PL2627631T3 - Pirrolidynony jako inhibitory metap2 - Google Patents

Pirrolidynony jako inhibitory metap2

Info

Publication number
PL2627631T3
PL2627631T3 PL11761005T PL11761005T PL2627631T3 PL 2627631 T3 PL2627631 T3 PL 2627631T3 PL 11761005 T PL11761005 T PL 11761005T PL 11761005 T PL11761005 T PL 11761005T PL 2627631 T3 PL2627631 T3 PL 2627631T3
Authority
PL
Poland
Prior art keywords
pyrrolidinones
metap2 inhibitors
metap2
inhibitors
Prior art date
Application number
PL11761005T
Other languages
English (en)
Polish (pl)
Inventor
Timo Heinrich
Frank Zenke
Michel Calderini
Djordje Musil
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL2627631T3 publication Critical patent/PL2627631T3/pl

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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PL11761005T 2010-10-13 2011-09-14 Pirrolidynony jako inhibitory metap2 PL2627631T3 (pl)

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SI2573073T1 (sl) * 2011-09-26 2015-02-27 Sanofi Pirazolokinolinonski derivati, njihova priprava in njihova terapevtska uporaba
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EP3045448A4 (en) * 2013-09-12 2017-01-25 Sumitomo Chemical Company Limited Nitrogen-containing saturated heterocyclic compound
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WO2017084096A1 (en) * 2015-11-20 2017-05-26 Eli Lilly And Company Pyrrolidinone compounds
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CA3068059A1 (en) * 2016-06-21 2017-12-28 The University Of Melbourne Activators of hiv latency
WO2018098781A1 (en) * 2016-12-01 2018-06-07 Eli Lilly And Company Pyrrolidinone compounds
EP3689870B1 (en) * 2017-09-27 2022-07-13 Kagoshima University Analgesic drug using pac1 receptor antagonistic drug
CN108409630B (zh) * 2018-02-07 2021-01-15 宁波大学 一种水相中3-羟基-2-吲哚酮衍生物的制备方法
BR112021014220A2 (pt) * 2019-01-22 2022-01-18 Merck Patent Gmbh Derivados heterocíclicos
CA3145579A1 (en) * 2019-07-03 2021-01-07 Merck Patent Gmbh Process for manufacturing (s)-3-hydroxy-1-(1h-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide
CN112480100B (zh) * 2019-09-11 2022-10-14 康威(广州)生物科技有限公司 吡咯烷酮衍生物
CN110759843A (zh) * 2019-09-30 2020-02-07 东北师范大学 一种氟叠氮取代的四元杂环化合物的制备和应用
CN115989027A (zh) 2020-07-09 2023-04-18 默克专利股份公司 甲硫氨酸氨肽酶2抑制剂和vegfr/vegf抑制剂的组合
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
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RS54629B1 (sr) 2016-08-31
MX2013004004A (es) 2013-04-24
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KR20130143053A (ko) 2013-12-30
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