EA201170934A1 - Новые формы свободного основания бендамустина - Google Patents

Новые формы свободного основания бендамустина

Info

Publication number
EA201170934A1
EA201170934A1 EA201170934A EA201170934A EA201170934A1 EA 201170934 A1 EA201170934 A1 EA 201170934A1 EA 201170934 A EA201170934 A EA 201170934A EA 201170934 A EA201170934 A EA 201170934A EA 201170934 A1 EA201170934 A1 EA 201170934A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bendamustin
foundation
free
new forms
forms
Prior art date
Application number
EA201170934A
Other languages
English (en)
Other versions
EA020767B1 (ru
Inventor
Лоран Д. Курвуазье
Марк Эддлстоун
Кертис Р. Холтиванджер
Роберт Э. Маккин
Original Assignee
Сефалон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42008533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201170934(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сефалон, Инк. filed Critical Сефалон, Инк.
Publication of EA201170934A1 publication Critical patent/EA201170934A1/ru
Publication of EA020767B1 publication Critical patent/EA020767B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описаны новые полиморфные формы свободного основания бендамустина, включая аморфное свободное основание бендамустина, шесть безводных кристаллических форм, четыре гидратные формы и пять сольватных форм, а также описаны способы их получения и применения.
EA201170934A 2009-01-15 2010-01-14 Новые формы свободного основания бендамустина EA020767B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14484309P 2009-01-15 2009-01-15
PCT/US2010/020992 WO2010083276A1 (en) 2009-01-15 2010-01-14 Novel forms of bendamustine free base

Publications (2)

Publication Number Publication Date
EA201170934A1 true EA201170934A1 (ru) 2011-12-30
EA020767B1 EA020767B1 (ru) 2015-01-30

Family

ID=42008533

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170934A EA020767B1 (ru) 2009-01-15 2010-01-14 Новые формы свободного основания бендамустина

Country Status (16)

Country Link
US (1) US8076366B2 (ru)
EP (1) EP2387400A1 (ru)
JP (1) JP2012515210A (ru)
KR (1) KR20110110293A (ru)
CN (2) CN103554030A (ru)
AU (2) AU2010204765A1 (ru)
BR (1) BRPI1004922A2 (ru)
CA (1) CA2749101A1 (ru)
EA (1) EA020767B1 (ru)
IL (1) IL213725A0 (ru)
MX (1) MX2011007557A (ru)
NZ (1) NZ594010A (ru)
SG (1) SG172810A1 (ru)
UA (1) UA109109C2 (ru)
WO (1) WO2010083276A1 (ru)
ZA (1) ZA201105099B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2516404A4 (en) * 2009-12-23 2013-04-17 Reddys Lab Ltd Dr PREPARATION OF BENDAMUSTINE AND ITS SALTS
LT2528602T (lt) 2010-01-28 2017-02-27 Eagle Pharmaceuticals, Inc. Bendamustino kompozicijos
US9273010B2 (en) * 2011-06-20 2016-03-01 Hetero Research Foundation Process for bendamustine hydrochloride
HUE062230T2 (hu) 2012-03-20 2023-10-28 Eagle Pharmaceuticals Inc Bendamusztin folyékony készítmények bendamusztinra reagáló állapotok kezelési eljárásban történõ alkalmazásra, ahol a betegek csökkentett térfogatú bevitelre szorulnak
CA2867295C (en) * 2012-03-20 2020-08-11 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
US20230241218A1 (en) * 2012-07-10 2023-08-03 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
JP6412676B2 (ja) * 2013-03-12 2018-10-24 セファロン、インク． ナノ粒子及びナノ粒子製剤
CN105142497B (zh) 2013-04-26 2018-01-12 维塔尔艺术与科学有限责任公司 轮廓线融合视野检查视力测试
US20240148696A1 (en) 2022-10-25 2024-05-09 Softkemo Pharma Inc. Lyophilized bendamustine-cyclodextrin composition

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Also Published As

Publication number Publication date
CN102281877B (zh) 2014-07-23
AU2010204765A1 (en) 2011-07-28
SG172810A1 (en) 2011-08-29
CA2749101A1 (en) 2010-07-22
US8076366B2 (en) 2011-12-13
US20100210701A1 (en) 2010-08-19
EA020767B1 (ru) 2015-01-30
JP2012515210A (ja) 2012-07-05
MX2011007557A (es) 2011-08-12
UA109109C2 (ru) 2015-07-27
ZA201105099B (en) 2012-03-28
BRPI1004922A2 (pt) 2019-09-24
CN103554030A (zh) 2014-02-05
IL213725A0 (en) 2011-07-31
KR20110110293A (ko) 2011-10-06
CN102281877A (zh) 2011-12-14
WO2010083276A1 (en) 2010-07-22
NZ594010A (en) 2013-08-30
EP2387400A1 (en) 2011-11-23
AU2016204902A1 (en) 2016-08-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU