EA024038B9 - Производные нитрила, их использование в фармацевтических целях и в композициях - Google Patents
Производные нитрила, их использование в фармацевтических целях и в композицияхInfo
- Publication number
- EA024038B9 EA024038B9 EA201101655A EA201101655A EA024038B9 EA 024038 B9 EA024038 B9 EA 024038B9 EA 201101655 A EA201101655 A EA 201101655A EA 201101655 A EA201101655 A EA 201101655A EA 024038 B9 EA024038 B9 EA 024038B9
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- nitrile derivatives
- compositions
- preparation
- disclosed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C255/03—Mononitriles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/34—Isothioureas having sulfur atoms of isothiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/36—Isothioureas having sulfur atoms of isothiourea groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Abstract
Раскрытое изобретение представляет собой производные нитрила и фармацевтические композиции, содержащие производные нитрила. Фармацевтические композиции содержат соединения формулы Iи фармацевтически приемлемые соли таких соединений. Также раскрытое изобретение представляет собой способы получения таких соединений, промежуточные продукты, используемые в изготовлении таких соединений, а также использование таких соединений в лечении гиперпролиферативных заболеваний, воспалительных заболеваний и вирусных и бактериальных инфекций и индукции апоптоза в раковых клетках.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18012109P | 2009-05-20 | 2009-05-20 | |
PCT/US2010/034838 WO2010135170A2 (en) | 2009-05-20 | 2010-05-14 | Nitrile derivatives and their pharmaceutical use and compositions |
Publications (4)
Publication Number | Publication Date |
---|---|
EA201101655A1 EA201101655A1 (ru) | 2012-06-29 |
EA201101655A8 EA201101655A8 (ru) | 2016-01-29 |
EA024038B1 EA024038B1 (ru) | 2016-08-31 |
EA024038B9 true EA024038B9 (ru) | 2016-10-31 |
Family
ID=42333455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101655A EA024038B9 (ru) | 2009-05-20 | 2010-05-14 | Производные нитрила, их использование в фармацевтических целях и в композициях |
Country Status (21)
Country | Link |
---|---|
US (2) | US8338454B2 (ru) |
EP (1) | EP2432464B1 (ru) |
JP (2) | JP5587987B2 (ru) |
KR (4) | KR20140130438A (ru) |
CN (1) | CN102438612B (ru) |
AR (1) | AR078509A1 (ru) |
AU (1) | AU2010249933B2 (ru) |
BR (1) | BRPI1009067A2 (ru) |
CA (1) | CA2762427C (ru) |
CL (1) | CL2011002907A1 (ru) |
DK (1) | DK2432464T3 (ru) |
EA (1) | EA024038B9 (ru) |
IL (1) | IL216462A (ru) |
MX (1) | MX2011012384A (ru) |
MY (1) | MY159756A (ru) |
NZ (1) | NZ596527A (ru) |
SG (1) | SG176170A1 (ru) |
TW (1) | TWI597062B (ru) |
UA (1) | UA109879C2 (ru) |
WO (1) | WO2010135170A2 (ru) |
ZA (1) | ZA201108458B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8895610B1 (en) | 2007-05-18 | 2014-11-25 | Heldi Kay | Platinum (IV) compounds targeting zinc finger domains |
US9610275B2 (en) * | 2009-05-20 | 2017-04-04 | Cellceutix Corporation | Nitrile derivatives and their pharmaceutical use and compositions |
MX2011012384A (es) * | 2009-05-20 | 2012-02-28 | Cellceutix Corp | Derivados nitrilo y sus usos y composiciones farmaceuticas. |
CN102464601A (zh) * | 2010-11-17 | 2012-05-23 | 何兰 | 含氰基硫脲类化合物及应用 |
WO2013012875A2 (en) | 2011-07-18 | 2013-01-24 | Mount Sinai School Of Medicine | Bacterial rnas as vaccine adjuvants |
EP3696276A1 (en) | 2013-02-25 | 2020-08-19 | Novartis AG | Novel androgen receptor mutation |
CN108752274B (zh) * | 2018-07-25 | 2022-03-29 | 遂成药业股份有限公司 | 一种5-异喹啉磺酰氯的制备方法 |
Citations (5)
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---|---|---|---|---|
