CN103153951B - 作为MetAP-2抑制剂的吡咯烷酮 - Google Patents
作为MetAP-2抑制剂的吡咯烷酮 Download PDFInfo
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- CN103153951B CN103153951B CN201180049753.6A CN201180049753A CN103153951B CN 103153951 B CN103153951 B CN 103153951B CN 201180049753 A CN201180049753 A CN 201180049753A CN 103153951 B CN103153951 B CN 103153951B
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- 0 CC(C)(C(CC*1C2=CC(*)=CCC2)C1=I)C(CCC1=CC=*CN1)=C Chemical compound CC(C)(C(CC*1C2=CC(*)=CCC2)C1=I)C(CCC1=CC=*CN1)=C 0.000 description 1
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010048374.5 | 2010-10-13 | ||
| DE102010048374A DE102010048374A1 (de) | 2010-10-13 | 2010-10-13 | Pyrrolidinone als MetAP-2 Inhibitoren |
| PCT/EP2011/004608 WO2012048775A1 (de) | 2010-10-13 | 2011-09-14 | Pyrrolidinone als metap-2 inhibitoren |
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| CN103153951A CN103153951A (zh) | 2013-06-12 |
| CN103153951B true CN103153951B (zh) | 2016-05-25 |
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| CN201180049753.6A Active CN103153951B (zh) | 2010-10-13 | 2011-09-14 | 作为MetAP-2抑制剂的吡咯烷酮 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8575349B2 (en) * | 2010-11-22 | 2013-11-05 | International Flavors & Fragrances Inc. | Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds |
| JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| ES2527188T3 (es) * | 2011-09-26 | 2015-01-21 | Sanofi | Derivados de pirazolquinolinona, su preparación y su uso terapéutico |
| DE102012006884A1 (de) * | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
| HK1223927A1 (en) * | 2013-09-12 | 2017-08-11 | Sumitomo Chemical Company, Limited | Nitrogen-containing saturated heterocyclic compound |
| NZ728847A (en) * | 2014-08-04 | 2023-05-26 | Merck Patent Gmbh | Pyrrolidinone derivatives as metap-2 inhibitors |
| WO2017004797A1 (en) * | 2015-07-08 | 2017-01-12 | Eli Lilly And Company | Pyrrolidinone compounds |
| WO2017084096A1 (en) * | 2015-11-20 | 2017-05-26 | Eli Lilly And Company | Pyrrolidinone compounds |
| US20190330167A1 (en) * | 2016-06-21 | 2019-10-31 | The Walter And Eliza Hall Institute Of Medical Research | Activators of hiv latency |
| WO2018098781A1 (en) * | 2016-12-01 | 2018-06-07 | Eli Lilly And Company | Pyrrolidinone compounds |
| JP7169592B2 (ja) * | 2017-09-27 | 2022-11-11 | 国立大学法人 鹿児島大学 | Pac1受容体拮抗薬を用いた鎮痛薬 |
| CN108409630B (zh) * | 2018-02-07 | 2021-01-15 | 宁波大学 | 一种水相中3-羟基-2-吲哚酮衍生物的制备方法 |
| EP3914590B1 (en) * | 2019-01-22 | 2022-09-28 | Merck Patent GmbH | Heterocyclic derivatives |
| KR20220028030A (ko) | 2019-07-03 | 2022-03-08 | 메르크 파텐트 게엠베하 | (s)-3-히드록시-1-(1h-인돌-5-일)-2-옥소-피롤리딘-3-카르복실산 3,5-디플루오로-벤질아미드의 제조 방법 |
| CN112480100B (zh) * | 2019-09-11 | 2022-10-14 | 康威(广州)生物科技有限公司 | 吡咯烷酮衍生物 |
| CN110759843A (zh) * | 2019-09-30 | 2020-02-07 | 东北师范大学 | 一种氟叠氮取代的四元杂环化合物的制备和应用 |
| US20230248695A1 (en) | 2020-07-09 | 2023-08-10 | Merck Patent Gmbh | Combinations of cancer therapeutics |
| CN112851561A (zh) * | 2021-01-29 | 2021-05-28 | 南京艾美斐生物医药科技有限公司 | 一种nr6a1蛋白受体抑制剂及其制备和应用 |
| JP2024512610A (ja) * | 2021-03-28 | 2024-03-19 | キャンウェル バイオテック リミテッド | Metap-2阻害剤、医薬組成物、及びそれらの治療方法 |
| WO2023144053A1 (en) | 2022-01-26 | 2023-08-03 | Merck Patent Gmbh | Heterocyclic derivatives |
