JP5911723B2 - 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 - Google Patents

細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 Download PDF

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JP5911723B2
JP5911723B2 JP2011509670A JP2011509670A JP5911723B2 JP 5911723 B2 JP5911723 B2 JP 5911723B2 JP 2011509670 A JP2011509670 A JP 2011509670A JP 2011509670 A JP2011509670 A JP 2011509670A JP 5911723 B2 JP5911723 B2 JP 5911723B2
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polymer
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block
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JP2011521054A5 (enExample
JP2011521054A (ja
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ステイトン、パトリック・エス．
ホフマン、アラン・エス．
コンバータイン、アンソニー・ジェイ．
ベノイト、ダニール
ドゥバル、クレイグ・エル．
ジョンソン、ポール
ガール、アンナ
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University of Washington
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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JP2011509670A 2008-05-13 2009-05-13 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 Expired - Fee Related JP5911723B2 (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US5290808P 2008-05-13 2008-05-13
US5291408P 2008-05-13 2008-05-13
US61/052,908 2008-05-13
US61/052,914 2008-05-13
US9129408P 2008-08-22 2008-08-22
US61/091,294 2008-08-22
US11204808P 2008-11-06 2008-11-06
US11205408P 2008-11-06 2008-11-06
US61/112,054 2008-11-06
US61/112,048 2008-11-06
US12076908P 2008-12-08 2008-12-08
US61/120,769 2008-12-08
US14077408P 2008-12-24 2008-12-24
US14077908P 2008-12-24 2008-12-24
US61/140,779 2008-12-24
US61/140,774 2008-12-24
US17137709P 2009-04-21 2009-04-21
US61/171,377 2009-04-21
PCT/US2009/043847 WO2009140427A2 (en) 2008-05-13 2009-05-13 Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Related Child Applications (1)

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JP2015200236A Division JP6239565B2 (ja) 2008-05-13 2015-10-08 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体

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JP2011521054A JP2011521054A (ja) 2011-07-21
JP2011521054A5 JP2011521054A5 (enExample) 2012-07-05
JP5911723B2 true JP5911723B2 (ja) 2016-04-27

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JP2011509670A Expired - Fee Related JP5911723B2 (ja) 2008-05-13 2009-05-13 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体
JP2015200236A Active JP6239565B2 (ja) 2008-05-13 2015-10-08 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体

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US (3) US9476063B2 (enExample)
EP (2) EP2281011B1 (enExample)
JP (2) JP5911723B2 (enExample)
KR (1) KR101661636B1 (enExample)
CN (2) CN103342789B (enExample)
AU (1) AU2009246327B8 (enExample)
BR (1) BRPI0912159B8 (enExample)
CA (3) CA3065577C (enExample)
ES (1) ES2404131T3 (enExample)
IL (1) IL209238A (enExample)
MX (1) MX2010012238A (enExample)
WO (1) WO2009140427A2 (enExample)
ZA (1) ZA201008729B (enExample)

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