UA109879C2 - Похідні нітрилу, їх застосування у фармацевтичних цілях і в композиції - Google Patents

Похідні нітрилу, їх застосування у фармацевтичних цілях і в композиції

Info

Publication number
UA109879C2
UA109879C2 UAA201201041A UAA201201041A UA109879C2 UA 109879 C2 UA109879 C2 UA 109879C2 UA A201201041 A UAA201201041 A UA A201201041A UA A201201041 A UAA201201041 A UA A201201041A UA 109879 C2 UA109879 C2 UA 109879C2
Authority
UA
Ukraine
Prior art keywords
compounds
nitrile derivatives
compositions
pharmaceutical purposes
preparation
Prior art date
Application number
UAA201201041A
Other languages
English (en)
Russian (ru)
Inventor
Крішна Менон
Уейн О. Аруда
Original Assignee
Селс'Ютікс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42333455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA109879(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Селс'Ютікс Корпорейшн filed Critical Селс'Ютікс Корпорейшн
Publication of UA109879C2 publication Critical patent/UA109879C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C255/03—Mononitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/34—Isothioureas having sulfur atoms of isothiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/36—Isothioureas having sulfur atoms of isothiourea groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Abstract

Розкритий винахід являє собою похідні нітрилу та фармацевтичні композиції, які містять похідні нітрилу. Фармацевтичні композиції містять сполуку формули І EMBED ISISServer I і фармацевтично прийнятні солі таких сполук. Також розкритий винахід являє собою засоби одержання таких сполук, проміжні продукти, використовувані у виготовленні таких сполук, а також використання таких сполук у лікуванні гіперпроліферативних захворювань, запальних захворювань, вірусних і бактеріальних інфекцій і індукції апоптозу в ракових клітинах.
UAA201201041A 2009-05-20 2010-05-14 Похідні нітрилу, їх застосування у фармацевтичних цілях і в композиції UA109879C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18012109P 2009-05-20 2009-05-20
PCT/US2010/034838 WO2010135170A2 (en) 2009-05-20 2010-05-14 Nitrile derivatives and their pharmaceutical use and compositions

Publications (1)

Publication Number Publication Date
UA109879C2 true UA109879C2 (uk) 2015-10-26

Family

ID=42333455

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201201041A UA109879C2 (uk) 2009-05-20 2010-05-14 Похідні нітрилу, їх застосування у фармацевтичних цілях і в композиції

Country Status (21)

Country Link
US (2) US8338454B2 (uk)
EP (1) EP2432464B1 (uk)
JP (2) JP5587987B2 (uk)
KR (4) KR20120016101A (uk)
CN (1) CN102438612B (uk)
AR (1) AR078509A1 (uk)
AU (1) AU2010249933B2 (uk)
BR (1) BRPI1009067A2 (uk)
CA (1) CA2762427C (uk)
CL (1) CL2011002907A1 (uk)
DK (1) DK2432464T3 (uk)
EA (1) EA024038B9 (uk)
IL (1) IL216462A (uk)
MX (1) MX2011012384A (uk)
MY (1) MY159756A (uk)
NZ (1) NZ596527A (uk)
SG (1) SG176170A1 (uk)
TW (1) TWI597062B (uk)
UA (1) UA109879C2 (uk)
WO (1) WO2010135170A2 (uk)
ZA (1) ZA201108458B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895610B1 (en) 2007-05-18 2014-11-25 Heldi Kay Platinum (IV) compounds targeting zinc finger domains
US9610275B2 (en) * 2009-05-20 2017-04-04 Cellceutix Corporation Nitrile derivatives and their pharmaceutical use and compositions
MX2011012384A (es) * 2009-05-20 2012-02-28 Cellceutix Corp Derivados nitrilo y sus usos y composiciones farmaceuticas.
CN102464601A (zh) * 2010-11-17 2012-05-23 何兰 含氰基硫脲类化合物及应用
WO2013012875A2 (en) 2011-07-18 2013-01-24 Mount Sinai School Of Medicine Bacterial rnas as vaccine adjuvants
EP3696276A1 (en) 2013-02-25 2020-08-19 Novartis AG Novel androgen receptor mutation
CN108752274B (zh) * 2018-07-25 2022-03-29 遂成药业股份有限公司 一种5-异喹啉磺酰氯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH499959A (de) * 1966-10-05 1970-12-15 Ciba Geigy Ag Schädlingsbekämpfungsmittel
JPS6310795A (ja) * 1986-03-25 1988-01-18 Takeda Chem Ind Ltd 選択性除草化合物
WO2007088545A2 (en) * 2006-02-02 2007-08-09 Chemagis Ltd. Novel process for preparing 1-(mercaptomethyl) cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof
WO2009089277A2 (en) * 2008-01-08 2009-07-16 The Trustees Of The University Of Pennsylvania Rel inhibitors and methods of use thereof
CN101550098B (zh) * 2009-01-14 2014-07-09 何兰 4-异硫尿基丁腈盐酸盐及其衍生物的用途
MX2011012384A (es) * 2009-05-20 2012-02-28 Cellceutix Corp Derivados nitrilo y sus usos y composiciones farmaceuticas.

