JP2013544781A5 - - Google Patents
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- Publication number
- JP2013544781A5 JP2013544781A5 JP2013533102A JP2013533102A JP2013544781A5 JP 2013544781 A5 JP2013544781 A5 JP 2013544781A5 JP 2013533102 A JP2013533102 A JP 2013533102A JP 2013533102 A JP2013533102 A JP 2013533102A JP 2013544781 A5 JP2013544781 A5 JP 2013544781A5
- Authority
- JP
- Japan
- Prior art keywords
- nasal
- nose
- carrier material
- powder
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012876 carrier material Substances 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010048374A DE102010048374A1 (de) | 2010-10-13 | 2010-10-13 | Pyrrolidinone als MetAP-2 Inhibitoren |
| DE102010048374.5 | 2010-10-13 | ||
| PCT/EP2011/004608 WO2012048775A1 (de) | 2010-10-13 | 2011-09-14 | Pyrrolidinone als metap-2 inhibitoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544781A JP2013544781A (ja) | 2013-12-19 |
| JP2013544781A5 true JP2013544781A5 (enExample) | 2016-02-25 |
| JP5931885B2 JP5931885B2 (ja) | 2016-06-08 |
Family
ID=44677838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533102A Active JP5931885B2 (ja) | 2010-10-13 | 2011-09-14 | ＭｅｔＡＰ２阻害剤としてのピロリジノン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8895535B2 (enExample) |
| EP (1) | EP2627631B1 (enExample) |
| JP (1) | JP5931885B2 (enExample) |
| KR (1) | KR101803126B1 (enExample) |
| CN (1) | CN103153951B (enExample) |
| AR (1) | AR083402A1 (enExample) |
| AU (1) | AU2011316199B2 (enExample) |
| BR (1) | BR112013008886B1 (enExample) |
| CA (1) | CA2814369C (enExample) |
| CY (1) | CY1117287T1 (enExample) |
| DE (1) | DE102010048374A1 (enExample) |
| DK (1) | DK2627631T3 (enExample) |
| EA (1) | EA022299B1 (enExample) |
| ES (1) | ES2563317T3 (enExample) |
| HR (1) | HRP20160249T1 (enExample) |
| HU (1) | HUE027149T2 (enExample) |
| IL (1) | IL225626A0 (enExample) |
| MX (1) | MX2013004004A (enExample) |
| PL (1) | PL2627631T3 (enExample) |
| RS (1) | RS54629B1 (enExample) |
| SG (1) | SG189853A1 (enExample) |
| SI (1) | SI2627631T1 (enExample) |
| WO (1) | WO2012048775A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575349B2 (en) * | 2010-11-22 | 2013-11-05 | International Flavors & Fragrances Inc. | Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds |
| JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| PL2573073T3 (pl) * | 2011-09-26 | 2015-04-30 | Sanofi Sa | Pochodne pirazolochinolinonu, ich wytwarzanie i ich zastosowanie terapeutyczne |
| DE102012006884A1 (de) * | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
| JPWO2015037716A1 (ja) * | 2013-09-12 | 2017-03-02 | 住友化学株式会社 | 含窒素飽和複素環化合物 |
| BR112017000730B8 (pt) * | 2014-08-04 | 2023-01-10 | Merck Patent Gmbh | Derivados de pirrolidinona como inibidores de metap-2, e medicamentos |
| WO2017004797A1 (en) * | 2015-07-08 | 2017-01-12 | Eli Lilly And Company | Pyrrolidinone compounds |
| WO2017084096A1 (en) * | 2015-11-20 | 2017-05-26 | Eli Lilly And Company | Pyrrolidinone compounds |
| WO2017219083A1 (en) * | 2016-06-21 | 2017-12-28 | The University Of Melbourne | Activators of hiv latency |
| WO2018098781A1 (en) * | 2016-12-01 | 2018-06-07 | Eli Lilly And Company | Pyrrolidinone compounds |
| WO2019065794A1 (ja) * | 2017-09-27 | 2019-04-04 | 国立大学法人鹿児島大学 | Ｐａｃ１受容体拮抗薬を用いた鎮痛薬 |
| CN108409630B (zh) * | 2018-02-07 | 2021-01-15 | 宁波大学 | 一种水相中3-羟基-2-吲哚酮衍生物的制备方法 |
| BR112021014220A2 (pt) | 2019-01-22 | 2022-01-18 | Merck Patent Gmbh | Derivados heterocíclicos |
| EP3994134B9 (en) * | 2019-07-03 | 2024-06-26 | Merck Patent GmbH | Process for manufacturing (s)-3-hydroxy-1-(1h-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide |
| CN112480100B (zh) * | 2019-09-11 | 2022-10-14 | 康威(广州)生物科技有限公司 | 吡咯烷酮衍生物 |
| CN110759843A (zh) * | 2019-09-30 | 2020-02-07 | 东北师范大学 | 一种氟叠氮取代的四元杂环化合物的制备和应用 |
| IL299715A (en) | 2020-07-09 | 2023-03-01 | Merck Patent Gmbh | Combination of methionine aminopeptidase 2 inhibitor and VEGFR/VEGF inhibitor |
| CN112851561A (zh) * | 2021-01-29 | 2021-05-28 | 南京艾美斐生物医药科技有限公司 | 一种nr6a1蛋白受体抑制剂及其制备和应用 |
| CA3213624A1 (en) * | 2021-03-28 | 2022-10-06 | Canwell Biotech Limited | Metap-2 inhibitors, pharmaceutical compositions and therapeutic methods thereof |
| WO2023144053A1 (en) | 2022-01-26 | 2023-08-03 | Merck Patent Gmbh | Heterocyclic derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| AR028537A1 (es) | 2000-04-14 | 2003-05-14 | Abbott Lab | Hidrazidas y alcoxiamidas inhibidoras de la angiogénesis |
| US20070161570A1 (en) | 2000-11-01 | 2007-07-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| AU2002306907A1 (en) | 2001-04-03 | 2002-10-21 | Smithkline Beecham Corporation | Method for inhibiting metap2 |
| US20030225054A1 (en) * | 2002-06-03 | 2003-12-04 | Jingwu Duan | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents |
| CA2502478A1 (en) | 2002-10-18 | 2004-05-06 | Basf Aktiengesellschaft | 1-phenylpyrrolidine-2-one-3-carboxamides |
| JP2006104280A (ja) | 2004-10-04 | 2006-04-20 | Toyo Tire & Rubber Co Ltd | 高熱伝導性加硫ゴム成形体及びダイアフラム |
| US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| US20070123508A1 (en) | 2005-05-27 | 2007-05-31 | Roger Olsson | PAR2-modulating compounds and their use |
| UY31984A (es) * | 2008-07-16 | 2010-02-26 | Boehringer Ingelheim Int | DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas. |
| WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
| CA2786603C (en) | 2010-01-08 | 2018-02-20 | James E. Vath | Fumagillol type compounds and methods of making and using same |
-
2010
- 2010-10-13 DE DE102010048374A patent/DE102010048374A1/de not_active Withdrawn
-
2011
- 2011-09-14 HU HUE11761005A patent/HUE027149T2/en unknown
- 2011-09-14 EA EA201300442A patent/EA022299B1/ru not_active IP Right Cessation
- 2011-09-14 HR HRP20160249TT patent/HRP20160249T1/hr unknown
- 2011-09-14 EP EP11761005.5A patent/EP2627631B1/de active Active
- 2011-09-14 SG SG2013026133A patent/SG189853A1/en unknown
- 2011-09-14 JP JP2013533102A patent/JP5931885B2/ja active Active
- 2011-09-14 KR KR1020137011998A patent/KR101803126B1/ko active Active
- 2011-09-14 US US13/878,574 patent/US8895535B2/en active Active
- 2011-09-14 WO PCT/EP2011/004608 patent/WO2012048775A1/de not_active Ceased
- 2011-09-14 MX MX2013004004A patent/MX2013004004A/es unknown
- 2011-09-14 AU AU2011316199A patent/AU2011316199B2/en active Active
- 2011-09-14 DK DK11761005.5T patent/DK2627631T3/en active
- 2011-09-14 CN CN201180049753.6A patent/CN103153951B/zh active Active
- 2011-09-14 CA CA2814369A patent/CA2814369C/en active Active
- 2011-09-14 SI SI201130753T patent/SI2627631T1/sl unknown
- 2011-09-14 BR BR112013008886-9A patent/BR112013008886B1/pt active IP Right Grant
- 2011-09-14 RS RS20160123A patent/RS54629B1/sr unknown
- 2011-09-14 PL PL11761005T patent/PL2627631T3/pl unknown
- 2011-09-14 ES ES11761005T patent/ES2563317T3/es active Active
- 2011-10-13 AR ARP110103781A patent/AR083402A1/es not_active Application Discontinuation
-
2013
- 2013-04-08 IL IL225626A patent/IL225626A0/en active IP Right Grant
-
2016
- 2016-03-15 CY CY20161100221T patent/CY1117287T1/el unknown
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