JP5769970B2 - ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 - Google Patents
ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 Download PDFInfo
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- JP5769970B2 JP5769970B2 JP2010533594A JP2010533594A JP5769970B2 JP 5769970 B2 JP5769970 B2 JP 5769970B2 JP 2010533594 A JP2010533594 A JP 2010533594A JP 2010533594 A JP2010533594 A JP 2010533594A JP 5769970 B2 JP5769970 B2 JP 5769970B2
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- alkyl
- alkyloxy
- oxo
- piperazin
- carbonyl
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- 0 *C(N1C(CC2)CC(*)=C(*)C2CC1)=O Chemical compound *C(N1C(CC2)CC(*)=C(*)C2CC1)=O 0.000 description 7
- WOCBDABWTRJDRW-UHFFFAOYSA-N C(CNC(C1)C2)C1c1c2nc[nH]1 Chemical compound C(CNC(C1)C2)C1c1c2nc[nH]1 WOCBDABWTRJDRW-UHFFFAOYSA-N 0.000 description 1
- GHIUGSXQLPFXHF-UHFFFAOYSA-N CC(C(C1)N(CC2)C(C(F)(F)F)=O)C2(C)c(cc2NCc3ccccc3)c1cc2[N+](O)=O Chemical compound CC(C(C1)N(CC2)C(C(F)(F)F)=O)C2(C)c(cc2NCc3ccccc3)c1cc2[N+](O)=O GHIUGSXQLPFXHF-UHFFFAOYSA-N 0.000 description 1
- QOMTZDZHZBHOIW-IRMRZWDPSA-N CC(C(C1)N(CC2)C(C(F)(F)F)=O)[C@]2(C)c2c1ccc1c2nc(C)[o]1 Chemical compound CC(C(C1)N(CC2)C(C(F)(F)F)=O)[C@]2(C)c2c1ccc1c2nc(C)[o]1 QOMTZDZHZBHOIW-IRMRZWDPSA-N 0.000 description 1
- LNRFEDKUXBKPAG-UHFFFAOYSA-N CC(C)(C(C1)N(CC2)C(OC)=O)C2(C)c2c1cccc2C#N Chemical compound CC(C)(C(C1)N(CC2)C(OC)=O)C2(C)c2c1cccc2C#N LNRFEDKUXBKPAG-UHFFFAOYSA-N 0.000 description 1
- OQBDUOXMTDHAEH-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)C(C2)C(C)(C)C1(C)c1c2cc2OCOc2c1)=O Chemical compound CC(C)(C)OC(N(CC1)C(C2)C(C)(C)C1(C)c1c2cc2OCOc2c1)=O OQBDUOXMTDHAEH-UHFFFAOYSA-N 0.000 description 1
- JGQTWXUPZNONKH-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)C(Cc2c3)C(C)(C)C1(C)c2ccc3N)=O Chemical compound CC(C)(C)OC(N(CC1)C(Cc2c3)C(C)(C)C1(C)c2ccc3N)=O JGQTWXUPZNONKH-UHFFFAOYSA-N 0.000 description 1
- BNFPJMRSHXHULA-WBVHZDCISA-N CC(C)([C@@H](C1)NCC2)[C@]2(C)c2c1cc1[o]c(C)nc1c2 Chemical compound CC(C)([C@@H](C1)NCC2)[C@]2(C)c2c1cc1[o]c(C)nc1c2 BNFPJMRSHXHULA-WBVHZDCISA-N 0.000 description 1
- QFBWWXSEUTZXRJ-ZGTOLYCTSA-N CC(C)([C@@H](Cc1c2[N+]([O-])=O)N(CC3)C(C(F)(F)F)=O)C3(C)c1ccc2O Chemical compound CC(C)([C@@H](Cc1c2[N+]([O-])=O)N(CC3)C(C(F)(F)F)=O)C3(C)c1ccc2O QFBWWXSEUTZXRJ-ZGTOLYCTSA-N 0.000 description 1
- DYLZMCYCFSFBTE-HGMXIMQMSA-N CC(C1)[C@](C)(C2)c3ccccc3CC2N1C#N Chemical compound CC(C1)[C@](C)(C2)c3ccccc3CC2N1C#N DYLZMCYCFSFBTE-HGMXIMQMSA-N 0.000 description 1
- BHAPUTMFAADDOH-UHFFFAOYSA-N CC1(CC2)c3ccccc3CC3[N]2(C(N)=O)[N-]C13 Chemical compound CC1(CC2)c3ccccc3CC3[N]2(C(N)=O)[N-]C13 BHAPUTMFAADDOH-UHFFFAOYSA-N 0.000 description 1
- OJEAAHCSZZWHFY-UHFFFAOYSA-N CC1(CCN(Cc(cc2)ccc2C(O)=O)CC1)O Chemical compound CC1(CCN(Cc(cc2)ccc2C(O)=O)CC1)O OJEAAHCSZZWHFY-UHFFFAOYSA-N 0.000 description 1
- CWQHAFWDQYSORS-XBDPRNKDSA-N CC1[C@@](C)(CC2)c3cc(-c4nnc[o]4)ccc3C[C@H]1N2C(OC(C)(C)C)=O Chemical compound CC1[C@@](C)(CC2)c3cc(-c4nnc[o]4)ccc3C[C@H]1N2C(OC(C)(C)C)=O CWQHAFWDQYSORS-XBDPRNKDSA-N 0.000 description 1
- YGSVZRIZCHZUHB-XWFMALBVSA-N CC1[C@@]2(C)c3cc(O)ccc3CC1N(C)CC2 Chemical compound CC1[C@@]2(C)c3cc(O)ccc3CC1N(C)CC2 YGSVZRIZCHZUHB-XWFMALBVSA-N 0.000 description 1
- IELRARRWZHRHBE-ARHKQHADSA-N CC1[C@]2(C)c3cc(-c4cccnc4)ccc3CC1NCC2 Chemical compound CC1[C@]2(C)c3cc(-c4cccnc4)ccc3CC1NCC2 IELRARRWZHRHBE-ARHKQHADSA-N 0.000 description 1
- LTJONDBMYKHBQC-ZZHQXOFYSA-N CC1[C@]2(C)c3cc(-c4cncnc4)ccc3CC1NCC2 Chemical compound CC1[C@]2(C)c3cc(-c4cncnc4)ccc3CC1NCC2 LTJONDBMYKHBQC-ZZHQXOFYSA-N 0.000 description 1
- HDNJOKPOABYTHM-KJHMKFEISA-N CC1[C@]2(C)c3cc(C(C=C4)=CN(C)C4=O)ccc3CC1NCC2 Chemical compound CC1[C@]2(C)c3cc(C(C=C4)=CN(C)C4=O)ccc3CC1NCC2 HDNJOKPOABYTHM-KJHMKFEISA-N 0.000 description 1
- NGEQBRDOBHEQIS-XATSIWNJSA-N CC1[C@]2(C)c3cc(C(C=CN4C)=CC4=O)ccc3CC1N(C)CC2 Chemical compound CC1[C@]2(C)c3cc(C(C=CN4C)=CC4=O)ccc3CC1N(C)CC2 NGEQBRDOBHEQIS-XATSIWNJSA-N 0.000 description 1
- QNLPPCGVHQDRBB-UHFFFAOYSA-N COC(C1(C2)c3cc(OC)ccc3CC2NCC1)=O Chemical compound COC(C1(C2)c3cc(OC)ccc3CC2NCC1)=O QNLPPCGVHQDRBB-UHFFFAOYSA-N 0.000 description 1
- CXTNTGBMBDRDET-IURRXHLWSA-N C[C@H](C(CN)CC(C)(C)C(Cc1c2)=C)c1ccc2S(N(C)C)(=O)=O Chemical compound C[C@H](C(CN)CC(C)(C)C(Cc1c2)=C)c1ccc2S(N(C)C)(=O)=O CXTNTGBMBDRDET-IURRXHLWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07120914.2 | 2007-11-16 | ||
| EP07120914 | 2007-11-16 | ||
| EP07123942 | 2007-12-21 | ||
| EP07123942.0 | 2007-12-21 | ||
| EP08155137.6 | 2008-04-24 | ||
| EP08155137 | 2008-04-24 | ||
| PCT/EP2008/065577 WO2009063061A2 (en) | 2007-11-16 | 2008-11-14 | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126666A Division JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503150A JP2011503150A (ja) | 2011-01-27 |
| JP2011503150A5 JP2011503150A5 (https=) | 2012-01-19 |
| JP5769970B2 true JP5769970B2 (ja) | 2015-08-26 |
Family
ID=40560240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533594A Active JP5769970B2 (ja) | 2007-11-16 | 2008-11-14 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
| JP2015126666A Active JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126666A Active JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8859580B2 (https=) |
| EP (1) | EP2220048B1 (https=) |
| JP (2) | JP5769970B2 (https=) |
| AR (1) | AR069545A1 (https=) |
| CA (1) | CA2704628C (https=) |
| CL (1) | CL2008003407A1 (https=) |
| TW (1) | TW200927115A (https=) |
| WO (1) | WO2009063061A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015199770A (ja) * | 2007-11-16 | 2015-11-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| EP2183228B1 (en) | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5734666B2 (ja) * | 2008-02-11 | 2015-06-17 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤 |
| CA2711757C (en) * | 2008-02-12 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5538356B2 (ja) * | 2008-03-18 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR071236A1 (es) | 2008-05-01 | 2010-06-02 | Vitae Pharmaceuticals Inc | Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1 |
| CA2723032A1 (en) * | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CL2009001059A1 (es) * | 2008-05-01 | 2010-11-12 | Boehringer Ingelheim Int | Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras. |
| US8765780B2 (en) | 2008-05-13 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
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| CL2008003407A1 (es) | 2010-01-11 |
| US20110190262A1 (en) | 2011-08-04 |
| JP2011503150A (ja) | 2011-01-27 |
| CA2704628C (en) | 2016-11-29 |
| WO2009063061A3 (en) | 2009-07-23 |
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