Also Published As

Publication number Publication date
JP2012527464A (ja) 2012-11-08
JP5587987B2 (ja) 2014-09-10
KR20140147111A (ko) 2014-12-29
CL2011002907A1 (es) 2012-05-04
TW201041576A (en) 2010-12-01
IL216462A0 (en) 2012-01-31
CA2762427C (en) 2015-12-22
KR20140130438A (ko) 2014-11-10
CN102438612A (zh) 2012-05-02
BRPI1009067A2 (pt) 2019-09-24
JP6192613B2 (ja) 2017-09-06
WO2010135170A2 (en) 2010-11-25
EA024038B1 (ru) 2016-08-31
KR20120016101A (ko) 2012-02-22
MY159756A (en) 2017-01-31
MX2011012384A (es) 2012-02-28
CA2762427A1 (en) 2010-11-25
AU2010249933A1 (en) 2011-12-22
SG176170A1 (en) 2011-12-29
CN102438612B (zh) 2016-02-03
EA024038B9 (ru) 2016-10-31
US8338454B2 (en) 2012-12-25
JP2014240398A (ja) 2014-12-25
EA201101655A8 (ru) 2016-01-29
TWI597062B (zh) 2017-09-01
WO2010135170A3 (en) 2011-01-13
AR078509A1 (es) 2011-11-16
KR101554964B1 (ko) 2015-09-23
NZ596527A (en) 2014-05-30
EP2432464B1 (en) 2019-01-09
AU2010249933B2 (en) 2014-01-16
EA201101655A1 (ru) 2012-06-29
KR20160010888A (ko) 2016-01-28
DK2432464T3 (en) 2019-04-23
US20130245062A1 (en) 2013-09-19
US20100298374A1 (en) 2010-11-25
US9340491B2 (en) 2016-05-17
IL216462A (en) 2017-04-30
EP2432464A2 (en) 2012-03-28
ZA201108458B (en) 2012-07-25
KR101632326B1 (ko) 2016-06-21

Similar Documents

Publication Publication Date Title
PH12016500024A1 (en) Bromodomain inhibitor
MY173422A (en) Purine derivatives for the treatment of viral infections
UA109010C2 (en) MORPHOLINOPYRIMIDINES AND THEIR APPLICATIONS IN THERAPY
PH12015500713B1 (en) Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
MX345928B (es) Composiciones terapeuticamente activas y metodos de uso de las mismas.
PH12015500274A1 (en) Alkylpyrimidine derivatives for the treatment of viral infections and further diseases
PH12014501469A1 (en) Bromodomain inhibitors
EA201100971A1 (ru) Производные пиримидининдола для лечения злокачественного новообразования
MX2014000341A (es) Novedosos derivados de trifluoro-metil-oxadiazol y su uso en el tratamiento de enfermedades.
MX2014012695A (es) Derivados de isoindolona.
MX2011008634A (es) Derivados de aminotetralina composiciones farmaceuticas que los contienen y su uso en terapia.
EA201001368A1 (ru) Гетероциклические производные мочевины и способы их применения-211
MX2012007175A (es) Derivados de imidazopiridina como inhibidores de jak.
UA104489C2 (uk) Сполуки для лікування дисліпідемії та споріднених хвороб
JO3115B1 (ar) مركبات بيريدازينون واستخدامها كمثبطات daao
MX2011011083A (es) Compuestos heterociclicos como inhibidores de mek.
UA109879C2 (uk) Похідні нітрилу, їх застосування у фармацевтичних цілях і в композиції
IN2012DN03182A (uk)
MX340574B (es) Imidazo pirazinas.
MX2010013310A (es) Derivados de heterociclil urea para el tratamiento de infecciones bacterianas.
MX341728B (es) Derivados sulfonamido de 3, 4/diarilpirazoles como inhibidores de proteina quinasa.
TN2012000242A1 (en) Heterocyclic sulfonamide derivatives
MX348758B (es) Derivados de sanglifehrina y metodos para su produccion.
MY166057A (en) Carbocyclic nucleosides and their pharmaceutical use and compositions
TN2014000077A1 (en) Pyridazinone compounds and their use as daao inhibitors