JP2018502956A5 - - Google Patents
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- Publication number
- JP2018502956A5 JP2018502956A5 JP2017533008A JP2017533008A JP2018502956A5 JP 2018502956 A5 JP2018502956 A5 JP 2018502956A5 JP 2017533008 A JP2017533008 A JP 2017533008A JP 2017533008 A JP2017533008 A JP 2017533008A JP 2018502956 A5 JP2018502956 A5 JP 2018502956A5
- Authority
- JP
- Japan
- Prior art keywords
- copolymer
- repeating units
- composition
- nucleic acid
- repeating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001577 copolymer Polymers 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 229920003118 cationic copolymer Polymers 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229920006301 statistical copolymer Polymers 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229920005684 linear copolymer Polymers 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14199439.2 | 2014-12-19 | ||
| EP14199439.2A EP3034539A1 (en) | 2014-12-19 | 2014-12-19 | Compositions for introducing nucleic acid into cells |
| PCT/EP2015/080669 WO2016097377A1 (en) | 2014-12-19 | 2015-12-18 | Compositions for introducing nucleic acid into cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502956A JP2018502956A (ja) | 2018-02-01 |
| JP2018502956A5 true JP2018502956A5 (enExample) | 2019-02-07 |
| JP6745272B2 JP6745272B2 (ja) | 2020-08-26 |
Family
ID=52292658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533008A Active JP6745272B2 (ja) | 2014-12-19 | 2015-12-18 | 核酸を細胞内へ導入するための組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11020487B2 (enExample) |
| EP (2) | EP3034539A1 (enExample) |
| JP (1) | JP6745272B2 (enExample) |
| KR (1) | KR102142180B1 (enExample) |
| CN (1) | CN107001627B (enExample) |
| AU (1) | AU2015366220B2 (enExample) |
| BR (1) | BR112017012482B1 (enExample) |
| CA (1) | CA2971284C (enExample) |
| DK (1) | DK3242903T3 (enExample) |
| ES (1) | ES2887404T3 (enExample) |
| RU (1) | RU2715227C2 (enExample) |
| WO (1) | WO2016097377A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3034539A1 (en) | 2014-12-19 | 2016-06-22 | Ethris GmbH | Compositions for introducing nucleic acid into cells |
| CA2990883A1 (en) | 2015-06-30 | 2017-01-05 | Ethris Gmbh | Atp-binding cassette family coding polyribonucleotides and formulations thereof |
| WO2018010815A1 (en) * | 2016-07-15 | 2018-01-18 | Biontech Rna Pharmaceuticals Gmbh | Formulation for administration of rna |
| BR112020013974A8 (pt) * | 2018-01-11 | 2022-10-18 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Ggmbh | Formulação para administração de rna |
| JP7256824B2 (ja) | 2018-04-25 | 2023-04-12 | エスリス ゲーエムベーハー | 粒子状製剤用の凍結保護剤 |
| JP7863882B2 (ja) * | 2019-12-17 | 2026-05-22 | ウニヴェルズィテート ゲント | ポリプロピレンイミンを含む非ウイルスベクター |
| CN111249476B (zh) * | 2020-02-19 | 2023-09-26 | 深圳厚存纳米药业有限公司 | 泊洛沙姆和/或泊洛沙胺与脂质组合中性复合物纳米粒 |
| MX2023009757A (es) | 2021-02-26 | 2023-09-04 | Ethris Gmbh | Formulaciones para la formacion de aerosoles y aerosoles para la administracion de acido nucleico. |
| WO2023049815A2 (en) * | 2021-09-22 | 2023-03-30 | Sirnaomics, Inc. | Improved nanoparticle formulations formed from histidine-lysine copolymers |
| CN118510549A (zh) * | 2021-09-22 | 2024-08-16 | 圣诺制药公司 | 具有减小的纳米颗粒尺寸和改善的多分散性指数的纳米颗粒药物组合物 |
| CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
| EP4327829A1 (en) | 2022-08-26 | 2024-02-28 | Ethris GmbH | Stabilization of lipid or lipidoid nanoparticle suspensions |
| EP4577243A1 (en) | 2022-08-26 | 2025-07-02 | Ethris GmbH | Stable lipid or lipidoid nanoparticle suspensions |
| WO2024240962A1 (en) | 2023-05-25 | 2024-11-28 | Ethris Gmbh | Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof |
| CN116478410B (zh) * | 2023-06-20 | 2023-09-12 | 觅投克(北京)生物医学技术有限公司 | 一种菊糖修饰的聚乙烯亚胺衍生物及其制备方法和应用 |
| CN121729225A (zh) | 2023-08-25 | 2026-03-24 | 埃泽瑞斯公司 | 具有增强药物应用的特定表面活性剂性质的稳定脂质和类脂质纳米颗粒制剂 |
| WO2025064850A1 (en) | 2023-09-22 | 2025-03-27 | BioNTech SE | Rna constructs with n-terminal degrons to enhance an immune response |
| WO2025106754A1 (en) | 2023-11-15 | 2025-05-22 | BioNTech SE | Coronavirus vaccine |
| FR3155424A1 (fr) | 2023-11-15 | 2025-05-23 | BioNTech SE | Compositions immunogènes contre le sars-cov-2 |
| WO2026047603A1 (en) | 2024-08-28 | 2026-03-05 | BioNTech SE | Sars-cov-2 immunogenic compositions |
| WO2026057626A1 (en) | 2024-09-11 | 2026-03-19 | BioNTech SE | Peptidoglycan hydrolases having multiple enzymatically active domains |
| WO2026057625A1 (en) | 2024-09-11 | 2026-03-19 | BioNTech SE | Peptidoglycan hydrolases having a chap domain with engineered active site |
| WO2026082899A2 (en) | 2024-10-16 | 2026-04-23 | BioNTech SE | Rna for preventing or treating tuberculosis |
