EA201291280A1 - Новая полиморфная форма основания иматиниба и получение её солей - Google Patents
Новая полиморфная форма основания иматиниба и получение её солейInfo
- Publication number
- EA201291280A1 EA201291280A1 EA201291280A EA201291280A EA201291280A1 EA 201291280 A1 EA201291280 A1 EA 201291280A1 EA 201291280 A EA201291280 A EA 201291280A EA 201291280 A EA201291280 A EA 201291280A EA 201291280 A1 EA201291280 A1 EA 201291280A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- imatinibe
- foundation
- salts
- obtaining
- polymorphic form
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Изобретение относится к способу получения нового полиморфа основания иматиниба, способу получения его соли мезилата и их включению в фармацевтические композиции, которые имеют улучшенную стабильность и чистоту, а также к способам их получения.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI201000181 | 2010-06-18 | ||
SI201000348 | 2010-10-27 | ||
SI201000398 | 2010-11-19 | ||
SI201100054 | 2011-02-22 | ||
PCT/EP2011/003025 WO2011157450A1 (en) | 2010-06-18 | 2011-06-17 | New polymorphic form of imatinib base and preparation of salts thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201291280A1 true EA201291280A1 (ru) | 2013-04-30 |
EA024088B1 EA024088B1 (ru) | 2016-08-31 |
Family
ID=44259640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201291280A EA024088B1 (ru) | 2010-06-18 | 2011-06-17 | α-ФОРМА МЕЗИЛАТА ИМАТИНИБА, СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЁ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2582689B1 (ru) |
EA (1) | EA024088B1 (ru) |
SI (1) | SI2582689T1 (ru) |
WO (1) | WO2011157450A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN2012DE00728A (ru) | 2012-03-13 | 2015-08-21 | Fresenius Kabi Oncology Ltd | |
GB201204810D0 (en) * | 2012-03-20 | 2012-05-02 | Pharos Pharmaceutical Oriented Services Ltd | Pharmaceutical compositions |
JP5928159B2 (ja) * | 2012-05-28 | 2016-06-01 | ニプロ株式会社 | 医薬組成物 |
KR101242955B1 (ko) * | 2012-06-25 | 2013-03-12 | 제일약품주식회사 | 이마티닙 메실레이트 결정형 α의 제조 방법 |
WO2014016848A2 (en) * | 2012-07-24 | 2014-01-30 | Laurus Labs Private Limited | Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof |
EP3007699A4 (en) * | 2013-06-12 | 2017-01-18 | Shilpa Medicare Limited | Crystalline imatinib mesylate process |
US20150044288A1 (en) * | 2013-07-31 | 2015-02-12 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
CN104974134B (zh) * | 2015-05-19 | 2017-01-18 | 江苏豪森药业集团有限公司 | 甲磺酸伊马替尼的精制方法 |
EA035891B1 (ru) | 2016-01-25 | 2020-08-27 | КРКА, д.д., НОВО МЕСТО | Быстродиспергируемая фармацевтическая композиция, включающая ингибитор тирозинкиназы |
US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
EP3969111A4 (en) | 2019-05-16 | 2023-08-16 | Aerovate Therapeutics, Inc. | INHALABLE FORMULATIONS FOR KINASE INHIBITION |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW225528B (ru) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
GB2398565A (en) | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
TR200504337T1 (tr) | 2003-06-02 | 2006-12-21 | Hetero Drugs Limited | Imatinib mezilat'ın yeni polimorfları |
AU2003242988A1 (en) | 2003-06-06 | 2005-01-04 | Adibhatla Kali Sathya Bhujanga Rao | Process for the preparation of the anti-cancer drug imatinib and its analogues |
MY144177A (en) | 2004-02-04 | 2011-08-15 | Novartis Ag | Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide. |
PL1720853T3 (pl) | 2004-02-11 | 2016-06-30 | Natco Pharma Ltd | Nowa odmiana polimorficzna metanosulfonianu imatynibu i sposób jej otrzymywania |
UA84462C2 (ru) * | 2004-04-02 | 2008-10-27 | Институт Фармацевтични | Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой |
TR200701870T1 (tr) | 2004-09-02 | 2007-05-21 | Cipla Limited | İmatinib mesilatın kararlı kristal formu ve bu formun hazırlanması için işlem. |
WO2006048890A1 (en) | 2004-11-04 | 2006-05-11 | Sun Pharmaceutical Industries Limited | Imatinib mesylate crystal form and process for preparation thereof |
WO2006054314A1 (en) | 2004-11-17 | 2006-05-26 | Natco Pharma Limited | Polymorphic forms of imatinib mesylate |
EP1833815B1 (en) | 2004-12-30 | 2010-09-15 | Instytut Farmaceutyczny | A process for preparation of imatinib base |
US7507821B2 (en) | 2004-12-30 | 2009-03-24 | Chemagis Ltd. | Process for preparing Imatinib |
US7879860B2 (en) | 2005-08-26 | 2011-02-01 | Novartis Ag | Delta and epsilon crystal forms of Imatinib mesylate |
EP1919893A2 (en) | 2006-04-27 | 2008-05-14 | Sicor, Inc. | Polymorphic forms of imatinib mesylate and processes for their preparation as well as of amorphous imatinib mesylate and form alpha |
US20060223817A1 (en) * | 2006-05-15 | 2006-10-05 | Chemagis Ltd. | Crystalline imatinib base and production process therefor |
KR20090061068A (ko) | 2006-10-26 | 2009-06-15 | 시코르, 인크. | 이매티닙의 제조 방법 |
JP5265562B2 (ja) | 2006-11-16 | 2013-08-14 | エッフェ.イー.エッセ. ファブリカ イタリアーナ シンテーティチ エッセ.ペー.アー. | イマチニブおよびその中間体の調製方法 |
CA2680249A1 (en) * | 2007-03-12 | 2008-09-18 | Dr. Reddy's Laboratories, Inc. | Imatinib mesylate |
WO2008136010A1 (en) * | 2007-05-07 | 2008-11-13 | Natco Pharma Limited | A process for the preparation of highly pure imatinib base |
EP2062885A1 (en) | 2007-11-21 | 2009-05-27 | Eczacibasi-Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. | Acid addition salts of imatinib and formulations comprising the same |
US7947699B2 (en) | 2008-01-10 | 2011-05-24 | Actavis Group Ptc Ehf | Anhydrous amorphous imatinib mesylate |
EP2291366A4 (en) * | 2008-05-26 | 2012-06-06 | Reddys Lab Ltd Dr | PREPARATION OF IMATINIB MESYLATE |
WO2009147626A2 (en) | 2008-06-06 | 2009-12-10 | Alembic Limited | Anhydrous amorphous form of imatinib mesylate |
PL215042B1 (pl) | 2008-08-01 | 2013-10-31 | Temapharm Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wytwarzania imatinibu |
US20100330130A1 (en) * | 2009-05-22 | 2010-12-30 | Actavis Group Ptc Ehf | Substantially pure imatinib or a pharmaceutically acceptable salt thereof |
WO2011039782A1 (en) | 2009-09-29 | 2011-04-07 | Ind-Swift Laboratories Limited | Processes for preparing imatinib and pharmaceutically acceptable salts thereof |
US20110306763A1 (en) | 2009-12-10 | 2011-12-15 | Shanghai Parling Pharmatech Co., Ltd. | Process for the preparation of imatinib and salts thereof |
-
2011
- 2011-06-17 EP EP11726356.6A patent/EP2582689B1/en active Active
- 2011-06-17 WO PCT/EP2011/003025 patent/WO2011157450A1/en active Application Filing
- 2011-06-17 EA EA201291280A patent/EA024088B1/ru not_active IP Right Cessation
- 2011-06-17 SI SI201131164A patent/SI2582689T1/sl unknown
Also Published As
Publication number | Publication date |
---|---|
EP2582689A1 (en) | 2013-04-24 |
EP2582689B1 (en) | 2017-03-01 |
SI2582689T1 (sl) | 2017-05-31 |
EA024088B1 (ru) | 2016-08-31 |
WO2011157450A1 (en) | 2011-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |