JP2009534471A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009534471A5 JP2009534471A5 JP2009507921A JP2009507921A JP2009534471A5 JP 2009534471 A5 JP2009534471 A5 JP 2009534471A5 JP 2009507921 A JP2009507921 A JP 2009507921A JP 2009507921 A JP2009507921 A JP 2009507921A JP 2009534471 A5 JP2009534471 A5 JP 2009534471A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pyrrolidin
- cyclohexyl
- halogens
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 25
- 150000002367 halogens Chemical class 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 3
- WEEMQMHXSFXJAH-HNNXBMFYSA-N (3r)-3-[[2,6-dichloro-4-(4-fluorophenyl)phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1=CC(F)=CC=C1C(C=C1Cl)=CC(Cl)=C1C[C@H]1C(=O)N(C2CCC(F)(F)CC2)CC1 WEEMQMHXSFXJAH-HNNXBMFYSA-N 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- LRGHOJRNCDCXOM-UHFFFAOYSA-N 3-[(2,6-dichloro-4-pyridin-3-ylphenyl)methyl]-1-(4-fluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)CCC1N1C(=O)C(CC=2C(=CC(=CC=2Cl)C=2C=NC=CC=2)Cl)CC1 LRGHOJRNCDCXOM-UHFFFAOYSA-N 0.000 claims 2
- YYGVNQGRTRZVKZ-UHFFFAOYSA-N 3-[(4-bromo-2-chlorophenyl)methyl]-1-(4-fluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)CCC1N1C(=O)C(CC=2C(=CC(Br)=CC=2)Cl)CC1 YYGVNQGRTRZVKZ-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- FONUFKXCIACMLK-JTQLQIEISA-N (3r)-3-[(2,6-dichloro-4-hydroxyphenyl)methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound ClC1=CC(O)=CC(Cl)=C1C[C@H]1C(=O)N(C2CCC(F)(F)CC2)CC1 FONUFKXCIACMLK-JTQLQIEISA-N 0.000 claims 1
- ULVDCLVSKMJNLI-VIQWUECVSA-N (3r)-3-[(2,6-dichloro-4-phenylmethoxyphenyl)methyl]-1-(4-fluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)CCC1N1C(=O)[C@H](CC=2C(=CC(OCC=3C=CC=CC=3)=CC=2Cl)Cl)CC1 ULVDCLVSKMJNLI-VIQWUECVSA-N 0.000 claims 1
- MGMRUPQEYPNFDM-ZDUSSCGKSA-N (3r)-3-[[2,6-dichloro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1=NN(C)C=C1C(C=C1Cl)=CC(Cl)=C1C[C@H]1C(=O)N(C2CCC(F)(F)CC2)CC1 MGMRUPQEYPNFDM-ZDUSSCGKSA-N 0.000 claims 1
- CSZVSFQKOSMQNU-HNNXBMFYSA-N (3r)-3-[[2,6-dichloro-4-(4-chlorophenyl)phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)(F)CCC1N1C(=O)[C@H](CC=2C(=CC(=CC=2Cl)C=2C=CC(Cl)=CC=2)Cl)CC1 CSZVSFQKOSMQNU-HNNXBMFYSA-N 0.000 claims 1
- MYKBUYJYIHFCRS-HNNXBMFYSA-N (3r)-3-[[2,6-dichloro-4-[4-(trifluoromethoxy)phenyl]phenyl]methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1C(C=C1Cl)=CC(Cl)=C1C[C@H]1C(=O)N(C2CCC(F)(F)CC2)CC1 MYKBUYJYIHFCRS-HNNXBMFYSA-N 0.000 claims 1
- ZZULEGMXZJPGGK-UHFFFAOYSA-N 3-[(2,6-dichloro-4-pyridin-3-ylphenyl)methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)(F)CCC1N1C(=O)C(CC=2C(=CC(=CC=2Cl)C=2C=NC=CC=2)Cl)CC1 ZZULEGMXZJPGGK-UHFFFAOYSA-N 0.000 claims 1
- RXNAJNCHFJQGSO-UHFFFAOYSA-N 3-[(4-bromo-2-chlorophenyl)methyl]-1-(4,4-difluorocyclohexyl)pyrrolidin-2-one Chemical compound C1CC(F)(F)CCC1N1C(=O)C(CC=2C(=CC(Br)=CC=2)Cl)CC1 RXNAJNCHFJQGSO-UHFFFAOYSA-N 0.000 claims 1
- RBXQDAZSSWYLOX-INIZCTEOSA-N 4-[3,5-dichloro-4-[[(3r)-1-(4,4-difluorocyclohexyl)-2-oxopyrrolidin-3-yl]methyl]phenyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C(C=C1Cl)=CC(Cl)=C1C[C@H]1C(=O)N(C2CCC(F)(F)CC2)CC1 RBXQDAZSSWYLOX-INIZCTEOSA-N 0.000 claims 1
- DEVYVYTWPIJPJZ-VLXSWZPNSA-N COc1cc(Cl)c(CC2CCN([C@H]3CC[C@H](F)CC3)C2=O)c(Cl)c1 Chemical compound COc1cc(Cl)c(CC2CCN([C@H]3CC[C@H](F)CC3)C2=O)c(Cl)c1 DEVYVYTWPIJPJZ-VLXSWZPNSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- ABMGMVVQYFPXDH-KRWDZBQOSA-N methyl 4-[3,5-dichloro-4-[[(3r)-1-(4,4-difluorocyclohexyl)-2-oxopyrrolidin-3-yl]methyl]phenyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C(C=C1Cl)=CC(Cl)=C1C[C@H]1C(=O)N(C2CCC(F)(F)CC2)CC1 ABMGMVVQYFPXDH-KRWDZBQOSA-N 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74544206P | 2006-04-24 | 2006-04-24 | |
| US60/745,442 | 2006-04-24 | ||
| PCT/US2007/067253 WO2007127704A1 (en) | 2006-04-24 | 2007-04-24 | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534471A JP2009534471A (ja) | 2009-09-24 |
| JP2009534471A5 true JP2009534471A5 (enExample) | 2010-05-13 |
| JP5118692B2 JP5118692B2 (ja) | 2013-01-16 |
Family
ID=38374154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507921A Expired - Fee Related JP5118692B2 (ja) | 2006-04-24 | 2007-04-24 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7998999B2 (enExample) |
| EP (1) | EP2049475B1 (enExample) |
| JP (1) | JP5118692B2 (enExample) |
| CN (1) | CN101432262B (enExample) |
| AT (1) | ATE543798T1 (enExample) |
| AU (1) | AU2007244971B2 (enExample) |
| BR (1) | BRPI0710468A2 (enExample) |
| CA (1) | CA2649111C (enExample) |
| CY (1) | CY1112398T1 (enExample) |
| DK (1) | DK2049475T3 (enExample) |
| EA (1) | EA016415B1 (enExample) |
| ES (1) | ES2378574T3 (enExample) |
| MX (1) | MX2008013658A (enExample) |
| PL (1) | PL2049475T3 (enExample) |
| PT (1) | PT2049475E (enExample) |
| SI (1) | SI2049475T1 (enExample) |
| WO (1) | WO2007127704A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| AU2007240458B2 (en) | 2006-04-21 | 2012-03-15 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| ES2533263T3 (es) | 2006-04-21 | 2015-04-08 | Eli Lilly And Company | Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 |
| PL2021336T3 (pl) * | 2006-04-24 | 2010-11-30 | Lilly Co Eli | Inhibitory dehydrogenazy 11-ß- hydroksysteroidowej typu 1 |
| DK2029529T3 (da) | 2006-04-24 | 2010-09-20 | Lilly Co Eli | Substitueret pyrrolidinone som inhibitor af 11-beta-hydroxysteroiddehydrogenase 1 |
| EA015516B1 (ru) | 2006-04-25 | 2011-08-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы 1 |
| WO2007127763A2 (en) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5101602B2 (ja) | 2006-04-25 | 2012-12-19 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| EA014719B1 (ru) | 2006-04-28 | 2011-02-28 | Эли Лилли Энд Компани | Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2018014337A1 (en) * | 2016-07-22 | 2018-01-25 | Eli Lilly And Company | 3-Chloro-N- [ (1R, 3S) -3- [5- (3, 5-dimethylimidazol-4-yl) -4H-1, 2, 4-triazol-3-yl] cyclohexyl] -N-methyl-benzamide |
| GB201702221D0 (en) | 2017-02-10 | 2017-03-29 | Univ Of Sussex | Compounds |
| CN108299272B (zh) * | 2018-01-31 | 2019-10-18 | 福州大学 | 一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法 |
| GB201803340D0 (en) | 2018-03-01 | 2018-04-18 | Univ Of Sussex | Compounds |
| RU2741910C2 (ru) * | 2019-07-09 | 2021-01-29 | Государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации | Соединения, обладающие антиишемическими, антиангинальными, цитопротективными свойствами, способ их получения и их применение, способ лечения нейродегенеративного заболевания, способ лечения психического расстройства |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DE122006000015I1 (de) | 1993-06-21 | 2006-06-29 | Novo Nordisk As | Asp-B28-Insulinkristalle |
| DK0792290T3 (da) | 1993-09-17 | 2001-10-01 | Novo Nordisk As | Acyleret insulin |
| US5504188A (en) | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| PT944648E (pt) | 1996-08-30 | 2007-06-26 | Novo Nordisk As | Derivados do glp-1. |
| SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| IL160065A0 (en) * | 2001-09-06 | 2004-06-20 | Schering Corp | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| MXPA06012932A (es) * | 2004-05-07 | 2007-01-26 | Janssen Pharmaceutica Nv | Derivados de pirrolidin-2-ona y piperidin-2-ona como inhibidores de 11-beta hidroxiesteroide deshidrogenasa. |
| ATE397586T1 (de) * | 2004-05-07 | 2008-06-15 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-on-derivate als 11-beta hydroxysteroid dehydrogenas inhibitoren |
| US8138342B2 (en) | 2004-10-12 | 2012-03-20 | High Point Pharmacueticals, LLC | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| EP1807072B1 (en) | 2004-10-29 | 2009-01-07 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| KR101368228B1 (ko) | 2004-11-10 | 2014-02-27 | 인사이트 코포레이션 | 락탐 화합물 및 약제로서의 이의 용도 |
| PT1830841E (pt) | 2004-12-20 | 2008-12-15 | Lilly Co Eli | Derivados de cicloalquil-lactamas como inibidores da 11-beta-hidroxiesteróide desidrogenase 1 |
| US7834194B2 (en) | 2004-12-21 | 2010-11-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2006104280A1 (ja) | 2005-03-31 | 2006-10-05 | Takeda Pharmaceutical Company Limited | 糖尿病の予防・治療剤 |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ES2533263T3 (es) | 2006-04-21 | 2015-04-08 | Eli Lilly And Company | Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 |
| AU2007240458B2 (en) | 2006-04-21 | 2012-03-15 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| DK2029529T3 (da) | 2006-04-24 | 2010-09-20 | Lilly Co Eli | Substitueret pyrrolidinone som inhibitor af 11-beta-hydroxysteroiddehydrogenase 1 |
| PL2021336T3 (pl) | 2006-04-24 | 2010-11-30 | Lilly Co Eli | Inhibitory dehydrogenazy 11-ß- hydroksysteroidowej typu 1 |
| WO2007127763A2 (en) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5101602B2 (ja) | 2006-04-25 | 2012-12-19 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| EA015516B1 (ru) | 2006-04-25 | 2011-08-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы 1 |
| EA014719B1 (ru) | 2006-04-28 | 2011-02-28 | Эли Лилли Энд Компани | Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-24 PL PL07761153T patent/PL2049475T3/pl unknown
- 2007-04-24 AU AU2007244971A patent/AU2007244971B2/en not_active Ceased
- 2007-04-24 EA EA200870472A patent/EA016415B1/ru not_active IP Right Cessation
- 2007-04-24 AT AT07761153T patent/ATE543798T1/de active
- 2007-04-24 PT PT07761153T patent/PT2049475E/pt unknown
- 2007-04-24 DK DK07761153.1T patent/DK2049475T3/da active
- 2007-04-24 JP JP2009507921A patent/JP5118692B2/ja not_active Expired - Fee Related
- 2007-04-24 MX MX2008013658A patent/MX2008013658A/es active IP Right Grant
- 2007-04-24 EP EP07761153A patent/EP2049475B1/en not_active Not-in-force
- 2007-04-24 BR BRPI0710468-5A patent/BRPI0710468A2/pt not_active IP Right Cessation
- 2007-04-24 ES ES07761153T patent/ES2378574T3/es active Active
- 2007-04-24 WO PCT/US2007/067253 patent/WO2007127704A1/en not_active Ceased
- 2007-04-24 SI SI200730873T patent/SI2049475T1/sl unknown
- 2007-04-24 US US12/297,877 patent/US7998999B2/en not_active Expired - Fee Related
- 2007-04-24 CN CN2007800148098A patent/CN101432262B/zh not_active Expired - Fee Related
- 2007-04-24 CA CA2649111A patent/CA2649111C/en not_active Expired - Fee Related
-
2012
- 2012-02-24 CY CY20121100194T patent/CY1112398T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009534471A5 (enExample) | ||
| JP2009534412A5 (enExample) | ||
| JP2009535356A5 (enExample) | ||
| JP2009534398A5 (enExample) | ||
| JP2009535362A5 (enExample) | ||
| JP2009534468A5 (enExample) | ||
| JP2009535358A5 (enExample) | ||
| JP2012510502A5 (enExample) | ||
| JP2010526146A5 (enExample) | ||
| JP2011512412A5 (enExample) | ||
| JP2010536766A5 (enExample) | ||
| JP2006508935A5 (enExample) | ||
| JP2007520440A5 (enExample) | ||
| JP2008523126A5 (enExample) | ||
| JP2011527334A5 (enExample) | ||
| JP2005112864A5 (enExample) | ||
| JP2010521514A5 (enExample) | ||
| NO20072371L (no) | Kinuklidinderivater og deres anvendelse som muskarine M3-reseptorantagonister | |
| JP2006524222A5 (enExample) | ||
| JP2005527627A5 (enExample) | ||
| JP2010280684A5 (enExample) | ||
| KR101360556B9 (ko) | 글리코피롤레이트 및 베타2 아드레날린 수용체아고니스트의 조합물 | |
| RU2015101032A (ru) | ДИАМИДНЫЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ АНТАГОНИСТА МУСКАРИНОВОГО РЕЦЕПТОРА И АКТИВНОСТЬЮ АГОНИСТА β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА | |
| JP2002513793A5 (enExample) | ||
| JP2013506674A5 (enExample) |