JP2014508610A5 - - Google Patents
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- Publication number
- JP2014508610A5 JP2014508610A5 JP2013557128A JP2013557128A JP2014508610A5 JP 2014508610 A5 JP2014508610 A5 JP 2014508610A5 JP 2013557128 A JP2013557128 A JP 2013557128A JP 2013557128 A JP2013557128 A JP 2013557128A JP 2014508610 A5 JP2014508610 A5 JP 2014508610A5
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- hyperbranched polymer
- cationic
- core portion
- polymer molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920000587 hyperbranched polymer Polymers 0.000 claims 30
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 13
- 125000002091 cationic group Chemical group 0.000 claims 13
- 229920000669 heparin Polymers 0.000 claims 13
- 229960002897 heparin Drugs 0.000 claims 13
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 5
- 239000002344 surface layer Substances 0.000 claims 4
- 239000003146 anticoagulant agent Substances 0.000 claims 3
- 229940127219 anticoagulant drug Drugs 0.000 claims 3
- 239000010410 layer Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229920000962 poly(amidoamine) Polymers 0.000 claims 3
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 229920006318 anionic polymer Polymers 0.000 claims 2
- 229920006317 cationic polymer Polymers 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 239000000412 dendrimer Substances 0.000 claims 2
- 229920000736 dendritic polymer Polymers 0.000 claims 2
- 230000001453 nonthrombogenic effect Effects 0.000 claims 2
- 229920000333 poly(propyleneimine) Polymers 0.000 claims 2
- 229920000768 polyamine Polymers 0.000 claims 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims 1
- 229920001586 anionic polysaccharide Polymers 0.000 claims 1
- 150000004836 anionic polysaccharides Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- SENLDUJVTGGYIH-UHFFFAOYSA-N n-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-[2-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]ethyl]amino]propanamide Chemical group NCCNC(=O)CCN(CCC(=O)NCCN)CCN(CCC(=O)NCCN)CCC(=O)NCCN SENLDUJVTGGYIH-UHFFFAOYSA-N 0.000 claims 1
- 150000003141 primary amines Chemical group 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451732P | 2011-03-11 | 2011-03-11 | |
| US61/451,732 | 2011-03-11 | ||
| PCT/EP2012/054179 WO2012123384A1 (en) | 2011-03-11 | 2012-03-09 | Improvements to immobilised biological entities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017225620A Division JP6643298B2 (ja) | 2011-03-11 | 2017-11-24 | 固定化された生物学的成分の改良 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508610A JP2014508610A (ja) | 2014-04-10 |
| JP2014508610A5 true JP2014508610A5 (enExample) | 2015-04-30 |
| JP6251039B2 JP6251039B2 (ja) | 2017-12-20 |
Family
ID=45814511
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557128A Active JP6251039B2 (ja) | 2011-03-11 | 2012-03-09 | 固定化された生物学的成分の改良 |
| JP2017225620A Active JP6643298B2 (ja) | 2011-03-11 | 2017-11-24 | 固定化された生物学的成分の改良 |
| JP2019161946A Pending JP2019202226A (ja) | 2011-03-11 | 2019-09-05 | 固定化された生物学的成分の改良 |
| JP2020195102A Active JP7222963B2 (ja) | 2011-03-11 | 2020-11-25 | 固定化された生物学的成分の改良 |
| JP2022196345A Pending JP2023017012A (ja) | 2011-03-11 | 2022-12-08 | 固定化された生物学的成分の改良 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017225620A Active JP6643298B2 (ja) | 2011-03-11 | 2017-11-24 | 固定化された生物学的成分の改良 |
| JP2019161946A Pending JP2019202226A (ja) | 2011-03-11 | 2019-09-05 | 固定化された生物学的成分の改良 |
| JP2020195102A Active JP7222963B2 (ja) | 2011-03-11 | 2020-11-25 | 固定化された生物学的成分の改良 |
| JP2022196345A Pending JP2023017012A (ja) | 2011-03-11 | 2022-12-08 | 固定化された生物学的成分の改良 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US9101696B2 (enExample) |
| EP (2) | EP2683420B1 (enExample) |
| JP (5) | JP6251039B2 (enExample) |
| KR (1) | KR101933237B1 (enExample) |
| CN (2) | CN105664252B (enExample) |
| BR (1) | BR112013023241B1 (enExample) |
| CA (1) | CA2828797C (enExample) |
| ES (2) | ES2955183T3 (enExample) |
| RU (1) | RU2625756C2 (enExample) |
| WO (1) | WO2012123384A1 (enExample) |
Families Citing this family (46)
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| CA2828797C (en) | 2011-03-11 | 2020-03-10 | Gore Enterprise Holdings, Inc. | Single point attachment of heparin to hyperbranched polymers and coatings thereof |
| US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
| US10376360B2 (en) | 2012-07-27 | 2019-08-13 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic valve apparatus and methods |
| US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
| US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
| US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
| US9737398B2 (en) | 2012-12-19 | 2017-08-22 | W. L. Gore & Associates, Inc. | Prosthetic valves, frames and leaflets and methods thereof |
| US10321986B2 (en) | 2012-12-19 | 2019-06-18 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic heart valve |
| RU2698315C2 (ru) | 2013-02-04 | 2019-08-26 | В.Л. Гор Энд Ассошиейтс, Инк. | Покрытие для подложки |
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| EP3687452B1 (en) | 2017-09-27 | 2026-07-15 | Edwards Lifesciences Corporation | Prosthetic valves with mechanically coupled leaflets |
| CA3078699C (en) | 2017-10-13 | 2023-10-10 | W.L. Gore & Associates, Inc. | Telescoping prosthetic valve and delivery system |
| EP3703616B1 (en) | 2017-10-31 | 2026-07-29 | Edwards Lifesciences Corporation | Medical valve and leaflet promoting tissue ingrowth |
| WO2019089135A1 (en) | 2017-10-31 | 2019-05-09 | W. L. Gore & Associates, Inc. | Transcatheter deployment systems and associated methods |
| US12453779B2 (en) * | 2018-03-07 | 2025-10-28 | Forschungsverbund Berlin E.V. | Chemoselective thiol-conjugation with alkene or alkyne-phosphonothiolates and -phosphonates |
| CA3093027A1 (en) * | 2018-03-09 | 2019-09-12 | Carmeda Ab | Improvements to processes for immobilising biological entities |
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| WO2020070258A1 (en) | 2018-10-03 | 2020-04-09 | Carmeda Ab | Immobilised biological entities |
| US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
| CN110028692B (zh) * | 2019-03-14 | 2020-11-03 | 江苏赛腾医疗科技有限公司 | 一种基于离子键-共价键协同表面肝素化抗凝血医用装置的制备方法 |
| JP7381601B2 (ja) | 2019-04-12 | 2023-11-15 | エドワーズ ライフサイエンシーズ コーポレイション | マルチパートフレーム及び関連するレジリエントブリッジ特徴部を備えた弁 |
| CN110464882A (zh) * | 2019-07-29 | 2019-11-19 | 东华大学 | 一种亲水抗菌可降解的输尿管支架管及其制备方法 |
| WO2021022211A1 (en) | 2019-08-01 | 2021-02-04 | W. L. Gore & Associates, Inc. | Transcatheter prosthetic valve with multi-part frame subcomponent transverse deformation resistance |
| CN114340726A (zh) | 2019-08-07 | 2022-04-12 | W.L.戈尔及同仁股份有限公司 | 用于光可激活的治疗介质的囊体递送装置 |
| CN111544646A (zh) * | 2020-03-30 | 2020-08-18 | 东华大学 | 表面接枝肝素涂层的小口径人工血管及其制备方法 |
| CA3213305A1 (en) | 2021-04-19 | 2022-10-27 | Mark D. Edmundson | Electrochemical analyte biosensors, associated compositions of matter, and methods for making and using same |
| EP4333922B8 (en) * | 2021-05-04 | 2025-12-31 | Institut national de la santé et de la recherche médicale (INSERM) | NEW DEVICES TO BE USED FOR THE TREATMENT OF CEREBRAL ANEURYSMS |
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| CN114392738B (zh) * | 2022-01-25 | 2023-01-10 | 同济大学 | 共价杂配体、炔基化超支化聚乙撑亚胺矿化法调制金纳米簇和方法、应用 |
| CN115381569A (zh) * | 2022-07-21 | 2022-11-25 | 南方科技大学 | Peek种植体表面改进方法和设备 |
| WO2025264890A1 (en) * | 2024-06-19 | 2025-12-26 | W. L. Gore & Associates, Inc. | Implantable absorbable tissue adhesives on biomaterials for long-term adhesion to biological tissues |
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| US8986713B2 (en) | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
| US9114194B2 (en) | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
| WO2008063157A2 (en) * | 2006-10-25 | 2008-05-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A nanoparticle-based anticoagulant |
| DE102008021894A1 (de) | 2008-05-02 | 2009-11-05 | Biotronik Vi Patent Ag | Implantat umfassend eine Oberfläche mit verringerter Thrombogenität |
| GB0816783D0 (en) | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
| GB201004101D0 (en) | 2010-03-12 | 2010-04-28 | Carmeda Ab | Immobilised biological entities |
| CA2828797C (en) * | 2011-03-11 | 2020-03-10 | Gore Enterprise Holdings, Inc. | Single point attachment of heparin to hyperbranched polymers and coatings thereof |
| GB2508574B (en) | 2012-06-24 | 2014-12-17 | Fasmatech Science And Technology Sa | Improvements in and relating to the control of ions |
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2012
- 2012-03-09 CA CA2828797A patent/CA2828797C/en active Active
- 2012-03-09 JP JP2013557128A patent/JP6251039B2/ja active Active
- 2012-03-09 BR BR112013023241-2A patent/BR112013023241B1/pt not_active IP Right Cessation
- 2012-03-09 CN CN201511008867.2A patent/CN105664252B/zh active Active
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- 2012-03-09 CN CN201280012639.0A patent/CN103596603B/zh active Active
- 2012-03-09 WO PCT/EP2012/054179 patent/WO2012123384A1/en not_active Ceased
- 2012-03-09 ES ES18170238T patent/ES2955183T3/es active Active
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- 2012-03-09 KR KR1020137026084A patent/KR101933237B1/ko active Active
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