JP2011503150A5 - - Google Patents
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- JP2011503150A5 JP2011503150A5 JP2010533594A JP2010533594A JP2011503150A5 JP 2011503150 A5 JP2011503150 A5 JP 2011503150A5 JP 2010533594 A JP2010533594 A JP 2010533594A JP 2010533594 A JP2010533594 A JP 2010533594A JP 2011503150 A5 JP2011503150 A5 JP 2011503150A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkyloxy
- oxo
- piperazin
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(N(CC1)C2CC(*)=C(*)C1C2)=O Chemical compound *C(N(CC1)C2CC(*)=C(*)C1C2)=O 0.000 description 3
- BJXTXJPIWACIGE-UHFFFAOYSA-N CC(CC1)(C2)c3n[nH]c(O)c3CC2N1C(c1ccccc1)=O Chemical compound CC(CC1)(C2)c3n[nH]c(O)c3CC2N1C(c1ccccc1)=O BJXTXJPIWACIGE-UHFFFAOYSA-N 0.000 description 1
- OWLQOGDUQQKVJE-UHFFFAOYSA-N CC(CC1)(C2)c3ncccc3CC2N1C(c1ccccc1)=O Chemical compound CC(CC1)(C2)c3ncccc3CC2N1C(c1ccccc1)=O OWLQOGDUQQKVJE-UHFFFAOYSA-N 0.000 description 1
- XIGIWJPCMRDPCW-UHFFFAOYSA-N CC(CC1)(CC(C2)N1C(c1ccccc1)=O)c1c2c(cccc2)c2[nH]1 Chemical compound CC(CC1)(CC(C2)N1C(c1ccccc1)=O)c1c2c(cccc2)c2[nH]1 XIGIWJPCMRDPCW-UHFFFAOYSA-N 0.000 description 1
- WWZVFPCAATXZIJ-OXJNMPFZSA-N C[C@@](C1)(C2)c3cc(OC)ccc3C[C@@H]1N2C(c1ccccc1)=O Chemical compound C[C@@](C1)(C2)c3cc(OC)ccc3C[C@@H]1N2C(c1ccccc1)=O WWZVFPCAATXZIJ-OXJNMPFZSA-N 0.000 description 1
- WWZVFPCAATXZIJ-UZLBHIALSA-N C[C@](C1)(C2)c3cc(OC)ccc3C[C@H]1N2C(c1ccccc1)=O Chemical compound C[C@](C1)(C2)c3cc(OC)ccc3C[C@H]1N2C(c1ccccc1)=O WWZVFPCAATXZIJ-UZLBHIALSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07120914.2 | 2007-11-16 | ||
| EP07120914 | 2007-11-16 | ||
| EP07123942 | 2007-12-21 | ||
| EP07123942.0 | 2007-12-21 | ||
| EP08155137 | 2008-04-24 | ||
| EP08155137.6 | 2008-04-24 | ||
| PCT/EP2008/065577 WO2009063061A2 (en) | 2007-11-16 | 2008-11-14 | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126666A Division JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503150A JP2011503150A (ja) | 2011-01-27 |
| JP2011503150A5 true JP2011503150A5 (https=) | 2012-01-19 |
| JP5769970B2 JP5769970B2 (ja) | 2015-08-26 |
Family
ID=40560240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533594A Active JP5769970B2 (ja) | 2007-11-16 | 2008-11-14 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
| JP2015126666A Active JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126666A Active JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8859580B2 (https=) |
| EP (1) | EP2220048B1 (https=) |
| JP (2) | JP5769970B2 (https=) |
| AR (1) | AR069545A1 (https=) |
| CA (1) | CA2704628C (https=) |
| CL (1) | CL2008003407A1 (https=) |
| TW (1) | TW200927115A (https=) |
| WO (1) | WO2009063061A2 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| TW200927115A (en) | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| JP5538239B2 (ja) * | 2008-02-12 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用 |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2009117109A1 (en) * | 2008-03-18 | 2009-09-24 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| US8242111B2 (en) * | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5696037B2 (ja) | 2008-05-01 | 2015-04-08 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| RU2531272C2 (ru) | 2008-05-01 | 2014-10-20 | Вайтаи Фармасьютиклз, Инк. | Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1 |
| AR071719A1 (es) | 2008-05-13 | 2010-07-07 | Boehringer Ingelheim Int | Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| EP2323994A1 (en) | 2008-07-25 | 2011-05-25 | Boehringer Ingelheim International GmbH | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| WO2010010157A2 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
| NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR073920A1 (es) | 2008-10-23 | 2010-12-09 | Boehringer Ingelheim Int | Derivados urea de nortropanos sustituidos, medicamentos que contienen dichos compuestos , su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa y proceso para su preparacion. |
| SI2361250T1 (sl) | 2008-12-22 | 2013-12-31 | Merck Patent Gmbh | Nove polimorfne oblike 6-(1-metil-1h-pirazol-4-il)-2-(3-(5-(2-morfolin-4-il-etoksi)-pirimidin- 2-il)-benzil)-2h-piridazin-3-on dihidrogenfosfata in postopki za proizvodnjo le-tega |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8703765B2 (en) | 2009-06-02 | 2014-04-22 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011056737A1 (en) | 2009-11-05 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Novel chiral phosphorus ligands |
| AR078887A1 (es) | 2009-11-06 | 2011-12-07 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen. |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2576570A1 (en) | 2010-05-26 | 2013-04-10 | Boehringer Ingelheim International GmbH | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| TWI537258B (zh) * | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8962660B2 (en) | 2013-03-14 | 2015-02-24 | Bristol-Myers Squibb Company | Oxabicyclo [2.2.2] acid GPR120 modulators |
| EP3022207A4 (en) * | 2013-07-15 | 2016-12-07 | Univ Texas | COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER, NEUROLOGICAL ILLNESS, ETHANOL DENTURE, SCARENESS, DEPRESSION AND NEUROPATHIC PAIN |
| JP7186994B2 (ja) * | 2015-08-28 | 2022-12-12 | 日本臓器製薬株式会社 | 新規な４－ベンゾアゾニン誘導体の製造方法 |
| EP3364976B1 (en) | 2015-10-19 | 2026-03-18 | Board of Regents, The University of Texas System | Piperazinyl norbenzomorphan compounds and methods for using the same |
| WO2017190109A1 (en) | 2016-04-29 | 2017-11-02 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
| WO2019121143A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Substituted cyclopropyl derivatives |
| CN115160341B (zh) * | 2022-07-18 | 2023-07-18 | 中国医学科学院医学实验动物研究所 | 苯并噁嗪类化合物及其药物用途 |
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| CA2735204C (en) * | 2008-08-25 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
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| US8680093B2 (en) * | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
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-
2008
- 2008-11-14 TW TW097144255A patent/TW200927115A/zh unknown
- 2008-11-14 US US12/742,680 patent/US8859580B2/en active Active
- 2008-11-14 CA CA2704628A patent/CA2704628C/en active Active
- 2008-11-14 CL CL2008003407A patent/CL2008003407A1/es unknown
- 2008-11-14 WO PCT/EP2008/065577 patent/WO2009063061A2/en not_active Ceased
- 2008-11-14 AR ARP080104991A patent/AR069545A1/es unknown
- 2008-11-14 EP EP08850194.5A patent/EP2220048B1/en active Active
- 2008-11-14 JP JP2010533594A patent/JP5769970B2/ja active Active
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2015
- 2015-06-24 JP JP2015126666A patent/JP6134754B2/ja active Active
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