BR112017012482B1 - Composição, usos de uma composição, e, métodos para liberar um ácido nucleico a uma célula ou tecido alvo e para a produção da composição - Google Patents
Composição, usos de uma composição, e, métodos para liberar um ácido nucleico a uma célula ou tecido alvo e para a produção da composição Download PDFInfo
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- BR112017012482B1 BR112017012482B1 BR112017012482-3A BR112017012482A BR112017012482B1 BR 112017012482 B1 BR112017012482 B1 BR 112017012482B1 BR 112017012482 A BR112017012482 A BR 112017012482A BR 112017012482 B1 BR112017012482 B1 BR 112017012482B1
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- Biomedical Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/EP2015/080669 WO2016097377A1 (en) | 2014-12-19 | 2015-12-18 | Compositions for introducing nucleic acid into cells |
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| EP3034539A1 (en) | 2014-12-19 | 2016-06-22 | Ethris GmbH | Compositions for introducing nucleic acid into cells |
| DE112016002962T5 (de) | 2015-06-30 | 2018-05-24 | Ethris Gmbh | Familie der ATP-bindenden Kassetten-codierende Polyribonucleotide und Formulierungen derselben |
| WO2018010815A1 (en) * | 2016-07-15 | 2018-01-18 | Biontech Rna Pharmaceuticals Gmbh | Formulation for administration of rna |
| CA3087442A1 (en) * | 2018-01-11 | 2019-07-18 | Biontech Rna Pharmaceuticals Gmbh | Formulation for administration of rna |
| ES2960936T3 (es) | 2018-04-25 | 2024-03-07 | Ethris Gmbh | Formulaciones a base de lípidos para el suministro de ARN |
| CN114829615B (zh) * | 2019-12-17 | 2025-01-10 | 根特大学 | 包含聚丙烯亚胺的非病毒载体 |
| CN111249476B (zh) * | 2020-02-19 | 2023-09-26 | 深圳厚存纳米药业有限公司 | 泊洛沙姆和/或泊洛沙胺与脂质组合中性复合物纳米粒 |
| EP4297722A1 (en) | 2021-02-26 | 2024-01-03 | Ethris GmbH | Formulations for aerosol formation and aerosols for the delivery of nucleic acid |
| EP4404979A4 (en) * | 2021-09-22 | 2025-10-08 | Sirnaomics Inc | PHARMACEUTICAL COMPOSITIONS OF NANOPARTICLES WITH REDUCED NANOPARTICLE SIZE AND IMPROVED POLYDISPERSITY INDEX |
| CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
| WO2024042236A1 (en) | 2022-08-26 | 2024-02-29 | Ethris Gmbh | Stable lipid or lipidoid nanoparticle suspensions |
| EP4327829A1 (en) | 2022-08-26 | 2024-02-28 | Ethris GmbH | Stabilization of lipid or lipidoid nanoparticle suspensions |
| WO2024240962A1 (en) | 2023-05-25 | 2024-11-28 | Ethris Gmbh | Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof |
| CN116478410B (zh) * | 2023-06-20 | 2023-09-12 | 觅投克(北京)生物医学技术有限公司 | 一种菊糖修饰的聚乙烯亚胺衍生物及其制备方法和应用 |
| WO2025045767A1 (en) | 2023-08-25 | 2025-03-06 | Ethris Gmbh | Stabilized lipid and lipidoid nanoparticle formulations with specific surfactant properties for enhanced pharmaceutical applications |
| WO2025064850A1 (en) | 2023-09-22 | 2025-03-27 | BioNTech SE | Rna constructs with n-terminal degrons to enhance an immune response |
| WO2025106754A1 (en) | 2023-11-15 | 2025-05-22 | BioNTech SE | Coronavirus vaccine |
| CA3254064A1 (en) | 2023-11-15 | 2025-05-21 | BioNTech SE | Immunogenic compositions against SARS-CoV-2 |
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| JPS5821590A (ja) | 1981-07-31 | 1983-02-08 | 株式会社東芝 | 制御棒駆動水圧装置 |
| JPS58215490A (ja) * | 1982-06-08 | 1983-12-14 | Nippon Shokubai Kagaku Kogyo Co Ltd | 石炭−水スラリ−用分散剤 |
| CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| DE19527102A1 (de) * | 1995-07-25 | 1997-01-30 | Bayer Ag | Neue Polyamine und ihre Verwendung in Lacken und Beschichtungen |
| US6017700A (en) | 1995-08-04 | 2000-01-25 | Bayer Corporation | Cationic oligonucleotides, and related methods of synthesis and use |
| FR2739292B1 (fr) * | 1995-09-28 | 1997-10-31 | Rhone Poulenc Rorer Sa | Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations |
| JP2003526692A (ja) * | 1997-08-01 | 2003-09-09 | サプラテック ファーマ インコーポレーテッド | ポリヌクレオチド組成物 |
| AU776715B2 (en) | 1999-06-25 | 2004-09-16 | Christian Plank | Combinations for introducing nucleic acids into cells |
| DE19933024C2 (de) | 1999-07-15 | 2003-03-13 | Medinnova Ges Med Innovationen | Kationische Blockcopolymere |
| EP1297169B1 (en) | 2000-06-26 | 2012-08-08 | Ethris Gmbh | Method for transfecting cells using a magnetic field |
| US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
| US20070269891A9 (en) | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
| JP4535229B2 (ja) | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
| JP5061349B2 (ja) | 2005-02-10 | 2012-10-31 | 国立大学法人 東京大学 | ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用 |
| JP5777846B2 (ja) | 2005-06-15 | 2015-09-09 | マサチューセッツ インスティテュート オブ テクノロジー | アミン含有脂質およびその使用 |
| HUE043492T2 (hu) | 2005-08-23 | 2019-08-28 | Univ Pennsylvania | Módosított nukleozidokat tartalmazó RNS és eljárások az alkalmazására |
| BRPI0619932A2 (pt) | 2005-12-15 | 2011-10-25 | Centre Nat Rech Scient | moléculas de oligonucleotìdeo-oligocátion, método para a obtenção das mesmas, reagentes de fosforamidita, método para uso em biologia e diagnóstico, e, composições farmacêuticas |
| US7700541B2 (en) | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| US20090042825A1 (en) * | 2007-08-06 | 2009-02-12 | Majed Matar | Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer |
| JP2011514423A (ja) * | 2008-03-14 | 2011-05-06 | エーゲン、インコーポレイテッド | 生分解性架橋分枝状ポリ（アルキレンイミン） |
| US8969353B2 (en) | 2008-11-07 | 2015-03-03 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US20110263025A1 (en) | 2008-12-02 | 2011-10-27 | University Of Utah Research Foundation | Biodegradable polydisulfide amines for gene delivery |
| ES2587963T3 (es) | 2009-07-31 | 2016-10-27 | Ethris Gmbh | ARN con una combinación de nucleótidos no modificados y modificados para la expresión de proteínas |
| WO2011154331A1 (en) | 2010-06-10 | 2011-12-15 | F. Hoffmann-La Roche Ag | Polymers for delivery of nucleic acids |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| US9931418B2 (en) | 2012-08-07 | 2018-04-03 | Northeastern University | Compositions for the delivery of RNA and drugs into cells |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| EP3034539A1 (en) | 2014-12-19 | 2016-06-22 | Ethris GmbH | Compositions for introducing nucleic acid into cells |
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| JP2018502956A (ja) | 2018-02-01 |
| CN107001627B (zh) | 2020-01-14 |
| WO2016097377A1 (en) | 2016-06-23 |
| CN107001627A (zh) | 2017-08-01 |
| AU2015366220B2 (en) | 2019-09-19 |
| CA2971284A1 (en) | 2016-06-23 |
| CA2971284C (en) | 2023-01-10 |
| RU2715227C2 (ru) | 2020-02-26 |
| DK3242903T3 (da) | 2021-09-27 |
| KR102142180B1 (ko) | 2020-08-07 |
| EP3034539A1 (en) | 2016-06-22 |
| JP6745272B2 (ja) | 2020-08-26 |
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| AU2015366220A1 (en) | 2017-06-01 |
| EP3242903A1 (en) | 2017-11-15 |
| RU2017122022A (ru) | 2018-12-24 |
| US11020487B2 (en) | 2021-06-01 |
| US20180236090A1 (en) | 2018-08-23 |
| KR20170097124A (ko) | 2017-08-25 |
| BR112017012482A2 (pt) | 2018-02-27 |
| EP3242903B1 (en) | 2021-07-28 |
| ES2887404T3 (es) | 2021-12-22 |
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