JP2014526447A5 - - Google Patents

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Publication number
JP2014526447A5
JP2014526447A5 JP2014528879A JP2014528879A JP2014526447A5 JP 2014526447 A5 JP2014526447 A5 JP 2014526447A5 JP 2014528879 A JP2014528879 A JP 2014528879A JP 2014528879 A JP2014528879 A JP 2014528879A JP 2014526447 A5 JP2014526447 A5 JP 2014526447A5
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JP
Japan
Prior art keywords
nasal
nose
carrier material
powder
inhaled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2014528879A
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English (en)
Japanese (ja)
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JP2014526447A (ja
JP6060163B2 (ja
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Priority claimed from DE102011112978A external-priority patent/DE102011112978A1/de
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Publication of JP2014526447A publication Critical patent/JP2014526447A/ja
Publication of JP2014526447A5 publication Critical patent/JP2014526447A5/ja
Application granted granted Critical
Publication of JP6060163B2 publication Critical patent/JP6060163B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2014528879A 2011-09-09 2012-08-13 キナーゼインヒビターとしてのベンゾニトリル誘導体 Expired - Fee Related JP6060163B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011112978A DE102011112978A1 (de) 2011-09-09 2011-09-09 Benzonitrilderivate
DE102011112978.6 2011-09-09
PCT/EP2012/003449 WO2013034238A1 (de) 2011-09-09 2012-08-13 Benzonitrilderivate als kinasehemmer

Publications (3)

Publication Number Publication Date
JP2014526447A JP2014526447A (ja) 2014-10-06
JP2014526447A5 true JP2014526447A5 (enExample) 2015-10-01
JP6060163B2 JP6060163B2 (ja) 2017-01-11

Family

ID=46679243

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014528879A Expired - Fee Related JP6060163B2 (ja) 2011-09-09 2012-08-13 キナーゼインヒビターとしてのベンゾニトリル誘導体

Country Status (27)

Country Link
US (1) US8969335B2 (enExample)
EP (1) EP2753615B1 (enExample)
JP (1) JP6060163B2 (enExample)
KR (1) KR101985984B1 (enExample)
CN (1) CN103930416B (enExample)
AR (1) AR087807A1 (enExample)
AU (1) AU2012306746B2 (enExample)
BR (1) BR112014005226A2 (enExample)
CA (1) CA2848148C (enExample)
DE (1) DE102011112978A1 (enExample)
DK (1) DK2753615T3 (enExample)
EA (1) EA025038B1 (enExample)
ES (1) ES2644128T3 (enExample)
HR (1) HRP20171296T1 (enExample)
HU (1) HUE036774T2 (enExample)
IL (1) IL231382A (enExample)
IN (1) IN2014KN00769A (enExample)
LT (1) LT2753615T (enExample)
MX (1) MX344335B (enExample)
NO (1) NO2753615T3 (enExample)
PL (1) PL2753615T3 (enExample)
PT (1) PT2753615T (enExample)
RS (1) RS56481B1 (enExample)
SG (1) SG2014015234A (enExample)
SI (1) SI2753615T1 (enExample)
WO (1) WO2013034238A1 (enExample)
ZA (1) ZA201402561B (enExample)

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GB201303109D0 (en) 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
WO2014177524A1 (en) 2013-05-01 2014-11-06 F. Hoffmann-La Roche Ag C-linked heterocycloalkyl substituted pyrimidines and their uses
JP6783224B2 (ja) 2014-04-04 2020-11-11 デル マー ファーマシューティカルズ 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
CN104201295B (zh) * 2014-09-16 2017-05-03 深圳市华星光电技术有限公司 Oled的封装方法及oled结构
NZ729618A (en) 2014-09-26 2018-07-27 Gilead Sciences Inc Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
WO2016057338A1 (en) * 2014-10-06 2016-04-14 Takeda Pharmaceutical Company Limited Heteroarylamide inhibitors of tbk1
CN106854174A (zh) * 2015-12-08 2017-06-16 湖南华腾制药有限公司 一种4位取代哌啶衍生物的制备方法
EP3394044A1 (en) * 2015-12-17 2018-10-31 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
US10894784B2 (en) 2015-12-18 2021-01-19 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
CN107286076A (zh) * 2016-04-05 2017-10-24 湖南华腾制药有限公司 一种哌啶类化合物的制备方法
CN107400082A (zh) * 2016-05-19 2017-11-28 湖南华腾制药有限公司 一种取代哌啶衍生物的制备方法
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
DE102016113714A1 (de) 2016-07-26 2018-02-01 Rosa Karl Transfektionsverfahren mit nicht-viralen Genliefersystemen
CN107698491A (zh) * 2016-08-08 2018-02-16 湖南华腾制药有限公司 一种取代哌啶衍生物的制备方法
CN107778215A (zh) * 2016-08-30 2018-03-09 湖南华腾制药有限公司 一种氟取代哌啶衍生物的制备方法
CN107778216A (zh) * 2016-08-30 2018-03-09 湖南华腾制药有限公司 一种氟取代哌啶衍生物的制备方法
CN108117510A (zh) * 2016-11-29 2018-06-05 湖南华腾制药有限公司 一种哌啶衍生物的制备方法
CN108610309A (zh) * 2016-12-13 2018-10-02 湖南华腾制药有限公司 一种哌啶衍生物的制备方法
GB201702947D0 (en) 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
CA3078583A1 (en) * 2017-10-17 2019-04-25 Merck Patent Gmbh Pyrimidine tbk/ikk.epsilon. inhibitor compounds and uses thereof
RU2020115596A (ru) * 2017-10-17 2021-11-18 Мерк Патент Гмбх ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ TBK/IKKε И ИХ ПРИМЕНЕНИЯ
WO2020118683A1 (en) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
WO2020206588A1 (en) * 2019-04-08 2020-10-15 Lynk Pharmaceuticals Co., Ltd. Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
CN110627775B (zh) * 2019-10-24 2026-01-30 特科罗生物科技(成都)有限公司 一种小分子化合物
CN112209886A (zh) * 2020-11-09 2021-01-12 沈阳药科大学 2-(3-氰基-4-烷氧基)苯基嘧啶衍生物及其制备方法和用途
CN113024565B (zh) * 2021-03-31 2022-09-13 上海启甄环境科技有限公司 一种放射性同位素碳-14标记依鲁替尼及其合成方法
WO2024239282A1 (zh) * 2023-05-24 2024-11-28 凌科药业(杭州)有限公司 一种药物组合物、外用制剂及其制备方法、应用

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SE0203754D0 (sv) 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
EP1648875A1 (en) 2003-07-30 2006-04-26 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
WO2007129044A1 (en) 2006-05-03 2007-11-15 Astrazeneca Ab Thiazole derivatives and their use as anti-tumour agents
WO2008065155A1 (en) * 2006-11-30 2008-06-05 Ingenium Pharmaceuticals Gmbh Cdk inhibitors for treating pain
US8486941B2 (en) 2007-03-12 2013-07-16 Ym Biosciences Australia Pty Ltd Phenyl amino pyrimidine compounds and uses thereof
WO2009030890A1 (en) 2007-09-03 2009-03-12 University Court Of The University Of Dundee Pyrimidine compounds for the treatment of cancer, septic shock and/or primary open angle glaucoma
ES2535166T3 (es) 2007-09-04 2015-05-06 The Scripps Research Institute Pirimidinil-aminas sustituidas como inhibidores de proteína-quinasas
JP2011500778A (ja) 2007-10-25 2011-01-06 アストラゼネカ・アクチエボラーグ ピリジン及びピラジン誘導体−０８３
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WO2010151747A1 (en) * 2009-06-26 2010-12-29 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimine compounds and methods of making and using same
CN102791697A (zh) 2009-10-12 2012-11-21 瑞科西有限公司 作为TBKL和/或IKKε抑制剂的氨基-嘧啶化合物
GB201012105D0 (en) 2010-07-19 2010-09-01 Domainex Ltd Novel pyrimidine compounds
EP2638018A1 (en) 2010-11-09 2013-09-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
BR112013026202A2 (pt) * 2011-04-12 2017-07-25 Myrexis Inc composições e usos terapêuticos de inibidores quinase epsilon relacionado a ikk e quinase i de ligação a tank

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