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| WO2006127396A1 (en) * | 2005-05-27 | 2006-11-30 | Acadia Pharmaceuticals Inc. | Par2-modulating compounds and their use |
| EP1864971A1 (en) * | 2005-03-31 | 2007-12-12 | Takeda Pharmaceutical Company Limited | Prophylactic/therapeutic agent for diabetes |
| WO2010007114A2 (en) * | 2008-07-16 | 2010-01-21 | Boehringer Ingelheim International Gmbh | New chemical compounds |
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| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| UY26664A1 (es) | 2000-04-14 | 2001-11-30 | Abbott Lab | Hidrazidas y alcoxiamidas inhibidoras de la angiogénesis. |
| US20070161570A1 (en) | 2000-11-01 | 2007-07-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| JP2004535377A (ja) | 2001-04-03 | 2004-11-25 | スミスクライン・ビーチャム・コーポレイション | Metap2を阻害する方法 |
| US20030225054A1 (en) * | 2002-06-03 | 2003-12-04 | Jingwu Duan | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents |
| CA2502478A1 (en) * | 2002-10-18 | 2004-05-06 | Basf Aktiengesellschaft | 1-phenylpyrrolidine-2-one-3-carboxamides |
| JP2006104280A (ja) | 2004-10-04 | 2006-04-20 | Toyo Tire & Rubber Co Ltd | 高熱伝導性加硫ゴム成形体及びダイアフラム |
| MX343135B (es) | 2010-01-08 | 2016-10-25 | Zafgen Corp * | Compuestos de tipo fumagilol y métodos de realización y uso de los mismos. |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
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2010
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- 2011-09-14 RS RS20160123A patent/RS54629B1/sr unknown
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1864971A1 (en) * | 2005-03-31 | 2007-12-12 | Takeda Pharmaceutical Company Limited | Prophylactic/therapeutic agent for diabetes |
| WO2006127396A1 (en) * | 2005-05-27 | 2006-11-30 | Acadia Pharmaceuticals Inc. | Par2-modulating compounds and their use |
| WO2010007114A2 (en) * | 2008-07-16 | 2010-01-21 | Boehringer Ingelheim International Gmbh | New chemical compounds |
Also Published As
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| MX2013004004A (es) | 2013-04-24 |
| JP2013544781A (ja) | 2013-12-19 |
| EA022299B1 (ru) | 2015-12-30 |
| HUE027149T2 (en) | 2016-10-28 |
| KR101803126B1 (ko) | 2017-11-29 |
| JP5931885B2 (ja) | 2016-06-08 |
| CA2814369A1 (en) | 2012-04-19 |
| AR083402A1 (es) | 2013-02-21 |
| RS54629B1 (sr) | 2016-08-31 |
| AU2011316199A1 (en) | 2013-05-02 |
| SI2627631T1 (sl) | 2016-04-29 |
| EP2627631B1 (de) | 2015-12-16 |
| EP2627631A1 (de) | 2013-08-21 |
| US20130296274A1 (en) | 2013-11-07 |
| CY1117287T1 (el) | 2017-04-26 |
| DK2627631T3 (en) | 2016-02-01 |
| BR112013008886B1 (pt) | 2021-07-13 |
| KR20130143053A (ko) | 2013-12-30 |
| PL2627631T3 (pl) | 2016-04-29 |
| SG189853A1 (en) | 2013-06-28 |
| AU2011316199B2 (en) | 2015-07-23 |
| CN103153951A (zh) | 2013-06-12 |
| CA2814369C (en) | 2019-01-15 |
| HK1186179A1 (zh) | 2014-03-07 |
| HRP20160249T1 (hr) | 2016-04-08 |
| EA201300442A1 (ru) | 2013-11-29 |
| ES2563317T3 (es) | 2016-03-14 |
| IL225626A0 (en) | 2013-06-27 |
| WO2012048775A1 (de) | 2012-04-19 |
| US8895535B2 (en) | 2014-11-25 |
| DE102010048374A1 (de) | 2012-04-19 |
| BR112013008886A2 (pt) | 2016-06-28 |
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