent/CA2517833A1/en not_active Abandoned
- 2004-03-31 JP JP2006509547A patent/JP4677518B2/ja not_active Expired - Fee Related
- 2004-03-31 MX MXPA05009818A patent/MXPA05009818A/es active IP Right Grant
- 2004-03-31 KR KR1020057018522A patent/KR20060013370A/ko not_active Abandoned
- 2004-03-31 US US10/815,417 patent/US7030240B2/en not_active Expired - Fee Related
-
2005
- 2005-10-28 NO NO20055029A patent/NO20055029L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004227913B2 (en) | 2010-12-02 |
| EP1622914A4 (en) | 2008-03-12 |
| CN1777612A (zh) | 2006-05-24 |
| EP1622914B1 (en) | 2011-06-01 |
| CA2517833A1 (en) | 2004-10-21 |
| NO20055029D0 (no) | 2005-10-28 |
| WO2004089312A3 (en) | 2005-05-12 |
| AU2004227913A1 (en) | 2004-10-21 |
| BRPI0408988A (pt) | 2006-03-28 |
| MXPA05009818A (es) | 2006-03-13 |
| JP4677518B2 (ja) | 2011-04-27 |
| NO20055029L (no) | 2005-12-08 |
| US20040248904A1 (en) | 2004-12-09 |
| NZ542236A (en) | 2008-05-30 |
| WO2004089312A2 (en) | 2004-10-21 |
| ATE511511T1 (de) | 2011-06-15 |
| EP1622914A2 (en) | 2006-02-08 |
| JP2006522141A (ja) | 2006-09-28 |
| US7030240B2 (en) | 2006-04-18 |
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