JP2016501523A5 - - Google Patents

Info

Publication number

JP2016501523A5

JP2016501523A5 JP2015545446A JP2015545446A JP2016501523A5 JP 2016501523 A5 JP2016501523 A5 JP 2016501523A5 JP 2015545446 A JP2015545446 A JP 2015545446A JP 2015545446 A JP2015545446 A JP 2015545446A JP 2016501523 A5 JP2016501523 A5 JP 2016501523A5

Authority

JP

Japan

Prior art keywords

cancer

percentile

individual

telomere length

composition

Prior art date

2013-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims description 41
• 206010028980 Neoplasm Diseases 0.000 claims description 39
• 102000055501 telomere Human genes 0.000 claims description 32
• 108091035539 telomere Proteins 0.000 claims description 32
• 210000003411 telomere Anatomy 0.000 claims description 31
• 201000011510 cancer Diseases 0.000 claims description 30
• 239000000203 mixture Substances 0.000 claims description 23
• 239000012472 biological sample Substances 0.000 claims description 19
• 239000003277 telomerase inhibitor Substances 0.000 claims description 17
• 229940123582 Telomerase inhibitor Drugs 0.000 claims description 15
• 108091034117 Oligonucleotide Proteins 0.000 claims description 9
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 6
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 6
• 206010005003 Bladder cancer Diseases 0.000 claims description 3
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• 238000011529 RT qPCR Methods 0.000 claims description 3
• 206010039491 Sarcoma Diseases 0.000 claims description 3
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• 238000002105 Southern blotting Methods 0.000 claims description 3
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
• 108010017842 Telomerase Proteins 0.000 claims description 3
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
• 230000000295 complement effect Effects 0.000 claims description 3
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• 201000010175 gallbladder cancer Diseases 0.000 claims description 3
• 206010017758 gastric cancer Diseases 0.000 claims description 3
• 208000005017 glioblastoma Diseases 0.000 claims description 3
• 201000005787 hematologic cancer Diseases 0.000 claims description 3
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 3
• 210000003494 hepatocyte Anatomy 0.000 claims description 3
• 229950004291 imetelstat Drugs 0.000 claims description 3
• 102000039446 nucleic acids Human genes 0.000 claims description 3
• 108020004707 nucleic acids Proteins 0.000 claims description 3
• 150000007523 nucleic acids Chemical class 0.000 claims description 3
• 230000002611 ovarian Effects 0.000 claims description 3
• 208000000587 small cell lung carcinoma Diseases 0.000 claims description 3
• 201000011549 stomach cancer Diseases 0.000 claims description 3
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• 239000012830 cancer therapeutic Substances 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 229940124597 therapeutic agent Drugs 0.000 claims description 2
• 210000004460 N cell Anatomy 0.000 claims 1
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