CN1777612A - 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物 - Google Patents

新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物 Download PDF

Info

Publication number
CN1777612A
CN1777612A CNA200480010507XA CN200480010507A CN1777612A CN 1777612 A CN1777612 A CN 1777612A CN A200480010507X A CNA200480010507X A CN A200480010507XA CN 200480010507 A CN200480010507 A CN 200480010507A CN 1777612 A CN1777612 A CN 1777612A
Authority
CN
China
Prior art keywords
compound
piperidin
pyrimidin
thieno
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200480010507XA
Other languages
English (en)
Chinese (zh)
Inventor
戴尔·S·德汉奥
奥恩·贝克尔
西尔维娅·诺伊曼
斯赖伊萨·罗·彻尤库
耶尔·玛安茨
莎伦·沙克赫
亚历山大·赫费茨
博厄兹·英巴尔
威基塔萨米·克萨范
什·巴－哈姆
塞卡·A·雷德戴
罗莎·E·梅莉德兹
安厄格·莎阿德恩杜
陈东丽
Original Assignee
PREDIX PHARMACEUTICALS HOLDING
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PREDIX PHARMACEUTICALS HOLDING filed Critical PREDIX PHARMACEUTICALS HOLDING
Publication of CN1777612A publication Critical patent/CN1777612A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA200480010507XA 2003-03-31 2004-03-31 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物 Pending CN1777612A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45883103P 2003-03-31 2003-03-31
US60/458,831 2003-03-31

Publications (1)

Publication Number Publication Date
CN1777612A true CN1777612A (zh) 2006-05-24

Family

ID=33159606

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200480010507XA Pending CN1777612A (zh) 2003-03-31 2004-03-31 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物

Country Status (13)

Country Link
US (1) US7030240B2 (enExample)
EP (1) EP1622914B1 (enExample)
JP (1) JP4677518B2 (enExample)
KR (1) KR20060013370A (enExample)
CN (1) CN1777612A (enExample)
AT (1) ATE511511T1 (enExample)
AU (1) AU2004227913B2 (enExample)
BR (1) BRPI0408988A (enExample)
CA (1) CA2517833A1 (enExample)
MX (1) MXPA05009818A (enExample)
NO (1) NO20055029L (enExample)
NZ (1) NZ542236A (enExample)
WO (1) WO2004089312A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104592248A (zh) * 2014-12-31 2015-05-06 芜湖杨燕制药有限公司 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法
CN105636965A (zh) * 2013-10-17 2016-06-01 安斯泰来制药株式会社 含硫二环式化合物
CN105829304A (zh) * 2013-12-20 2016-08-03 中国人民解放军军事医学科学院毒物药物研究所 N,n’取代哌啶胺类化合物、其制备方法及用途

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612078B2 (en) 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
JP2008517061A (ja) * 2004-10-20 2008-05-22 コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー 抗腫瘍剤としての化合物及びそれらの使用
CA2595607C (en) * 2005-01-25 2014-07-15 Epix Delaware, Inc. Substituted arylamine compounds and their use as 5-ht6 modulators
EP2010505B1 (en) 2006-03-28 2012-12-05 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP2896624B1 (en) * 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
CN101820882A (zh) * 2007-09-04 2010-09-01 Epix特拉华公司 用于治疗纤维变性的哌啶基氨基噻吩并[2,3-d]嘧啶类化合物
WO2010065743A2 (en) 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
JP6042331B2 (ja) 2010-07-23 2016-12-14 プレジデント アンド フェローズ オブ ハーバード カレッジ プロテアソーム活性を向上させる三環系化合物
EP3239154A1 (en) * 2011-01-10 2017-11-01 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2012140642A1 (en) 2011-04-10 2012-10-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
BR112015014034A2 (pt) 2013-01-10 2017-07-11 Nimbus Iris Inc inibidores de irak e usos dos mesmos
CN106232122A (zh) 2013-09-27 2016-12-14 林伯士艾瑞斯公司 Irak抑制剂和其用途
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
US10588907B2 (en) 2015-06-04 2020-03-17 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
BR112018068703B1 (pt) 2016-03-16 2024-02-06 Kura Oncology, Inc. Inibidores substituídos de menin-mll e métodos de uso
KR102419524B1 (ko) 2016-03-16 2022-07-08 쿠라 온콜로지, 인크. 메닌-mll의 가교된 이환식 억제제 및 사용 방법
CN117298275A (zh) 2017-03-24 2023-12-29 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
WO2018226976A1 (en) 2017-06-08 2018-12-13 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
TW201920170A (zh) 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA933923A (en) 1969-12-19 1973-09-18 Eichenberger Kurt Process for the manufacture of new thiopyranes
GB1570494A (en) * 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
WO1984001151A1 (en) * 1982-09-24 1984-03-29 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
DE4008726A1 (de) * 1990-03-19 1991-09-26 Basf Ag Thieno(2,3-d)pyrimidinderivate
GB9117459D0 (en) * 1991-08-13 1991-09-25 Smithkline Beecham Plc Novel compounds
US5227387A (en) 1991-09-03 1993-07-13 Dowelanco Quinoline nematicidal method
US5137894A (en) * 1991-12-05 1992-08-11 New James S 4-(4-Piperidinyl-thieno[3,2-c]pyridine derivatives of n-alkylglutarimides
DE4208254A1 (de) 1992-03-14 1993-09-16 Hoechst Ag Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
GB9306460D0 (en) 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
DE19636769A1 (de) * 1996-09-10 1998-03-12 Basf Ag 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
US6211195B1 (en) * 1997-04-22 2001-04-03 Neurocrine Biosciences, Inc. CRF antagonistic thiophenopyridines
DE19724980A1 (de) * 1997-06-13 1998-12-17 Basf Ag 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
DE19756388A1 (de) * 1997-12-18 1999-06-24 Hoechst Marion Roussel De Gmbh Substituierte 2-Aryl-4-amino-chinazoline
DE19815026A1 (de) 1998-04-03 1999-10-07 Hoechst Schering Agrevo Gmbh Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
AU763033B2 (en) 1999-10-01 2003-07-10 Japan Energy Corporation Novel quinazoline derivatives
EP1401840A4 (en) * 2001-04-30 2007-05-16 Bayer Corp NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D | PYRIMIDINE
EP1270568A1 (en) 2001-06-19 2003-01-02 Biofrontera Pharmaceuticals AG 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist
WO2004017950A2 (en) 2002-08-22 2004-03-04 Piramed Limited Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105636965A (zh) * 2013-10-17 2016-06-01 安斯泰来制药株式会社 含硫二环式化合物
US9642852B2 (en) 2013-10-17 2017-05-09 Astellas Pharma Inc. Sulfur-containing bicyclic compound
CN105636965B (zh) * 2013-10-17 2017-11-24 安斯泰来制药株式会社 含硫二环式化合物
CN105829304A (zh) * 2013-12-20 2016-08-03 中国人民解放军军事医学科学院毒物药物研究所 N,n’取代哌啶胺类化合物、其制备方法及用途
US10023565B2 (en) 2013-12-20 2018-07-17 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China N,N′ substituted piperidinamine compounds, and preparation method and usage thereof
CN105829304B (zh) * 2013-12-20 2019-09-20 中国人民解放军军事医学科学院毒物药物研究所 N,n’取代哌啶胺类化合物、其制备方法及用途
CN104592248A (zh) * 2014-12-31 2015-05-06 芜湖杨燕制药有限公司 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法

