JO3587B1 - أشكال جرعات بينداموستين عن طريق الفم - Google Patents

أشكال جرعات بينداموستين عن طريق الفم

Info

Publication number
JO3587B1
JO3587B1 JOP/2011/0180A JOP20110180A JO3587B1 JO 3587 B1 JO3587 B1 JO 3587B1 JO P20110180 A JOP20110180 A JO P20110180A JO 3587 B1 JO3587 B1 JO 3587B1
Authority
JO
Jordan
Prior art keywords
bendamustine
dosage forms
oral dosage
pharmaceutically acceptable
solvate
Prior art date
Application number
JOP/2011/0180A
Other languages
English (en)
Inventor
Margaretha Olthoff
Jeffrey Colledge
Original Assignee
Astellas Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44243599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3587(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astellas Deutschland Gmbh filed Critical Astellas Deutschland Gmbh
Application granted granted Critical
Publication of JO3587B1 publication Critical patent/JO3587B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بتركيبة صيدلانية تؤخذ عن طريق الفم، وتشتمل على بنداميوستين أو إستر أو ملح أو ذوابة منه مقبولين صيدلانيًا كمكون فعال، وسواغ مقبول صيدلانيًا، يكون عبارة عن مادة خافضة للتوتر السطحي آلفة للماء وغير أيونية مقبولة صيدلانيًا.
JOP/2011/0180A 2010-06-02 2011-06-01 أشكال جرعات بينداموستين عن طريق الفم JO3587B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10075231 2010-06-02
EP11075047 2011-03-14

Publications (1)

Publication Number Publication Date
JO3587B1 true JO3587B1 (ar) 2020-07-05

Family

ID=44243599

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2011/0180A JO3587B1 (ar) 2010-06-02 2011-06-01 أشكال جرعات بينداموستين عن طريق الفم

Country Status (26)

Country Link
US (2) US20130202693A1 (ar)
EP (1) EP2575784B1 (ar)
JP (2) JP6209446B2 (ar)
KR (1) KR101830142B1 (ar)
CN (1) CN103037851A (ar)
AR (1) AR081835A1 (ar)
AU (1) AU2011260615B2 (ar)
BR (1) BR112012030654B1 (ar)
CA (1) CA2800279A1 (ar)
CL (1) CL2012003341A1 (ar)
CO (1) CO6640318A2 (ar)
DK (1) DK2575784T3 (ar)
EA (1) EA031793B1 (ar)
ES (1) ES2690257T3 (ar)
IL (1) IL223311B (ar)
JO (1) JO3587B1 (ar)
MX (1) MX2012013872A (ar)
MY (1) MY173873A (ar)
NZ (1) NZ603872A (ar)
PH (1) PH12012502281B1 (ar)
PL (1) PL2575784T3 (ar)
PT (1) PT2575784T (ar)
SG (1) SG186099A1 (ar)
TW (1) TWI500431B (ar)
WO (1) WO2011151087A1 (ar)
ZA (1) ZA201208823B (ar)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130210879A1 (en) * 2012-02-14 2013-08-15 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
EP2641592A1 (en) 2012-03-23 2013-09-25 Salmon Pharma GmbH Pharmaceutical formulation comprising bendamustine
CA2873646C (en) * 2012-05-18 2022-04-26 Genentech, Inc. High-concentration monoclonal antibody formulations
GB201212010D0 (en) * 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
CA2890462A1 (en) 2012-11-12 2014-05-15 Ignyta, Inc. Bendamustine derivatives and methods of using same
HK1216240A1 (zh) 2012-11-14 2016-10-28 W. R. Grace & Co.-Conn. 含有生物活性材料与无序无机氧化物的组合物
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions

Family Cites Families (28)

* Cited by examiner, † Cited by third party
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DE159289C (ar) * 1903-10-08 1905-03-16
US20030044434A1 (en) * 1997-07-29 2003-03-06 Ping Gao Self-emulsifying formulation for lipophilic compounds
FR2781373B1 (fr) * 1998-07-07 2001-09-21 Pf Medicament Formulations thixotropes pour le remplissage de gelules
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
AU2002258013A1 (en) 2001-04-10 2002-10-28 Fakhreddin Jamali Animal model for evaluating analgesics
US20030105141A1 (en) * 2001-04-17 2003-06-05 Ping Gao Finely self-emulsifiable pharmaceutical composition
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
US7423004B2 (en) 2003-01-31 2008-09-09 Smithkline Beecham Corporation Solid dispersion compositions
JP2006514119A (ja) 2003-02-12 2006-04-27 アール アンド ピー コリア カンパニー リミテッド 溶解率が向上した難溶性薬剤の溶媒系
US7871607B2 (en) * 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
CN101052396A (zh) * 2004-11-05 2007-10-10 赛福伦公司 癌症治疗
TW200621240A (en) * 2004-11-05 2006-07-01 Salmedix Inc Cancer treatments
EP1674082A1 (de) * 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
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CA2656540A1 (en) * 2006-06-30 2008-01-10 Mcneil-Ppc, Inc. Ibuprofen-containing liquid filled hard capsules
EP2144601A4 (en) * 2007-04-05 2012-10-10 Univ Kansas RAPID DISSOLVING PHARMACEUTICAL COMPOSITIONS COMPRISING PULLULANE
CA2692977A1 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
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KR100913644B1 (ko) 2007-10-09 2009-08-24 제일약품주식회사 활성성분으로 시부트라민 유리염기를 함유하는 약제학적조성물 및 그 제조방법
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
RS57142B1 (sr) * 2008-06-06 2018-07-31 Boehringer Ingelheim Int Farmaceutski dozni oblik u vidu kapsule koji sadrži formulaciju suspenzije indolinon derivata
US8349353B2 (en) * 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
UA107186C2 (xx) * 2008-12-03 2014-12-10 Тверді форми дозування бендамустину
BRPI0922806B8 (pt) * 2008-12-03 2021-05-25 Astellas Deutschland Gmbh composição farmacêutica oral compreendendo bendamustina
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Also Published As

Publication number Publication date
JP2013527207A (ja) 2013-06-27
US20150374670A1 (en) 2015-12-31
AR081835A1 (es) 2012-10-24
WO2011151087A1 (en) 2011-12-08
NZ603872A (en) 2014-07-25
US10993933B2 (en) 2021-05-04
BR112012030654A2 (pt) 2016-08-16
KR20130086157A (ko) 2013-07-31
DK2575784T3 (en) 2018-10-15
ES2690257T3 (es) 2018-11-20
MY173873A (en) 2020-02-25
EP2575784A1 (en) 2013-04-10
CL2012003341A1 (es) 2013-06-28
CN103037851A (zh) 2013-04-10
TWI500431B (zh) 2015-09-21
MX2012013872A (es) 2013-04-03
CO6640318A2 (es) 2013-03-22
JP6209446B2 (ja) 2017-10-04
US20130202693A1 (en) 2013-08-08
TW201210635A (en) 2012-03-16
PH12012502281B1 (en) 2017-10-20
EA201291104A1 (ru) 2013-06-28
KR101830142B1 (ko) 2018-02-20
PT2575784T (pt) 2018-10-26
BR112012030654B1 (pt) 2021-11-09
CA2800279A1 (en) 2011-12-08
IL223311B (en) 2018-04-30
JP6373300B2 (ja) 2018-08-15
JP2016153438A (ja) 2016-08-25
PH12012502281A1 (en) 2013-02-11
IL223311A0 (en) 2013-02-03
ZA201208823B (en) 2014-01-29
EA031793B1 (ru) 2019-02-28
AU2011260615B2 (en) 2016-11-17
AU2011260615A1 (en) 2013-01-10
SG186099A1 (en) 2013-01-30
PL2575784T3 (pl) 2019-03-29
EP2575784B1 (en) 2018-08-08

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