CL2009000742A1 - Forma solida cristalina de clorhidrato de bendamustina, designada como forma 1; composicion farmaceutica que la comprende; metodo de preparacion de la composicion farmaceutica; y uso en el tratamiento de leucemia linfocitica cronica, enfermedad de hodgkin, linfoma no hodgkiniano, mieloma multiple o cancer de mama. - Google Patents
Forma solida cristalina de clorhidrato de bendamustina, designada como forma 1; composicion farmaceutica que la comprende; metodo de preparacion de la composicion farmaceutica; y uso en el tratamiento de leucemia linfocitica cronica, enfermedad de hodgkin, linfoma no hodgkiniano, mieloma multiple o cancer de mama.Info
- Publication number
- CL2009000742A1 CL2009000742A1 CL2009000742A CL2009000742A CL2009000742A1 CL 2009000742 A1 CL2009000742 A1 CL 2009000742A1 CL 2009000742 A CL2009000742 A CL 2009000742A CL 2009000742 A CL2009000742 A CL 2009000742A CL 2009000742 A1 CL2009000742 A1 CL 2009000742A1
- Authority
- CL
- Chile
- Prior art keywords
- hodgkin
- pharmaceutical composition
- lymphoma
- disease
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- ZHSKUOZOLHMKEA-UHFFFAOYSA-N 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 ZHSKUOZOLHMKEA-UHFFFAOYSA-N 0.000 title abstract 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 title abstract 2
- 206010006187 Breast cancer Diseases 0.000 title abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 2
- 208000017604 Hodgkin disease Diseases 0.000 title abstract 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 title abstract 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 title abstract 2
- 208000034578 Multiple myelomas Diseases 0.000 title abstract 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 title abstract 2
- 206010035226 Plasma cell myeloma Diseases 0.000 title abstract 2
- 229960001215 bendamustine hydrochloride Drugs 0.000 title abstract 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3975208P | 2008-03-26 | 2008-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000742A1 true CL2009000742A1 (es) | 2009-11-13 |
Family
ID=41051023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000742A CL2009000742A1 (es) | 2008-03-26 | 2009-03-26 | Forma solida cristalina de clorhidrato de bendamustina, designada como forma 1; composicion farmaceutica que la comprende; metodo de preparacion de la composicion farmaceutica; y uso en el tratamiento de leucemia linfocitica cronica, enfermedad de hodgkin, linfoma no hodgkiniano, mieloma multiple o cancer de mama. |
Country Status (12)
| Country | Link |
|---|---|
| US (9) | US20090264488A1 (https=) |
| EP (2) | EP2271315B1 (https=) |
| JP (1) | JP5536753B2 (https=) |
| CN (3) | CN105693620A (https=) |
| AR (1) | AR072777A1 (https=) |
| CA (1) | CA2718939A1 (https=) |
| CL (1) | CL2009000742A1 (https=) |
| ES (1) | ES2605205T3 (https=) |
| HK (1) | HK1220966A1 (https=) |
| MX (2) | MX339878B (https=) |
| TW (1) | TWI472515B (https=) |
| WO (1) | WO2009120386A2 (https=) |
Families Citing this family (42)
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| US8436190B2 (en) * | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| EP2219605B1 (en) * | 2007-10-09 | 2015-08-19 | US Worldmeds LLC | Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| EP2326306A1 (en) * | 2008-09-25 | 2011-06-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
| UA107186C2 (xx) * | 2008-12-03 | 2014-12-10 | Тверді форми дозування бендамустину | |
| WO2010144675A1 (en) * | 2009-06-10 | 2010-12-16 | Plus Chemicals Sa | Polymorphs of bendamustine hcl and processes for preparation thereof |
| EP2516404A4 (en) | 2009-12-23 | 2013-04-17 | Reddys Lab Ltd Dr | PREPARATION OF BENDAMUSTINE AND ITS SALTS |
| PL3158991T3 (pl) | 2010-01-28 | 2021-09-27 | Eagle Pharmaceuticals, Inc. | Preparaty bendamustyny |
| US20130202693A1 (en) | 2010-06-02 | 2013-08-08 | Astellas Deutschland Gmbh | Oral Dosage Forms of Bendamustine |
| JO3659B1 (ar) | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| CN101948437B (zh) * | 2010-06-28 | 2012-08-29 | 江苏奥赛康药业股份有限公司 | 一种盐酸苯达莫司汀的精制方法 |
| US20130217888A1 (en) | 2010-11-01 | 2013-08-22 | Shailpa Medicare Limited | Process for preparing bendamus tine hydrochloride monohydrate |
| WO2012103226A2 (en) * | 2011-01-25 | 2012-08-02 | Dr. Reddy's Laboratories Ltd. | Bendamustine formulations |
| WO2012106117A1 (en) * | 2011-01-31 | 2012-08-09 | Cephalon, Inc. | Methods for the preparation of bendamustine |
| EP2760842B1 (en) | 2011-09-26 | 2016-11-16 | Fresenius Kabi Oncology Ltd | An improved process for the preparation of bendamustine hydrochloride |
| CN102351799B (zh) * | 2011-10-24 | 2014-02-26 | 江苏奥赛康药业股份有限公司 | 一种盐酸苯达莫司汀晶型及其制备方法 |
| EP2617716A1 (en) | 2012-01-18 | 2013-07-24 | Arevipharma GmbH | Process for the preparation of bendamustine hydrochloride and related compounds |
| CA2867295C (en) | 2012-03-20 | 2020-08-11 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| PL2827863T3 (pl) | 2012-03-20 | 2019-07-31 | Eagle Pharmaceuticals, Inc. | Ciekła kompozycja do zastosowania w sposobie leczenia stanów reagujących na bendamustynę u pacjentów wymagających obniżonych objętości do podawania |
| US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| WO2013150020A1 (en) | 2012-04-03 | 2013-10-10 | Synthon Bv | Process for making bendamustine |
| PT2656843E (pt) | 2012-04-26 | 2015-04-14 | Helmut Schickaneder | Ésteres de bendamustina e compostos relacionados e a sua utilização médica |
| US9801859B2 (en) * | 2012-09-18 | 2017-10-31 | Innopharma Licensing, Llc | Bendamustine formulations |
| BR112015010501A2 (pt) | 2012-11-12 | 2017-07-11 | Ignyta Inc | composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada |
| EP2958554B1 (en) | 2013-02-19 | 2018-06-06 | Synthon BV | Stable compositions of bendamustine |
| US9315469B2 (en) | 2013-03-14 | 2016-04-19 | Johnson Matthey Public Limited Company | Process for drying bendamustine hydrochloride monohydrate |
| WO2014170769A2 (en) * | 2013-04-15 | 2014-10-23 | Shilpa Medicare Limited | Bendamustine lyophilized pharmaceutical compositions |
| ES2957541T3 (es) | 2013-08-27 | 2024-01-22 | Vasilios Voudouris | Composiciones farmacéuticas de bendamustina |
| CA2941632C (en) | 2014-03-13 | 2023-10-24 | Vasilios VOUDOURIS | Bendamustine solid dispersions and continuous infusion |
| EP2985038A1 (en) | 2014-08-12 | 2016-02-17 | Azad Pharma AG | Lyophilized API preparation |
| US10342769B2 (en) | 2014-11-14 | 2019-07-09 | Navinta Iii Inc | Carmustine pharmaceutical composition |
| US9603930B2 (en) | 2014-12-04 | 2017-03-28 | Navinta, Llc | Liquid bendamustine formulation |
| CN107921072A (zh) * | 2015-06-09 | 2018-04-17 | 雷柏奥提斯有限公司 | 微生物群恢复治疗（mrt）组合物和制造方法 |
| US10905677B2 (en) | 2016-08-31 | 2021-02-02 | Navinta, Llc | Bendamustine solution formulations |
| US11826466B2 (en) | 2016-08-31 | 2023-11-28 | Navinta, Llc | Bendamustine solution formulations |
| SG11202003098WA (en) | 2017-10-05 | 2020-05-28 | Tube Pharmaceuticals Gmbh | Oral bendamustine formulations |
| WO2019091373A1 (zh) * | 2017-11-07 | 2019-05-16 | 江苏恒瑞医药股份有限公司 | 一种盐酸苯达莫司汀的晶体及其制备方法 |
| EA037673B1 (ru) * | 2018-07-04 | 2021-04-29 | Тютор С.А.С.И.Ф.И.А. | Способ получения фармацевтической композиции, содержащей бендамустин, фармацевтическая композиция бендамустина |
| ES3055021T3 (en) | 2018-08-17 | 2026-02-09 | Hospira Australia Pty Ltd | Liquid bendamustine pharmaceutical compositions |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
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| EP1444989A1 (en) | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
| CA2516191A1 (en) * | 2003-02-14 | 2004-09-02 | Salmedix, Inc | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers |
| CN1829514A (zh) * | 2003-07-25 | 2006-09-06 | 惠氏公司 | Cci－779冻干制剂 |
| JP2008519047A (ja) | 2004-11-05 | 2008-06-05 | セフアロン・インコーポレーテツド | 癌処置 |
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| UA94036C2 (ru) * | 2005-01-14 | 2011-04-11 | Сефалон, Инк. | Фармацевтическая композиция бендамустина, предназначенная для лиофилизации |
| US8436190B2 (en) * | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
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| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| ITUD20070130A1 (it) | 2007-07-23 | 2009-01-24 | C M E Spa Sa | Macchina e procedimento per la produzione di elementi strutturali per l'edilizia in materiale cementizio aventi uno o piu' inserti in materiale polimerico |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| EP2326306A1 (en) | 2008-09-25 | 2011-06-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
| MX2011011109A (es) | 2009-04-28 | 2011-11-18 | Cephalon Inc | Formulaciones orales de bendamustina. |
-
2009
- 2009-03-23 AR ARP090101039A patent/AR072777A1/es not_active Application Discontinuation
- 2009-03-26 CN CN201610027378.XA patent/CN105693620A/zh active Pending
- 2009-03-26 ES ES09723661.6T patent/ES2605205T3/es active Active
- 2009-03-26 WO PCT/US2009/001956 patent/WO2009120386A2/en not_active Ceased
- 2009-03-26 CN CN2009801107677A patent/CN101980698B/zh active Active
- 2009-03-26 TW TW098110003A patent/TWI472515B/zh active
- 2009-03-26 CN CN201310415249.4A patent/CN103550159B/zh active Active
- 2009-03-26 US US12/411,929 patent/US20090264488A1/en not_active Abandoned
- 2009-03-26 EP EP09723661.6A patent/EP2271315B1/en active Active
- 2009-03-26 CL CL2009000742A patent/CL2009000742A1/es unknown
- 2009-03-26 MX MX2013011045A patent/MX339878B/es unknown
- 2009-03-26 EP EP16188467.1A patent/EP3150197A1/en not_active Withdrawn
- 2009-03-26 JP JP2011501846A patent/JP5536753B2/ja active Active
- 2009-03-26 MX MX2010010398A patent/MX2010010398A/es active IP Right Grant
- 2009-03-26 CA CA2718939A patent/CA2718939A1/en not_active Abandoned
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2011
- 2011-11-22 US US13/301,979 patent/US8445524B2/en active Active
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2013
- 2013-05-01 US US13/874,575 patent/US8669279B2/en active Active
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2014
- 2014-03-07 US US14/200,738 patent/US8883836B2/en active Active
- 2014-11-03 US US14/531,023 patent/US20150051258A1/en not_active Abandoned
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2016
- 2016-02-17 US US15/045,523 patent/US9533955B2/en active Active
- 2016-07-26 HK HK16108932.6A patent/HK1220966A1/zh unknown
- 2016-11-23 US US15/359,777 patent/US10039750B2/en active Active
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2018
- 2018-07-17 US US16/037,560 patent/US10517852B2/en active Active
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2019
- 2019-11-18 US US16/686,751 patent/US20200323824A1/en not_active Abandoned
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