MXPA05009818A - Nuevos compuestos de piperidinilamino-tieno[2,3-d] pirimidina. - Google Patents

Nuevos compuestos de piperidinilamino-tieno[2,3-d] pirimidina.

Info

Publication number
MXPA05009818A
MXPA05009818A MXPA05009818A MXPA05009818A MXPA05009818A MX PA05009818 A MXPA05009818 A MX PA05009818A MX PA05009818 A MXPA05009818 A MX PA05009818A MX PA05009818 A MXPA05009818 A MX PA05009818A MX PA05009818 A MXPA05009818 A MX PA05009818A
Authority
MX
Mexico
Prior art keywords
piperidinylamino
thieno
pyrimidine compounds
new
novel
Prior art date
Application number
MXPA05009818A
Other languages
English (en)
Inventor
Sekar A Reddy
Original Assignee
Predix Pharmaceuticals Holding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Predix Pharmaceuticals Holding filed Critical Predix Pharmaceuticals Holding
Publication of MXPA05009818A publication Critical patent/MXPA05009818A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Abstract

La presente invencion se relaciona con antagonistas del receptor 5-HT. Se describen novedosos compuestos de piperidinilamino-tieno[2,3-d]pirimidina representados por la formula I y la sintesis y usos de los mismos para el tratamiento de enfermedades mediadas directa o indirectamente por los receptores 5-HT. Estas condiciones incluyen trastornos del sistema nervioso central, tales como: ansiedad, depresion, esquizofrenia, dano neural, derrame cerebral y migrana. Tambien se incluyen los metodos de preparacion y novedosos intermediarios y sales farmaceuticas de los mismos.
MXPA05009818A 2003-03-31 2004-03-31 Nuevos compuestos de piperidinilamino-tieno[2,3-d] pirimidina. MXPA05009818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45883103P 2003-03-31 2003-03-31
PCT/US2004/009944 WO2004089312A2 (en) 2003-03-31 2004-03-31 New piperidinylamino-thieno[2,3-d] pyrimidine compounds

Publications (1)

Publication Number Publication Date
MXPA05009818A true MXPA05009818A (es) 2006-03-13

Family

ID=33159606

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009818A MXPA05009818A (es) 2003-03-31 2004-03-31 Nuevos compuestos de piperidinilamino-tieno[2,3-d] pirimidina.

Country Status (13)

Country Link
US (1) US7030240B2 (es)
EP (1) EP1622914B1 (es)
JP (1) JP4677518B2 (es)
KR (1) KR20060013370A (es)
CN (1) CN1777612A (es)
AT (1) ATE511511T1 (es)
AU (1) AU2004227913B2 (es)
BR (1) BRPI0408988A (es)
CA (1) CA2517833A1 (es)
MX (1) MXPA05009818A (es)
NO (1) NO20055029L (es)
NZ (1) NZ542236A (es)
WO (1) WO2004089312A2 (es)

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US7407966B2 (en) 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
JP2008517061A (ja) * 2004-10-20 2008-05-22 コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー 抗腫瘍剤としての化合物及びそれらの使用
KR20070097590A (ko) 2005-01-25 2007-10-04 에픽스 델라웨어, 인코포레이티드 치환된 아릴아민 화합물 및 5―ｈｔ6 조절제로서의 이의용도
US8349850B2 (en) 2006-03-28 2013-01-08 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP2896624B1 (en) * 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
CA2698377A1 (en) * 2007-09-04 2009-03-12 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-d] pyrimidine compounds for treating fibrosis
WO2010065743A2 (en) 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
AU2011281015B2 (en) 2010-07-23 2015-09-24 President And Fellows Of Harvard College Tricyclic proteasome activity enhancing compounds
US8703941B2 (en) * 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
EP3581567A1 (en) 2011-04-10 2019-12-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
US9085586B2 (en) 2012-07-11 2015-07-21 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
US9175007B2 (en) 2013-01-10 2015-11-03 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
RU2016110852A (ru) 2013-09-27 2017-10-30 Нимбус Айрис, Инк. Ингибиторы irak и их применения
TWI648281B (zh) * 2013-10-17 2019-01-21 日商安斯泰來製藥股份有限公司 含硫二環式化合物
CN105829304B (zh) * 2013-12-20 2019-09-20 中国人民解放军军事医学科学院毒物药物研究所 N,n’取代哌啶胺类化合物、其制备方法及用途
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
CN104592248A (zh) * 2014-12-31 2015-05-06 芜湖杨燕制药有限公司 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
US10588907B2 (en) 2015-06-04 2020-03-17 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
EP4219449A3 (en) 2016-03-16 2023-10-11 Kura Oncology, Inc. Substituted indole derivatives and methods of preparation thereof
CN109640987B (zh) 2016-03-16 2022-12-02 库拉肿瘤学公司 Menin-mll的桥联双环抑制剂及使用方法
US11944627B2 (en) 2017-03-24 2024-04-02 Kura Oncology, Inc. Methods for treating hematological malignancies and Ewing's sarcoma
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

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Also Published As

Publication number Publication date
US7030240B2 (en) 2006-04-18
CA2517833A1 (en) 2004-10-21
EP1622914B1 (en) 2011-06-01
JP4677518B2 (ja) 2011-04-27
CN1777612A (zh) 2006-05-24
NZ542236A (en) 2008-05-30
ATE511511T1 (de) 2011-06-15
NO20055029D0 (no) 2005-10-28
NO20055029L (no) 2005-12-08
EP1622914A2 (en) 2006-02-08
AU2004227913A1 (en) 2004-10-21
KR20060013370A (ko) 2006-02-09
JP2006522141A (ja) 2006-09-28
WO2004089312A3 (en) 2005-05-12
BRPI0408988A (pt) 2006-03-28
US20040248904A1 (en) 2004-12-09
AU2004227913B2 (en) 2010-12-02
WO2004089312A2 (en) 2004-10-21
EP1622914A4 (en) 2008-03-12

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