MX2011011526A - Formulacion lipida de promotor de apoptosis. - Google Patents
Formulacion lipida de promotor de apoptosis.Info
- Publication number
- MX2011011526A MX2011011526A MX2011011526A MX2011011526A MX2011011526A MX 2011011526 A MX2011011526 A MX 2011011526A MX 2011011526 A MX2011011526 A MX 2011011526A MX 2011011526 A MX2011011526 A MX 2011011526A MX 2011011526 A MX2011011526 A MX 2011011526A
- Authority
- MX
- Mexico
- Prior art keywords
- lipid formulation
- apoptosis promoter
- bcl
- abt
- phospholipid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composición farmacéutica que se puede suministrar por vía oral comprende un sistema portador de fármaco que tiene un compuesto inhibidor de proteína de la familia de Bcl-2, por ejemplo, ABT-263, en solución en un vehículo sustancialmente no acuoso que comprende por lo menos un fosfolípido y un agente de solubilización farmacéuticamente aceptable. La composición es apropiada para administración oral a un individuo en necesidad de lo mismo para tratamiento de una enfermedad caracterizada por sobre-expresión de una o más proteínas anti-apoptóticas de la familia de Bcl-2, por ejemplo cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17424509P | 2009-04-30 | 2009-04-30 | |
PCT/US2010/033074 WO2010127192A1 (en) | 2009-04-30 | 2010-04-30 | Lipid formulation of apoptosis promoter |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011011526A true MX2011011526A (es) | 2011-11-18 |
Family
ID=42732500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011011526A MX2011011526A (es) | 2009-04-30 | 2010-04-30 | Formulacion lipida de promotor de apoptosis. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20100280031A1 (es) |
EP (1) | EP2424500A1 (es) |
JP (1) | JP2012525434A (es) |
KR (1) | KR20120013416A (es) |
CN (1) | CN102458361A (es) |
AR (1) | AR076512A1 (es) |
AU (1) | AU2010242925A1 (es) |
BR (1) | BRPI1014368A2 (es) |
CA (1) | CA2758534A1 (es) |
IL (1) | IL215473A0 (es) |
MX (1) | MX2011011526A (es) |
RU (1) | RU2011148518A (es) |
SG (1) | SG175147A1 (es) |
TW (1) | TW201043605A (es) |
UY (1) | UY32600A (es) |
WO (1) | WO2010127192A1 (es) |
ZA (1) | ZA201107593B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI471321B (zh) | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Bcl-2族群抑制劑之口服醫藥劑型 |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
EP3238709B1 (en) * | 2011-04-28 | 2020-07-01 | Platform Brightworks Two, Ltd. | Improved parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same |
CN102836160A (zh) * | 2012-10-10 | 2012-12-26 | 武汉大学 | 一种治疗癌症的组合药物 |
TR201703149A2 (tr) * | 2017-03-01 | 2018-09-21 | Univ Yeditepe | Kemoterapi̇k i̇laç kompozi̇syonu |
JP2022553820A (ja) | 2019-11-05 | 2022-12-26 | アッヴィ・インコーポレイテッド | 骨髄線維症及びmpn関連障害をナビトクラクスで処置する際に使用するための投与レジメン |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665379A (en) * | 1990-09-28 | 1997-09-09 | Pharmacia & Upjohn Aktiebolag | Lipid particle forming matrix, preparation and use thereof |
US5536729A (en) * | 1993-09-30 | 1996-07-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
IL111004A (en) * | 1993-09-30 | 1998-06-15 | American Home Prod | Oral formulations of rapamycin |
US5759548A (en) * | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5538737A (en) * | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
BE1011899A6 (fr) * | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US20020055631A1 (en) * | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
PL364910A1 (en) * | 2001-01-31 | 2004-12-27 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
US7973161B2 (en) * | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
KR101509440B1 (ko) * | 2005-05-12 | 2015-04-07 | 애브비 바하마스 리미티드 | 아폽토시스 촉진제 |
CA2626579A1 (en) * | 2005-10-25 | 2007-05-03 | Abbott Laboratories | Formulation comprising a drug of low water solubility and method of use thereof |
MX2010003642A (es) * | 2007-10-12 | 2010-08-09 | Massachusetts Inst Technology | Nanotecnologia de vacuna. |
CA2708223A1 (en) * | 2007-12-06 | 2009-06-11 | Andrew Krivoshik | Oral compositions of abt-263 for treating cancer |
US8728516B2 (en) * | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
US8362013B2 (en) * | 2009-04-30 | 2013-01-29 | Abbvie Inc. | Salt of ABT-263 and solid-state forms thereof |
US20100297194A1 (en) * | 2009-04-30 | 2010-11-25 | Nathaniel Catron | Formulation for oral administration of apoptosis promoter |
US20100278921A1 (en) * | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
BRPI1014027A2 (pt) * | 2009-06-18 | 2019-09-24 | Abbott Lab | suspensão de fármaco de nanopartícula estável. |
WO2011034934A1 (en) * | 2009-09-20 | 2011-03-24 | Abbott Laboratories | Abt-263 crystalline forms and solvates for use in treating bcl-2 protein related diseases |
-
2010
- 2010-04-29 US US12/770,122 patent/US20100280031A1/en not_active Abandoned
- 2010-04-30 MX MX2011011526A patent/MX2011011526A/es not_active Application Discontinuation
- 2010-04-30 RU RU2011148518/15A patent/RU2011148518A/ru unknown
- 2010-04-30 CA CA2758534A patent/CA2758534A1/en not_active Abandoned
- 2010-04-30 TW TW099113988A patent/TW201043605A/zh unknown
- 2010-04-30 CN CN2010800296388A patent/CN102458361A/zh active Pending
- 2010-04-30 UY UY0001032600A patent/UY32600A/es not_active Application Discontinuation
- 2010-04-30 SG SG2011073640A patent/SG175147A1/en unknown
- 2010-04-30 KR KR1020117028612A patent/KR20120013416A/ko not_active Application Discontinuation
- 2010-04-30 AR ARP100101470A patent/AR076512A1/es not_active Application Discontinuation
- 2010-04-30 WO PCT/US2010/033074 patent/WO2010127192A1/en active Application Filing
- 2010-04-30 EP EP10718372A patent/EP2424500A1/en not_active Withdrawn
- 2010-04-30 AU AU2010242925A patent/AU2010242925A1/en not_active Abandoned
- 2010-04-30 BR BRPI1014368A patent/BRPI1014368A2/pt not_active IP Right Cessation
- 2010-04-30 JP JP2012508758A patent/JP2012525434A/ja not_active Withdrawn
-
2011
- 2011-10-02 IL IL215473A patent/IL215473A0/en unknown
- 2011-10-17 ZA ZA2011/07593A patent/ZA201107593B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR076512A1 (es) | 2011-06-15 |
RU2011148518A (ru) | 2013-06-10 |
CN102458361A (zh) | 2012-05-16 |
IL215473A0 (en) | 2011-12-29 |
EP2424500A1 (en) | 2012-03-07 |
BRPI1014368A2 (pt) | 2016-04-05 |
TW201043605A (en) | 2010-12-16 |
CA2758534A1 (en) | 2010-11-04 |
JP2012525434A (ja) | 2012-10-22 |
UY32600A (es) | 2010-12-31 |
SG175147A1 (en) | 2011-11-28 |
KR20120013416A (ko) | 2012-02-14 |
AU2010242925A1 (en) | 2011-11-10 |
WO2010127192A1 (en) | 2010-11-04 |
ZA201107593B (en) | 2012-06-27 |
US20100280031A1 (en) | 2010-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |