WO2015003479A3 - 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法 - Google Patents

一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法 Download PDF

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Publication number
WO2015003479A3
WO2015003479A3 PCT/CN2014/000836 CN2014000836W WO2015003479A3 WO 2015003479 A3 WO2015003479 A3 WO 2015003479A3 CN 2014000836 W CN2014000836 W CN 2014000836W WO 2015003479 A3 WO2015003479 A3 WO 2015003479A3
Authority
WO
WIPO (PCT)
Prior art keywords
pellet
orally administered
infants
children
preparation
Prior art date
Application number
PCT/CN2014/000836
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English (en)
French (fr)
Other versions
WO2015003479A2 (zh
Inventor
孙卫东
任逢晓
Original Assignee
Sun Weidong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Weidong filed Critical Sun Weidong
Publication of WO2015003479A2 publication Critical patent/WO2015003479A2/zh
Publication of WO2015003479A3 publication Critical patent/WO2015003479A3/zh
Priority to US14/992,038 priority Critical patent/US9585845B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种适用于婴幼儿及儿童的口服微丸组合物及其制备方法。该口服微丸组合物由含药丸芯和包衣层组成，含药丸芯中的药物为奥司他韦或其药学上可接受的盐，其占微丸总重量的10%-40%，包衣层所用材料为聚丙烯酸树脂IV，其占微丸总重量的1%-50%，该微丸粒径为0.10-0.50mm。
PCT/CN2014/000836 2013-07-11 2014-09-10 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法 WO2015003479A2 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/992,038 US9585845B2 (en) 2013-07-11 2016-01-11 Oral pharmaceutical composition comprising oseltamivir and method of preparing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310290958.4 2013-07-11
CN201310290958.4A CN103315965B (zh) 2013-07-11 2013-07-11 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/992,038 Continuation-In-Part US9585845B2 (en) 2013-07-11 2016-01-11 Oral pharmaceutical composition comprising oseltamivir and method of preparing the same

Publications (2)

Publication Number Publication Date
WO2015003479A2 WO2015003479A2 (zh) 2015-01-15
WO2015003479A3 true WO2015003479A3 (zh) 2015-03-05

Family

ID=49185202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/000836 WO2015003479A2 (zh) 2013-07-11 2014-09-10 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法

Country Status (3)

Country Link
US (1) US9585845B2 (zh)
CN (1) CN103315965B (zh)
WO (1) WO2015003479A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103315965B (zh) * 2013-07-11 2015-08-05 河南中帅医药科技股份有限公司 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法
CN104490801A (zh) * 2014-11-27 2015-04-08 河南中帅医药科技股份有限公司 一种适用于婴幼儿及儿童的可压碎片及其制备方法
WO2016088010A1 (en) * 2014-12-01 2016-06-09 Lupin Atlantis Holdings Sa Oseltamivir compositions
CN106236714A (zh) * 2015-06-05 2016-12-21 广东东阳光药业有限公司 一种磷酸奥司他韦片剂及其制备方法
CN106237337B (zh) * 2016-08-05 2019-11-08 河南中帅医药科技股份有限公司 一种液体药物制剂用防腐组合物
JP6778051B2 (ja) * 2016-08-18 2020-10-28 沢井製薬株式会社 オセルタミビルリン酸塩含有医薬組成物
CN106617285B (zh) * 2016-09-27 2019-11-08 湖北中烟工业有限责任公司 一种变色烟用香料珠及其制备方法
CN112587483A (zh) * 2020-12-16 2021-04-02 上海应用技术大学 一种具有掩味效果的小儿复方感冒干混悬剂及其制备方法和应用
CN114869845A (zh) * 2022-05-07 2022-08-09 江苏大学 一种磷酸奥司他韦缓释混悬剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050175689A1 (en) * 2003-10-27 2005-08-11 Yamanouchi Pharmaceutical Co., Ltd. Coated fine particles containing drug for intrabuccally fast disintegrating tablet
CN1820744A (zh) * 2006-04-04 2006-08-23 中国人民解放军军事医学科学院毒物药物研究所 磷酸奥司他韦颗粒剂及其制备方法
WO2010143207A1 (en) * 2009-06-11 2010-12-16 Rubicon Research Private Limited Taste-masked oral formulations of influenza antivirals
CN103315965A (zh) * 2013-07-11 2013-09-25 孙卫东 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102068425A (zh) * 2011-02-12 2011-05-25 李春娟 改良的磷酸奥司他韦药物组合物
CN102172348B (zh) * 2011-02-12 2013-02-20 北京博康宁生物医药科技有限公司 固体的磷酸奥司他韦药物组合物
CN102225058A (zh) * 2011-06-22 2011-10-26 中国药科大学 磷酸奥司他韦吸入粉雾剂及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050175689A1 (en) * 2003-10-27 2005-08-11 Yamanouchi Pharmaceutical Co., Ltd. Coated fine particles containing drug for intrabuccally fast disintegrating tablet
CN1820744A (zh) * 2006-04-04 2006-08-23 中国人民解放军军事医学科学院毒物药物研究所 磷酸奥司他韦颗粒剂及其制备方法
WO2010143207A1 (en) * 2009-06-11 2010-12-16 Rubicon Research Private Limited Taste-masked oral formulations of influenza antivirals
CN103315965A (zh) * 2013-07-11 2013-09-25 孙卫东 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法

Also Published As

Publication number Publication date
WO2015003479A2 (zh) 2015-01-15
CN103315965B (zh) 2015-08-05
US20160120820A1 (en) 2016-05-05
CN103315965A (zh) 2013-09-25
US9585845B2 (en) 2017-03-07

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