CN113412260A - 己酮糖激酶抑制剂及其用途 - Google Patents
己酮糖激酶抑制剂及其用途 Download PDFInfo
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- CN113412260A CN113412260A CN202080008816.2A CN202080008816A CN113412260A CN 113412260 A CN113412260 A CN 113412260A CN 202080008816 A CN202080008816 A CN 202080008816A CN 113412260 A CN113412260 A CN 113412260A
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Abstract
本发明涉及医药技术领域，具体涉及己酮糖激酶抑制剂化合物、其药学上可接受的盐、其酯或其立体异构体，含有所述化合物、其药学上可接受的盐、其酯或其立体异构体的药物组合物及制剂，制备所述化合物、其药学上可接受的盐、其酯或其立体异构体的方法，以及所述化合物、其药学上可接受的盐、其酯或其立体异构体在制备治疗和/或预防由KHK介导的疾病及相关疾病的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
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| CN201910085547 | 2019-01-29 | ||
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| CN2019103164171 | 2019-04-19 | ||
| CN201910985433X | 2019-10-17 | ||
| CN201910985433 | 2019-10-17 | ||
| PCT/CN2020/073813 WO2020156445A1 (zh) | 2019-01-29 | 2020-01-22 | 己酮糖激酶抑制剂及其用途 |
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| CN113412260A true CN113412260A (zh) | 2021-09-17 |
| CN113412260B CN113412260B (zh) | 2022-08-02 |
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| CN202080008816.2A Active CN113412260B (zh) | 2019-01-29 | 2020-01-22 | 己酮糖激酶抑制剂及其用途 |
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| US (1) | US20220106299A1 (zh) |
| EP (1) | EP3919484B1 (zh) |
| JP (1) | JP7248255B2 (zh) |
| KR (1) | KR102686216B1 (zh) |
| CN (2) | CN116023365A (zh) |
| AU (1) | AU2020214064B2 (zh) |
| CA (1) | CA3127130A1 (zh) |
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| WO (1) | WO2020156445A1 (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114846009A (zh) * | 2019-12-24 | 2022-08-02 | 杭州中美华东制药有限公司 | 具有khk抑制作用的化合物 |
| CN115667244A (zh) * | 2020-04-20 | 2023-01-31 | 株式会社Lg化学 | 3-氮杂二环烷基衍生物及包含其的药物组合物 |
| CN116023365A (zh) * | 2019-01-29 | 2023-04-28 | 轩竹生物科技股份有限公司 | 己酮糖激酶抑制剂及其用途 |
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| GB202001856D0 (en) | 2020-02-11 | 2020-03-25 | Inorbit Therapeutics Ab | Compounds useful in inhibiting ketohexokinase and methods of making and using the same |
| EP4190776A4 (en) * | 2020-07-28 | 2024-02-28 | Shandong Xuanzhu Pharma Co., Ltd. | SALT AND CRYSTAL FORM OF A KETOHEXOCINASE INHIBITOR AND USE THEREOF |
| CN114181198A (zh) * | 2020-09-15 | 2022-03-15 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类己酮糖激酶抑制剂及其用途 |
| CN112028839B (zh) * | 2020-09-30 | 2022-04-12 | 中国海洋大学 | 一种医药中间体环烷烃并嘧啶二酮化合物的合成方法 |
| CN116635377A (zh) | 2020-12-25 | 2023-08-22 | 四川海思科制药有限公司 | 己酮糖激酶抑制剂及其用途 |
| AU2022252182A1 (en) | 2021-03-29 | 2023-09-28 | Gilead Sciences, Inc. | Khk inhibitors |
| WO2022211595A1 (ko) * | 2021-04-01 | 2022-10-06 | 주식회사 엘지화학 | 옥사디아졸 화합물 및 이를 포함하는 약제학적 조성물 |
| WO2022262841A1 (zh) * | 2021-06-17 | 2022-12-22 | 杭州中美华东制药有限公司 | 一种螺环化合物的盐型、晶型及其制备方法 |
| WO2023121378A1 (ko) * | 2021-12-24 | 2023-06-29 | 주식회사 엘지화학 | (s)-2-(2-메틸아제티딘-1-일)피리미딘 유도체 및 이를 포함하는 약제학적 조성물 |
| WO2023151473A1 (zh) * | 2022-02-09 | 2023-08-17 | 上海研健新药研发有限公司 | 一种khk抑制剂，其制备方法和应用 |
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- 2020-01-22 EP EP20749439.4A patent/EP3919484B1/en active Active
- 2020-01-22 CN CN202210795995.XA patent/CN116023365A/zh active Pending
- 2020-01-22 CA CA3127130A patent/CA3127130A1/en active Pending
- 2020-01-22 WO PCT/CN2020/073813 patent/WO2020156445A1/zh active Application Filing
- 2020-01-22 JP JP2021543534A patent/JP7248255B2/ja active Active
- 2020-01-22 CN CN202080008816.2A patent/CN113412260B/zh active Active
- 2020-01-22 AU AU2020214064A patent/AU2020214064B2/en active Active
- 2020-01-22 SG SG11202107389SA patent/SG11202107389SA/en unknown
- 2020-01-22 US US17/426,675 patent/US20220106299A1/en active Pending
- 2020-01-22 KR KR1020217027576A patent/KR102686216B1/ko active IP Right Grant
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| CN116023365A (zh) * | 2019-01-29 | 2023-04-28 | 轩竹生物科技股份有限公司 | 己酮糖激酶抑制剂及其用途 |
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| CN114846009B (zh) * | 2019-12-24 | 2023-12-12 | 杭州中美华东制药有限公司 | 具有khk抑制作用的化合物 |
| CN115667244A (zh) * | 2020-04-20 | 2023-01-31 | 株式会社Lg化学 | 3-氮杂二环烷基衍生物及包含其的药物组合物 |
| CN115667244B (zh) * | 2020-04-20 | 2024-04-12 | 株式会社Lg化学 | 3-氮杂二环烷基衍生物及包含其的药物组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102686216B1 (ko) | 2024-07-19 |
| CA3127130A1 (en) | 2020-08-06 |
| WO2020156445A1 (zh) | 2020-08-06 |
| AU2020214064A1 (en) | 2021-08-05 |
| CN113412260B (zh) | 2022-08-02 |
| CN116023365A (zh) | 2023-04-28 |
| US20220106299A1 (en) | 2022-04-07 |
| SG11202107389SA (en) | 2021-08-30 |
| KR20210120080A (ko) | 2021-10-06 |
| EP3919484A1 (en) | 2021-12-08 |
| JP2022518823A (ja) | 2022-03-16 |
| EP3919484B1 (en) | 2023-05-24 |
| JP7248255B2 (ja) | 2023-03-29 |
| AU2020214064B2 (en) | 2022-10-20 |
| EP3919484A4 (en) | 2021-12-08 |
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