Also Published As

Publication number Publication date
KR20060013370A (ko) 2006-02-09
EP1622914A2 (en) 2006-02-08
BRPI0408988A (pt) 2006-03-28
US7030240B2 (en) 2006-04-18
CA2517833A1 (en) 2004-10-21
JP4677518B2 (ja) 2011-04-27
WO2004089312A2 (en) 2004-10-21
US20040248904A1 (en) 2004-12-09
MXPA05009818A (es) 2006-03-13
EP1622914B1 (en) 2011-06-01
NO20055029L (no) 2005-12-08
AU2004227913B2 (en) 2010-12-02
WO2004089312A3 (en) 2005-05-12
JP2006522141A (ja) 2006-09-28
NZ542236A (en) 2008-05-30
NO20055029D0 (no) 2005-10-28
ATE511511T1 (de) 2011-06-15
AU2004227913A1 (en) 2004-10-21
EP1622914A4 (en) 2008-03-12

Similar Documents

Publication Publication Date Title
CN1777612A (zh) 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物
CN101048412A (zh) 哌啶基氨基－噻吩并[2,3－d]嘧啶化合物
CN1304382C (zh) 用于治疗炎性、免疫或心血管疾病的新的p2x7受体拮抗剂
CN1052004C (zh) 杂环化合物及其制备和应用
CN1171889C (zh) 作为p38蛋白激酶的抑制剂的杂烷基氨基－取代的双环氮杂环类化合物
CN1193025C (zh) 新的1,3－二氢－2h－吲哚－2－酮衍生物,它们的制备方法以及含有它们的药物组合物
CN1118452C (zh) 1－[(1－取代－4－哌啶基)甲基]－4－哌啶衍生物、其生产方法、含有该化合物的药物组合物和这些化合物的中间体
CN1088917A (zh) 取代的苄氨基含氮非芳族杂环化合物
CN1585749A (zh) 类大麻苷受体配体
CN1711265A (zh) 新型氨基－取代的二氢嘧啶并[4,5－d]嘧啶酮衍生物、其制备方法及其作为药剂的应用
CN1361779A (zh) 新化合物
CN1053429A (zh) 吲哚取代五元芳杂环化合物
CN1684962A (zh) 吲唑、苯并噻唑和苯并异噻唑，以及它们的制备和用途
CN1753670A (zh) 新苯并咪唑和咪唑并吡啶衍生物及其作为药物的用途
CN1099755A (zh) 环状衍生物、含该衍生物的药物组合物及制备方法
CN1111242A (zh) 苯磺酰胺衍生物及其制备方法
CN1671696A (zh) 激酶抑制剂
CN1809568A (zh) 作为dpp－iv抑制剂的吡啶并2,1－a－异喹啉衍生物
CN1161334A (zh) 新的取代胍衍生物，其制备方法和其药物用途)
CN1802369A (zh) Cgrp受体拮抗剂
CN1556705A (zh) 7,8,9,10-四氢-6H-氮杂卓并、6,7,8,9-四氢-吡啶并和2,3-二氢-2H-吡咯并[2,1-b]-喹唑啉酮衍生物
CN1432015A (zh) 可用作细胞增殖抑制剂的被1,1－二氧代异噻唑烷取代的吲唑
CN1642927A (zh) 环状酰胺
CN1871244A (zh) 作为腺苷受体配体的噻唑并吡啶衍生物
CN1859914A (zh) 苯基吡咯烷醚速激肽受体拮抗剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: PIXAR DELAWARE CO., LTD.

Free format text: FORMER OWNER: PREDIX PHARMACEUTICALS HOLDING

Effective date: 20061229

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20061229

Address after: Delaware

Applicant after: Pixar Delaware

Address before: Massachusetts, USA

Applicant before: Predix Pharmaceuticals Holding

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20060524