JP2018529717A5 - - Google Patents

Info

Publication number

JP2018529717A5

JP2018529717A5 JP2018516214A JP2018516214A JP2018529717A5 JP 2018529717 A5 JP2018529717 A5 JP 2018529717A5 JP 2018516214 A JP2018516214 A JP 2018516214A JP 2018516214 A JP2018516214 A JP 2018516214A JP 2018529717 A5 JP2018529717 A5 JP 2018529717A5

Authority

JP

Japan

Prior art keywords

alkyl

pharmaceutically acceptable

acceptable salt

antigen

compound

Prior art date

2016-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims 20
• 125000000217 alkyl group Chemical group 0.000 claims 19
• 150000001875 compounds Chemical class 0.000 claims 19
• 102000036639 antigens Human genes 0.000 claims 16
• 108091007433 antigens Proteins 0.000 claims 16
• 239000000427 antigen Substances 0.000 claims 15
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 239000012646 vaccine adjuvant Substances 0.000 claims 8
• 229940124931 vaccine adjuvant Drugs 0.000 claims 8
• 125000003545 alkoxy group Chemical group 0.000 claims 5
• 125000005843 halogen group Chemical group 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 125000002947 alkylene group Chemical group 0.000 claims 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• 125000004430 oxygen atom Chemical group O* 0.000 claims 4
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
• 239000007764 o/w emulsion Substances 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 125000004434 sulfur atom Chemical group 0.000 claims 3
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
• CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 2
• 244000052769 pathogen Species 0.000 claims 2
• 230000001717 pathogenic effect Effects 0.000 claims 2
• 229920001993 poloxamer 188 Polymers 0.000 claims 2
• 229940044519 poloxamer 188 Drugs 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 229940031439 squalene Drugs 0.000 claims 2
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 2
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
• KMBRETKMIXPCMR-GITNALPWSA-N 6-amino-2-(2,3-dihydroxypropoxy)-9-[[4-[[[(4E,8E,12E,16E,20E)-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaenyl]-methylamino]methyl]phenyl]methyl]-7H-purin-8-one Chemical compound CN(CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)Cc1ccc(Cn2c3nc(OCC(O)CO)nc(N)c3[nH]c2=O)cc1 KMBRETKMIXPCMR-GITNALPWSA-N 0.000 claims 1
• 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 1
• 239000004147 Sorbitan trioleate Substances 0.000 claims 1
• ZBNRGEMZNWHCGA-WECPCUOASA-N [(2R)-2-hydroxy-2-[(2R,3R,4S)-4-[(Z)-octadec-9-enoyl]oxy-3-[(E)-octadec-9-enoyl]oxyoxolan-2-yl]ethyl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC(=O)CCCCCCC\C=C\CCCCCCCC ZBNRGEMZNWHCGA-WECPCUOASA-N 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 238000002619 cancer immunotherapy Methods 0.000 claims 1
• 239000012830 cancer therapeutic Substances 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 239000003623 enhancer Substances 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 230000003308 immunostimulating effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 229960000391 sorbitan trioleate Drugs 0.000 claims 1
• 235000019337 sorbitan trioleate Nutrition 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 125000000547 substituted alkyl group Chemical group 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1