JP2011515472A5 - - Google Patents
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- Publication number
- JP2011515472A5 JP2011515472A5 JP2011501846A JP2011501846A JP2011515472A5 JP 2011515472 A5 JP2011515472 A5 JP 2011515472A5 JP 2011501846 A JP2011501846 A JP 2011501846A JP 2011501846 A JP2011501846 A JP 2011501846A JP 2011515472 A5 JP2011515472 A5 JP 2011515472A5
- Authority
- JP
- Japan
- Prior art keywords
- patent document
- bendamustine hydrochloride
- ribosepharm
- discloses
- bendamustine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZHSKUOZOLHMKEA-UHFFFAOYSA-N 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 ZHSKUOZOLHMKEA-UHFFFAOYSA-N 0.000 description 3
- 229960001215 bendamustine hydrochloride Drugs 0.000 description 3
- XKJMBINCVNINCA-UHFFFAOYSA-N Alfalone Chemical compound CON(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XKJMBINCVNINCA-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- TWBJYCLUHINEDN-UHFFFAOYSA-N 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydrate;hydrochloride Chemical compound O.Cl.ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 TWBJYCLUHINEDN-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960002707 bendamustine Drugs 0.000 description 1
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3975208P | 2008-03-26 | 2008-03-26 | |
| US61/039,752 | 2008-03-26 | ||
| PCT/US2009/001956 WO2009120386A2 (en) | 2008-03-26 | 2009-03-26 | Novel solid forms of bendamustine hydrochloride |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515472A JP2011515472A (ja) | 2011-05-19 |
| JP2011515472A5 true JP2011515472A5 (https=) | 2013-05-23 |
| JP5536753B2 JP5536753B2 (ja) | 2014-07-02 |
Family
ID=41051023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501846A Active JP5536753B2 (ja) | 2008-03-26 | 2009-03-26 | ベンダムスチン塩酸塩の新規固体形態 |
Country Status (12)
| Country | Link |
|---|---|
| US (9) | US20090264488A1 (https=) |
| EP (2) | EP2271315B1 (https=) |
| JP (1) | JP5536753B2 (https=) |
| CN (3) | CN101980698B (https=) |
| AR (1) | AR072777A1 (https=) |
| CA (1) | CA2718939A1 (https=) |
| CL (1) | CL2009000742A1 (https=) |
| ES (1) | ES2605205T3 (https=) |
| HK (1) | HK1220966A1 (https=) |
| MX (2) | MX339878B (https=) |
| TW (1) | TWI472515B (https=) |
| WO (1) | WO2009120386A2 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8436190B2 (en) * | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| EP2583670A1 (en) * | 2007-10-09 | 2013-04-24 | US Worldmeds LLC | Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| CA2735899A1 (en) * | 2008-09-25 | 2010-04-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
| UA107186C2 (xx) * | 2008-12-03 | 2014-12-10 | Тверді форми дозування бендамустину | |
| WO2010144675A1 (en) * | 2009-06-10 | 2010-12-16 | Plus Chemicals Sa | Polymorphs of bendamustine hcl and processes for preparation thereof |
| EP2516404A4 (en) | 2009-12-23 | 2013-04-17 | Reddys Lab Ltd Dr | PREPARATION OF BENDAMUSTINE AND ITS SALTS |
| SMT201700043T1 (it) | 2010-01-28 | 2017-03-08 | Eagle Pharmaceuticals Inc | Formulazioni di bendamustina |
| JO3659B1 (ar) | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| JO3587B1 (ar) | 2010-06-02 | 2020-07-05 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم |
| CN101948437B (zh) * | 2010-06-28 | 2012-08-29 | 江苏奥赛康药业股份有限公司 | 一种盐酸苯达莫司汀的精制方法 |
| EP2635558A4 (en) * | 2010-11-01 | 2014-08-06 | Shilpa Medicare Ltd | PROCESS FOR PREPARING BENDAMUSTINE HYDROCHLORIDE MONOHYDRATE |
| US20140142153A1 (en) * | 2011-01-25 | 2014-05-22 | Dr. Reddy's Laboratories, Inc. | Bendamustine formulations |
| AU2012212622A1 (en) * | 2011-01-31 | 2013-07-11 | Cephalon, Inc. | Methods for the preparation of bendamustine |
| EP2760842B1 (en) | 2011-09-26 | 2016-11-16 | Fresenius Kabi Oncology Ltd | An improved process for the preparation of bendamustine hydrochloride |
| CN102351799B (zh) * | 2011-10-24 | 2014-02-26 | 江苏奥赛康药业股份有限公司 | 一种盐酸苯达莫司汀晶型及其制备方法 |
| EP2617716A1 (en) | 2012-01-18 | 2013-07-24 | Arevipharma GmbH | Process for the preparation of bendamustine hydrochloride and related compounds |
| JP6250628B2 (ja) | 2012-03-20 | 2017-12-20 | イーグル・ファーマシューティカルズ・インコーポレーテッド | ベンダムスチンの製剤 |
| US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| CN104271135B (zh) | 2012-03-20 | 2017-05-17 | 赛多斯有限责任公司 | 在要求减少施用容量的患者中治疗苯达莫司汀响应性状况的方法 |
| WO2013150020A1 (en) | 2012-04-03 | 2013-10-10 | Synthon Bv | Process for making bendamustine |
| DK2656843T3 (en) | 2012-04-26 | 2015-04-20 | Helmut Schickaneder | Esters of bendamustine and related compounds, and medical use thereof |
| US9801859B2 (en) * | 2012-09-18 | 2017-10-31 | Innopharma Licensing, Llc | Bendamustine formulations |
| KR20150086308A (ko) | 2012-11-12 | 2015-07-27 | 이그니타, 인코포레이티드 | 벤다무스틴 유도체 및 그의 사용 방법 |
| EP2958554B1 (en) | 2013-02-19 | 2018-06-06 | Synthon BV | Stable compositions of bendamustine |
| US9315469B2 (en) | 2013-03-14 | 2016-04-19 | Johnson Matthey Public Limited Company | Process for drying bendamustine hydrochloride monohydrate |
| WO2014170769A2 (en) * | 2013-04-15 | 2014-10-23 | Shilpa Medicare Limited | Bendamustine lyophilized pharmaceutical compositions |
| EP3043648B1 (en) | 2013-08-27 | 2023-09-20 | Vasilios VOUDOURIS | Bendamustine pharmaceutical compositions |
| EP3116481A1 (en) | 2014-03-13 | 2017-01-18 | Vasilios VOUDOURIS | Bendamustine solid dispersions and continuous infusion |
| EP2985038A1 (en) | 2014-08-12 | 2016-02-17 | Azad Pharma AG | Lyophilized API preparation |
| US10342769B2 (en) | 2014-11-14 | 2019-07-09 | Navinta Iii Inc | Carmustine pharmaceutical composition |
| US9603930B2 (en) | 2014-12-04 | 2017-03-28 | Navinta, Llc | Liquid bendamustine formulation |
| ES2889902T3 (es) * | 2015-06-09 | 2022-01-14 | Rebiotix Inc | Métodos de fabricación de composiciones para terapia de restauración de la microbiota (TRM) |
| US10905677B2 (en) | 2016-08-31 | 2021-02-02 | Navinta, Llc | Bendamustine solution formulations |
| US11826466B2 (en) | 2016-08-31 | 2023-11-28 | Navinta, Llc | Bendamustine solution formulations |
| RU2020115024A (ru) | 2017-10-05 | 2021-11-08 | Тьюб Фармасьютикалз Гмбх | Препараты бендамустина для перорального введения |
| CN111093654B (zh) * | 2017-11-07 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 一种盐酸苯达莫司汀的晶体及其制备方法 |
| EA037673B1 (ru) * | 2018-07-04 | 2021-04-29 | Тютор С.А.С.И.Ф.И.А. | Способ получения фармацевтической композиции, содержащей бендамустин, фармацевтическая композиция бендамустина |
| EP3836921B1 (en) | 2018-08-17 | 2025-10-08 | Hospira Australia Pty Ltd | Liquid bendamustine pharmaceutical compositions |
| WO2022103639A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Methods of treating autoimmune or inflammatory conditions with cannabidiol or its derivatives/analogs |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| JP2024537431A (ja) | 2021-10-22 | 2024-10-10 | プロジェクト ファーマシューティクス ゲーエムベーハー | 液状薬学的製剤 |
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-
2009
- 2009-03-23 AR ARP090101039A patent/AR072777A1/es not_active Application Discontinuation
- 2009-03-26 TW TW098110003A patent/TWI472515B/zh active
- 2009-03-26 MX MX2013011045A patent/MX339878B/es unknown
- 2009-03-26 MX MX2010010398A patent/MX2010010398A/es active IP Right Grant
- 2009-03-26 EP EP09723661.6A patent/EP2271315B1/en active Active
- 2009-03-26 CN CN2009801107677A patent/CN101980698B/zh active Active
- 2009-03-26 EP EP16188467.1A patent/EP3150197A1/en not_active Withdrawn
- 2009-03-26 JP JP2011501846A patent/JP5536753B2/ja active Active
- 2009-03-26 WO PCT/US2009/001956 patent/WO2009120386A2/en not_active Ceased
- 2009-03-26 CA CA2718939A patent/CA2718939A1/en not_active Abandoned
- 2009-03-26 US US12/411,929 patent/US20090264488A1/en not_active Abandoned
- 2009-03-26 CL CL2009000742A patent/CL2009000742A1/es unknown
- 2009-03-26 CN CN201610027378.XA patent/CN105693620A/zh active Pending
- 2009-03-26 CN CN201310415249.4A patent/CN103550159B/zh active Active
- 2009-03-26 ES ES09723661.6T patent/ES2605205T3/es active Active
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2011
- 2011-11-22 US US13/301,979 patent/US8445524B2/en active Active
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2013
- 2013-05-01 US US13/874,575 patent/US8669279B2/en active Active
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2014
- 2014-03-07 US US14/200,738 patent/US8883836B2/en active Active
- 2014-11-03 US US14/531,023 patent/US20150051258A1/en not_active Abandoned
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2016
- 2016-02-17 US US15/045,523 patent/US9533955B2/en active Active
- 2016-07-26 HK HK16108932.6A patent/HK1220966A1/zh unknown
- 2016-11-23 US US15/359,777 patent/US10039750B2/en active Active
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2018
- 2018-07-17 US US16/037,560 patent/US10517852B2/en active Active
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2019
- 2019-11-18 US US16/686,751 patent/US20200323824A1/en not_active Abandoned
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