JP2013538214A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013538214A5 JP2013538214A5 JP2013526335A JP2013526335A JP2013538214A5 JP 2013538214 A5 JP2013538214 A5 JP 2013538214A5 JP 2013526335 A JP2013526335 A JP 2013526335A JP 2013526335 A JP2013526335 A JP 2013526335A JP 2013538214 A5 JP2013538214 A5 JP 2013538214A5
- Authority
- JP
- Japan
- Prior art keywords
- syk
- pharmaceutically acceptable
- osteoclasts
- optionally
- nasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008927.5 | 2010-08-27 | ||
| EP10008927 | 2010-08-27 | ||
| PCT/EP2011/003830 WO2012025186A1 (en) | 2010-08-27 | 2011-07-29 | Triazolopyrazine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013538214A JP2013538214A (ja) | 2013-10-10 |
| JP2013538214A5 true JP2013538214A5 (enExample) | 2015-07-16 |
| JP5951610B2 JP5951610B2 (ja) | 2016-07-13 |
Family
ID=44629489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526335A Expired - Fee Related JP5951610B2 (ja) | 2010-08-27 | 2011-07-29 | トリアゾロピラジン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9023851B2 (enExample) |
| EP (1) | EP2609098B1 (enExample) |
| JP (1) | JP5951610B2 (enExample) |
| KR (1) | KR20130110163A (enExample) |
| CN (1) | CN103068828B (enExample) |
| AR (1) | AR082726A1 (enExample) |
| AU (1) | AU2011295440B2 (enExample) |
| BR (1) | BR112013004517A2 (enExample) |
| CA (1) | CA2809331C (enExample) |
| EA (1) | EA201300282A1 (enExample) |
| ES (1) | ES2614128T3 (enExample) |
| IL (1) | IL224869A (enExample) |
| MX (1) | MX2013002198A (enExample) |
| SG (1) | SG188296A1 (enExample) |
| WO (1) | WO2012025186A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2674451T3 (es) * | 2012-02-21 | 2018-06-29 | Merck Patent Gmbh | 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 |
| HK1203948A1 (en) * | 2012-03-07 | 2015-11-06 | Merck Patent Gmbh | Triazolopyrazine derivatives |
| CA2879570A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| CN104640850A (zh) * | 2012-10-26 | 2015-05-20 | 霍夫曼-拉罗奇有限公司 | 3,4-二取代的1h-吡唑和4,5-二取代的噻唑的syk抑制剂 |
| CN105026398B (zh) * | 2013-03-05 | 2018-05-18 | 默克专利股份公司 | 用于治疗疾病诸如癌症的三唑并[4,5-d]嘧啶衍生物 |
| WO2014135245A1 (en) * | 2013-03-05 | 2014-09-12 | Merck Patent Gmbh | 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents |
| CN105164136B (zh) * | 2013-05-06 | 2017-12-22 | 默克专利股份公司 | 作为激酶抑制剂的大环化合物 |
| WO2015017402A1 (en) * | 2013-07-29 | 2015-02-05 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the treatment of biofilm infections |
| US9856263B2 (en) | 2014-04-28 | 2018-01-02 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
| KR101756934B1 (ko) | 2014-07-08 | 2017-07-12 | 연세대학교 산학협력단 | 피롤로[1,2-a]피라진 유도체, 이의 약학적으로 허용가능한 염, 이들 화합물의 제조방법 및 이를 유효성분으로 함유하는 골다공증 치료 또는 예방용 약학조성물 |
| NZ754364A (en) | 2016-12-22 | 2023-04-28 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
| US20190292188A1 (en) | 2018-02-27 | 2019-09-26 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
| MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
| CN113166153B (zh) | 2018-07-05 | 2024-11-01 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| CA3159348A1 (en) | 2019-11-08 | 2021-05-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115916747A (zh) * | 2020-07-01 | 2023-04-04 | 四川海思科制药有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2434871C2 (ru) * | 2005-02-03 | 2011-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Пирролопиримидины, применимые в качестве ингибиторов протеинкиназы |
| JP4652906B2 (ja) * | 2005-06-30 | 2011-03-16 | 富士夫 宮脇 | 振動型マイクロインジェクション装置 |
| JP5256047B2 (ja) * | 2006-01-27 | 2013-08-07 | シャンハイ ヘンルイ ファーマシューティカル カンパニー リミテッド | ピロロ［３，２−ｃ］ピリジン−４−オン２−インドリノン（ｉｎｄｏｌｉｎｏｎｅ）プロテインキナーゼ阻害剤 |
| WO2008057994A2 (en) * | 2006-11-03 | 2008-05-15 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7834024B2 (en) | 2007-03-26 | 2010-11-16 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| CA2728893C (en) | 2008-04-16 | 2017-03-14 | Portola Pharmaceuticals, Inc. | Inhibitors of syk protein kinase |
| AU2009259867A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
| RU2560153C2 (ru) | 2008-06-20 | 2015-08-20 | Дженентек, Инк. | Триазолпиридиновые соединения, ингибирующие jak, и способы |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| MX2011012961A (es) * | 2009-06-05 | 2012-01-30 | Cephalon Inc | Preparacion y usos de derivados de 1,2,4-triazolo[1,5a]-piridina. |
| PE20121511A1 (es) | 2010-01-15 | 2012-12-06 | Janssen Pharmaceuticals Inc | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
-
2011
- 2011-07-29 KR KR20137007843A patent/KR20130110163A/ko not_active Withdrawn
- 2011-07-29 EP EP11738630.0A patent/EP2609098B1/en not_active Not-in-force
- 2011-07-29 WO PCT/EP2011/003830 patent/WO2012025186A1/en not_active Ceased
- 2011-07-29 JP JP2013526335A patent/JP5951610B2/ja not_active Expired - Fee Related
- 2011-07-29 EA EA201300282A patent/EA201300282A1/ru unknown
- 2011-07-29 CN CN201180041643.5A patent/CN103068828B/zh not_active Expired - Fee Related
- 2011-07-29 SG SG2013014006A patent/SG188296A1/en unknown
- 2011-07-29 ES ES11738630.0T patent/ES2614128T3/es active Active
- 2011-07-29 AU AU2011295440A patent/AU2011295440B2/en not_active Ceased
- 2011-07-29 MX MX2013002198A patent/MX2013002198A/es not_active Application Discontinuation
- 2011-07-29 CA CA2809331A patent/CA2809331C/en not_active Expired - Fee Related
- 2011-07-29 US US13/819,120 patent/US9023851B2/en active Active
- 2011-07-29 BR BR112013004517A patent/BR112013004517A2/pt not_active Application Discontinuation
- 2011-08-26 AR ARP110103111 patent/AR082726A1/es unknown
-
2013
- 2013-02-21 IL IL224869A patent/IL224869A/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013538214A5 (enExample) | ||
| US10568868B2 (en) | Methods and compositions for treating metabolic reprogramming disorders | |
| ES2761406T3 (es) | Protección transitoria de células normales durante una quimioterapia | |
| JP2013534227A5 (enExample) | ||
| JP2014526447A5 (enExample) | ||
| JP2014509313A5 (enExample) | ||
| ES2875584T3 (es) | Formulación para inhalación líquida que comprende RPL554 | |
| US20180303838A1 (en) | Transient protection of hematopoietic stem and progenitor cells against ionizing radiation | |
| AU2024219564A1 (en) | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs | |
| JP2013544781A5 (enExample) | ||
| ES2795879T3 (es) | Aplicaciones terapéuticas de ectoína | |
| UA121104C2 (uk) | Гетероциклічні сполуки і їх застосування | |
| US11980633B2 (en) | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors | |
| EA201491674A1 (ru) | Новые фармацевтические композиции | |
| JP2015505541A5 (enExample) | ||
| US20240293557A1 (en) | Proteolysis targeting chimeras and methods of use thereof | |
| CN105939717A (zh) | 治疗和预防同种抗体驱动的慢性移植物抗宿主病的方法 | |
| US11844779B2 (en) | PKC-Delta-I inhibitor formulations and uses thereof | |
| KR101838764B1 (ko) | (ｅ)-4-카복시스티릴-4-클로로벤질설폰의 개선된 안정한 수성 제형 | |
| ES2530223T3 (es) | Combinación de insulina con derivados de triazina y su uso para tratar la diabetes | |
| US20240299558A1 (en) | Proteolysis targeting chimeras and polypharmacological agents targeting bcl-2, and methods of use thereof | |
| US20230241034A1 (en) | Microtubule polymerization inhibitor prodrugs and methods of using the same | |
| ES3023840T3 (en) | Pirfenidone derivatives for modulation of b lymphocyte activity and organ protection | |
| AU2008240118B2 (en) | Methods for treating neoplasia with combination of chemotherapeutic agents and radiation | |
| IT9022104A1 (it) | Composizioni per la terapia mucolitica |