BRPI1004922A2 - composição farmacêutica, forma cristalina da base livre de bendamustina e método de tratamento de leucemia linfocítica crônica, doença de hodgkin, linfoma não-hodgkin, mieloma múltiplo ou câncer da mama - Google Patents
composição farmacêutica, forma cristalina da base livre de bendamustina e método de tratamento de leucemia linfocítica crônica, doença de hodgkin, linfoma não-hodgkin, mieloma múltiplo ou câncer da mamaInfo
- Publication number
- BRPI1004922A2 BRPI1004922A2 BRPI1004922A BRPI1004922A BRPI1004922A2 BR PI1004922 A2 BRPI1004922 A2 BR PI1004922A2 BR PI1004922 A BRPI1004922 A BR PI1004922A BR PI1004922 A BRPI1004922 A BR PI1004922A BR PI1004922 A2 BRPI1004922 A2 BR PI1004922A2
- Authority
- BR
- Brazil
- Prior art keywords
- hodgkin
- lymphoma
- disease
- treatment
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14484309P | 2009-01-15 | 2009-01-15 | |
PCT/US2010/020992 WO2010083276A1 (en) | 2009-01-15 | 2010-01-14 | Novel forms of bendamustine free base |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1004922A2 true BRPI1004922A2 (pt) | 2019-09-24 |
Family
ID=42008533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1004922A BRPI1004922A2 (pt) | 2009-01-15 | 2010-01-14 | composição farmacêutica, forma cristalina da base livre de bendamustina e método de tratamento de leucemia linfocítica crônica, doença de hodgkin, linfoma não-hodgkin, mieloma múltiplo ou câncer da mama |
Country Status (16)
Country | Link |
---|---|
US (1) | US8076366B2 (pt) |
EP (1) | EP2387400A1 (pt) |
JP (1) | JP2012515210A (pt) |
KR (1) | KR20110110293A (pt) |
CN (2) | CN103554030A (pt) |
AU (2) | AU2010204765A1 (pt) |
BR (1) | BRPI1004922A2 (pt) |
CA (1) | CA2749101A1 (pt) |
EA (1) | EA020767B1 (pt) |
IL (1) | IL213725A0 (pt) |
MX (1) | MX2011007557A (pt) |
NZ (1) | NZ594010A (pt) |
SG (1) | SG172810A1 (pt) |
UA (1) | UA109109C2 (pt) |
WO (1) | WO2010083276A1 (pt) |
ZA (1) | ZA201105099B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2516404A4 (en) * | 2009-12-23 | 2013-04-17 | Reddys Lab Ltd Dr | PREPARATION OF BENDAMUSTINE AND ITS SALTS |
LT2528602T (lt) | 2010-01-28 | 2017-02-27 | Eagle Pharmaceuticals, Inc. | Bendamustino kompozicijos |
US9273010B2 (en) * | 2011-06-20 | 2016-03-01 | Hetero Research Foundation | Process for bendamustine hydrochloride |
HUE062230T2 (hu) | 2012-03-20 | 2023-10-28 | Eagle Pharmaceuticals Inc | Bendamusztin folyékony készítmények bendamusztinra reagáló állapotok kezelési eljárásban történõ alkalmazásra, ahol a betegek csökkentett térfogatú bevitelre szorulnak |
CA2867295C (en) * | 2012-03-20 | 2020-08-11 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
JP6412676B2 (ja) * | 2013-03-12 | 2018-10-24 | セファロン、インク. | ナノ粒子及びナノ粒子製剤 |
CN105142497B (zh) | 2013-04-26 | 2018-01-12 | 维塔尔艺术与科学有限责任公司 | 轮廓线融合视野检查视力测试 |
US20240148696A1 (en) | 2022-10-25 | 2024-05-09 | Softkemo Pharma Inc. | Lyophilized bendamustine-cyclodextrin composition |
Family Cites Families (40)
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---|---|---|---|---|
DE159877C (pt) | ||||
DE80967C (pt) | ||||
DE159289C (pt) | 1903-10-08 | 1905-03-16 | ||
DE293808C (pt) | ||||
DD159289A1 (de) | 1981-06-01 | 1983-03-02 | Uwe Olthoff | Verfahren zur herstellung stabiler injektionsloesungen von n-lostverbindungen |
DD159877A1 (de) * | 1981-06-12 | 1983-04-13 | Wolfgang Krueger | Verfahren zur herstellung von 4-[1-methyl-5-bis(2-chloraethyl)amino-benzimidazolyl-2]-buttersaeure |
US5204335A (en) | 1986-10-31 | 1993-04-20 | Asta Pharma Aktiengesellschaft | Ifosfamide lyophilisate and process for its preparation |
US5227373A (en) | 1991-10-23 | 1993-07-13 | Bristol-Myers Squibb Co. | Lyophilized ifosfamide compositions |
EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
AU688792B2 (en) | 1993-10-27 | 1998-03-19 | Pharmacia & Upjohn Company | Stabilized prostaglandin e1 |
US5561121A (en) | 1993-11-09 | 1996-10-01 | American Cyanamid Company | Stable lyophilized thiotepa composition |
US5955504A (en) | 1995-03-13 | 1999-09-21 | Loma Linda University Medical Center | Colorectal chemoprotective composition and method of preventing colorectal cancer |
DE19529057B4 (de) | 1995-08-08 | 2007-12-13 | Baxter Healthcare S.A. | Ifosfamid-Lyophilisat-Zubereitungen |
US6077850A (en) | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
US20040072889A1 (en) | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
US6034256A (en) | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
NZ509376A (en) | 1998-07-09 | 2003-10-31 | Francis A Nardella | Indole or carbazole derivatives for the treatment of chronic lyphocytic leukemia |
US5972912A (en) | 1998-12-17 | 1999-10-26 | S.P. Pharmaceuticals | Method for lyophilizing ifosfamide |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
DE10016077A1 (de) | 2000-03-31 | 2001-12-13 | Cellcontrol Biomedical Lab Gmb | Verfahren und Vorrichtung zum automatischen Nachweisen einer Wirkung eines zellbeeinflussenden Mittels auf lebende Zellen |
US20040152672A1 (en) | 2000-08-09 | 2004-08-05 | Carson Dennis A. | Indole compounds useful for the treatment of cancer |
WO2002048141A1 (en) | 2000-12-11 | 2002-06-20 | Takeda Chemical Industries, Ltd. | Medicinal compositions improved in solublity in water |
AU2002221115A1 (en) | 2000-12-11 | 2002-06-24 | Takeda Chemical Industries Ltd. | Medicinal compositions having improved absorbability |
CN1568166A (zh) | 2001-10-15 | 2005-01-19 | 荷姆泰克股份有限公司 | 预防再狭窄的涂层支架 |
US6613927B1 (en) | 2002-02-08 | 2003-09-02 | American Pharmaceutical Partners, Inc. | Sterile lyophilized ifosfamide and associated methods |
DE10306724A1 (de) | 2002-02-28 | 2003-09-18 | G O T Therapeutics Gmbh | Vesikuläre Verkapselung von Bendamustin |
AU2003221517B2 (en) | 2002-03-22 | 2010-02-18 | Christian Straka | Cytocapacity test |
WO2003086470A2 (en) | 2002-04-17 | 2003-10-23 | Deutsches Krebsforschungszentrum | Smac-peptides as therapeutics against cancer and autoimmune diseases |
EP1354952A1 (en) | 2002-04-17 | 2003-10-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Smac-peptides as therapeutics against cancer and autoimmune diseases |
AU2003240391B8 (en) | 2002-05-09 | 2009-08-06 | Hemoteq Ag | Compounds and method for coating surfaces in a haemocompatible manner |
AU2003258061A1 (en) | 2002-08-02 | 2004-02-23 | Salmedix, Inc. | Therapeutic inhibitionof protein kinases in cancer cells |
DE10304403A1 (de) | 2003-01-28 | 2004-08-05 | Röhm GmbH & Co. KG | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
EP1444989A1 (en) | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
US7157551B2 (en) | 2003-02-14 | 2007-01-02 | Cephalon, Inc. | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers |
KR20060052880A (ko) | 2003-07-25 | 2006-05-19 | 와이어쓰 | 동결건조된 cci- 779 제형 |
US8436190B2 (en) * | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
AU2009302493B2 (en) * | 2008-10-08 | 2015-04-09 | Cephalon Llc | Processes for the preparation of bendamustine |
-
2010
- 2010-01-14 CA CA2749101A patent/CA2749101A1/en not_active Abandoned
- 2010-01-14 JP JP2011546322A patent/JP2012515210A/ja active Pending
- 2010-01-14 EA EA201170934A patent/EA020767B1/ru not_active IP Right Cessation
- 2010-01-14 NZ NZ594010A patent/NZ594010A/xx unknown
- 2010-01-14 EP EP10701071A patent/EP2387400A1/en not_active Withdrawn
- 2010-01-14 WO PCT/US2010/020992 patent/WO2010083276A1/en active Application Filing
- 2010-01-14 BR BRPI1004922A patent/BRPI1004922A2/pt not_active IP Right Cessation
- 2010-01-14 SG SG2011047875A patent/SG172810A1/en unknown
- 2010-01-14 US US12/687,398 patent/US8076366B2/en not_active Expired - Fee Related
- 2010-01-14 UA UAA201109971A patent/UA109109C2/uk unknown
- 2010-01-14 CN CN201310425128.8A patent/CN103554030A/zh active Pending
- 2010-01-14 AU AU2010204765A patent/AU2010204765A1/en not_active Abandoned
- 2010-01-14 CN CN201080004743.6A patent/CN102281877B/zh not_active Expired - Fee Related
- 2010-01-14 KR KR1020117018325A patent/KR20110110293A/ko not_active Application Discontinuation
- 2010-01-14 MX MX2011007557A patent/MX2011007557A/es active IP Right Grant
-
2011
- 2011-06-22 IL IL213725A patent/IL213725A0/en unknown
- 2011-07-11 ZA ZA2011/05099A patent/ZA201105099B/en unknown
-
2016
- 2016-07-13 AU AU2016204902A patent/AU2016204902A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN102281877B (zh) | 2014-07-23 |
AU2010204765A1 (en) | 2011-07-28 |
SG172810A1 (en) | 2011-08-29 |
CA2749101A1 (en) | 2010-07-22 |
US8076366B2 (en) | 2011-12-13 |
US20100210701A1 (en) | 2010-08-19 |
EA020767B1 (ru) | 2015-01-30 |
EA201170934A1 (ru) | 2011-12-30 |
JP2012515210A (ja) | 2012-07-05 |
MX2011007557A (es) | 2011-08-12 |
UA109109C2 (uk) | 2015-07-27 |
ZA201105099B (en) | 2012-03-28 |
CN103554030A (zh) | 2014-02-05 |
IL213725A0 (en) | 2011-07-31 |
KR20110110293A (ko) | 2011-10-06 |
CN102281877A (zh) | 2011-12-14 |
WO2010083276A1 (en) | 2010-07-22 |
NZ594010A (en) | 2013-08-30 |
EP2387400A1 (en) | 2011-11-23 |
AU2016204902A1 (en) | 2016-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |