JP2011251959A5 - - Google Patents
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- Publication number
- JP2011251959A5 JP2011251959A5 JP2011100277A JP2011100277A JP2011251959A5 JP 2011251959 A5 JP2011251959 A5 JP 2011251959A5 JP 2011100277 A JP2011100277 A JP 2011100277A JP 2011100277 A JP2011100277 A JP 2011100277A JP 2011251959 A5 JP2011251959 A5 JP 2011251959A5
- Authority
- JP
- Japan
- Prior art keywords
- excipients
- particle size
- preparation
- particle
- ambroxol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 claims 1
- 229960005174 ambroxol Drugs 0.000 claims 1
- -1 aminoalkyl methacrylate Chemical compound 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 239000007771 core particle Substances 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011100277A JP6084355B2 (ja) | 2010-05-06 | 2011-04-28 | アンブロキソール含有製剤粒子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010106158 | 2010-05-06 | ||
| JP2010106158 | 2010-05-06 | ||
| JP2011100277A JP6084355B2 (ja) | 2010-05-06 | 2011-04-28 | アンブロキソール含有製剤粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011251959A JP2011251959A (ja) | 2011-12-15 |
| JP2011251959A5 true JP2011251959A5 (enExample) | 2014-05-08 |
| JP6084355B2 JP6084355B2 (ja) | 2017-02-22 |
Family
ID=45416214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011100277A Active JP6084355B2 (ja) | 2010-05-06 | 2011-04-28 | アンブロキソール含有製剤粒子 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6084355B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5758552B2 (ja) * | 2013-05-08 | 2015-08-05 | 全星薬品工業株式会社 | 機能性高分子皮膜で被覆された高含量薬物粒子およびそれを含む錠剤ならびにそれらの製造方法 |
| KR102083621B1 (ko) * | 2013-06-13 | 2020-03-02 | 한미약품 주식회사 | 암브록솔 및 레보드로프로피진을 포함하는 안정성이 개선된 경구용 액상 제제 |
| CN104606170A (zh) * | 2015-02-04 | 2015-05-13 | 上海华源安徽仁济制药有限公司 | 一种盐酸氨溴索胶囊及其制备方法 |
| CN107569473B (zh) * | 2017-09-28 | 2021-01-19 | 南京易亨制药有限公司 | 一种盐酸氨溴索缓释胶囊及其制备方法 |
| CN111135152A (zh) * | 2020-01-19 | 2020-05-12 | 安徽省先锋制药有限公司 | 一种盐酸氨溴索胶囊的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0774166B2 (ja) * | 1987-02-06 | 1995-08-09 | 信越化学工業株式会社 | 徐放性被覆薬剤の製造方法 |
| IT1252185B (it) * | 1991-12-11 | 1995-06-05 | Therapicon Srl | Preparazioni farmaceutiche a liberazione programmata |
| JP3170069B2 (ja) * | 1992-10-06 | 2001-05-28 | 日水製薬株式会社 | 徐放性顆粒剤 |
| JPH09315969A (ja) * | 1996-05-24 | 1997-12-09 | Taiyo Yakuhin Kogyo Kk | イブジラスト含有徐放性医薬品組成物及びその製造方法 |
| JP3677156B2 (ja) * | 1997-09-05 | 2005-07-27 | 武田薬品工業株式会社 | 医薬 |
| JPH11209306A (ja) * | 1998-01-20 | 1999-08-03 | Nichiko Pharmaceutical Co Ltd | 高薬物含有率徐放製剤の製法 |
| JP4367722B2 (ja) * | 1998-04-17 | 2009-11-18 | 大正製薬株式会社 | マルチプルユニットタイプ徐放性錠剤 |
| JP4974419B2 (ja) * | 2001-06-12 | 2012-07-11 | 東和薬品株式会社 | 薬物含有徐放性顆粒およびそれを含む錠剤 |
| JP4494712B2 (ja) * | 2002-11-12 | 2010-06-30 | 大日本住友製薬株式会社 | マルチプルユニット型徐放性製剤 |
| JP2008201706A (ja) * | 2007-02-20 | 2008-09-04 | Kowa Pharmaceutical Co Ltd | 小型徐放性錠剤 |
-
2011
- 2011-04-28 JP JP2011100277A patent/JP6084355B2/ja active Active
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