| WO2026119817A1 (en) | 2024-12-02 | 2026-06-11 | BioNTech SE | Agents and methods for targeted delivery of immune effector cells |
| WO2026125590A1 (en) | 2024-12-13 | 2026-06-18 | BioNTech SE | Measuring nucleic acid integrity |
| WO2026125598A1 (en) | 2024-12-13 | 2026-06-18 | BioNTech SE | Measuring nucleic acid integrity |
| WO2026148356A1 (en) | 2025-01-06 | 2026-07-09 | BioNTech SE | Coronavirus and influenza immunogenic combinations |
| WO2026150132A1 (en) | 2025-01-12 | 2026-07-16 | BioNTech SE | Combination therapy comprising an rna cancer vaccine and a multispecific binding agent targeting pd-1/pd-l1 and vegf/vegfr for cancer treatment |
| WO2026162682A1 (en) | 2025-01-29 | 2026-08-06 | BioNTech SE | Compositions for delivery of plasmodium rh5 antigens and related methods |
| WO2026162552A1 (en) | 2025-01-31 | 2026-08-06 | BioNTech SE | Agents and methods for targeted delivery to cells |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| JPS5821590A (ja) | 1981-07-31 | 1983-02-08 | 株式会社東芝 | 制御棒駆動水圧装置 |
| JPS58215490A (ja) * | 1982-06-08 | 1983-12-14 | Nippon Shokubai Kagaku Kogyo Co Ltd | 石炭−水スラリ−用分散剤 |
| CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| DE19527102A1 (de) * | 1995-07-25 | 1997-01-30 | Bayer Ag | Neue Polyamine und ihre Verwendung in Lacken und Beschichtungen |
| US6017700A (en) | 1995-08-04 | 2000-01-25 | Bayer Corporation | Cationic oligonucleotides, and related methods of synthesis and use |
| FR2739292B1 (fr) * | 1995-09-28 | 1997-10-31 | Rhone Poulenc Rorer Sa | Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations |
| JP2003526692A (ja) * | 1997-08-01 | 2003-09-09 | サプラテック ファーマ インコーポレーテッド | ポリヌクレオチド組成物 |
| WO2001000708A1 (de) | 1999-06-25 | 2001-01-04 | Christian Plank | Kombinationen zur einführung von nucleinsäuren in zellen |
| DE19933024C2 (de) | 1999-07-15 | 2003-03-13 | Medinnova Ges Med Innovationen | Kationische Blockcopolymere |
| WO2002000870A2 (en) | 2000-06-26 | 2002-01-03 | Christian Plank | Method for transfecting cells using a magnetic field |
| US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
| US20070269891A9 (en) | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
| JP4535229B2 (ja) | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
| WO2006085664A1 (ja) | 2005-02-10 | 2006-08-17 | The University Of Tokyo | ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用 |
| WO2006138380A2 (en) | 2005-06-15 | 2006-12-28 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
| KR101388320B1 (ko) | 2005-12-15 | 2014-04-22 | 뽈리쁠뤼스-트랑스펙씨옹 | 양이온성 올리고뉴클레오티드, 이를 제조하기 위한 자동화방법 및 이의 용도 |
| US7700541B2 (en) | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| US20090042825A1 (en) * | 2007-08-06 | 2009-02-12 | Majed Matar | Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer |
| EP2271699A1 (en) * | 2008-03-14 | 2011-01-12 | Egen, Inc. | Biodegradable cross-linked branched poly (alkylene imines) |
| WO2010053572A2 (en) | 2008-11-07 | 2010-05-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| WO2010065660A2 (en) | 2008-12-02 | 2010-06-10 | University Of Utah Research Foundation | Biodegradable polydisulfide amines for gene delivery |
| EA022786B1 (ru) | 2009-07-31 | 2016-03-31 | Этрис Гмбх | Рнк с комбинацией из немодифицированных и модифицированных нуклеотидов для экспрессии белков |
| WO2011154331A1 (en) | 2010-06-10 | 2011-12-15 | F. Hoffmann-La Roche Ag | Polymers for delivery of nucleic acids |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| US9931418B2 (en) | 2012-08-07 | 2018-04-03 | Northeastern University | Compositions for the delivery of RNA and drugs into cells |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| EP3034539A1 (en) | 2014-12-19 | 2016-06-22 | Ethris GmbH | Compositions for introducing nucleic acid into cells |
-
2014
- 2014-12-19 EP EP14199439.2A patent/EP3034539A1/en not_active Withdrawn
-
2015
- 2015-12-18 EP EP15823330.4A patent/EP3242903B1/en active Active
- 2015-12-18 ES ES15823330T patent/ES2887404T3/es active Active
- 2015-12-18 AU AU2015366220A patent/AU2015366220B2/en not_active Ceased
- 2015-12-18 RU RU2017122022A patent/RU2715227C2/ru active
- 2015-12-18 CA CA2971284A patent/CA2971284C/en active Active
- 2015-12-18 WO PCT/EP2015/080669 patent/WO2016097377A1/en not_active Ceased
- 2015-12-18 KR KR1020177019543A patent/KR102142180B1/ko active Active
- 2015-12-18 DK DK15823330.4T patent/DK3242903T3/da active
- 2015-12-18 BR BR112017012482-3A patent/BR112017012482B1/pt active IP Right Grant
- 2015-12-18 CN CN201580068845.7A patent/CN107001627B/zh active Active
- 2015-12-18 JP JP2017533008A patent/JP6745272B2/ja active Active
- 2015-12-18 US US15/537,096 patent/US11020487B2/en active Active
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