GB1202736A (en) * | 1966-10-05 | 1970-08-19 | Ciba Ltd | Herbicidal and fungicidal preparations |
EP0239064A2 (en) * | 1986-03-25 | 1987-09-30 | Takeda Chemical Industries, Ltd. | Herbicidal compounds, their production and use |
WO2007088545A2 (en) * | 2006-02-02 | 2007-08-09 | Chemagis Ltd. | Novel process for preparing 1-(mercaptomethyl) cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof |
WO2009089277A2 (en) * | 2008-01-08 | 2009-07-16 | The Trustees Of The University Of Pennsylvania | Rel inhibitors and methods of use thereof |
CN101550098A (zh) * | 2009-01-14 | 2009-10-07 | 何兰 | 4-异硫尿基丁腈盐酸盐及其衍生物的用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011012384A (es) * | 2009-05-20 | 2012-02-28 | Cellceutix Corp | Derivados nitrilo y sus usos y composiciones farmaceuticas. |
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2010
- 2010-05-14 MX MX2011012384A patent/MX2011012384A/es active IP Right Grant
- 2010-05-14 CA CA2762427A patent/CA2762427C/en not_active Expired - Fee Related
- 2010-05-14 UA UAA201201041A patent/UA109879C2/ru unknown
- 2010-05-14 EA EA201101655A patent/EA024038B9/ru not_active IP Right Cessation
- 2010-05-14 WO PCT/US2010/034838 patent/WO2010135170A2/en active Application Filing
- 2010-05-14 JP JP2012511907A patent/JP5587987B2/ja not_active Expired - Fee Related
- 2010-05-14 CN CN201080022390.2A patent/CN102438612B/zh not_active Expired - Fee Related
- 2010-05-14 NZ NZ596527A patent/NZ596527A/en not_active IP Right Cessation
- 2010-05-14 SG SG2011085537A patent/SG176170A1/en unknown
- 2010-05-14 KR KR1020147022683A patent/KR20140130438A/ko active Application Filing
- 2010-05-14 KR KR1020167000622A patent/KR101632326B1/ko active IP Right Grant
- 2010-05-14 MY MYPI2011005529A patent/MY159756A/en unknown
- 2010-05-14 US US12/780,132 patent/US8338454B2/en active Active
- 2010-05-14 KR KR1020147029698A patent/KR101554964B1/ko active IP Right Grant
- 2010-05-14 KR KR1020117027471A patent/KR20120016101A/ko active Application Filing
- 2010-05-14 AU AU2010249933A patent/AU2010249933B2/en not_active Ceased
- 2010-05-14 EP EP10724172.1A patent/EP2432464B1/en not_active Not-in-force
- 2010-05-14 DK DK10724172.1T patent/DK2432464T3/en active
- 2010-05-14 BR BRPI1009067A patent/BRPI1009067A2/pt not_active IP Right Cessation
- 2010-05-17 TW TW099115663A patent/TWI597062B/zh not_active IP Right Cessation
- 2010-05-17 AR ARP100101715A patent/AR078509A1/es unknown
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2011
- 2011-11-17 IL IL216462A patent/IL216462A/en not_active IP Right Cessation
- 2011-11-17 ZA ZA2011/08458A patent/ZA201108458B/en unknown
- 2011-11-18 CL CL2011002907A patent/CL2011002907A1/es unknown
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2012
- 2012-11-27 US US13/685,879 patent/US9340491B2/en active Active
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2014
- 2014-07-24 JP JP2014151080A patent/JP6192613B2/ja not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1202736A (en) * | 1966-10-05 | 1970-08-19 | Ciba Ltd | Herbicidal and fungicidal preparations |
EP0239064A2 (en) * | 1986-03-25 | 1987-09-30 | Takeda Chemical Industries, Ltd. | Herbicidal compounds, their production and use |
WO2007088545A2 (en) * | 2006-02-02 | 2007-08-09 | Chemagis Ltd. | Novel process for preparing 1-(mercaptomethyl) cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof |
WO2009089277A2 (en) * | 2008-01-08 | 2009-07-16 | The Trustees Of The University Of Pennsylvania | Rel inhibitors and methods of use thereof |
CN101550098A (zh) * | 2009-01-14 | 2009-10-07 | 何兰 | 4-异硫尿基丁腈盐酸盐及其衍生物的用途 |
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