ES2318577T3 - Derivados de cicloalquil lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1'. - Google Patents
Derivados de cicloalquil lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1'. Download PDFInfo
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- ES2318577T3 ES2318577T3 ES05819201T ES05819201T ES2318577T3 ES 2318577 T3 ES2318577 T3 ES 2318577T3 ES 05819201 T ES05819201 T ES 05819201T ES 05819201 T ES05819201 T ES 05819201T ES 2318577 T3 ES2318577 T3 ES 2318577T3
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract
Un compuesto representado estructuralmente por la fórmula (I): ** ver fórmula** o una sal farmacéuticamente aceptable del mismo, en la que G 1 es metileno o etileno; L es grupo de engarce divalente seleccionado entre alquileno C 1-C 4, -S-, -CH(OH)-, y -O-; R 1 es hidrógeno, hidroxi, -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos), -alcoxi (C1- C6) (opcionalmente sustituido con de uno a tres halógenos), o -CH2OR 7 , en la que R 7 es hidrógeno o -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos); R 1a es hidrógeno o -CH3 (opcionalmente sustituido con de uno a tres halógenos); R 2 es ** ver fórmula** en las que la línea discontinua representa el punto de unión a la posición R 2 en la fórmula I; en la que X es hidrógeno, hidroxi, -O-CH3, -CH2OH, o -O-C(O)-fenil-NO2; en la que Y es hidrógeno o metilo, con la condición de que al menos uno de X e Y no sea hidrógeno; en la que opcionalmente X e Y junto con el carbono al que están unidos forman carbonilo; en la que R 8 es independientemente hidrógeno, hidroxi, o -alquilo (C1-C4); R 9 es independientemente hidrógeno, hidroxi, -alquilo (C1-C4), o fenilo; R 10 es independientemente en cada aparición hidrógeno, hidroxi, o -alquilo (C1-C4); y G 2 es metileno, etileno, o 1-propileno; R 3 es hidrógeno, hidroxilo (con la condición de que cuando L es -S- o -CH(OH)- entonces R 3 no puede ser hidroxi), o -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos); cada uno de R 4 y R 5 es independientemente hidrógeno, hidroxi, -C(O)OH, -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos), -alcoxi (C1- C6) (opcionalmente sustituido con de uno a tres halógenos), halógeno, ciano, -CF3, -OCF3, -alquil (C1-C4)-C(O)OH, -alquil (C 1-C 4)-C(O)Oalquil (C 1-C 4), o -alquil (C 1-C 4)-OH; R 5a y R 5b son independientemente hidrógeno o halógeno; R 6 es hidrógeno, hidroxi, -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos), -alcoxi (C1- C6) (opcionalmente sustituido con de uno a tres halógenos), -O-alquinilo (C2-C6), halógeno, ciano, -NH2, -CF3, -SCF3, -C(O) Oalquil (C1-C4), -cicloalquilo (C3-C8), -O-SO2-alquilo (C1-C4), -O-SO2-CF3, -O-fenilo, -O-alquil (C1- C 4)-fenilo, -O-fenil-C(O)O-alquilo (C 1-C 4), -O-alquil (C 1-C 4)-fenil-C(O)O-alquilo (C 1-C 4), -NH-fenilo, -CH 2-fenilo, -O-(C 1-C 4) alquil-piridinilo, Ar 1 , Het 1 , Ar 2 , Het 2 , -C(O)alquilo (C 1-C 4), -C(O)-Ar 2 , -C(O)-Het 2 , -NHSO 2-alquilo (C 1- C4), -NHSO2-fenil(R 19 )(R 19 ), -alquil (C1-C4)-C(O)N(R 11 )(R 12 ), o alquil (C1-C4)-N(R 13 )(R 14 ); en la que cada uno de R 11 y R 12 es independientemente hidrógeno o -alquilo (C1-C4), o R 11 y R 12 tomados junto con el nitrógeno al que están unidos forman piperidinilo, piperazinilo, o pirrolidinilo (donde opcionalmente el anillo de piperidinilo, piperazinilo, o pirrolidinilo está sustituido una vez con -alquilo (C 1-C 4)); en la que cada uno de R 13 y R 14 es independientemente hidrógeno o -alquil (C 1-C 4) (opcionalmente sustituido con de uno a tres halógenos), o R 13 y R 14 tomados junto con el nitrógeno al que están unidos forman piperidinilo, pirrolidinilo, o piperazinilo; con la condición de que cuando L es -O- o -S-, entonces R 6 no es hidrógeno; Ar 1 es fenilo o naftilo; Ar 2 es Ar 1 opcional e independientemente sustituido de una a tres veces con halógeno, hidroxi, -C(O)OH, -alcoxi (C1-C6), ciano, -CF3, -alquilo (C1-C4), -alquil (C1-C4)-C(O)OH, -Oalquil (C1-C4)-C(O)OH, -alquil (C1-C4)- N(R 15 )(R 16 ), -O-alquil (C 1-C 4)-N(R 15 )(R 16 ), -O-alquil (C 1-C 4)-C(O)O-alquilo (C 1-C 4), -O-alquil (C 1-C 4)-piperidinilo, imidazolilo, piridinilo, o -alquil (C 1-C 4)-imidazolilo; en la que cada uno de R 15 y R 16 es independientemente hidrógeno o -alquilo (C1-C4), o R 15 y R 16 tomados junto con el nitrógeno al que están unidos forman piperidinilo, pirrolidinilo, morfolinilo, o imidazolilo; Het 1 es independientemente imidazolilo, oxadiazolilo, pirazolilo, pirrolilo, tetrazolilo, tiadiazolilo, triazolilo, pirrolidinilo, morfolinilo, piridinilo, piperidinilo, pirimidinilo, pirazinilo, piperazinilo, piridazinilo, furanilo, tiofenilo, tiazolilo, oxazolilo, isoxazolilo, isotiazolilo, indolilo, isoindolilo, indolinilo, benzofuranilo, benzotiofenilo, quinolinilo, isoquinolinilo, quinoxalinilo, quinazolinilo, o ftalazinilo; Het 2 es Het 1 opcional e independientemente sustituido de una a tres veces con halógeno, hidroxi, -alcoxi (C1-C6) (opcionalmente sustituido con de uno a tres halógenos), -C(O)OH, -NH2, ciano, -CF3, -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos), -alquil (C1-C4)-C(O)OH, -Oalquil (C1-C4)-C(O)OH, -C(O)O-alquilo (C1-C4), -alquil (C 1-C 4)-N(R 17 )(R 18 ), -Oalquil (C 1-C 4)-N(R 17 )(R 18 ), imidazolilo, piridinilo, o -alquil (C 1-C 4)-imidazolilo; en la que cada uno de R 17 y R 18 es independientemente hidrógeno o -alquilo (C 1-C 4) (opcionalmente sustituido con de uno a tres halógenos), o R 17 y R 18 tomados junto con el nitrógeno al que están unidos forman piperidinilo o pirrolidinilo; R 19 es hidrógeno, halógeno, o -alquilo (C1-C4) (opcionalmente sustituido con de uno a tres halógenos); y R 20 es hidroxi, -alquilo (C 1-C 4) (opcionalmente sustituido con de uno a tres halógenos), -CH 2OH, o fenilo; con la condición de que un compuesto de fórmula (I) no sea 1-ciclohexil-3-fenoxi-pirrolidin-2-ona o 1-ciclohexil-3-fenilsulfanil-pirrolidin-2-ona.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US62320304P | 2004-10-29 | 2004-10-29 | |
US623203P | 2004-10-29 |
Publications (1)
Publication Number | Publication Date |
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ES2318577T3 true ES2318577T3 (es) | 2009-05-01 |
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Application Number | Title | Priority Date | Filing Date |
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ES05819201T Active ES2318577T3 (es) | 2004-10-29 | 2005-10-26 | Derivados de cicloalquil lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1'. |
Country Status (10)
Country | Link |
---|---|
US (2) | US7713979B2 (es) |
EP (1) | EP1807072B1 (es) |
AT (1) | ATE419848T1 (es) |
DE (1) | DE602005012306D1 (es) |
DK (1) | DK1807072T3 (es) |
ES (1) | ES2318577T3 (es) |
PL (1) | PL1807072T3 (es) |
PT (1) | PT1807072E (es) |
SI (1) | SI1807072T1 (es) |
WO (1) | WO2006049952A1 (es) |
Families Citing this family (80)
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US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
EP1781598A1 (en) | 2004-07-08 | 2007-05-09 | Warner-Lambert Company LLC | Androgen modulators |
ES2308602T3 (es) * | 2004-12-20 | 2008-12-01 | Eli Lilly And Company | Derivados de cicloalquil lactamas como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa 1. |
US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
MX2007008239A (es) | 2005-01-05 | 2007-08-17 | Abbott Lab | Inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1. |
US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
EP1846363B1 (en) | 2005-01-05 | 2012-04-25 | Abbott Laboratories | Adamantyl derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
US7579360B2 (en) | 2005-06-09 | 2009-08-25 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
AU2007204825B2 (en) * | 2006-01-13 | 2011-07-14 | Corteva Agriscience Llc | 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides |
NZ571175A (en) | 2006-04-21 | 2011-10-28 | Lilly Co Eli | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
MX2008013485A (es) | 2006-04-21 | 2008-10-30 | Lilly Co Eli | Derivados de lactamas de bifenilamida como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
CN101426780B (zh) * | 2006-04-21 | 2013-06-26 | 伊莱利利公司 | 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的环己基咪唑内酰胺衍生物 |
WO2007127688A2 (en) * | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
CN101432262B (zh) * | 2006-04-24 | 2011-06-01 | 伊莱利利公司 | 作为11-β-羟类固醇脱氢酶1的抑制剂的环己基取代的吡咯烷酮类 |
EP2029529B1 (en) * | 2006-04-24 | 2010-07-07 | Eli Lilly & Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
US8148534B2 (en) | 2006-04-25 | 2012-04-03 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
ATE471311T1 (de) * | 2006-04-25 | 2010-07-15 | Lilly Co Eli | Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1 |
JP5189079B2 (ja) | 2006-04-25 | 2013-04-24 | イーライ リリー アンド カンパニー | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
CN101448816B (zh) * | 2006-04-28 | 2013-08-07 | 伊莱利利公司 | 作为11-β-羟类固醇脱氢酶1的抑制剂的哌啶基取代的吡咯烷酮类 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−2,4−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
EP1935420A1 (en) | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
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DE812551C (de) * | 1949-05-13 | 1951-09-03 | Basf Ag | Verfahren zur Herstellung von Pyrrolidon-Derivaten |
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WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
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-
2005
- 2005-10-26 EP EP05819201A patent/EP1807072B1/en not_active Not-in-force
- 2005-10-26 AT AT05819201T patent/ATE419848T1/de active
- 2005-10-26 WO PCT/US2005/038369 patent/WO2006049952A1/en active Application Filing
- 2005-10-26 DK DK05819201T patent/DK1807072T3/da active
- 2005-10-26 PL PL05819201T patent/PL1807072T3/pl unknown
- 2005-10-26 DE DE602005012306T patent/DE602005012306D1/de active Active
- 2005-10-26 ES ES05819201T patent/ES2318577T3/es active Active
- 2005-10-26 PT PT05819201T patent/PT1807072E/pt unknown
- 2005-10-26 SI SI200530646T patent/SI1807072T1/sl unknown
- 2005-10-26 US US11/718,111 patent/US7713979B2/en not_active Expired - Fee Related
-
2010
- 2010-03-19 US US12/727,871 patent/US20100184764A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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DE602005012306D1 (de) | 2009-02-26 |
PT1807072E (pt) | 2009-02-16 |
US20100184764A1 (en) | 2010-07-22 |
US20080275043A1 (en) | 2008-11-06 |
EP1807072B1 (en) | 2009-01-07 |
EP1807072A1 (en) | 2007-07-18 |
PL1807072T3 (pl) | 2009-06-30 |
ATE419848T1 (de) | 2009-01-15 |
DK1807072T3 (da) | 2009-03-16 |
WO2006049952A1 (en) | 2006-05-11 |
US7713979B2 (en) | 2010-05-11 |
SI1807072T1 (sl) | 2009-06-30 |
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